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GENE：PGAM5

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PGAM5
FullNmae PGAM family member 5, mitochondrial serine/threonine protein phosphatase
LocusType gene with protein product
Status Approved
HGNC_id HGNC:28763
EnsembleID ENSG00000247077
Uniprot Q96HS1

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PGAM5 oxeiptosis 38115663 The reduction of TM4 cell viability induced by TDCIPP may be related to ROS-mediated regulation of the KEAP1/PGAM5/AIFM1 pathway, leading to oxeiptosis. retulator signature
PGAM5 oxeiptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
PGAM5 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PGAM5 necroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
PGAM5 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
PGAM5 GO:0004722,GO:0004722,GO:0004722,GO:0005096,GO:0005515,GO:0005739,GO:0005739,GO:0005741,GO:0005743,GO:0016236,GO:0016791,GO:0017018,GO:0035970,GO:0044877,GO:0070266,GO:0090141,GO:0120163

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PGAM5 hsa:192111 path:hsa04137 Mitophagy - animal - Homo sapiens (human)
PGAM5 hsa:192111 path:hsa04217 Necroptosis - Homo sapiens (human)
PGAM5 hsa:192111 path:hsa04668 TNF signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
GLUD1 PGAM5 11274345 16469705 17603935 18641653 19037093 19498109 19524512 19524513 19632174 20823910 20861672 21133840 21232017 22265414 22421439 23010170 23073834 23627914 24366341 26024392 26192618 26587781 26653790 26807733 26853145 26900751 27558815 27833036 27959630 28498367 28574505 28645028 interaction type N/A ACSN
GLUL PGAM5 11274345 16469705 17603935 18641653 19037093 19498109 19524512 19524513 19632174 20823910 20861672 21133840 21232017 22265414 22421439 23010170 23073834 23627914 24366341 26024392 26192618 26587781 26653790 26807733 26853145 26900751 27558815 27833036 27959630 28498367 28574505 28645028 interaction type N/A ACSN
MLKL PGAM5 11274345 16469705 17603935 18641653 19037093 19498109 19524512 19524513 19632174 20823910 20861672 21133840 21232017 22265414 22421439 23010170 23073834 23627914 24366341 26024392 26192618 26587781 26653790 26807733 26853145 26900751 27558815 27833036 27959630 28498367 28574505 28645028 interaction type N/A ACSN
PYGL PGAM5 11274345 16469705 17603935 18641653 19037093 19498109 19524512 19524513 19632174 20823910 20861672 21133840 21232017 22265414 22421439 23010170 23073834 23627914 24366341 26024392 26192618 26587781 26653790 26807733 26853145 26900751 27558815 27833036 27959630 28498367 28574505 28645028 interaction type N/A ACSN
RIPK1 PGAM5 11274345 16469705 17603935 18641653 19037093 19498109 19524512 19524513 19632174 20823910 20861672 21133840 21232017 22265414 22421439 23010170 23073834 23627914 24366341 26024392 26192618 26587781 26653790 26807733 26853145 26900751 27558815 27833036 27959630 28498367 28574505 28645028 interaction type N/A ACSN
RIPK3 PGAM5 11274345 16469705 17603935 18641653 19037093 19498109 19524512 19524513 19632174 20823910 20861672 21133840 21232017 22265414 22421439 23010170 23073834 23627914 24366341 26024392 26192618 26587781 26653790 26807733 26853145 26900751 27558815 27833036 27959630 28498367 28574505 28645028 interaction type N/A ACSN
SUZ12 PGAM5 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB
RNF2 PGAM5 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB
BMI1 PGAM5 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 PGAM5 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TAL1 PGAM5 20028976 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
EGR1 PGAM5 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00003FBC84 PGAM5 23313552 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000156390 PGAM5 23592263 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000C4DB5 PGAM5 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000007F792 PGAM5 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000EC1BE PGAM5 20371350 21572407 22012620 23446348 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00000C5BAA PGAM5 20371350 21572407 22012620 23446348 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000075BDAA PGAM5 20371350 21572407 22012620 23446348 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00001481F9 PGAM5 20371350 21572407 22012620 23446348 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS0000475586 PGAM5 20371350 21572407 22012620 23446348 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00000913AC PGAM5 20371350 21572407 22012620 23446348 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS0000355E82 PGAM5 23313552 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002A8BC6 PGAM5 23313552 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075A760 PGAM5 23313552 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002152A8 PGAM5 23313552 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000137EDE PGAM5 23313552 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000019907A PGAM5 23313552 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001C770D PGAM5 23313552 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000006372A PGAM5 23313552 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001C0099 PGAM5 23313552 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000041FA2C PGAM5 23313552 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000008A99 PGAM5 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000009A9A2 PGAM5 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002578DA PGAM5 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000047A8F PGAM5 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000054A671 PGAM5 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000214763 PGAM5 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
LMNA PGAM5 24234451 25348397 29568061 association pull down ComPPI,IntAct
