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GENE：EPAS1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol EPAS1
FullNmae endothelial PAS domain protein 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:3374
EnsembleID ENSG00000116016
Uniprot Q99814

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
EPAS1 mpt 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
EPAS1 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
EPAS1 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
EPAS1 GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0000981,GO:0001223,GO:0001228,GO:0001525,GO:0001666,GO:0001892,GO:0001974,GO:0002027,GO:0002070,GO:0005515,GO:0005654,GO:0005667,GO:0005829,GO:0006357,GO:0007005,GO:0007165,GO:0007601,GO:0016607,GO:0030218,GO:0030324,GO:0042415,GO:0042789,GO:0043129,GO:0043565,GO:0043619,GO:0045944,GO:0046982,GO:0046982,GO:0048625,GO:0060586,GO:0061629,GO:0071456,GO:0071456,GO:0120162,GO:2000434

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
EPAS1 hsa:2034 path:hsa05200 Pathways in cancer - Homo sapiens (human)
EPAS1 hsa:2034 path:hsa05211 Renal cell carcinoma - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
EPAS1 EGLN1 17353276 23180781 physical association pull down InnateDB
EGLN3 EPAS1 17353276 23180781 physical association pull down InnateDB
EIF3E EPAS1 17324924 23180781 physical association anti tag coimmunoprecipitation,two hybrid InnateDB
EPAS1 BAX 17324924 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR EPAS1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 EPAS1 11799066 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator,chromatin immunoprecipitation assay TFlink
ESR1 EPAS1 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
ETS1 EPAS1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 EPAS1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 EPAS1 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA3 EPAS1 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 EPAS1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 EPAS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA EPAS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF EPAS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 EPAS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 EPAS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 EPAS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS EPAS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A EPAS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF EPAS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 EPAS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 EPAS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 EPAS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HIF3A EPAS1 19755485 trascriptional regulation,stimulation inferred by curator TFlink
HOXA1 EPAS1 17213808 trascriptional regulation,stimulation inferred by curator TFlink
RELA EPAS1 20495570 trascriptional regulation,stimulation inferred by curator TFlink
STAT3 EPAS1 23991099 trascriptional regulation,stimulation inferred by curator TFlink
USF2 EPAS1 23991099 trascriptional regulation,stimulation inferred by curator TFlink
YY1 EPAS1 19483472 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00002367FA EPAS1 22745131 rna interference,inhibition quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00002367FA EPAS1 22745131 25416803 mrna cleavage,inhibition quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00004F4657 EPAS1 23222716 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000042E1F EPAS1 24194900 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS00002075FA EPAS1 24194900 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
CSNK1D EPAS1 22135298 phosphorylation N/A PhosphoSite
PDPK1 EPAS1 22135298 phosphorylation N/A PhosphoSite
EGLN3 EPAS1 25361965 interaction type N/A PTMCode2
EPAS1 EGLN3 25361965 interaction type N/A PTMCode2
EPAS1 BBS4 25361965 interaction type N/A PTMCode2
BBS4 EPAS1 25361965 interaction type N/A PTMCode2
EPAS1 ARNT2 25361965 interaction type N/A PTMCode2
ARNT2 EPAS1 25361965 interaction type N/A PTMCode2
EPAS1 PRKD1 25361965 interaction type N/A PTMCode2
PRKD1 EPAS1 25361965 interaction type N/A PTMCode2
EPAS1 ARNT 25361965 interaction type N/A PTMCode2
ARNT EPAS1 25361965 interaction type N/A PTMCode2
EPAS1 EGLN1 25361965 interaction type N/A PTMCode2
EGLN1 EPAS1 25361965 interaction type N/A PTMCode2
EPAS1 ARNTL 25361965 interaction type N/A PTMCode2
ARNTL EPAS1 25361965 interaction type N/A PTMCode2
