Gene Information gene info

  1. Home

GENE：RHEB

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol RHEB
FullNmae Ras homolog, mTORC1 binding
LocusType gene with protein product
Status Approved
HGNC_id HGNC:10011
EnsembleID ENSG00000106615
Uniprot Q15382

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
RHEB mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
RHEB autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
RHEB autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
RHEB GO:0000139,GO:0000287,GO:0003924,GO:0003924,GO:0003924,GO:0005515,GO:0005525,GO:0005525,GO:0005525,GO:0005681,GO:0005765,GO:0005765,GO:0005789,GO:0005829,GO:0005886,GO:0007165,GO:0007264,GO:0012505,GO:0014069,GO:0014069,GO:0016020,GO:0016241,GO:0019003,GO:0019003,GO:0019901,GO:0030295,GO:0031669,GO:0032008,GO:0043539,GO:0048709,GO:0048714,GO:0051726,GO:0070062,GO:0120163,GO:1904263,GO:2000074

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
RHEB hsa:6009 path:hsa04072 Phospholipase D signaling pathway - Homo sapiens (human)
RHEB hsa:6009 path:hsa04140 Autophagy - animal - Homo sapiens (human)
RHEB hsa:6009 path:hsa04150 mTOR signaling pathway - Homo sapiens (human)
RHEB hsa:6009 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
RHEB hsa:6009 path:hsa04152 AMPK signaling pathway - Homo sapiens (human)
RHEB hsa:6009 path:hsa04211 Longevity regulating pathway - Homo sapiens (human)
RHEB hsa:6009 path:hsa04218 Cellular senescence - Homo sapiens (human)
RHEB hsa:6009 path:hsa04714 Thermogenesis - Homo sapiens (human)
RHEB hsa:6009 path:hsa04910 Insulin signaling pathway - Homo sapiens (human)
RHEB hsa:6009 path:hsa04919 Thyroid hormone signaling pathway - Homo sapiens (human)
RHEB hsa:6009 path:hsa05163 Human cytomegalovirus infection - Homo sapiens (human)
RHEB hsa:6009 path:hsa05165 Human papillomavirus infection - Homo sapiens (human)
RHEB hsa:6009 path:hsa05168 Herpes simplex virus 1 infection - Homo sapiens (human)
RHEB hsa:6009 path:hsa05231 Choline metabolism in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
RHEB FKBP8 12906785 17991864 18466115 19022819 19143635 23087689 26192618 association N/A ACSN
TSC1 RHEB 12906785 14551205 16636147 17604271 17680028 17693255 19022819 20146692 26192618 interaction type N/A ACSN
TSC2 RHEB 12842888 12906785 15854902 16636147 17680028 19022819 20146692 20226003 21071413 23180781 23331499 26192618 interaction type,stimulation,physical association pull down ACSN,InnateDB,SignaLink,SignaLink
RHEB DEPTOR 12150925 12408816 12906785 15755954 16469695 17680028 18466115 18492954 19022819 19143635 19568798 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 26192618 26597054 28216025 interaction type N/A ACSN
RHEB MLST8 12906785 16636147 17604271 18466115 19022819 19143635 23087689 26192618 interaction type N/A ACSN
RHEB MTOR 12906785 15854902 15878852 16098514 16636147 17470430 17604271 18466115 18550814 19022819 19143635 20226003 21071413 23087689 23180781 23331499 26192618 interaction type,stimulation,physical association anti tag coimmunoprecipitation,pull down ACSN,InnateDB,SignaLink,SignaLink
RHEB RPTOR 12906785 15854902 15878852 16636147 17470430 17604271 18466115 19022819 19143635 23087689 23180781 26192618 interaction type,physical association anti tag coimmunoprecipitation,pull down ACSN,InnateDB
RHEB RAC1 12906785 16636147 17604271 18466115 19022819 19143635 23087689 26192618 interaction type N/A ACSN
FKBP8 RHEB 18658153 18676370 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
RHEB ATM 15854902 23180781 physical association pull down InnateDB
RHEB ATR 15854902 23180781 physical association pull down InnateDB
RHEB PLD1 18550814 23180781 physical association pull down InnateDB
RHEB BNIP3 17928295 23180781 physical association two hybrid InnateDB
BNIP3L RHEB 17928295 23180781 physical association two hybrid InnateDB
RHEB RABAC1 17928295 23180781 physical association two hybrid InnateDB
BRAF RHEB 12214276 15150271 23180781 physical association anti tag coimmunoprecipitation InnateDB
MLST8 RHEB 15854902 15878852 17470430 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
RHEB RHEB 15854902 20006481 26467481 bind,up-regulates activity N/A Signor

