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GENE：PRKAG3

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PRKAG3
FullNmae protein kinase AMP-activated non-catalytic subunit gamma 3
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9387
EnsembleID ENSG00000115592
Uniprot Q9UGI9

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PRKAG3 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PRKAG3 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
PRKAG3 GO:0004679,GO:0005515,GO:0005524,GO:0005615,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005978,GO:0006096,GO:0006468,GO:0006633,GO:0014873,GO:0016208,GO:0019887,GO:0019901,GO:0019901,GO:0031588,GO:0031588,GO:0031588,GO:0031669,GO:0035556,GO:0050790

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PRKAG3 hsa:53632 path:hsa04068 FoxO signaling pathway - Homo sapiens (human)
PRKAG3 hsa:53632 path:hsa04152 AMPK signaling pathway - Homo sapiens (human)
PRKAG3 hsa:53632 path:hsa04211 Longevity regulating pathway - Homo sapiens (human)
PRKAG3 hsa:53632 path:hsa04213 Longevity regulating pathway - multiple species - Homo sapiens (human)
PRKAG3 hsa:53632 path:hsa04371 Apelin signaling pathway - Homo sapiens (human)
PRKAG3 hsa:53632 path:hsa04530 Tight junction - Homo sapiens (human)
PRKAG3 hsa:53632 path:hsa04710 Circadian rhythm - Homo sapiens (human)
PRKAG3 hsa:53632 path:hsa04714 Thermogenesis - Homo sapiens (human)
PRKAG3 hsa:53632 path:hsa04910 Insulin signaling pathway - Homo sapiens (human)
PRKAG3 hsa:53632 path:hsa04920 Adipocytokine signaling pathway - Homo sapiens (human)
PRKAG3 hsa:53632 path:hsa04921 Oxytocin signaling pathway - Homo sapiens (human)
PRKAG3 hsa:53632 path:hsa04922 Glucagon signaling pathway - Homo sapiens (human)
PRKAG3 hsa:53632 path:hsa04931 Insulin resistance - Homo sapiens (human)
PRKAG3 hsa:53632 path:hsa04932 Non-alcoholic fatty liver disease - Homo sapiens (human)
PRKAG3 hsa:53632 path:hsa04936 Alcoholic liver disease - Homo sapiens (human)
PRKAG3 hsa:53632 path:hsa05410 Hypertrophic cardiomyopathy - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR PRKAG3 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
FOXA1 PRKAG3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 PRKAG3 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
PRKAB1 PRKAG3 25361965 interaction type N/A PTMCode2
PRKAG3 PRKAB1 25361965 interaction type N/A PTMCode2
PRKAG3 PRKAA1 25361965 interaction type N/A PTMCode2
PRKAA1 PRKAG3 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PRKAA2 PRKAG3 25348397 N/A physical interaction ComPPI
BAG3 PRKAG3 25348397 N/A physical interaction ComPPI
CRYAB PRKAG3 25348397 N/A physical interaction ComPPI
KRTAP19-5 PRKAG3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PRKAA1 PRKAG3 14525934 25348397 8626596 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
KLC1 PRKAG3 25348397 N/A physical interaction ComPPI
CLTCL1 PRKAG3 25348397 N/A physical interaction ComPPI
BRCA1 PRKAG3 25348397 N/A physical interaction ComPPI
PFDN1 PRKAG3 25348397 N/A physical interaction ComPPI
PRKAB2 PRKAG3 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PRKAG3 PRKAB1 25348397 N/A physical interaction ComPPI
PRKAG3 LMCD1 25348397 N/A physical interaction ComPPI
PRKAG3 NGRN 25348397 N/A physical interaction ComPPI
PRKAG3 COA8 25348397 N/A physical interaction ComPPI
ULK1 PRKAG3 21460634 27898060 inhibition N/A OmniPath
ULK2 PRKAG3 21460634 27898060 inhibition N/A OmniPath

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