GENE：LAMP2
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | LAMP2 |
| FullNmae | lysosomal associated membrane protein 2 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:6501 |
| EnsembleID | ENSG00000005893 |
| Uniprot | P13473 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| LAMP2 | lysosomal_cd | 36341760 | 220 lysosome-dependent cell death genes. | retulator signature |
| LAMP2 | lysosomal_cd | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
| LAMP2 | autophagy | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| LAMP2 | autophagy | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| LAMP2 | GO:0000421,GO:0005515,GO:0005615,GO:0005764,GO:0005765,GO:0005765,GO:0005765,GO:0005770,GO:0005886,GO:0005886,GO:0006605,GO:0009267,GO:0009267,GO:0016020,GO:0017038,GO:0019899,GO:0019904,GO:0030670,GO:0031088,GO:0031088,GO:0031647,GO:0031902,GO:0031902,GO:0035577,GO:0043202,GO:0043231,GO:0044754,GO:0046716,GO:0050821,GO:0061684,GO:0061684,GO:0061684,GO:0061740,GO:0061740,GO:0061740,GO:0070062,GO:0070062,GO:0097352,GO:0097352,GO:0098857,GO:0101003,GO:1905146 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| LAMP2 | hsa:3920 | path:hsa04140 | Autophagy - animal - Homo sapiens (human) |
| LAMP2 | hsa:3920 | path:hsa04142 | Lysosome - Homo sapiens (human) |
| LAMP2 | hsa:3920 | path:hsa04145 | Phagosome - Homo sapiens (human) |
| LAMP2 | hsa:3920 | path:hsa05152 | Tuberculosis - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | LAMP2 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ESR1 | LAMP2 | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| ETS1 | LAMP2 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA2 | LAMP2 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA3 | LAMP2 | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXA1 | LAMP2 | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | LAMP2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | LAMP2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | LAMP2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | LAMP2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | LAMP2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | LAMP2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | LAMP2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | LAMP2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS000009262D | LAMP2 | 18591254 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS000007D64A | LAMP2 | 20371350 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000F0F49 | LAMP2 | 20371350 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000040EE1D | LAMP2 | 20371350 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000041CB9C | LAMP2 | 20371350 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000171CD1 | LAMP2 | 20371350 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000007F792 | LAMP2 | 23824327 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS000076B539 | LAMP2 | 23824327 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS00002C02E4 | LAMP2 | 23824327 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS000042619A | LAMP2 | 23824327 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS00002FC5B0 | LAMP2 | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001A7F58 | LAMP2 | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001B341F | LAMP2 | 25416803 26993299 | mrna cleavage,inhibition | miRNA interference luciferase reporter assay | TarBase |
| URS00000821E0 | LAMP2 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS0000209F04 | LAMP2 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS00004BC299 | LAMP2 | 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS00002E628F | LAMP2 | 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS000043D2C1 | LAMP2 | 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| BCAS2 | LAMP2 | 25348397 | N/A | physical interaction | ComPPI |
| LGALS3 | LAMP2 | 25348397 | N/A | physical interaction | ComPPI |
| DDX21 | LAMP2 | 25348397 | N/A | physical interaction | ComPPI |
| HSPA8 | LAMP2 | 23455607 24234451 25348397 | colocalization | physical interaction,fluorescence microscopy | ComPPI,IntAct |
| NPM1 | LAMP2 | 25348397 | N/A | physical interaction | ComPPI |
| SNRPA1 | LAMP2 | 25348397 | N/A | physical interaction | ComPPI |