VHL EPAS1 25361965 interaction type N/A PTMCode2
EPAS1 VHL 25361965 interaction type N/A PTMCode2
BBS2 EPAS1 25361965 interaction type N/A PTMCode2
EPAS1 BBS2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PIAS2 EPAS1 25348397 N/A anti tag coimmunoprecipitation ComPPI
DPY30 EPAS1 25348397 N/A physical interaction ComPPI
FBP1 EPAS1 24234451 25043030 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
NPM1 EPAS1 25348397 N/A physical interaction ComPPI
PSMC3 EPAS1 25348397 N/A physical interaction ComPPI
SMARCC1 EPAS1 25348397 N/A physical interaction ComPPI
EMD EPAS1 25348397 N/A physical interaction ComPPI
BATF EPAS1 25348397 N/A physical interaction ComPPI
MED8 EPAS1 25348397 N/A physical interaction ComPPI
EIF3E EPAS1 14525934 17324924 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,fluorescence microscopy,in vivo,two hybrid ComPPI,HPRD,IntAct
BBS2 EPAS1 18000879 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
EGLN3 EPAS1 14525934 15474027 17353276 24234451 25348397 physical association experimental interaction detection,pull down,physical interaction,in vitro ComPPI,HPRD,IntAct
SP1 EPAS1 17024177 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
JUN EPAS1 25348397 N/A physical interaction ComPPI
CREBBP EPAS1 25348397 N/A physical interaction ComPPI
SUMO1 EPAS1 20661221 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
EP300 EPAS1 14525934 15261140 24234451 25348397 physical association experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
SMAD3 EPAS1 14525934 15231748 21057546 24234451 25241761 25348397 27898060 physical association two hybrid,physical interaction,proximity ligation assay,two hybrid ComPPI,HPRD,IntAct,OmniPath
HIF1A EPAS1 25348397 N/A physical interaction ComPPI
PRKD1 EPAS1 14525934 17024177 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
SPP1 EPAS1 25348397 N/A physical interaction ComPPI
RBM4 EPAS1 25348397 N/A anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI
MYBL2 EPAS1 25348397 N/A physical interaction ComPPI
MED1 EPAS1 25348397 N/A physical interaction ComPPI
MED24 EPAS1 25348397 N/A physical interaction ComPPI
UBC EPAS1 25348397 N/A physical interaction ComPPI
HSP90AA1 EPAS1 25348397 N/A physical interaction ComPPI
APC EPAS1 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
TFAP2A EPAS1 25348397 N/A physical interaction ComPPI
PHB EPAS1 25348397 N/A physical interaction ComPPI
SMARCA4 EPAS1 25348397 N/A physical interaction ComPPI
SIN3A EPAS1 25348397 N/A physical interaction ComPPI
IKBKB EPAS1 25348397 N/A physical interaction ComPPI
STAT5A EPAS1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ARID1B EPAS1 25348397 N/A physical interaction ComPPI
SQSTM1 EPAS1 25348397 N/A physical interaction ComPPI
EWSR1 EPAS1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PSMD1 EPAS1 25348397 N/A physical interaction ComPPI
PKM EPAS1 25348397 N/A anti bait coimmunoprecipitation ComPPI
XPO1 EPAS1 25348397 N/A physical interaction ComPPI
SMARCB1 EPAS1 25348397 N/A physical interaction ComPPI
MED22 EPAS1 25348397 N/A physical interaction ComPPI
MED11 EPAS1 25348397 N/A physical interaction ComPPI
VHL EPAS1 10353251 10823831 10878807 11292862 11331613 12604794 14525934 14691554 15611064 17339318 17967880 17986458 21685897 23401859 24234451 25348397 25500545 26342197 27898060 association two hybrid,experimental interaction detection,far western blotting,physical interaction,in vivo ComPPI,HPRD,IntAct,OmniPath
WRNIP1 EPAS1 25348397 N/A physical interaction ComPPI
AKAP8L EPAS1 25348397 N/A physical interaction ComPPI
PHB2 EPAS1 25348397 N/A physical interaction ComPPI
HSPA4 EPAS1 25348397 N/A physical interaction ComPPI
MEF2C EPAS1 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
DROSHA EPAS1 24234451 25348397 26766590 27898060 association anti bait coimmunoprecipitation ComPPI,IntAct,OmniPath
MED23 EPAS1 25348397 N/A physical interaction ComPPI
NDN EPAS1 25348397 N/A physical interaction ComPPI
CTNNB1 EPAS1 25348397 N/A physical interaction ComPPI
USP8 EPAS1 24234451 24378640 25348397 physical association anti bait coimmunoprecipitation,pull down ComPPI,IntAct
MAP1LC3A EPAS1 25348397 N/A physical interaction ComPPI
MED17 EPAS1 25348397 N/A physical interaction ComPPI
SIRT1 EPAS1 25348397 N/A physical interaction ComPPI
ELOB EPAS1 25348397 N/A physical interaction ComPPI
HIF3A EPAS1 25348397 N/A physical interaction ComPPI
F12 EPAS1 21512133 25348397 27898060 N/A physical interaction ComPPI,OmniPath
MED25 EPAS1 25348397 N/A physical interaction ComPPI