Source Target Pmid Interactiontype Methods Database
RPTOR RHEB 20005715 interaction type N/A PSP
TRAF2 RHEB 20005715 interaction type N/A PSP,SignaLink
TSC1 RHEB 20005715 interaction type N/A PSP,SignaLink
RPTOR RHEB 15854902 15854902 20005715 20005715 21071413 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
ESR1 RHEB 18414489 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 RHEB 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 RHEB 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
PRDM14 RHEB 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 RHEB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA RHEB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF RHEB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 RHEB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 RHEB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 RHEB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 RHEB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS RHEB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A RHEB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF RHEB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 RHEB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 RHEB 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000338542 RHEB 20584899 rna interference,inhibition experimental interaction detection miRSponge
URS0000338542 RHEB 18668040 20584899 23807165 25416803 mrna cleavage,inhibition array technology,experimental interaction detection TarBase
URS00000EC1BE RHEB 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000035CC3E RHEB 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
MAPKAPK5 RHEB 22135298 phosphorylation N/A PhosphoSite
RHEB BRAF 25361965 interaction type N/A PTMCode2
BRAF RHEB 25361965 interaction type N/A PTMCode2
RHEB TSC1 25361965 interaction type N/A PTMCode2
TSC1 RHEB 25361965 interaction type N/A PTMCode2
RHEB RPTOR 25361965 interaction type N/A PTMCode2
RPTOR RHEB 25361965 interaction type N/A PTMCode2
RHEB PLD1 25361965 interaction type N/A PTMCode2
PLD1 RHEB 25361965 interaction type N/A PTMCode2
RAF1 RHEB 25361965 interaction type N/A PTMCode2
RHEB RAF1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
EIF1B RHEB 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PDE6D RHEB 11980706 14525934 23698361 24234451 25348397 physical association two hybrid,experimental interaction detection,fluorescent resonance energy transfer,physical interaction,in vivo,two hybrid ComPPI,HPRD,IntAct
RELL2 RHEB 25348397 N/A physical interaction ComPPI
LDHB RHEB 25348397 N/A physical interaction ComPPI
RAC1 RHEB 25348397 N/A physical interaction ComPPI
APPBP2 RHEB 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RABAC1 RHEB 25348397 N/A physical interaction ComPPI
HRAS RHEB 25348397 N/A physical interaction ComPPI
ATR RHEB 14525934 15854902 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
NEDD9 RHEB 25348397 N/A physical interaction ComPPI
RAB7A RHEB 15809346 25348397 26344197 27898060 N/A physical interaction ComPPI,OmniPath
UBB RHEB 25348397 N/A physical interaction ComPPI
APOE RHEB 25348397 N/A physical interaction ComPPI
TNF RHEB 25348397 N/A physical interaction ComPPI
TSC2 RHEB 12842888 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
RAP1A RHEB 25348397 N/A physical interaction ComPPI
ATM RHEB 14525934 15854902 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
TRAF2 RHEB 20368287 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
RPS6KB1 RHEB 25348397 N/A physical interaction ComPPI
TPT1 RHEB 17301792 24234451 25348397 27898060 N/A pull down,physical interaction,gdp/gtp exchange assay ComPPI,IntAct,OmniPath
PSEN2 RHEB 21163940 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
HTT RHEB 25348397 N/A physical interaction ComPPI
