GENE：LAMTOR2
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | LAMTOR2 |
| FullNmae | late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:29796 |
| EnsembleID | ENSG00000116586 |
| Uniprot | Q9Y2Q5 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| LAMTOR2 | ferroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| LAMTOR2 | autophagy | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| LAMTOR2 | autophagy | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| LAMTOR2 | GO:0001558,GO:0005085,GO:0005515,GO:0005765,GO:0005765,GO:0005765,GO:0005765,GO:0005770,GO:0005886,GO:0008104,GO:0010008,GO:0010761,GO:0031902,GO:0032008,GO:0032008,GO:0035579,GO:0038202,GO:0043410,GO:0060090,GO:0070821,GO:0071230,GO:0071230,GO:0071230,GO:0071986,GO:0071986,GO:0071986,GO:0150116,GO:1902414,GO:1904263,GO:1990877 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| LAMTOR2 | hsa:28956 | path:hsa04150 | mTOR signaling pathway - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ETS1 | LAMTOR2 | 20019798 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| CTCF | LAMTOR2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | LAMTOR2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| MAP2K1 | LAMTOR2 | 25348397 | N/A | physical interaction | ComPPI |
| LAMTOR3 | LAMTOR2 | 11266467 14525934 20381137 21516116 21988832 22980980 24234451 25348397 25416956 25561175 | association,physical association | anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,two hybrid array,in vitro,in vivo,two hybrid prey pooling approach,validated two hybrid,two hybrid | ComPPI,HPRD,IntAct |
| ATP6AP2 | LAMTOR2 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| RAB9A | LAMTOR2 | 24234451 25348397 29568061 | association | proximity-dependent biotin identification | ComPPI,IntAct |
| ECE1 | LAMTOR2 | 25348397 | N/A | physical interaction | ComPPI |
| MTOR | LAMTOR2 | 22980980 24234451 25348397 | association | cross-linking study,physical interaction | ComPPI,IntAct |
| LAMTOR2 | FLOT1 | 25348397 | N/A | physical interaction | ComPPI |
| LAMTOR2 | SDHB | 25348397 | N/A | physical interaction | ComPPI |
| LAMTOR2 | DYNLRB1 | 25348397 | N/A | physical interaction | ComPPI |
| LAMTOR2 | MRPS21 | 25348397 | N/A | physical interaction | ComPPI |
| LAMTOR2 | ILF3 | 25348397 | N/A | physical interaction | ComPPI |
| LAMTOR2 | LAMTOR5 | 22980980 24234451 25348397 25561175 25567906 | association | affinity chromatography technology,anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| LAMTOR2 | RRAGD | 20381137 24234451 25348397 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| LAMTOR2 | RRAGB | 20381137 22980980 24234451 25348397 25567906 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| LAMTOR2 | RRAGC | 20381137 22980980 24234451 25348397 25561175 25567906 | association | affinity chromatography technology,anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| LAMTOR2 | RPTOR | 22980980 24234451 25348397 | association | cross-linking study,physical interaction | ComPPI,IntAct |
| LAMTOR2 | RRAGA | 20381137 22980980 24234451 25348397 25561175 25567906 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| ATP6V1B2 | LAMTOR2 | 24234451 25348397 25567906 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |