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GENE：LAMTOR3

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol LAMTOR3
FullNmae late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
LocusType gene with protein product
Status Approved
HGNC_id HGNC:15606
EnsembleID ENSG00000109270
Uniprot Q9UHA4

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
LAMTOR3 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
LAMTOR3 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
LAMTOR3 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
LAMTOR3 GO:0005085,GO:0005515,GO:0005765,GO:0005765,GO:0005765,GO:0005886,GO:0005925,GO:0008104,GO:0010008,GO:0019209,GO:0031902,GO:0032008,GO:0032008,GO:0035579,GO:0038202,GO:0043410,GO:0060090,GO:0070062,GO:0070821,GO:0071230,GO:0071230,GO:0071230,GO:0071986,GO:0071986,GO:0071986,GO:1902414,GO:1904263,GO:1990877

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
LAMTOR3 hsa:8649 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
LAMTOR3 hsa:8649 path:hsa04150 mTOR signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
MAPK1 LAMTOR3 11266467 23180781 physical association pull down InnateDB
LAMTOR3 ELAVL1 19322201 23180781 physical association anti tag coimmunoprecipitation InnateDB
LAMTOR3 MAPK3 23331499 9733512 stimulation N/A SignaLink
LAMTOR3 MAP2K1 11266467 15547943 23331499 9733512 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
LAMTOR3 MAPK3 20005715 interaction type N/A PSP
LAMTOR3 MAPK1 20005715 interaction type N/A PSP
LAMTOR3 MAP2K1 20005715 interaction type N/A PSP,SignaLink
LAMTOR3 MAPK1 11266467 11266467 18988627 20005715 20005715 21071413 N/A N/A SignaLink
LAMTOR3 MAPK3 20005715 20005715 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
ETS1 LAMTOR3 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 LAMTOR3 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TP53 LAMTOR3 18922183 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 LAMTOR3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF LAMTOR3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF LAMTOR3 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000204177 LAMTOR3 24374217 25416803 mrna cleavage,inhibition clip TarBase
URS000047A67D LAMTOR3 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00005ACA7C LAMTOR3 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000331800 LAMTOR3 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002B0920 LAMTOR3 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001EFEC1 LAMTOR3 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000285DCB LAMTOR3 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00004C5774 LAMTOR3 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002D2333 LAMTOR3 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000085F64 LAMTOR3 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000076B539 LAMTOR3 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000250A40 LAMTOR3 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000031D186 LAMTOR3 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000002569A LAMTOR3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000009C45F LAMTOR3 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PDE4DIP LAMTOR3 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NDUFB9 LAMTOR3 25348397 N/A physical interaction ComPPI
RAB14 LAMTOR3 25348397 N/A physical interaction ComPPI
APOL6 LAMTOR3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ZBTB43 LAMTOR3 25348397 N/A physical interaction ComPPI
RPS7 LAMTOR3 25348397 N/A physical interaction ComPPI
VAMP2 LAMTOR3 25348397 N/A physical interaction ComPPI
TOMM22 LAMTOR3 25348397 N/A physical interaction ComPPI
LAMTOR4 LAMTOR3 22980980 24234451 25348397 25561175 association anti tag coimmunoprecipitation ComPPI,IntAct
MRM3 LAMTOR3 25348397 N/A physical interaction ComPPI
WDR83 LAMTOR3 25348397 N/A physical interaction ComPPI
PEF1 LAMTOR3 25348397 N/A physical interaction ComPPI
BORCS6 LAMTOR3 25348397 N/A physical interaction ComPPI
MAPK1 LAMTOR3 11266467 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
MAPK3 LAMTOR3 14525934 25348397 9733512 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
SUFU LAMTOR3 14525934 14611647 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
RHOB LAMTOR3 25348397 N/A physical interaction ComPPI
CDKN2A LAMTOR3 25348397 N/A physical interaction ComPPI
PICALM LAMTOR3 25348397 N/A physical interaction ComPPI
PTPN1 LAMTOR3 25348397 N/A physical interaction ComPPI
SSBP1 LAMTOR3 25348397 N/A physical interaction ComPPI
ZSCAN4 LAMTOR3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MAP2K1 LAMTOR3 14525934 25348397 9733512 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
LAMTOR3 LAMTOR2 11266467 14525934 20381137 21516116 21988832 22980980 24234451 25348397 25416956 25561175 association,physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,two hybrid array,in vitro,in vivo,two hybrid prey pooling approach,validated two hybrid,two hybrid ComPPI,HPRD,IntAct
