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GENE：MFN2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MFN2
FullNmae mitofusin 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:16877
EnsembleID ENSG00000116688
Uniprot O95140

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MFN2 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MFN2 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MFN2 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
MFN2 cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
MFN2 GO:0001825,GO:0003924,GO:0005515,GO:0005525,GO:0005739,GO:0005741,GO:0005741,GO:0005829,GO:0006626,GO:0006915,GO:0006986,GO:0007006,GO:0008053,GO:0008053,GO:0008053,GO:0008053,GO:0015630,GO:0031625,GO:0034497,GO:0046580,GO:0048593,GO:0048662,GO:0051646,GO:0051646,GO:0061734,GO:0120162,GO:1904707,GO:1905461

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
MFN2 hsa:9927 path:hsa04137 Mitophagy - animal - Homo sapiens (human)
MFN2 hsa:9927 path:hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human)
MFN2 hsa:9927 path:hsa05012 Parkinson disease - Homo sapiens (human)
MFN2 hsa:9927 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
MAVS MFN2 19690333 20661427 23180781 physical association anti tag coimmunoprecipitation InnateDB
SMAD2 MFN2 18729074 23180781 physical association tandem affinity purification InnateDB

Source Target Pmid Interactiontype Methods Database
E2F4 MFN2 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 MFN2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 MFN2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 MFN2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 MFN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF MFN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 MFN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS MFN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A MFN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 MFN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
PPARGC1A MFN2 17828388 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000AA464 MFN2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00005651EE MFN2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001C308D MFN2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000170CF4 MFN2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000EED18 MFN2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000DDD35 MFN2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000239117 MFN2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000040EE1D MFN2 25416803 27693395 mrna cleavage,inhibition quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase
URS00000600E6 MFN2 23954742 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00004B4B85 MFN2 20371350 22012620 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000003575B MFN2 20371350 22012620 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00001067D1 MFN2 20371350 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000039E1E1 MFN2 25416803 27565029 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase
URS00002075FA MFN2 25416803 27640178 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
MAPK9 MFN2 25348397 N/A physical interaction ComPPI
TCHP MFN2 20930847 24234451 25348397 27898060 physical association anti tag coimmunoprecipitation ComPPI,IntAct,OmniPath
VCP MFN2 23498974 24234451 25348397 27898060 physical association anti tag coimmunoprecipitation ComPPI,IntAct,OmniPath
MARCHF5 MFN2 14525934 16936636 23727017 24234451 25348397 26186194 26210454 27898060 physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct,OmniPath
SAMM50 MFN2 24234451 25348397 27059175 physical association anti tag coimmunoprecipitation ComPPI,IntAct
SMAD2 MFN2 25348397 N/A tandem affinity purification ComPPI
UBB MFN2 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
UBC MFN2 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
RPS27A MFN2 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
UBA52 MFN2 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
UBE2N MFN2 25348397 N/A physical interaction ComPPI
NTRK1 MFN2 25348397 N/A physical interaction ComPPI
HUWE1 MFN2 25348397 N/A physical interaction ComPPI
HDAC6 MFN2 25348397 N/A physical interaction ComPPI
BAK1 MFN2 17606912 19168699 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PRKN MFN2 23620051 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MAVS MFN2 25348397 N/A physical interaction ComPPI
SLC25A38 MFN2 25348397 N/A physical interaction ComPPI
MFN2 NXF1 25348397 N/A physical interaction ComPPI
MFN2 MFN1 19052620 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MFN2 REEP5 25348397 N/A physical interaction ComPPI
MFN2 GHITM 25348397 N/A physical interaction ComPPI
MFN2 VSIG1 25348397 N/A physical interaction ComPPI
MFN2 LRRK2 24234451 24282027 25348397 colocalization,physical association anti tag coimmunoprecipitation,confocal microscopy ComPPI,IntAct
PINK1 MFN2 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
HSCB MFN2 24234451 25348397 28380382 association anti bait coimmunoprecipitation ComPPI,IntAct
MFN2 MFN2 19052620 24234451 physical association anti tag coimmunoprecipitation IntAct
MAPK9 MFN2 22748923 27898060 inhibition N/A OmniPath
MAVS MFN2 19690333 20661427 27898060 N/A N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00009B1033 MFN2 27087310 direct interaction,inhibition N/A NPInter

Visualization










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