Gene Information gene info

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GENE：NBR1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol NBR1
FullNmae NBR1 autophagy cargo receptor
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6746
EnsembleID ENSG00000188554
Uniprot Q14596

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
NBR1 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
NBR1 GO:0000407,GO:0005515,GO:0005654,GO:0005739,GO:0005758,GO:0005764,GO:0005770,GO:0005776,GO:0005778,GO:0005829,GO:0008270,GO:0016020,GO:0016236,GO:0016236,GO:0016604,GO:0030500,GO:0031430,GO:0032872,GO:0043130,GO:0043130,GO:0043231,GO:0043235,GO:0045668,GO:0051019

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
NBR1 hsa:4077 path:hsa04137 Mitophagy - animal - Homo sapiens (human)
NBR1 hsa:4077 path:hsa04140 Autophagy - animal - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
NBR1 SQSTM1 12813044 23180781 physical association anti tag coimmunoprecipitation,two hybrid InnateDB
NBR1 NBR1 12813044 23180781 physical association anti tag coimmunoprecipitation InnateDB
GABARAPL2 NBR1 19250911 23022382 23180781 physical association two hybrid,pull down InnateDB
GABARAP NBR1 19250911 23022382 23180781 physical association pull down InnateDB
MAP1LC3B NBR1 19250911 23022382 23180781 physical association pull down InnateDB
NBR1 MAP1LC3A 19250911 23022382 23180781 physical association pull down InnateDB
NBR1 MAP1LC3C 19250911 23022382 23180781 physical association pull down InnateDB
GABARAPL1 NBR1 23022382 23180781 physical association pull down InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 NBR1 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA3 NBR1 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXA1 NBR1 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 NBR1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 NBR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA NBR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF NBR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 NBR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 NBR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS NBR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A NBR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 NBR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 NBR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MYC NBR1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00003D5391 NBR1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000035CC3E NBR1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00002075FA NBR1 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
USP8 NBR1 25361965 interaction type N/A PTMCode2
NBR1 USP8 25361965 interaction type N/A PTMCode2
FEZ1 NBR1 25361965 interaction type N/A PTMCode2
NBR1 FEZ1 25361965 interaction type N/A PTMCode2
GABARAPL2 NBR1 25361965 interaction type N/A PTMCode2
NBR1 GABARAPL2 25361965 interaction type N/A PTMCode2
RPS27A NBR1 25361965 interaction type N/A PTMCode2
NBR1 RPS27A 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
GABARAPL2 NBR1 19250911 20562859 24234451 25348397 association,physical association anti tag coimmunoprecipitation,two hybrid,pull down,physical interaction ComPPI,IntAct
CALM1 NBR1 25348397 N/A physical interaction ComPPI
KEAP1 NBR1 25348397 N/A physical interaction ComPPI
MAP1LC3B NBR1 19250911 20562859 24234451 24879152 25348397 colocalization,physical association pull down,physical interaction,confocal microscopy ComPPI,IntAct
JUNB NBR1 25348397 N/A physical interaction ComPPI
SPRED2 NBR1 25348397 N/A physical interaction ComPPI
JUN NBR1 24234451 25348397 25609649 association anti bait coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
UBE2D2 NBR1 25348397 N/A physical interaction ComPPI
TTN NBR1 25348397 N/A two hybrid,physical interaction,in vitro ComPPI
NBR1 CIB1 25348397 N/A two hybrid,physical interaction,in vitro ComPPI
NBR1 FEZ1 25348397 N/A two hybrid,physical interaction,in vivo ComPPI
NBR1 VTA1 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
NBR1 SQSTM1 19250911 20562859 20808283 24234451 24879152 25348397 colocalization,association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction,in vitro,confocal microscopy ComPPI,IntAct
NBR1 GABARAP 19250911 20562859 24234451 24879152 25348397 physical association anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
NBR1 ITSN2 25348397 N/A physical interaction ComPPI
NBR1 MAP1LC3A 19250911 19427866 24234451 25348397 colocalization,physical association pull down,physical interaction,fluorescence microscopy ComPPI,IntAct
NBR1 USP8 19427866 24234451 25348397 colocalization,physical association two hybrid,pull down,physical interaction,fluorescence microscopy ComPPI,IntAct
NBR1 UBC 19250911 19427866 23649778 24234451 24692539 24879152 25348397 27898060 colocalization,physical association pull down,physical interaction,fluorescence microscopy ComPPI,IntAct,OmniPath
NBR1 GABARAPL1 19250911 20562859 24234451 25348397 association,physical association anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
NBR1 MAP1LC3C 19250911 20562859 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
NBR1 ATXN1L 25348397 N/A physical interaction ComPPI
NBR1 HTT 20417604 24234451 25348397 colocalization,physical association anti tag coimmunoprecipitation,physical interaction,confocal microscopy ComPPI,IntAct
NBR1 GSK3A 20368287 24234451 24879152 25348397 phosphorylation reaction,physical association pull down,physical interaction,protein kinase assay ComPPI,IntAct
NBR1 CEP55 25348397 N/A physical interaction ComPPI
NBR1 TNK2 25348397 N/A physical interaction ComPPI
NBR1 GSK3B 24234451 24879152 25348397 29568061 phosphorylation reaction,association,physical association pull down,physical interaction,protein kinase assay,proximity-dependent biotin identification ComPPI,IntAct
NBR1 TOLLIP 24234451 25042851 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NBR1 SYT4 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
NBR1 SCGN 25348397 N/A physical interaction ComPPI
NBR1 LTBR 25348397 N/A physical interaction ComPPI
NBR1 VAPB 25348397 N/A physical interaction ComPPI
NBR1 MAP3K3 25348397 N/A physical interaction ComPPI
NBR1 MAP2K4 25348397 N/A physical interaction ComPPI
NBR1 CEP135 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
NBR1 GTSE1 25348397 N/A physical interaction ComPPI
NBR1 SSH3 25348397 N/A physical interaction ComPPI
NBR1 SPPL2B 25348397 N/A physical interaction ComPPI
NBR1 CORO6 25348397 N/A physical interaction ComPPI
NBR1 MRPL41 25348397 N/A physical interaction ComPPI
NBR1 LYPD4 25348397 N/A physical interaction ComPPI
NBR1 UBE2D3 25348397 N/A physical interaction ComPPI
NBR1 HNRNPL 25348397 N/A physical interaction ComPPI
NBR1 SOD1 21252941 24234451 25348397 colocalization fluorescence microscopy ComPPI,IntAct
UBB NBR1 19250911 24234451 25348397 colocalization confocal microscopy ComPPI,IntAct
TNIP1 NBR1 24234451 30561431 association virotrap IntAct
MAP1B NBR1 22654911 27898060 N/A N/A OmniPath
NBR1 GABARAP 19250911 20562859 21620860 23022382 24879152 27898060 stimulant N/A OmniPath
MAP1LC3B NBR1 19250911 20562859 21620860 23022382 24879152 27898060 inhibition N/A OmniPath
NBR1 GABARAPL1 19250911 20562859 21620860 23022382 27898060 stimulant N/A OmniPath
NBR1 MAP1LC3A 19250911 19427866 21620860 21935636 23022382 27898060 stimulant N/A OmniPath
NBR1 SQSTM1 12813044 15802564 16861740 19250911 20808283 21935636 24879152 25007327 27898060 stimulant N/A OmniPath
NBR1 GABARAPL2 19250911 20562859 21620860 23022382 27898060 stimulant N/A OmniPath
MAP1LC3C NBR1 19250911 20562859 21620860 23022382 27898060 inhibition N/A OmniPath

Visualization










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