LAMTOR3 CDKN2A 25348397 N/A physical interaction ComPPI
LAMTOR3 CPNE6 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
LAMTOR3 UBR1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
LAMTOR3 ADAMTS10 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
LAMTOR3 QARS1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
LAMTOR3 CEBPZ 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
LAMTOR3 ELAVL1 25348397 N/A physical interaction ComPPI
LAMTOR3 RAB21 25348397 N/A physical interaction ComPPI
LAMTOR3 NNT 25348397 N/A physical interaction ComPPI
LAMTOR3 NDUFA2 25348397 N/A physical interaction ComPPI
LAMTOR3 ATP6V1E1 25348397 N/A physical interaction ComPPI
LAMTOR3 MPV17 25348397 N/A physical interaction ComPPI
LAMTOR3 DDX28 25348397 N/A physical interaction ComPPI
LAMTOR3 RALB 25348397 N/A physical interaction ComPPI
LAMTOR3 LAMTOR1 22980980 24234451 25348397 25561175 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LAMTOR3 MRPS35 25348397 N/A physical interaction ComPPI
LAMTOR3 RAB5C 25348397 N/A physical interaction ComPPI
LAMTOR3 MRPL22 25348397 N/A physical interaction ComPPI
LAMTOR3 TSR1 25348397 N/A physical interaction ComPPI
LAMTOR3 NDUFB11 25348397 N/A physical interaction ComPPI
LAMTOR3 MSLN 25348397 N/A physical interaction ComPPI
LAMTOR3 LPCAT1 25348397 N/A physical interaction ComPPI
LAMTOR3 NDUFB7 25348397 N/A physical interaction ComPPI
LAMTOR3 COX15 25348397 N/A physical interaction ComPPI
LAMTOR3 PUF60 25348397 N/A physical interaction ComPPI
LAMTOR3 TOMM70 25348397 N/A physical interaction ComPPI
LAMTOR3 MTCH1 25348397 N/A physical interaction ComPPI
LAMTOR3 NDUFB5 25348397 N/A physical interaction ComPPI
LAMTOR3 PTRH2 25348397 N/A physical interaction ComPPI
LAMTOR3 TOMM40 25348397 N/A physical interaction ComPPI
LAMTOR3 MRPL43 25348397 N/A physical interaction ComPPI
LAMTOR3 UQCRQ 25348397 N/A physical interaction ComPPI
LAMTOR3 NUP58 25348397 N/A physical interaction ComPPI
LAMTOR3 RAB31 25348397 N/A physical interaction ComPPI
LAMTOR3 RALA 25348397 N/A physical interaction ComPPI
LAMTOR3 MRPS9 25348397 N/A physical interaction ComPPI
LAMTOR3 NDUFB4 25348397 N/A physical interaction ComPPI
LAMTOR3 RPS18 25348397 N/A physical interaction ComPPI
LAMTOR3 SPCS2 25348397 N/A physical interaction ComPPI
LAMTOR3 MRPL47 25348397 N/A physical interaction ComPPI
LAMTOR3 PRR3 25348397 N/A physical interaction ComPPI
LAMTOR3 MICOS13 25348397 N/A physical interaction ComPPI
LAMTOR3 TMCO1 25348397 N/A physical interaction ComPPI
LAMTOR3 MRPL51 25348397 N/A physical interaction ComPPI
LAMTOR3 VDAC3 25348397 N/A physical interaction ComPPI
LAMTOR3 MRPL39 25348397 N/A physical interaction ComPPI
LAMTOR3 RAB2A 25348397 N/A physical interaction ComPPI
LAMTOR3 MBD2 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
LAMTOR3 IBTK 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
LAMTOR3 NIF3L1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
LAMTOR3 MOV10 25348397 N/A physical interaction ComPPI
LAMTOR3 RRAGD 20381137 24234451 25348397 25561175 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LAMTOR3 RRAGB 20381137 22980980 24234451 25348397 25561175 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LAMTOR3 RRAGC 20381137 22980980 24234451 25348397 25561175 association affinity chromatography technology,anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LAMTOR3 LAMTOR5 22980980 24234451 25348397 25561175 association anti tag coimmunoprecipitation ComPPI,IntAct
LAMTOR3 SLC38A9 24234451 25348397 25561175 association,physical association anti tag coimmunoprecipitation ComPPI,IntAct
LAMTOR3 FNIP2 24234451 25348397 25561175 association anti tag coimmunoprecipitation ComPPI,IntAct
LAMTOR3 RRAGA 24234451 25348397 25561175 association anti tag coimmunoprecipitation ComPPI,IntAct
LAMTOR3 ATP6V0D1 24234451 25348397 25561175 association anti tag coimmunoprecipitation ComPPI,IntAct
LAMTOR3 FLCN 24234451 25348397 25561175 association anti tag coimmunoprecipitation ComPPI,IntAct
LAMTOR3 RPTOR 24234451 25348397 25561175 association anti tag coimmunoprecipitation ComPPI,IntAct
LAMTOR3 TFE3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
LAMTOR3 TGM7 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
LAMTOR3 RAB9A 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
LAMTOR3 TGOLN2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
MAP2K2 LAMTOR3 14525934 25348397 9733512 N/A experimental interaction detection,in vitro ComPPI,HPRD
ILF2 LAMTOR3 25348397 N/A physical interaction ComPPI
BHMT LAMTOR3 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
LAMTOR3 MAP2K1 11266467 15547943 27898060 9733512 stimulant N/A OmniPath
LAMTOR3 MAPK3 27898060 9733512 stimulant N/A OmniPath
MAPK1 LAMTOR3 11266467 27898060 N/A N/A OmniPath
LAMTOR3 MAPK1 11266467 27898060 9733512 stimulant N/A OmniPath
LAMTOR3 MAP4K1 27898060 9733512 stimulant N/A OmniPath
LAMTOR3 ZFYVE28 19460345 27898060 N/A N/A OmniPath

Visualization










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