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GENE：MLST8

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MLST8
FullNmae MTOR associated protein, LST8 homolog
LocusType gene with protein product
Status Approved
HGNC_id HGNC:24825
EnsembleID ENSG00000167965
Uniprot Q9BVC4

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MLST8 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MLST8 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
MLST8 GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0006974,GO:0007010,GO:0010507,GO:0030307,GO:0030838,GO:0031669,GO:0031929,GO:0031931,GO:0031931,GO:0031931,GO:0031932,GO:0031932,GO:0031932,GO:0032008,GO:0032956,GO:0032956,GO:0038202,GO:0043066,GO:0043539,GO:0045821,GO:0046889,GO:0050731,GO:0071456,GO:0071470,GO:1905857

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
MLST8 hsa:64223 path:hsa04136 Autophagy - other - Homo sapiens (human)
MLST8 hsa:64223 path:hsa04140 Autophagy - animal - Homo sapiens (human)
MLST8 hsa:64223 path:hsa04150 mTOR signaling pathway - Homo sapiens (human)
MLST8 hsa:64223 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
MLST8 hsa:64223 path:hsa04714 Thermogenesis - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
MLST8 DEPTOR 11274345 11756498 12150925 12408816 12906785 15749884 15755954 16469695 16713974 17404308 17461779 17604271 17680028 18000759 18372248 18492954 19022819 19143635 19143636 19151919 19446321 19568798 19706736 19864431 20547845 20805416 21157483 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 26192618 27331412 28216025 interaction type N/A ACSN
MLST8 RPTOR 10702316 11108711 11274345 11756498 12150925 12408816 12533512 12709531 12713446 12718876 12844354 12867079 12906785 15314020 15749884 15755954 15905173 16286006 16469695 16679021 16713974 16915281 16919458 17052453 17053147 17368478 17404308 17604271 17680028 18000759 18030348 18046414 18048642 18372248 18391071 18423201 18492954 19022819 19143636 19151919 19225151 19244117 19339977 19446321 19568798 19597330 19706736 19720745 19864431 19930715 20138985 20547845 20647036 20805416 20832730 20932932 21157483 21177869 21233202 21474067 21981924 22504639 23087689 23180781 24795729 24973821 25002027 25682865 25730849 26159692 26192618 26597054 27328425 27331412 27510662 27572739 28216025 interaction type,physical association anti tag coimmunoprecipitation ACSN,InnateDB
MTOR MLST8 10702316 10722653 11108711 11274345 11756498 12150925 12408816 12533512 12709531 12713446 12844354 12867079 12906785 15268862 15314020 15749884 15755954 15905173 16286006 16469695 16556040 16678438 16679021 16713974 16915281 17052453 17053147 17277771 17368478 17404308 17461779 17604271 17680028 18000759 18046414 18048642 18372248 18391071 18423201 18481918 18492954 18566586 18570873 18614546 18925875 19022819 19027299 19143635 19143636 19151919 19225151 19244117 19339977 19446321 19568798 19597330 19706736 19720745 19864431 19930715 20027184 20138985 20338997 20547845 20647036 20805416 20832730 20932932 21157483 21177869 21233202 21474067 21533173 21621563 21708191 21981924 22504639 23087689 23180781 24795729 24973821 25002027 25682865 25730849 26159692 26192618 26597054 27328425 27331412 27510662 27572739 28216025 9069260 interaction type,physical association anti tag coimmunoprecipitation ACSN,InnateDB
MLST8 MAPKAP1 10722653 11274345 11756498 12408816 12906785 16469695 16556040 16678438 16919458 17461779 17680028 18000759 18481918 18492954 18566586 18570873 18925875 19022819 19027299 19143635 19151919 19446321 19568798 19706736 19720745 20027184 20338997 21157483 21474067 21533173 21621563 21708191 21981924 23087689 23180781 24795729 24973821 25002027 25730849 26159692 26192618 27331412 28216025 9069260 interaction type,physical association anti tag coimmunoprecipitation ACSN,InnateDB
MLST8 PRR5 12408816 12906785 16469695 17461779 17680028 18492954 18566586 19022819 19143635 19568798 21157483 21981924 23087689 23180781 24795729 24973821 25002027 25730849 26159692 26192618 28216025 interaction type,physical association anti tag coimmunoprecipitation ACSN,InnateDB
MLST8 RICTOR 10722653 11274345 11756498 12408816 12906785 16469695 16556040 16678438 16919458 17461779 17599906 17680028 18000759 18030348 18481918 18492954 18505677 18566586 18570873 18925875 19022819 19027299 19143635 19151919 19446321 19568798 19706736 19720745 20027184 20338997 21157483 21474067 21533173 21621563 21708191 21981924 23087689 23180781 24795729 24973821 25002027 25730849 26159692 26192618 27331412 28216025 9069260 interaction type,physical association anti tag coimmunoprecipitation,two hybrid ACSN,InnateDB
