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GENE：RPTOR

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol RPTOR
FullNmae regulatory associated protein of MTOR complex 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:30287
EnsembleID ENSG00000141564
Uniprot Q8N122

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
RPTOR autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
RPTOR autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
RPTOR GO:0001002,GO:0001003,GO:0001006,GO:0001156,GO:0001558,GO:0001938,GO:0005515,GO:0005654,GO:0005654,GO:0005737,GO:0005737,GO:0005764,GO:0005764,GO:0005765,GO:0005765,GO:0005829,GO:0005829,GO:0006974,GO:0008361,GO:0009267,GO:0009410,GO:0010494,GO:0010506,GO:0010507,GO:0010507,GO:0010800,GO:0019901,GO:0030291,GO:0030295,GO:0030307,GO:0030307,GO:0030307,GO:0030425,GO:0030674,GO:0030674,GO:0031267,GO:0031669,GO:0031669,GO:0031669,GO:0031929,GO:0031931,GO:0031931,GO:0031931,GO:0032008,GO:0033138,GO:0035176,GO:0038202,GO:0038202,GO:0038202,GO:0043025,GO:0044877,GO:0045672,GO:0045821,GO:0045945,GO:0046889,GO:0071230,GO:0071230,GO:0071233,GO:0071456,GO:0071470,GO:0071889,GO:0071902,GO:0071902,GO:0140767,GO:1900087,GO:1901331,GO:1905857

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
RPTOR hsa:57521 path:hsa04136 Autophagy - other - Homo sapiens (human)
RPTOR hsa:57521 path:hsa04140 Autophagy - animal - Homo sapiens (human)
RPTOR hsa:57521 path:hsa04150 mTOR signaling pathway - Homo sapiens (human)
RPTOR hsa:57521 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
RPTOR hsa:57521 path:hsa04152 AMPK signaling pathway - Homo sapiens (human)
RPTOR hsa:57521 path:hsa04211 Longevity regulating pathway - Homo sapiens (human)
RPTOR hsa:57521 path:hsa04213 Longevity regulating pathway - multiple species - Homo sapiens (human)
RPTOR hsa:57521 path:hsa04714 Thermogenesis - Homo sapiens (human)
RPTOR hsa:57521 path:hsa04910 Insulin signaling pathway - Homo sapiens (human)
RPTOR hsa:57521 path:hsa05131 Shigellosis - Homo sapiens (human)
RPTOR hsa:57521 path:hsa05206 MicroRNAs in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
MLST8 RPTOR 10702316 11108711 11274345 11756498 12150925 12408816 12533512 12709531 12713446 12718876 12844354 12867079 12906785 15314020 15749884 15755954 15905173 16286006 16469695 16679021 16713974 16915281 16919458 17052453 17053147 17368478 17404308 17604271 17680028 18000759 18030348 18046414 18048642 18372248 18391071 18423201 18492954 19022819 19143636 19151919 19225151 19244117 19339977 19446321 19568798 19597330 19706736 19720745 19864431 19930715 20138985 20547845 20647036 20805416 20832730 20932932 21157483 21177869 21233202 21474067 21981924 22504639 23087689 23180781 24795729 24973821 25002027 25682865 25730849 26159692 26192618 26597054 27328425 27331412 27510662 27572739 28216025 interaction type,physical association anti tag coimmunoprecipitation ACSN,InnateDB
MTOR RPTOR 10702316 11108711 11274345 11756498 12150925 12408816 12533512 12709531 12713446 12844354 12867079 12906785 15268862 15314020 15749884 15755954 15905173 16286006 16469695 16679021 16713974 16915281 17052453 17053147 17277771 17368478 17386266 17404308 17604271 17680028 18000759 18046414 18048642 18372248 18391071 18423201 18492954 18519641 18614546 19022819 19143636 19151919 19225151 19244117 19339977 19446321 19568798 19597330 19706736 19720745 19864431 19930715 20138985 20547845 20647036 20805416 20832730 20932932 21157483 21177869 21233202 21474067 21981924 22504639 23087689 23180781 24795729 24973821 25002027 25682865 25730849 26159692 26192618 26597054 27328425 27331412 27510662 27572739 28216025 interaction type,physical association anti tag coimmunoprecipitation ACSN,InnateDB
RPTOR DEPTOR 11274345 11756498 12150925 12408816 12906785 15749884 15755954 16469695 16713974 17404308 17604271 17680028 18000759 18372248 18492954 19022819 19143636 19151919 19446321 19568798 19706736 19864431 20547845 20805416 21157483 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 26192618 27331412 28216025 interaction type N/A ACSN
RPTOR PPARGC1A 12150925 12408816 12533512 12906785 15755954 16469695 17680028 18046414 18048642 18492954 19022819 19568798 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 26192618 28216025 interaction type N/A ACSN
