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GENE：LAMTOR5

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol LAMTOR5
FullNmae late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
LocusType gene with protein product
Status Approved
HGNC_id HGNC:17955
EnsembleID ENSG00000134248
Uniprot O43504

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
LAMTOR5 lysosomal_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
LAMTOR5 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
LAMTOR5 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
LAMTOR5 GO:0005085,GO:0005085,GO:0005515,GO:0005764,GO:0005764,GO:0005765,GO:0005765,GO:0005765,GO:0005829,GO:0008361,GO:0009615,GO:0010628,GO:0019079,GO:0031902,GO:0032008,GO:0032757,GO:0032991,GO:0038202,GO:0043123,GO:0043154,GO:0051092,GO:0060090,GO:0061462,GO:0071230,GO:0071230,GO:0071230,GO:0071986,GO:0071986,GO:0071986,GO:1900182,GO:1904263,GO:1904263,GO:1905636,GO:1990877

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
LAMTOR5 hsa:10542 path:hsa04150 mTOR signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 LAMTOR5 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 LAMTOR5 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 LAMTOR5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA LAMTOR5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF LAMTOR5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 LAMTOR5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS LAMTOR5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A LAMTOR5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF LAMTOR5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 LAMTOR5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ERCC2 LAMTOR5 22387547 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000EEE35 LAMTOR5 23266610 rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00000EEE35 LAMTOR5 23266610 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00000F31F4 LAMTOR5 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00000B59A2 LAMTOR5 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS0000170CF4 LAMTOR5 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00002E628F LAMTOR5 25416803 26583881 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
ATM LAMTOR5 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
SGTB LAMTOR5 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MYOG LAMTOR5 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
RABIF LAMTOR5 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
MEOX2 LAMTOR5 25348397 N/A physical interaction ComPPI
TGFB1 LAMTOR5 25348397 N/A physical interaction ComPPI
TAF9 LAMTOR5 25348397 N/A physical interaction ComPPI
SKP1 LAMTOR5 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
LAMTOR4 LAMTOR5 22980980 23414517 24234451 25348397 25561175 association,physical association affinity chromatography technology,anti tag coimmunoprecipitation,physical interaction,two hybrid fragment pooling approach ComPPI,IntAct
SMAD4 LAMTOR5 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
BORCS6 LAMTOR5 25348397 N/A physical interaction ComPPI
SHB LAMTOR5 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
C9 LAMTOR5 25348397 N/A physical interaction ComPPI
DSTN LAMTOR5 25348397 N/A physical interaction ComPPI
STAT4 LAMTOR5 22740693 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
SFPQ LAMTOR5 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
ITGB1 LAMTOR5 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
PPARA LAMTOR5 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
GAPDH LAMTOR5 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
GIT1 LAMTOR5 14525934 16169070 23414517 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
BAG6 LAMTOR5 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NCOA6 LAMTOR5 25348397 N/A physical interaction ComPPI
RBP4 LAMTOR5 25348397 N/A physical interaction ComPPI
HSPA5 LAMTOR5 25348397 N/A physical interaction ComPPI
E2F1 LAMTOR5 25348397 N/A physical interaction ComPPI
SIN3A LAMTOR5 25348397 N/A physical interaction ComPPI
SERPINA1 LAMTOR5 25348397 N/A physical interaction ComPPI
LAMTOR3 LAMTOR5 22980980 24234451 25348397 25561175 association anti tag coimmunoprecipitation ComPPI,IntAct
DNAJA3 LAMTOR5 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
EEF1A1 LAMTOR5 14525934 16169070 23414517 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
GORASP2 LAMTOR5 25348397 N/A physical interaction ComPPI
ECT2 LAMTOR5 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
ZNF592 LAMTOR5 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
