Gene Information gene info

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GENE：HBB

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol HBB
FullNmae hemoglobin subunit beta
LocusType gene with protein product
Status Approved
HGNC_id HGNC:4827
EnsembleID ENSG00000244734
Uniprot P68871

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
HBB autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
HBB GO:0004601,GO:0004601,GO:0005344,GO:0005344,GO:0005515,GO:0005576,GO:0005615,GO:0005829,GO:0005833,GO:0005833,GO:0005833,GO:0005833,GO:0005833,GO:0008217,GO:0015670,GO:0015671,GO:0015671,GO:0015671,GO:0015671,GO:0019825,GO:0019825,GO:0020037,GO:0030185,GO:0030185,GO:0030492,GO:0031720,GO:0031720,GO:0031721,GO:0031838,GO:0031838,GO:0042542,GO:0042744,GO:0042744,GO:0043177,GO:0045429,GO:0046872,GO:0070062,GO:0070293,GO:0070527,GO:0071682,GO:0072562,GO:0097746,GO:0098869,GO:1904724,GO:1904813

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
HBB hsa:3043 path:hsa05143 African trypanosomiasis - Homo sapiens (human)
HBB hsa:3043 path:hsa05144 Malaria - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PITX3 HBB 22278372 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
DLX4 HBB 1984681 trascriptional regulation,stimulation electrophoretic mobility shift assay,DNase I footprinting TFlink
ESR2 HBB 20034404 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA1 HBB 15358512 15833715 19941826 20564185 2461328 3243278 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay,DNase I footprinting TFlink
GATA2 HBB 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
MYC HBB 12695333 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 HBB 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TP53 HBB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPB HBB 15833715 trascriptional regulation,stimulation inferred by curator TFlink
CEBPG HBB 15833715 trascriptional regulation,stimulation inferred by curator TFlink
KLF1 HBB 21539536 trascriptional regulation,stimulation inferred by curator TFlink
NFE2L2 HBB 15206576 trascriptional regulation,stimulation inferred by curator TFlink
NFYA HBB 15833715 trascriptional regulation,stimulation inferred by curator TFlink
NFYB HBB 15833715 trascriptional regulation,stimulation inferred by curator TFlink
NFYC HBB 15833715 trascriptional regulation,stimulation inferred by curator TFlink
POU2F2 HBB 2302733 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
HBA1 HBB 25361965 interaction type N/A PTMCode2
HBB HBA1 25361965 interaction type N/A PTMCode2
HBB HP 25361965 interaction type N/A PTMCode2
HP HBB 25361965 interaction type N/A PTMCode2
HBB HBB 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
HBZ HBB 11159543 11747442 14525934 24234451 25348397 27898060 6683087 physical association affinity chromatography technology,experimental interaction detection,in vitro,electrophoretic mobility-based method ComPPI,HPRD,IntAct,OmniPath
HSPA8 HBB 25348397 N/A physical interaction ComPPI
HBQ1 HBB 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
H2BC4 HBB 25348397 N/A physical interaction ComPPI
MCM2 HBB 25348397 N/A physical interaction ComPPI
HBA1 HBB 10390349 10930828 11724557 12122004 14525934 1552945 15835899 16169070 24234451 25348397 27898060 29997244 6644819 6683087 8980683 9441940 9830011 9894000 physical association bioluminescence resonance energy transfer,two hybrid,experimental interaction detection,x-ray crystallography,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,luminescence based mammalian interactome mapping,electrophoretic mobility-based method,two hybrid prey pooling approach,two hybrid ComPPI,HPRD,IntAct,OmniPath