MLST8 PPARGC1A 12150925 12408816 12533512 12906785 15755954 16469695 17680028 18046414 18048642 18492954 19022819 19568798 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 26192618 28216025 interaction type N/A ACSN
MLST8 YY1 12150925 12408816 12533512 12906785 15755954 16469695 17680028 18046414 18048642 18492954 19022819 19568798 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 26192618 28216025 interaction type N/A ACSN
RAC1 MLST8 10702316 10722653 11274345 11756498 12150925 12408816 12906785 15749884 15755954 16469695 16556040 16678438 16713974 17404308 17461779 17604271 17680028 18000759 18372248 18481918 18492954 18570873 18925875 19022819 19027299 19143635 19143636 19151919 19225151 19244117 19446321 19568798 19706736 19720745 19864431 20027184 20138985 20338997 20547845 20805416 21157483 21474067 21533173 21621563 21708191 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 26192618 27331412 28216025 9069260 interaction type N/A ACSN
MLST8 EIF4E 11108711 12150925 12408816 12709531 12844354 12867079 12906785 15314020 15755954 15905173 16286006 16469695 16679021 17368478 17680028 18391071 18492954 19022819 19339977 19568798 19597330 19864431 20647036 20932932 21157483 21177869 21233202 21981924 23087689 24795729 24973821 25002027 25682865 25730849 26159692 26192618 28216025 interaction type N/A ACSN
MLST8 EIF4B 12150925 12408816 12844354 12867079 12906785 15755954 15905173 16286006 16469695 16679021 17368478 17680028 18391071 18492954 19022819 19339977 19568798 19597330 19864431 20647036 21157483 21177869 21233202 21981924 23087689 24795729 24973821 25002027 25730849 26159692 26192618 28216025 interaction type N/A ACSN
MLST8 RPS6 12150925 12408816 12844354 12867079 12906785 15755954 15905173 16286006 16469695 16679021 17368478 17680028 18391071 18492954 19022819 19339977 19568798 19597330 19864431 20647036 21157483 21177869 21233202 21981924 23087689 24795729 24973821 25002027 25730849 26159692 26192618 28216025 interaction type N/A ACSN
RHEB MLST8 12906785 16636147 17604271 18466115 19022819 19143635 23087689 26192618 interaction type N/A ACSN
MLST8 FOXP3 12150925 12408816 12906785 15755954 16469695 17604271 17680028 18372248 18492954 19022819 19446321 19568798 19706736 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 26192618 28216025 interaction type N/A ACSN
SQSTM1 MLST8 15340068 16252010 20531300 21981924 25002027 26192618 26587781 28574505 interaction type N/A ACSN
MLST8 MYC 12150925 12408816 12906785 15755954 16469695 17604271 17680028 18372248 18492954 19022819 19446321 19568798 19706736 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 26192618 28216025 interaction type N/A ACSN
MLST8 MMP2 12150925 12408816 12906785 15755954 16469695 17680028 18492954 19022819 19568798 19864431 19930715 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 26192618 26597054 27328425 27510662 27572739 28216025 interaction type N/A ACSN
PTP4A3 MLST8 17409395 19440036 19945467 20609352 21084277 23691193 24030100 24376839 24696260 25136802 26192618 26597054 27328425 27572739 interaction type N/A ACSN
MLST8 MMP9 12150925 12408816 12906785 15755954 16469695 17680028 18492954 19022819 19568798 19864431 19930715 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 26192618 26597054 27328425 27510662 27572739 28216025 interaction type N/A ACSN
PML MLST8 16915281 20452955 26192618 interaction type N/A ACSN
MLST8 ESRRA 12150925 12408816 12533512 12906785 15755954 16314495 16469695 17680028 18046414 18048642 18492954 19022819 19568798 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 26192618 28216025 interaction type N/A ACSN
MLST8 COX5A 12150925 12408816 12533512 12906785 15755954 16469695 17680028 18046414 18048642 18492954 19022819 19568798 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 26192618 28216025 interaction type N/A ACSN
MLST8 IDH3A 12150925 12408816 12533512 12906785 15755954 16469695 17680028 18046414 18048642 18492954 19022819 19568798 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 26192618 28216025 interaction type N/A ACSN
MLST8 GZMA 12150925 12408816 12906785 15749884 15755954 16469695 16713974 17404308 17604271 17680028 18372248 18492954 19022819 19143636 19446321 19568798 19706736 19864431 20547845 20805416 21157483 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 26192618 28216025 interaction type N/A ACSN