RPTOR YY1 12150925 12408816 12533512 12906785 15755954 16469695 17680028 18046414 18048642 18492954 19022819 19568798 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 26192618 28216025 interaction type N/A ACSN
RPTOR FKBP8 12150925 15755954 16469695 17991864 19864431 23087689 26159692 26192618 association N/A ACSN
RPTOR EIF4E 11108711 12150925 12408816 12709531 12844354 12867079 12906785 15314020 15755954 15905173 16286006 16469695 16679021 17368478 17680028 18391071 18492954 19022819 19339977 19568798 19597330 19864431 20647036 20932932 21157483 21177869 21233202 21981924 23087689 24795729 24973821 25002027 25682865 25730849 26159692 26192618 28216025 interaction type N/A ACSN
RPTOR EIF4B 12150925 12408816 12844354 12867079 12906785 15755954 15905173 16286006 16469695 16679021 17368478 17680028 18391071 18492954 19022819 19339977 19568798 19597330 19864431 20647036 21157483 21177869 21233202 21981924 23087689 24795729 24973821 25002027 25730849 26159692 26192618 28216025 interaction type N/A ACSN
RPTOR RPS6 12150925 12408816 12844354 12867079 12906785 15755954 15905173 16286006 16469695 16679021 17368478 17680028 18391071 18492954 19022819 19339977 19568798 19597330 19864431 20647036 21157483 21177869 21233202 21981924 23087689 24795729 24973821 25002027 25730849 26159692 26192618 28216025 interaction type N/A ACSN
RAC1 RPTOR 10702316 11274345 11756498 12150925 12408816 12906785 15749884 15755954 16469695 16713974 17404308 17604271 17680028 18000759 18372248 18492954 19022819 19143636 19151919 19225151 19244117 19446321 19568798 19706736 19864431 20138985 20547845 20805416 21157483 21474067 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 26192618 27331412 28216025 interaction type N/A ACSN
RHEB RPTOR 12906785 15854902 15878852 16636147 17470430 17604271 18466115 19022819 19143635 23087689 23180781 26192618 interaction type,physical association anti tag coimmunoprecipitation,pull down ACSN,InnateDB
RPTOR FOXP3 12150925 12408816 12906785 15755954 16469695 17604271 17680028 18372248 18492954 19022819 19446321 19568798 19706736 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 26192618 28216025 interaction type N/A ACSN
RPTOR MYC 12150925 12408816 12906785 15755954 16469695 17604271 17680028 18372248 18492954 19022819 19446321 19568798 19706736 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 26192618 28216025 interaction type N/A ACSN
RPTOR MMP2 12150925 12408816 12906785 15755954 16469695 17680028 18492954 19022819 19568798 19864431 19930715 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 26192618 26597054 27328425 27510662 27572739 28216025 interaction type N/A ACSN
PTP4A3 RPTOR 17409395 19440036 19945467 20609352 21084277 23691193 24030100 24376839 24696260 25136802 26192618 26597054 27328425 27572739 interaction type N/A ACSN
RPTOR MMP9 12150925 12408816 12906785 15755954 16469695 17680028 18492954 19022819 19568798 19864431 19930715 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 26192618 26597054 27328425 27510662 27572739 28216025 interaction type N/A ACSN
RPTOR HIF1A 12150925 12777372 15755954 15854902 16469695 16915281 17991864 19299511 19864431 19942859 20484410 22025673 22841746 23087689 26159692 26192618 interaction type N/A ACSN
PML RPTOR 16915281 20452955 26192618 interaction type N/A ACSN
RPTOR ESRRA 12150925 12408816 12533512 12906785 15755954 16314495 16469695 17680028 18046414 18048642 18492954 19022819 19568798 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 26192618 28216025 interaction type N/A ACSN
RPTOR COX5A 12150925 12408816 12533512 12906785 15755954 16469695 17680028 18046414 18048642 18492954 19022819 19568798 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 26192618 28216025 interaction type N/A ACSN
RPTOR IDH3A 12150925 12408816 12533512 12906785 15755954 16469695 17680028 18046414 18048642 18492954 19022819 19568798 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 26192618 28216025 interaction type N/A ACSN
RPTOR ATG13 11274345 11756498 12150925 12408816 12906785 15755954 16469695 17680028 18000759 18492954 19022819 19151919 19225151 19446321 19568798 19706736 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 26192618 27331412 28216025 interaction type N/A ACSN