RAF1 RHEB 14525934 16803888 19222999 24234451 25348397 9001246 N/A two hybrid,experimental interaction detection,pull down,physical interaction,in vitro,two hybrid ComPPI,HPRD,IntAct
ITGB8 RHEB 25348397 N/A physical interaction ComPPI
RHEB MTOR 14525934 15854902 15878852 16098514 16631613 18550814 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
RHEB BRAF 14525934 16803888 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
RHEB RPTOR 14525934 16631613 24234451 25348397 25446900 physical association experimental interaction detection,physical interaction,in vitro,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
RHEB TSC1 25348397 N/A physical interaction ComPPI
RHEB RAB9A 25348397 N/A physical interaction ComPPI
RHEB A2M 21163940 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
RHEB ECSIT 21163940 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
RHEB PSEN1 25348397 N/A physical interaction ComPPI
RHEB BNIP3 25348397 N/A physical interaction ComPPI
RHEB BNIP3L 25348397 N/A physical interaction ComPPI
RHEB NCAM1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
RHEB FKBP8 25348397 N/A physical interaction ComPPI
RHEB PLD1 18550814 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
RHEB VPS4A 25348397 N/A physical interaction ComPPI
RHEB CREB3 21516116 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
RHEB DUSP19 25348397 N/A physical interaction ComPPI
RHEB SPATA19 25348397 N/A physical interaction ComPPI
RHEB NFATC2IP 25348397 N/A physical interaction ComPPI
RHEB IL20RA 25348397 N/A physical interaction ComPPI
RHEB LAMP2 25348397 N/A physical interaction ComPPI
RHEB SRPRB 25348397 N/A physical interaction ComPPI
RHEB SLC15A1 25348397 N/A physical interaction ComPPI
RHEB ENPP7 25348397 N/A physical interaction ComPPI
RHEB LGALS7 25348397 N/A physical interaction ComPPI
RHEB TMEM52B 25348397 N/A physical interaction ComPPI
RHEB TRIM25 25348397 N/A physical interaction ComPPI
ARIH2 RHEB 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
FOXO RHEB 25348397 N/A physical interaction ComPPI
MKI67 RHEB 24234451 26949251 association anti tag coimmunoprecipitation IntAct
PLD1 RHEB 18550814 27898060 N/A N/A OmniPath
RHEB PLD1 18550814 27898060 stimulant N/A OmniPath
GAPDH RHEB 19451232 27898060 inhibition N/A OmniPath
BNIP3 RHEB 17928295 19136941 27898060 inhibition N/A OmniPath
RHEB BNIP3 17928295 27898060 N/A N/A OmniPath
RHEB BRAF 12214276 15150271 16803888 18452278 18669648 18691976 19651622 20068231 20166139 27898060 inhibition N/A OmniPath
ATR RHEB 15854902 27898060 N/A N/A OmniPath
RHEB ATR 15854902 27898060 N/A N/A OmniPath
RHEB MLST8 12718876 15854902 15878852 17470430 27898060 stimulant N/A OmniPath
MLST8 RHEB 15854902 15878852 17470430 27898060 N/A N/A OmniPath
RHEB ATM 15854902 27898060 N/A N/A OmniPath
RHEB RAF1 15150271 15854902 16803888 19222999 27898060 9001246 stimulant N/A OmniPath
TSC2 RHEB 12771962 12820960 12842888 12869586 12906785 15340059 15854902 16636147 17077083 20226003 27898060 inhibition,stimulant N/A OmniPath
RHEB TSC2 12771962 12820960 12842888 12869586 15340059 15854902 16636147 17077083 20226003 27898060 N/A N/A OmniPath
RHEB BNIP3L 17928295 27898060 N/A N/A OmniPath
RHEB RPTOR 15854902 15878852 16631613 17470430 24337580 25446900 27898060 stimulant N/A OmniPath
RPTOR RHEB 15854902 15878852 16631613 17470430 24337580 25446900 27898060 N/A N/A OmniPath
MTOR RHEB 15772076 15854902 15878852 16098514 16631613 16915281 17470430 18075516 18550814 20006481 27898060 N/A N/A OmniPath
RHEB MTOR 15772076 15854902 15878852 16098514 16631613 16915281 17470430 18075516 18550814 20006481 27898060 stimulant N/A OmniPath
FKBP8 RHEB 17991864 18658153 18676370 27898060 N/A N/A OmniPath
RHEB FKBP8 17991864 18658153 18676370 19222999 27898060 inhibition N/A OmniPath
MAPKAPK5 RHEB 21336308 27898060 N/A N/A OmniPath
TSC1 RHEB 20006481 27898060 inhibition N/A OmniPath
RHEB RABAC1 17928295 27898060 N/A N/A OmniPath

Visualization










  Return