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GENE：LAMTOR4

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol LAMTOR4
FullNmae late endosomal/lysosomal adaptor, MAPK and MTOR activator 4
LocusType gene with protein product
Status Approved
HGNC_id HGNC:33772
EnsembleID ENSG00000188186
Uniprot Q0VGL1

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
LAMTOR4 lysosomal_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
LAMTOR4 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
LAMTOR4 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
LAMTOR4 GO:0005085,GO:0005085,GO:0005515,GO:0005764,GO:0005764,GO:0005765,GO:0005765,GO:0005765,GO:0008361,GO:0031902,GO:0032008,GO:0032008,GO:0038202,GO:0043231,GO:0060090,GO:0061462,GO:0071230,GO:0071230,GO:0071230,GO:0071986,GO:0071986,GO:0071986,GO:1904263,GO:1990877

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
LAMTOR4 hsa:389541 path:hsa04150 mTOR signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 LAMTOR4 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 LAMTOR4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA LAMTOR4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 LAMTOR4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS LAMTOR4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF LAMTOR4 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00001012BC LAMTOR4 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000F0F49 LAMTOR4 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001597DC LAMTOR4 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
LAMTOR4 RRAGB 24234451 25348397 25561175 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LAMTOR4 LAMTOR5 22980980 23414517 24234451 25348397 25561175 association,physical association affinity chromatography technology,anti tag coimmunoprecipitation,physical interaction,two hybrid fragment pooling approach ComPPI,IntAct
LAMTOR4 CCR1 25348397 N/A physical interaction ComPPI
LAMTOR4 SNCA 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LAMTOR4 BIRC5 25348397 N/A physical interaction ComPPI
LAMTOR4 DUSP22 25348397 N/A physical interaction ComPPI
LAMTOR4 RPTOR 22980980 24234451 25348397 25561175 association anti tag coimmunoprecipitation,cross-linking study ComPPI,IntAct
LAMTOR4 MTOR 22980980 24234451 25348397 association cross-linking study ComPPI,IntAct
LAMTOR4 LAMTOR3 22980980 24234451 25348397 25561175 association anti tag coimmunoprecipitation ComPPI,IntAct
LAMTOR4 RRAGC 22980980 24234451 25348397 25561175 association affinity chromatography technology,anti tag coimmunoprecipitation ComPPI,IntAct
LAMTOR4 RRAGA 22980980 24234451 25348397 25561175 association anti tag coimmunoprecipitation ComPPI,IntAct
LAMTOR4 RRAGD 24234451 25348397 25561175 association anti tag coimmunoprecipitation ComPPI,IntAct
LAMTOR4 KSR1 24234451 25348397 27086506 association anti tag coimmunoprecipitation ComPPI,IntAct

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