MLST8 IL10 12150925 12408816 12906785 15749884 15755954 16469695 16713974 17404308 17604271 17680028 18372248 18492954 19022819 19143636 19446321 19568798 19706736 19864431 20547845 20805416 21157483 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 26192618 28216025 interaction type N/A ACSN
MLST8 IFNG 12150925 12408816 12906785 15755954 16469695 17604271 17680028 18372248 18492954 19022819 19143636 19446321 19568798 19706736 19864431 20805416 21157483 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 26192618 28216025 interaction type N/A ACSN
MLST8 GZMB 12150925 12408816 12906785 15749884 15755954 16469695 16713974 17404308 17604271 17680028 18372248 18492954 19022819 19143636 19446321 19568798 19706736 19864431 20547845 20805416 21157483 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 26192618 28216025 interaction type N/A ACSN
MLST8 AKT1 10722653 10949026 11274345 11715018 11756412 11756498 11923280 12408816 12906785 15169778 15808505 16469695 16697215 17052453 17461779 17680028 18000759 18372248 18492954 18570873 18636226 18925875 19022819 19143635 19151919 19568798 19720745 20027184 20138985 20214616 20338997 20398329 20832730 21157483 21474067 21981924 23087689 24795729 24973821 25002027 25730849 26159692 26192618 27331412 28216025 9812896 interaction type N/A ACSN
MLST8 SGK1 10722653 11274345 11756498 12408816 12906785 16469695 17461779 17680028 18000759 18492954 18570873 18925875 19022819 19143635 19151919 19568798 19720745 20027184 20338997 21157483 21474067 21981924 23087689 24795729 24973821 25002027 25730849 26159692 26192618 27331412 28216025 interaction type N/A ACSN
PRKCA MLST8 10679481 10871288 16492141 18851840 20027184 21474067 26192618 interaction type N/A ACSN
MLST8 ATG13 11274345 11756498 12150925 12408816 12906785 15755954 16469695 17680028 18000759 18492954 19022819 19151919 19225151 19446321 19568798 19706736 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 26192618 27331412 28216025 interaction type N/A ACSN
MLST8 FKBP8 17991864 23180781 physical association anti tag coimmunoprecipitation InnateDB
MLST8 PRR5L 17461779 23180781 physical association anti tag coimmunoprecipitation InnateDB
MLST8 MTOR 12718876 15066126 16919458 17277771 18030348 23180781 physical association anti tag coimmunoprecipitation InnateDB
MLST8 TSC1 18411301 23180781 physical association anti tag coimmunoprecipitation InnateDB
TSC2 MLST8 18411301 23180781 physical association anti tag coimmunoprecipitation InnateDB
MLST8 RHEB 15854902 15878852 17470430 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
MLST8 IKBKB 18755269 23180781 physical association anti tag coimmunoprecipitation InnateDB
MLST8 CHUK 18755269 23180781 physical association anti tag coimmunoprecipitation InnateDB
SUZ12 MLST8 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 MLST8 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
E2F1 MLST8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 MLST8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 MLST8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF MLST8 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000555DA6 MLST8 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
RICTOR MLST8 25361965 interaction type N/A PTMCode2
MLST8 RICTOR 25361965 interaction type N/A PTMCode2
AKT1S1 MLST8 25361965 interaction type N/A PTMCode2
MLST8 AKT1S1 25361965 interaction type N/A PTMCode2
MAPKAP1 MLST8 25361965 interaction type N/A PTMCode2
MLST8 MAPKAP1 25361965 interaction type N/A PTMCode2
RPTOR MLST8 25361965 interaction type N/A PTMCode2
MLST8 RPTOR 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
STAT1 MLST8 25348397 N/A physical interaction ComPPI
ATXN1 MLST8 23275563 24234451 25348397 physical association physical interaction,two hybrid prey pooling approach ComPPI,IntAct
KEAP1 MLST8 25348397 N/A physical interaction ComPPI
ETV3 MLST8 25348397 N/A physical interaction ComPPI
PRMT1 MLST8 23455924 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
XPO6 MLST8 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TUBA4A MLST8 25348397 N/A physical interaction ComPPI
EIF4EBP1 MLST8 25348397 N/A physical interaction ComPPI
SQSTM1 MLST8 25348397 N/A physical interaction ComPPI
XPO1 MLST8 25348397 N/A physical interaction ComPPI
TUBA1A MLST8 25348397 N/A physical interaction ComPPI
MELK MLST8 25348397 N/A physical interaction ComPPI
