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GENE：DYNC1LI2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol DYNC1LI2
FullNmae dynein cytoplasmic 1 light intermediate chain 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:2966
EnsembleID ENSG00000135720
Uniprot O43237

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
DYNC1LI2 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
DYNC1LI2 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
DYNC1LI2 cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
DYNC1LI2 GO:0000226,GO:0000776,GO:0005524,GO:0005770,GO:0005813,GO:0005829,GO:0005868,GO:0005874,GO:0007018,GO:0016020,GO:0030286,GO:0042802,GO:0045504,GO:0051642,GO:1990090

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
DYNC1LI2 hsa:1783 path:hsa04145 Phagosome - Homo sapiens (human)
DYNC1LI2 hsa:1783 path:hsa04814 Motor proteins - Homo sapiens (human)
DYNC1LI2 hsa:1783 path:hsa04962 Vasopressin-regulated water reabsorption - Homo sapiens (human)
DYNC1LI2 hsa:1783 path:hsa05132 Salmonella infection - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR DYNC1LI2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 DYNC1LI2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 DYNC1LI2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF DYNC1LI2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 DYNC1LI2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 DYNC1LI2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 DYNC1LI2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A DYNC1LI2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF DYNC1LI2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000009262D DYNC1LI2 18591254 25416803 mrna cleavage,inhibition array technology TarBase
URS00000D2680 DYNC1LI2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00004283FE DYNC1LI2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000308E4D DYNC1LI2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000345DEB DYNC1LI2 21572407 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000042E1F DYNC1LI2 21572407 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00000600E6 DYNC1LI2 21572407 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS000049FAE8 DYNC1LI2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000043D2C1 DYNC1LI2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000008AA34 DYNC1LI2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000118224 DYNC1LI2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002C02E4 DYNC1LI2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000045DBD DYNC1LI2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000037D7E5 DYNC1LI2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00003883FE DYNC1LI2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000006FDD4 DYNC1LI2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000DDD35 DYNC1LI2 21572407 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 DYNC1LI2 21572407 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 DYNC1LI2 21572407 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00002075FA DYNC1LI2 21572407 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS000039E1E1 DYNC1LI2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000251D0B DYNC1LI2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000315338 DYNC1LI2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00001C11BC DYNC1LI2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000031602A DYNC1LI2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002C0FCB DYNC1LI2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000236310 DYNC1LI2 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS000018C928 DYNC1LI2 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00000C85B2 DYNC1LI2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00002FC5B0 DYNC1LI2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000027352D DYNC1LI2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00003D4175 DYNC1LI2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000B989F DYNC1LI2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000043C1C3 DYNC1LI2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000048BA36 DYNC1LI2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00003FBC84 DYNC1LI2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000075AB0E DYNC1LI2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00001C0099 DYNC1LI2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000006372A DYNC1LI2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000039A052 DYNC1LI2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00001CC4BD DYNC1LI2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000B0E50 DYNC1LI2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00005E1A16 DYNC1LI2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000355E82 DYNC1LI2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000045147B DYNC1LI2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00001A7F58 DYNC1LI2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000041FA2C DYNC1LI2 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
SNW1 DYNC1LI2 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CDC5L DYNC1LI2 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
DYNLL1 DYNC1LI2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RPS26 DYNC1LI2 25348397 N/A physical interaction ComPPI
RACK1 DYNC1LI2 25348397 N/A physical interaction ComPPI
FLNA DYNC1LI2 25348397 N/A physical interaction ComPPI
CUL3 DYNC1LI2 25348397 N/A physical interaction ComPPI
DYNC1LI1 DYNC1LI2 25348397 N/A physical interaction ComPPI
NTRK1 DYNC1LI2 25348397 N/A physical interaction ComPPI
YBX1 DYNC1LI2 25348397 N/A physical interaction ComPPI
DYNLT3 DYNC1LI2 25348397 N/A physical interaction ComPPI
CFTR DYNC1LI2 25348397 N/A physical interaction ComPPI
HNRNPA2B1 DYNC1LI2 25348397 N/A physical interaction ComPPI
DYNC1H1 DYNC1LI2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ELAVL1 DYNC1LI2 25348397 N/A physical interaction ComPPI
DYNLT1 DYNC1LI2 24234451 25348397 27173435 association,physical association physical interaction,tandem affinity purification,inference by socio-affinity scoring ComPPI,IntAct
NIN DYNC1LI2 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
DYNLRB1 DYNC1LI2 25348397 N/A physical interaction ComPPI
NMT1 DYNC1LI2 25348397 N/A physical interaction ComPPI
DMTN DYNC1LI2 14525934 16169070 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
RPSA DYNC1LI2 25348397 N/A physical interaction ComPPI
NINL DYNC1LI2 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
APP DYNC1LI2 25348397 N/A physical interaction ComPPI
DYNC1I1 DYNC1LI2 25348397 N/A physical interaction ComPPI
DYNC1LI2 RPS23 25348397 N/A physical interaction ComPPI
DYNC1LI2 RPS5 25348397 N/A physical interaction ComPPI

Source Target Pmid Interactiontype Methods Database
URS00009BD9F3 DYNC1LI2 27087310 direct interaction,inhibition N/A NPInter

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