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GENE：PRKAG1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PRKAG1
FullNmae protein kinase AMP-activated non-catalytic subunit gamma 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9385
EnsembleID ENSG00000181929
Uniprot P54619

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PRKAG1 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PRKAG1 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
PRKAG1 GO:0004672,GO:0004691,GO:0005515,GO:0005524,GO:0005634,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006110,GO:0006468,GO:0006468,GO:0006633,GO:0007165,GO:0007283,GO:0008603,GO:0010628,GO:0016020,GO:0016208,GO:0016208,GO:0019887,GO:0019887,GO:0019901,GO:0019901,GO:0031588,GO:0031588,GO:0031588,GO:0031669,GO:0031669,GO:0043531,GO:0045860,GO:0050790,GO:0051170

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PRKAG1 hsa:5571 path:hsa04068 FoxO signaling pathway - Homo sapiens (human)
PRKAG1 hsa:5571 path:hsa04152 AMPK signaling pathway - Homo sapiens (human)
PRKAG1 hsa:5571 path:hsa04211 Longevity regulating pathway - Homo sapiens (human)
PRKAG1 hsa:5571 path:hsa04213 Longevity regulating pathway - multiple species - Homo sapiens (human)
PRKAG1 hsa:5571 path:hsa04371 Apelin signaling pathway - Homo sapiens (human)
PRKAG1 hsa:5571 path:hsa04530 Tight junction - Homo sapiens (human)
PRKAG1 hsa:5571 path:hsa04710 Circadian rhythm - Homo sapiens (human)
PRKAG1 hsa:5571 path:hsa04714 Thermogenesis - Homo sapiens (human)
PRKAG1 hsa:5571 path:hsa04910 Insulin signaling pathway - Homo sapiens (human)
PRKAG1 hsa:5571 path:hsa04920 Adipocytokine signaling pathway - Homo sapiens (human)
PRKAG1 hsa:5571 path:hsa04921 Oxytocin signaling pathway - Homo sapiens (human)
PRKAG1 hsa:5571 path:hsa04922 Glucagon signaling pathway - Homo sapiens (human)
PRKAG1 hsa:5571 path:hsa04931 Insulin resistance - Homo sapiens (human)
PRKAG1 hsa:5571 path:hsa04932 Non-alcoholic fatty liver disease - Homo sapiens (human)
PRKAG1 hsa:5571 path:hsa04936 Alcoholic liver disease - Homo sapiens (human)
PRKAG1 hsa:5571 path:hsa05410 Hypertrophic cardiomyopathy - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PRKAB1 PRKAG1 20005715 interaction type N/A PSP