CCT7 MLST8 25348397 N/A physical interaction ComPPI
PFDN5 MLST8 25348397 N/A physical interaction ComPPI
ACAT2 MLST8 25348397 N/A physical interaction ComPPI
FKBP8 MLST8 25348397 N/A physical interaction ComPPI
FOXF2 MLST8 25348397 N/A physical interaction ComPPI
XPO4 MLST8 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TRIM25 MLST8 25348397 N/A physical interaction ComPPI
MTOR MLST8 12408816 12718876 14525934 15066126 17461779 20562859 24234451 25348397 26348909 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,molecular sieving,x-ray crystallography,physical interaction,ion exchange chromatography,in vivo,inference by socio-affinity scoring ComPPI,HPRD,IntAct
MLST8 RPTOR 12408816 12718876 14525934 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
MLST8 KRT85 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MLST8 CCT2 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MLST8 RICTOR 17461779 21376236 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
MLST8 PRR5 17461779 24234451 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MLST8 ULK1 25348397 N/A physical interaction ComPPI
MLST8 DEPTOR 19446321 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MLST8 A2M 21163940 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MLST8 MOV10 25348397 N/A physical interaction ComPPI
MLST8 NXF1 25348397 N/A physical interaction ComPPI
MLST8 SUZ12 25348397 N/A physical interaction ComPPI
MLST8 CCT6B 25348397 N/A physical interaction ComPPI
MLST8 SETX 25348397 N/A physical interaction ComPPI
MLST8 PRAME 25348397 N/A physical interaction ComPPI
MLST8 LYPLA2 25348397 N/A physical interaction ComPPI
MLST8 DYNC2I1 25348397 N/A physical interaction ComPPI
MLST8 USP54 25348397 N/A physical interaction ComPPI
MLST8 APPL2 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,validated two hybrid ComPPI,IntAct
MLST8 KIF11 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MLST8 MTMR3 24234451 25348397 26787466 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MLST8 ZNRF2 25348397 N/A physical interaction ComPPI
MLST8 CCT3 25348397 N/A physical interaction ComPPI
MLST8 SLC30A4 25348397 N/A physical interaction ComPPI
MLST8 CLMP 25348397 N/A physical interaction ComPPI
MLST8 THADA 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
MLST8 ZUP1 25348397 N/A physical interaction ComPPI
MLST8 RPS9 17461779 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
MLST8 ARHGAP8 25348397 N/A anti tag coimmunoprecipitation ComPPI
MLST8 PRR5L 17461779 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
MLST8 MAPKAP1 17461779 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
MLST8 NUDC 24234451 25036637 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
MLST8 MLST8 20562859 24234451 physical association anti tag coimmunoprecipitation IntAct
FBP1 MLST8 20457600 20617129 27898060 N/A N/A OmniPath
MLST8 CHUK 18755269 27898060 N/A N/A OmniPath
RICTOR MLST8 16919458 17461779 17565979 17599906 18030348 18505677 18925875 22084251 27898060 N/A N/A OmniPath
RHEB MLST8 12718876 15854902 15878852 17470430 27898060 stimulant N/A OmniPath
MLST8 RHEB 15854902 15878852 17470430 27898060 N/A N/A OmniPath
SUZ12 MLST8 24457600 27898060 N/A N/A OmniPath
MLST8 TSC2 18411301 27898060 N/A N/A OmniPath
RPTOR MLST8 12408816 12718876 16798736 16919458 17565979 18030348 20169205 20562859 21321085 24403073 27898060 N/A N/A OmniPath
MLST8 RPTOR 12408816 12718876 16798736 16919458 17565979 18030348 20169205 20562859 21321085 24403073 27898060 N/A N/A OmniPath
MTOR MLST8 12408816 12718876 12719976 15066126 15268862 15459249 16183647 16798736 16919458 17277771 17461779 18030348 18505677 18614546 18851840 19446321 20427287 20562859 20801936 21321085 22084251 22258093 23636326 26186194 27898060 N/A N/A OmniPath
MLST8 MTOR 12408816 12718876 12719976 15066126 15268862 15459249 16183647 16798736 16919458 17277771 17461779 18030348 18505677 18614546 18851840 19446321 20427287 20562859 20801936 21321085 22084251 22258093 23636326 26186194 27898060 stimulant N/A OmniPath
FKBP8 MLST8 17991864 27898060 N/A N/A OmniPath
MLST8 TSC1 18411301 27898060 N/A N/A OmniPath
MLST8 IKBKB 18755269 27898060 N/A N/A OmniPath
PRR5L MLST8 17461779 27898060 N/A N/A OmniPath
MLST8 PRR5L 17461779 27898060 N/A N/A OmniPath
MLST8 MAPKAP1 16919458 27898060 N/A N/A OmniPath
PRR5 MLST8 17461779 27898060 N/A N/A OmniPath

Visualization










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