RBM8A HBB 25348397 N/A physical interaction ComPPI
PNKP HBB 25348397 N/A physical interaction ComPPI
HBG2 HBB 11827978 14525934 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
HSPA1A HBB 24234451 25156257 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
HSPA1B HBB 25348397 N/A two hybrid,physical interaction ComPPI
SEMG2 HBB 25348397 N/A physical interaction ComPPI
PDLIM7 HBB 25348397 N/A physical interaction ComPPI
MAPK6 HBB 25348397 N/A physical interaction ComPPI
PABPC1 HBB 25348397 N/A physical interaction ComPPI
MDM4 HBB 25348397 N/A physical interaction ComPPI
PSMC5 HBB 25348397 N/A physical interaction ComPPI
UPF2 HBB 25348397 N/A physical interaction ComPPI
CYTIP HBB 25348397 N/A physical interaction ComPPI
CDK2 HBB 25348397 N/A physical interaction ComPPI
SMG6 HBB 25348397 N/A physical interaction ComPPI
COPS3 HBB 25348397 N/A physical interaction ComPPI
UPF3B HBB 25348397 N/A physical interaction ComPPI
UPF1 HBB 25348397 N/A physical interaction ComPPI
IGHM HBB 15174051 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
DACH1 HBB 25348397 N/A physical interaction ComPPI
BMP5 HBB 25348397 N/A physical interaction ComPPI
PLXNB1 HBB 25348397 N/A physical interaction ComPPI
UPF3A HBB 25348397 N/A physical interaction ComPPI
AKT1 HBB 25348397 N/A physical interaction ComPPI
GRID1 HBB 25348397 N/A physical interaction ComPPI
LPAR2 HBB 25348397 N/A physical interaction ComPPI
CEP250 HBB 25348397 N/A physical interaction ComPPI
PAN2 HBB 25348397 N/A physical interaction ComPPI
EIF4A3 HBB 25348397 N/A physical interaction ComPPI
UCHL5 HBB 25348397 N/A physical interaction ComPPI
SMG7 HBB 25348397 N/A physical interaction ComPPI
MED4 HBB 25348397 N/A physical interaction ComPPI
HBB SELENOT 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
HBB HP 14525934 25348397 7378053 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
HBB DMWD 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HBB GDAP1 25348397 N/A physical interaction ComPPI
HBB FAM189B 25348397 N/A physical interaction ComPPI
HBB DHRS2 25348397 N/A physical interaction ComPPI
HBB GDPD1 25348397 N/A physical interaction ComPPI
HBB MGAT4B 25348397 N/A physical interaction ComPPI
HBB NDUFAF5 25348397 N/A physical interaction ComPPI
HBB AGA 25348397 N/A physical interaction ComPPI
HBB PNPLA1 25348397 N/A physical interaction ComPPI
HBB PGPEP1 25348397 N/A physical interaction ComPPI
HBB TMEM92 25348397 N/A physical interaction ComPPI
HBB JOSD2 25348397 N/A physical interaction ComPPI
HBB ERBB3 25348397 N/A physical interaction ComPPI
HBB TP53 25348397 N/A physical interaction ComPPI
HBB MSL2 25348397 N/A physical interaction ComPPI
HBB GSTT1 25348397 N/A physical interaction ComPPI
HBB SLC2A14 25348397 N/A physical interaction ComPPI
HBB H2BC11 25348397 N/A physical interaction ComPPI
HBB GK 25348397 N/A physical interaction ComPPI
HBB FAM234B 25348397 N/A physical interaction ComPPI
HBB FRMD1 25348397 N/A physical interaction ComPPI
HBB APCDD1 25348397 N/A physical interaction ComPPI
HBB CYLD 25348397 N/A physical interaction ComPPI
HBB HSD17B10 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
HBB BCAR1 24234451 25348397 28007913 association anti bait coimmunoprecipitation ComPPI,IntAct
HBB HBB 14525934 1512262 6644819 6726807 N/A experimental interaction detection HPRD
MKI67 HBB 24234451 26949251 association anti tag coimmunoprecipitation IntAct
NCL HBB 16508016 27898060 stimulant N/A OmniPath
HP HBB 27898060 7378053 9315856 inhibition N/A OmniPath
ARSA HBB 237937 27898060 stimulant N/A OmniPath
HBB CD163 16522161 27898060 stimulant N/A OmniPath

Visualization










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