Gene Information gene info

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GENE：MFN1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MFN1
FullNmae mitofusin 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:18262
EnsembleID ENSG00000171109
Uniprot Q8IWA4

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MFN1 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
MFN1 GO:0003924,GO:0003924,GO:0003924,GO:0005515,GO:0005525,GO:0005739,GO:0005741,GO:0005741,GO:0008053,GO:0008053,GO:0008053,GO:0010918,GO:0016020,GO:0042802,GO:0046039,GO:0051646,GO:0051646,GO:0098799

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
MFN1 hsa:55669 path:hsa04137 Mitophagy - animal - Homo sapiens (human)
MFN1 hsa:55669 path:hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human)
MFN1 hsa:55669 path:hsa05012 Parkinson disease - Homo sapiens (human)
MFN1 hsa:55669 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
MAVS MFN1 20019757 20661427 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR MFN1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 MFN1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 MFN1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 MFN1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 MFN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS MFN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 MFN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00002FC5B0 MFN1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00001A7F58 MFN1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS000075AB14 MFN1 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000482389 MFN1 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00004CFC54 MFN1 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000075AAA0 MFN1 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000042E1F MFN1 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000DDD35 MFN1 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00002075FA MFN1 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000600E6 MFN1 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000039E1E1 MFN1 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 MFN1 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 MFN1 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000070CD2 MFN1 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000508C13 MFN1 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000041E949 MFN1 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000346991 MFN1 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000027080C MFN1 23446348 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
TOMM22 MFN1 25348397 N/A physical interaction ComPPI
MARCHF5 MFN1 20103533 23253261 24722297 25348397 27898060 N/A physical interaction ComPPI,OmniPath
FLNC MFN1 25348397 N/A physical interaction ComPPI
NTRK1 MFN1 25348397 N/A physical interaction ComPPI
CCNB1 MFN1 25348397 N/A physical interaction ComPPI
BAK1 MFN1 14525934 17606912 19168699 24234451 25348397 association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
PRKN MFN1 25348397 N/A physical interaction ComPPI
ILF2 MFN1 25348397 N/A physical interaction ComPPI
PLK2 MFN1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FAF2 MFN1 25348397 N/A physical interaction ComPPI
TSC22D1 MFN1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
MAVS MFN1 20019757 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
SLC25A38 MFN1 25348397 N/A physical interaction ComPPI
MFN2 MFN1 19052620 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MFN1 MGRN1 25348397 N/A physical interaction ComPPI
MFN1 TMBIM4 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
MAVS MFN1 20019757 20661427 27898060 N/A N/A OmniPath

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