GENE：PRKAG2
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | PRKAG2 |
| FullNmae | protein kinase AMP-activated non-catalytic subunit gamma 2 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:9386 |
| EnsembleID | ENSG00000106617 |
| Uniprot | Q9UGJ0 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| PRKAG2 | autophagy | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| PRKAG2 | autophagy | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| PRKAG2 | GO:0004679,GO:0004862,GO:0005515,GO:0005524,GO:0005615,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005977,GO:0006110,GO:0006468,GO:0006469,GO:0006633,GO:0006754,GO:0008603,GO:0008607,GO:0010800,GO:0016126,GO:0016208,GO:0019217,GO:0019887,GO:0019901,GO:0019901,GO:0030295,GO:0031588,GO:0031588,GO:0031588,GO:0031669,GO:0035556,GO:0043531,GO:0045860,GO:0046320,GO:0046324,GO:0050790 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| PRKAG2 | hsa:51422 | path:hsa04068 | FoxO signaling pathway - Homo sapiens (human) |
| PRKAG2 | hsa:51422 | path:hsa04152 | AMPK signaling pathway - Homo sapiens (human) |
| PRKAG2 | hsa:51422 | path:hsa04211 | Longevity regulating pathway - Homo sapiens (human) |
| PRKAG2 | hsa:51422 | path:hsa04213 | Longevity regulating pathway - multiple species - Homo sapiens (human) |
| PRKAG2 | hsa:51422 | path:hsa04371 | Apelin signaling pathway - Homo sapiens (human) |
| PRKAG2 | hsa:51422 | path:hsa04530 | Tight junction - Homo sapiens (human) |
| PRKAG2 | hsa:51422 | path:hsa04710 | Circadian rhythm - Homo sapiens (human) |
| PRKAG2 | hsa:51422 | path:hsa04714 | Thermogenesis - Homo sapiens (human) |
| PRKAG2 | hsa:51422 | path:hsa04910 | Insulin signaling pathway - Homo sapiens (human) |
| PRKAG2 | hsa:51422 | path:hsa04920 | Adipocytokine signaling pathway - Homo sapiens (human) |
| PRKAG2 | hsa:51422 | path:hsa04921 | Oxytocin signaling pathway - Homo sapiens (human) |
| PRKAG2 | hsa:51422 | path:hsa04922 | Glucagon signaling pathway - Homo sapiens (human) |
| PRKAG2 | hsa:51422 | path:hsa04931 | Insulin resistance - Homo sapiens (human) |
| PRKAG2 | hsa:51422 | path:hsa04932 | Non-alcoholic fatty liver disease - Homo sapiens (human) |
| PRKAG2 | hsa:51422 | path:hsa04936 | Alcoholic liver disease - Homo sapiens (human) |
| PRKAG2 | hsa:51422 | path:hsa05410 | Hypertrophic cardiomyopathy - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| PRKAB1 | PRKAG2 | 20005715 | interaction type | N/A | PSP |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | PRKAG2 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| E2F4 | PRKAG2 | 17531812 18971253 | trascriptional regulation,stimulation | chromatin immunoprecipitation array,inferred by curator | TFlink |
| ESR1 | PRKAG2 | 18414489 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | PRKAG2 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA2 | PRKAG2 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| TFAP2C | PRKAG2 | 20629094 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| TP73 | PRKAG2 | 21245298 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| SMARCA4 | PRKAG2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | PRKAG2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | PRKAG2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | PRKAG2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | PRKAG2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | PRKAG2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | PRKAG2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | PRKAG2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| PRDM14 | PRKAG2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | PRKAG2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | PRKAG2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | PRKAG2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| VDR | PRKAG2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | PRKAG2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ZNF263 | PRKAG2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| PRKAA2 | PRKAG2 | 20562859 24234451 25348397 | physical association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| WDR83 | PRKAG2 | 25348397 | N/A | physical interaction | ComPPI |
| NF2 | PRKAG2 | 25348397 | N/A | physical interaction | ComPPI |
| PRKAA1 | PRKAG2 | 20562859 23455922 24234451 25348397 | association,physical association | anti tag coimmunoprecipitation,physical interaction,tandem affinity purification | ComPPI,IntAct |
| PHKG2 | PRKAG2 | 25348397 | N/A | physical interaction | ComPPI |
| HNRNPL | PRKAG2 | 25348397 | N/A | physical interaction | ComPPI |
| GEMIN2 | PRKAG2 | 25348397 | N/A | physical interaction | ComPPI |
| FKBP4 | PRKAG2 | 20562859 24234451 25348397 | physical association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| MAP1LC3A | PRKAG2 | 20562859 24234451 25348397 | physical association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| PGK1 | PRKAG2 | 20562859 24234451 25348397 | physical association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| ELAVL1 | PRKAG2 | 25348397 | N/A | physical interaction | ComPPI |
| GANAB | PRKAG2 | 20562859 24234451 25348397 | physical association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| EIF3A | PRKAG2 | 20562859 24234451 25348397 | physical association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| PRKAB2 | PRKAG2 | 10698692 14525934 20562859 24234451 25348397 | physical association | anti tag coimmunoprecipitation,two hybrid,physical interaction,two hybrid | ComPPI,HPRD,IntAct |
| PRKAG1 | PRKAG2 | 10698692 14525934 20562859 24234451 25348397 | physical association | anti tag coimmunoprecipitation,two hybrid,physical interaction,two hybrid | ComPPI,HPRD,IntAct |
| PRKAB1 | PRKAG2 | 10698692 14525934 20562859 24234451 25348397 | physical association | anti tag coimmunoprecipitation,two hybrid,physical interaction,two hybrid | ComPPI,HPRD,IntAct |
| PRKAG2 | MAP1B | 20562859 24234451 25348397 | physical association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| PRKAG2 | PFAS | 20562859 24234451 25348397 | physical association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| PRKAG2 | TARS1 | 20562859 24234451 25348397 | physical association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| PRKAG2 | GMPS | 20562859 24234451 25348397 | physical association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| PRKAG2 | MAP1A | 25348397 | N/A | physical interaction | ComPPI |
| PRKAG2 | ASNS | 25348397 | N/A | physical interaction | ComPPI |
| PRKAG2 | DCLRE1C | 25348397 | N/A | physical interaction | ComPPI |
| PRKAG2 | STIM2 | 25348397 | N/A | physical interaction | ComPPI |
| PRKAG2 | NEFH | 25348397 | N/A | physical interaction | ComPPI |
| PRKAG2 | ULK2 | 20562859 24234451 25348397 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| PRKAG2 | DAPK1 | 24234451 25348397 29513927 | N/A | protein array | ComPPI,IntAct |
| PRKAG2 | MFHAS1 | 24234451 25348397 29513927 | N/A | protein array | ComPPI,IntAct |
| PRKAG2 | PRKAG2 | 20562859 24234451 | physical association | anti tag coimmunoprecipitation | IntAct |
| PDIA6 | PRKAG2 | 24234451 30021884 | physical association | cross-linking study | IntAct |