| PCNA | LAMP2 | 25348397 | N/A | physical interaction | ComPPI |
| TUBB | LAMP2 | 25348397 | N/A | physical interaction | ComPPI |
| GNL3L | LAMP2 | 25348397 | N/A | physical interaction | ComPPI |
| LYN | LAMP2 | 25348397 | N/A | physical interaction | ComPPI |
| CREBBP | LAMP2 | 25348397 | N/A | physical interaction | ComPPI |
| EP300 | LAMP2 | 25348397 | N/A | physical interaction | ComPPI |
| HIF1A | LAMP2 | 19458911 23880665 25348397 27898060 | N/A | physical interaction | ComPPI,OmniPath |
| TUBG1 | LAMP2 | 25348397 | N/A | physical interaction | ComPPI |
| TUBA1B | LAMP2 | 25348397 | N/A | physical interaction | ComPPI |
| JAK1 | LAMP2 | 25348397 | N/A | physical interaction | ComPPI |
| RBM14 | LAMP2 | 25348397 | N/A | physical interaction | ComPPI |
| SUB1 | LAMP2 | 25348397 | N/A | physical interaction | ComPPI |
| CDC6 | LAMP2 | 25348397 | N/A | physical interaction | ComPPI |
| HNRNPU | LAMP2 | 25348397 | N/A | physical interaction | ComPPI |
| EWSR1 | LAMP2 | 25348397 | N/A | physical interaction | ComPPI |
| TNF | LAMP2 | 25348397 | N/A | physical interaction | ComPPI |
| NR2F2 | LAMP2 | 25348397 | N/A | physical interaction | ComPPI |
| EPRS1 | LAMP2 | 25348397 | N/A | physical interaction | ComPPI |
| RBBP4 | LAMP2 | 25348397 | N/A | physical interaction | ComPPI |
| BRF2 | LAMP2 | 25348397 | N/A | physical interaction | ComPPI |
| MDM2 | LAMP2 | 25348397 | N/A | physical interaction | ComPPI |
| ADRB2 | LAMP2 | 19424180 24234451 25348397 | colocalization | fluorescence microscopy | ComPPI,IntAct |
| NCSTN | LAMP2 | 25348397 | N/A | physical interaction | ComPPI |
| RHEB | LAMP2 | 25348397 | N/A | physical interaction | ComPPI |
| PIAS4 | LAMP2 | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| UCHL1 | LAMP2 | 14525934 18550537 25348397 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| CTSA | LAMP2 | 12505983 14525934 25348397 27898060 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD,OmniPath |
| LAMP2 | ELAVL1 | 25348397 | N/A | physical interaction | ComPPI |
| LAMP2 | MCM7 | 25348397 | N/A | physical interaction | ComPPI |
| LAMP2 | SF3B3 | 25348397 | N/A | physical interaction | ComPPI |
| LAMP2 | PRPF19 | 25348397 | N/A | physical interaction | ComPPI |
| LAMP2 | SRP14 | 25348397 | N/A | physical interaction | ComPPI |
| LAMP2 | PDS5B | 25348397 | N/A | physical interaction | ComPPI |
| LAMP2 | RFC1 | 25348397 | N/A | physical interaction | ComPPI |
| LAMP2 | SF3B6 | 25348397 | N/A | physical interaction | ComPPI |
| LAMP2 | SAFB | 25348397 | N/A | physical interaction | ComPPI |
| LAMP2 | HP1BP3 | 25348397 | N/A | physical interaction | ComPPI |
| LAMP2 | THOC6 | 25348397 | N/A | physical interaction | ComPPI |
| LAMP2 | SNCA | 25348397 | N/A | physical interaction | ComPPI |
| LAMP2 | NEK6 | 25348397 | N/A | physical interaction | ComPPI |
| LAMP2 | STK39 | 25348397 | N/A | physical interaction | ComPPI |
| LAMP2 | GUF1 | 25348397 | N/A | physical interaction | ComPPI |
| LAMP2 | CDYL | 25348397 | N/A | physical interaction | ComPPI |
| LAMP2 | GPD1L | 25348397 | N/A | physical interaction | ComPPI |
| LAMP2 | ORC5 | 25348397 | N/A | physical interaction | ComPPI |
| LAMP2 | XRCC3 | 25348397 | N/A | physical interaction | ComPPI |
| LAMP2 | PPTC7 | 25348397 | N/A | physical interaction | ComPPI |
| LAMP2 | RAB18 | 25348397 | N/A | physical interaction | ComPPI |
| LAMP2 | TAZ | 25348397 | N/A | physical interaction | ComPPI |
| LAMP2 | TTK | 25348397 | N/A | physical interaction | ComPPI |
| LAMP2 | SOD1 | 21252941 24234451 25348397 | colocalization | fluorescence microscopy | ComPPI,IntAct |
| LAMP2 | LRRK2 | 23455607 24234451 25348397 | colocalization,physical association | anti tag coimmunoprecipitation,confocal microscopy | ComPPI,IntAct |
| LAMP2 | RRAGB | 23394946 24234451 25348397 | physical association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| LAMP2 | RPTOR | 23953116 24234451 25348397 | physical association | proximity ligation assay | ComPPI,IntAct |
| VPS35 | LAMP2 | 25348397 | N/A | physical interaction | ComPPI |
| DDX19B | LAMP2 | 25348397 | N/A | physical interaction | ComPPI |
| APEH | LAMP2 | 25348397 | N/A | physical interaction | ComPPI |
| OTULIN | LAMP2 | 25348397 | N/A | physical interaction | ComPPI |