PCBD1 PGAM5 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
YWHAG PGAM5 25348397 N/A in vivo ComPPI
XIAP PGAM5 25348397 N/A physical interaction ComPPI
BMI1 PGAM5 25348397 N/A physical interaction ComPPI
KEAP1 PGAM5 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
STRN PGAM5 24234451 24366813 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
BCL2L1 PGAM5 25348397 N/A physical interaction ComPPI
NF2 PGAM5 25348397 N/A physical interaction ComPPI
SETDB1 PGAM5 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
JUN PGAM5 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
COPS5 PGAM5 25348397 N/A physical interaction ComPPI
NFE2L2 PGAM5 25348397 N/A physical interaction ComPPI
GLI1 PGAM5 25348397 N/A physical interaction ComPPI
PAXIP1 PGAM5 25348397 N/A physical interaction ComPPI
RBX1 PGAM5 25348397 N/A physical interaction ComPPI
CUL3 PGAM5 25348397 N/A physical interaction ComPPI
STRN3 PGAM5 24234451 24366813 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NTRK1 PGAM5 25348397 N/A physical interaction ComPPI
CANX PGAM5 24234451 25348397 29568061 association pull down ComPPI,IntAct
TNS2 PGAM5 24234451 25348397 28330616 association pull down,proximity-dependent biotin identification ComPPI,IntAct
HSPA1A PGAM5 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
HSPA1B PGAM5 25348397 N/A two hybrid,physical interaction,two hybrid fragment pooling approach ComPPI
MAP3K5 PGAM5 19590015 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ECT2 PGAM5 25348397 N/A physical interaction ComPPI
ZBTB16 PGAM5 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
HUWE1 PGAM5 25348397 N/A physical interaction ComPPI
CUL4B PGAM5 25348397 N/A physical interaction ComPPI
CDK2 PGAM5 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TUBA1A PGAM5 24234451 25348397 29568061 association pull down ComPPI,IntAct
RNF2 PGAM5 25348397 N/A physical interaction ComPPI
YAP1 PGAM5 25348397 N/A physical interaction ComPPI
MDC1 PGAM5 25348397 N/A physical interaction ComPPI
RIPK1 PGAM5 25348397 N/A anti tag coimmunoprecipitation ComPPI
RIPK3 PGAM5 22265414 24234451 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation ComPPI,IntAct
VCAM1 PGAM5 22623428 24234451 25348397 association cross-linking study ComPPI,IntAct
DNM1L PGAM5 25348397 N/A anti tag coimmunoprecipitation ComPPI
USP11 PGAM5 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PRKN PGAM5 25348397 N/A physical interaction ComPPI
HDAC5 PGAM5 25348397 N/A physical interaction ComPPI
TJP2 PGAM5 24234451 24255178 25348397 colocalization physical interaction,proximity-dependent biotin identification ComPPI,IntAct
BARD1 PGAM5 25348397 N/A physical interaction ComPPI
TRIM25 PGAM5 25348397 N/A physical interaction ComPPI
BIRC2 PGAM5 25348397 N/A physical interaction ComPPI
ESR1 PGAM5 21182205 24234451 25348397 association affinity chromatography technology,cosedimentation through density gradient,physical interaction ComPPI,IntAct
BRCA1 PGAM5 25348397 N/A physical interaction ComPPI
BAP1 PGAM5 24234451 25348397 27705803 association tandem affinity purification ComPPI,IntAct
TGOLN2 PGAM5 24234451 25348397 29568061 association pull down ComPPI,IntAct
ZRANB1 PGAM5 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MAGOH PGAM5 23084401 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HAUS1 PGAM5 25348397 N/A physical interaction ComPPI
RNPS1 PGAM5 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
RRP1B PGAM5 20926688 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
EIF4A3 PGAM5 23084401 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SUZ12 PGAM5 25348397 N/A physical interaction ComPPI
EZR PGAM5 24234451 25348397 29568061 association pull down ComPPI,IntAct
HDGF PGAM5 21907836 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
CYLD PGAM5 25348397 N/A physical interaction ComPPI
PGAM5 OSBPL10 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PGAM5 SLX4 19596235 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PGAM5 MRPL58 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
PGAM5 AGO4 19167051 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PGAM5 SIRT7 25348397 N/A physical interaction ComPPI
PGAM5 FN1 19738201 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
PGAM5 ASB3 25348397 N/A physical interaction ComPPI
PGAM5 ASB10 25348397 N/A physical interaction ComPPI
PGAM5 ASB14 25348397 N/A physical interaction ComPPI
PGAM5 CCDC8 25348397 N/A physical interaction ComPPI
PGAM5 MYH7B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PGAM5 TUBA1C 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PGAM5 ZSCAN26 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PGAM5 AIFM1 24234451 25348397 29568061 association pull down,physical interaction ComPPI,IntAct
PGAM5 ZNF746 25348397 N/A physical interaction ComPPI
PGAM5 G3BP1 25348397 N/A physical interaction ComPPI
PGAM5 CLEC14A 25348397 N/A physical interaction ComPPI
PGAM5 ASXL1 24234451 25348397 27705803 association tandem affinity purification ComPPI,IntAct
PGAM5 ZC3H18 24234451 25348397 29298432 association anti tag coimmunoprecipitation ComPPI,IntAct
PINK1 PGAM5 25348397 N/A physical interaction ComPPI
AKT1 PGAM5 15575970 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PGAM5 CHICO 22068330 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PGAM5 GTF2F2 24234451 30021884 physical association cross-linking study IntAct
LRRC8E PGAM5 24234451 30021884 physical association cross-linking study IntAct
L1TD1 PGAM5 24234451 25702638 association anti bait coimmunoprecipitation IntAct
PGAM5 MAP3K5 19590015 27898060 N/A N/A OmniPath
PGAM5 NFE2L2 18387606 27898060 inhibition,stimulant N/A OmniPath
PGAM5 KEAP1 17046835 18387606 19615732 24127568 27898060 N/A N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00008C2905 PGAM5 27087310 direct interaction,inhibition N/A NPInter

Visualization










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