Source Target Pmid Interactiontype Methods Database
E2F4 PRKAG1 17531812 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 PRKAG1 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 PRKAG1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PRKAG1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000070B1D PRKAG1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000209F04 PRKAG1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000023133F PRKAG1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00005D986D PRKAG1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00004F4657 PRKAG1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00000F31F4 PRKAG1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000331800 PRKAG1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00002B0920 PRKAG1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000077DDE PRKAG1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000224AEA PRKAG1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001CE046 PRKAG1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000353492 PRKAG1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000021D7C8 PRKAG1 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PRKAG1 PRKAA1 25361965 interaction type N/A PTMCode2
PRKAA1 PRKAG1 25361965 interaction type N/A PTMCode2
PRKAG1 PRKAA2 25361965 interaction type N/A PTMCode2
PRKAA2 PRKAG1 25361965 interaction type N/A PTMCode2
CAMKK2 PRKAG1 25361965 interaction type N/A PTMCode2
PRKAG1 CAMKK2 25361965 interaction type N/A PTMCode2
PRKAB1 PRKAG1 25361965 interaction type N/A PTMCode2
PRKAG1 PRKAB1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
KRTAP9-2 PRKAG1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
EIF3G PRKAG1 21516116 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SNW1 PRKAG1 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CBSL PRKAG1 25348397 N/A physical interaction ComPPI
KRTAP10-5 PRKAG1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PLEKHF2 PRKAG1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PRKAA2 PRKAG1 14525934 20562859 24234451 25348397 25416956 9224708 physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,two hybrid array,in vivo,two hybrid prey pooling approach,validated two hybrid ComPPI,HPRD,IntAct
HSPA8 PRKAG1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
KRTAP10-11 PRKAG1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
KRTAP4-12 PRKAG1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
KRTAP4-2 PRKAG1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
VCP PRKAG1 25348397 N/A physical interaction ComPPI
KEAP1 PRKAG1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
MCM2 PRKAG1 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TEKT1 PRKAG1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
MEOX1 PRKAG1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PRKAA1 PRKAG1 14525934 16306228 20562859 22363791 23455922 24234451 25348397 25416956 25852190 8663446 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,two hybrid array,in vitro,tandem affinity purification,two hybrid prey pooling approach,validated two hybrid ComPPI,HPRD,IntAct
PHKG2 PRKAG1 25348397 N/A physical interaction ComPPI
WWP2 PRKAG1 25348397 N/A physical interaction ComPPI
MCL1 PRKAG1 25348397 N/A physical interaction ComPPI
KSR2 PRKAG1 24234451 25348397 27086506 association anti tag coimmunoprecipitation ComPPI,IntAct
TNFAIP1 PRKAG1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
HNRNPL PRKAG1 25348397 N/A physical interaction ComPPI
PA2G4 PRKAG1 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EGFR PRKAG1 25348397 N/A physical interaction ComPPI
FKBP4 PRKAG1 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
YAP1 PRKAG1 24234451 25348397 25751139 association physical interaction,tandem affinity purification ComPPI,IntAct
GABARAP PRKAG1 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
TRAK2 PRKAG1 25348397 N/A physical interaction ComPPI
PGK1 PRKAG1 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PAX6 PRKAG1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ULK1 PRKAG1 20562859 21072212 24234451 25348397 25686248 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FAS PRKAG1 25348397 N/A physical interaction ComPPI
PRKAB2 PRKAG1 10698692 14525934 20562859 21988832 24234451 25348397 25416956 physical association anti tag coimmunoprecipitation,two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid,two hybrid ComPPI,HPRD,IntAct
PRKAG1 PRKAB1 10698692 14525934 18480843 20562859 21988832 22363791 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,two hybrid ComPPI,HPRD,IntAct
PRKAG1 PRKAG2 10698692 14525934 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
PRKAG1 KCNN4 14525934 19052260 25348397 27898060 N/A two hybrid,experimental interaction detection,in vivo,two hybrid ComPPI,HPRD,OmniPath
PRKAG1 FNIP1 25348397 N/A anti tag coimmunoprecipitation,physical interaction,physical interaction ComPPI
PRKAG1 BABAM1 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PRKAG1 CAMKK2 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PRKAG1 TARS1 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PRKAG1 PAICS 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PRKAG1 AP1S3 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PRKAG1 ACACA 25348397 N/A physical interaction ComPPI
PRKAG1 CBS 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PRKAG1 C1ORF94 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PRKAG1 KRTAP10-3 25348397 N/A physical interaction ComPPI
PRKAG1 MAST3 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PRKAG1 TUBB8 25348397 N/A physical interaction ComPPI
PRKAG1 ATP2B3 25348397 N/A physical interaction ComPPI
PRKAG1 GLMP 25348397 N/A physical interaction ComPPI
PRKAG1 MFSD4B 25348397 N/A physical interaction ComPPI
PRKAG1 INTS14 25348397 N/A physical interaction ComPPI
PRKAG1 SLC2A8 25348397 N/A physical interaction ComPPI
PRKAG1 DCLRE1C 25348397 N/A physical interaction ComPPI
PRKAG1 STIM2 25348397 N/A physical interaction ComPPI
PRKAG1 CUTA 25348397 N/A physical interaction ComPPI
PRKAG1 CCKBR 25348397 N/A physical interaction ComPPI
PRKAG1 TRIM11 25348397 N/A physical interaction ComPPI
PRKAG1 FLCN 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
PRKAG1 ULK2 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
PRKAG1 KRTAP9-8 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PRKAG1 KRTAP1-1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PRKAG1 PLEKHA7 24234451 25348397 28877994 association anti bait coimmunoprecipitation ComPPI,IntAct
PRKAG1 PRKAG1 20562859 24234451 physical association anti tag coimmunoprecipitation IntAct
PRKAG1 PRKAA2 10698692 16054041 17012231 20562859 25416956 26186194 27898060 9224708 stimulant N/A OmniPath
STK11 PRKAG1 15509864 15661536 27898060 stimulant N/A OmniPath
PRKAG1 ULK1 20562859 21383122 25686248 27898060 N/A N/A OmniPath
PPM1A PRKAG1 20010958 27898060 inhibition N/A OmniPath
CAMKK2 PRKAG1 16054096 17244528 27898060 stimulant N/A OmniPath
KLKB1 PRKAG1 18353705 27898060 stimulant N/A OmniPath

Visualization










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