ATP6AP2 LAMTOR5 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ZBTB16 LAMTOR5 14525934 16169070 23414517 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
ACAA2 LAMTOR5 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
TCAP LAMTOR5 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
YTHDC1 LAMTOR5 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
HSPA9 LAMTOR5 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
UTP14A LAMTOR5 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
CEP126 LAMTOR5 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
RAB9A LAMTOR5 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
GIT2 LAMTOR5 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
GPRASP1 LAMTOR5 14525934 16169070 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
PDK1 LAMTOR5 25348397 N/A physical interaction ComPPI
CLIC5 LAMTOR5 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
LRIF1 LAMTOR5 14525934 16169070 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
TCF12 LAMTOR5 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
EIF4B LAMTOR5 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
RIF1 LAMTOR5 16169070 24234451 25348397 physical association two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
KIF1B LAMTOR5 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
MTOR LAMTOR5 22980980 24234451 25348397 association cross-linking study ComPPI,IntAct
SNX5 LAMTOR5 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
EIF3A LAMTOR5 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
PEG10 LAMTOR5 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
MYF6 LAMTOR5 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
SORT1 LAMTOR5 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LAMTOR2 LAMTOR5 22980980 24234451 25348397 25561175 25567906 association affinity chromatography technology,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TBC1D4 LAMTOR5 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
MT2A LAMTOR5 25348397 N/A physical interaction ComPPI
RPTOR LAMTOR5 22980980 24234451 25348397 25561175 association anti tag coimmunoprecipitation,cross-linking study ComPPI,IntAct
HEBP2 LAMTOR5 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
RRAGC LAMTOR5 22980980 24234451 25348397 25561175 association affinity chromatography technology,anti tag coimmunoprecipitation ComPPI,IntAct
RRAGB LAMTOR5 22980980 24234451 25348397 25561175 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RRAGD LAMTOR5 24234451 25348397 25561175 association anti tag coimmunoprecipitation ComPPI,IntAct
TOP2B LAMTOR5 25348397 N/A physical interaction ComPPI
DBI LAMTOR5 25348397 N/A physical interaction ComPPI
RRAGA LAMTOR5 22980980 24234451 25348397 25561175 association anti tag coimmunoprecipitation ComPPI,IntAct
CD74 LAMTOR5 25348397 N/A physical interaction ComPPI
LAMTOR1 LAMTOR5 22980980 24234451 25348397 25561175 colocalization,association affinity chromatography technology,anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction,confocal microscopy ComPPI,IntAct
MAF1 LAMTOR5 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
LAMTOR5 EEF1A1P5 25348397 N/A physical interaction ComPPI
LAMTOR5 AK6 25348397 N/A physical interaction ComPPI
LAMTOR5 CEP70 25348397 N/A physical interaction ComPPI
LAMTOR5 MOV10 25348397 N/A physical interaction ComPPI
LAMTOR5 NXF1 25348397 N/A physical interaction ComPPI
LAMTOR5 ASGR1 25348397 N/A physical interaction ComPPI
LAMTOR5 CFB 25348397 N/A physical interaction ComPPI
LAMTOR5 ALB 25348397 N/A physical interaction ComPPI
LAMTOR5 GBA2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LAMTOR5 TP53 25348397 N/A physical interaction ComPPI
LAMTOR5 MCPH1 25348397 N/A physical interaction ComPPI
LAMTOR5 SLC38A9 24234451 25348397 25561175 25567906 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LAMTOR5 VOPP1 16169070 24234451 25348397 physical association two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
LAMTOR5 AKR1C2 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
LAMTOR5 ANKRD46 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
LAMTOR5 MED12L 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
LAMTOR5 MKLN1 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
LAMTOR5 KMT2E 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
LAMTOR5 MYH3 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
BHMT LAMTOR5 25348397 N/A physical interaction ComPPI
ATP6V1C1 LAMTOR5 25348397 N/A physical interaction ComPPI
STAT4 LAMTOR5 22740693 27898060 stimulant N/A OmniPath

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