MED14 EPAS1 25348397 N/A physical interaction ComPPI
MED12 EPAS1 25348397 N/A physical interaction ComPPI
MED26 EPAS1 25348397 N/A physical interaction ComPPI
PDK1 EPAS1 17024177 24234451 25348397 phosphorylation reaction protein kinase assay ComPPI,IntAct
GTF3C3 EPAS1 25348397 N/A physical interaction ComPPI
ARNTL EPAS1 11018023 14525934 24234451 25348397 9576906 physical association two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD,IntAct
BBS4 EPAS1 18000879 24234451 25348397 physical association two hybrid,coimmunoprecipitation,physical interaction ComPPI,IntAct
TRIM25 EPAS1 25348397 N/A physical interaction ComPPI
ELP1 EPAS1 25348397 N/A physical interaction ComPPI
ELAVL1 EPAS1 25348397 N/A physical interaction ComPPI
ESR1 EPAS1 25348397 N/A physical interaction ComPPI
MCM3 EPAS1 25348397 N/A physical interaction ComPPI
KDM1A EPAS1 25348397 N/A physical interaction ComPPI
MED15 EPAS1 25348397 N/A physical interaction ComPPI
STUB1 EPAS1 25348397 N/A physical interaction ComPPI
CNOT7 EPAS1 25348397 N/A physical interaction ComPPI
SMARCC2 EPAS1 25348397 N/A physical interaction ComPPI
ARNTL2 EPAS1 11018023 14525934 24234451 25348397 physical association two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD,IntAct
PSMB1 EPAS1 25348397 N/A physical interaction ComPPI
TERF2IP EPAS1 21044950 24234451 25348397 physical association physical interaction,bimolecular fluorescence complementation ComPPI,IntAct
SOX10 EPAS1 25348397 N/A physical interaction ComPPI
EPAS1 MAX 14525934 17418410 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
EPAS1 EGLN2 14525934 15474027 17353276 24234451 25348397 physical association experimental interaction detection,pull down,physical interaction,in vitro ComPPI,HPRD,IntAct
EPAS1 EGLN1 14525934 15474027 17353276 24234451 25348397 physical association experimental interaction detection,pull down,physical interaction,in vitro,gal4 vp16 complementation ComPPI,HPRD,IntAct
EPAS1 ARNT 11018023 14525934 19129502 23434853 24234451 25348397 9079689 physical association anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,nuclear magnetic resonance,x-ray crystallography,physical interaction,amplified luminescent proximity homogeneous assay,two hybrid ComPPI,HPRD,IntAct
EPAS1 ARNT2 25348397 N/A physical interaction ComPPI
EPAS1 MCM7 25348397 N/A physical interaction ComPPI
EPAS1 HSP90AA2P 25348397 N/A physical interaction ComPPI
EPAS1 KLHL20 21888897 25348397 27898060 N/A physical interaction ComPPI,OmniPath
EPAS1 ETS1 25348397 N/A physical interaction ComPPI
EPAS1 DPF2 25348397 N/A physical interaction ComPPI
EPAS1 MITF 25348397 N/A physical interaction ComPPI
EPAS1 SSBP3 25348397 N/A physical interaction ComPPI
EPAS1 MED10 25348397 N/A physical interaction ComPPI
EPAS1 MED16 25348397 N/A physical interaction ComPPI
EPAS1 MED20 25348397 N/A physical interaction ComPPI
EPAS1 MED27 25348397 N/A physical interaction ComPPI
EPAS1 MED4 25348397 N/A physical interaction ComPPI
EPAS1 MED29 25348397 N/A physical interaction ComPPI
EPAS1 CNOT1 25348397 N/A physical interaction ComPPI
EPAS1 CNOT10 25348397 N/A physical interaction ComPPI
EPAS1 SMARCA2 25348397 N/A physical interaction ComPPI
EPAS1 NCAPD3 25348397 N/A physical interaction ComPPI
EPAS1 DCAF7 25348397 N/A physical interaction ComPPI
EPAS1 TRIM33 25348397 N/A physical interaction ComPPI
EPAS1 BAG2 25348397 N/A physical interaction ComPPI
EPAS1 DNAJA2 25348397 N/A physical interaction ComPPI
EPAS1 BCL7C 25348397 N/A physical interaction ComPPI
EPAS1 YTHDF2 25348397 N/A physical interaction ComPPI
EPAS1 BBS1 18000879 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
EPAS1 BATF2 25348397 N/A physical interaction ComPPI
EPAS1 DBP 25348397 N/A physical interaction ComPPI
EPAS1 DDIT3 25348397 N/A physical interaction ComPPI
EPAS1 LAMP1 25348397 N/A physical interaction ComPPI
EPAS1 IKBKG 25348397 N/A physical interaction ComPPI
EPAS1 EIF4E2 22678294 24234451 25348397 association,physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
EPAS1 EIF4A1 22678294 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
EPAS1 SSX4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MED18 EPAS1 25348397 N/A physical interaction ComPPI
BATF3 EPAS1 25348397 N/A physical interaction ComPPI
MED7 EPAS1 25348397 N/A physical interaction ComPPI
PDPK1 EPAS1 17024177 27898060 N/A N/A OmniPath
HIF1AN EPAS1 12573436 27898060 inhibition,stimulant N/A OmniPath

Visualization










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