RPTOR SQSTM1 12150925 12777372 15340068 15755954 15854902 16252010 16469695 17991864 19299511 19864431 19942859 20484410 20531300 21981924 22025673 23087689 25002027 26159692 26192618 26587781 28574505 interaction type N/A ACSN
RPTOR GZMA 12150925 12408816 12906785 15749884 15755954 16469695 16713974 17404308 17604271 17680028 18372248 18492954 19022819 19143636 19446321 19568798 19706736 19864431 20547845 20805416 21157483 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 26192618 28216025 interaction type N/A ACSN
RPTOR IL10 12150925 12408816 12906785 15749884 15755954 16469695 16713974 17404308 17604271 17680028 18372248 18492954 19022819 19143636 19446321 19568798 19706736 19864431 20547845 20805416 21157483 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 26192618 28216025 interaction type N/A ACSN
RPTOR IFNG 12150925 12408816 12906785 15755954 16469695 17604271 17680028 18372248 18492954 19022819 19143636 19446321 19568798 19706736 19864431 20805416 21157483 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 26192618 28216025 interaction type N/A ACSN
RPTOR GZMB 12150925 12408816 12906785 15749884 15755954 16469695 16713974 17404308 17604271 17680028 18372248 18492954 19022819 19143636 19446321 19568798 19706736 19864431 20547845 20805416 21157483 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 26192618 28216025 interaction type N/A ACSN
AKT1 RPTOR 10722653 10949026 11715018 11756412 11923280 15169778 15808505 16697215 17052453 17680028 18372248 18570873 18636226 20138985 20214616 20398329 20832730 26192618 9812896 interaction type N/A ACSN
RPTOR MTOR 12150925 12150926 12718876 15066126 15268862 15467718 15809305 16603397 16847060 16919458 16962653 17043309 17277771 17461779 17599906 17604271 18030348 18570873 18614546 18676370 19114562 19145465 23180781 physical association anti tag coimmunoprecipitation InnateDB
FKBP8 RPTOR 17991864 23180781 physical association anti tag coimmunoprecipitation InnateDB
AKT1S1 RPTOR 17517883 17604271 18030348 18215133 23180781 phosphorylation reaction,physical association anti tag coimmunoprecipitation,far western blotting,pull down,in-gel kinase assay,protein kinase assay InnateDB
PRR5L RPTOR 18030348 23180781 phosphorylation reaction in-gel kinase assay InnateDB
RPTOR RRAGD 18497260 23180781 physical association anti tag coimmunoprecipitation InnateDB
RRAGA RPTOR 18497260 23180781 physical association anti tag coimmunoprecipitation InnateDB
RPTOR RRAGC 18497260 23180781 physical association anti tag coimmunoprecipitation InnateDB
RPTOR RRAGB 18497260 23180781 physical association anti tag coimmunoprecipitation InnateDB
EIF4EBP1 RPTOR 12150926 12604610 12747827 15066126 16824195 17502379 19272448 23180781 phosphorylation reaction,physical association anti tag coimmunoprecipitation,far western blotting,pull down,in-gel kinase assay InnateDB
HIF1A RPTOR 17502379 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
EIF3B RPTOR 16286006 23180781 physical association anti tag coimmunoprecipitation InnateDB
RPTOR PREX1 17565979 23180781 physical association anti tag coimmunoprecipitation InnateDB
YWHAZ RPTOR 18439900 23180781 physical association anti tag coimmunoprecipitation InnateDB
YWHAG RPTOR 18439900 23180781 physical association anti tag coimmunoprecipitation InnateDB
PLD2 RPTOR 16837165 23180781 physical association anti tag coimmunoprecipitation InnateDB
TIRAP RPTOR 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
RPTOR PLD2 20005715 interaction type N/A PSP
RPTOR RPS6KB1 20005715 interaction type N/A PSP
RPTOR MTOR 20005715 interaction type N/A PSP
RPTOR FKBP1A 20005715 interaction type N/A PSP
RPTOR PDK1 20005715 interaction type N/A PSP
RPTOR RHEB 20005715 interaction type N/A PSP
RPTOR FKBP1A 15268862 15467718 20005715 21071413 N/A N/A SignaLink
RPTOR MTOR 12150925 12150925 12150926 12150926 12604610 12665511 12719976 15066126 15268862 15268862 15459249 15467718 16183647 16354680 16603397 16631613 16798736 16837165 16847060 16919458 17043309 17461779 20005715 20005715 20427287 21045808 21071413 N/A N/A SignaLink
RPTOR PDK1 12150926 20005715 20005715 21071413 N/A N/A SignaLink
RPTOR PLD2 20005715 20005715 N/A N/A SignaLink
RPTOR RHEB 15854902 15854902 20005715 20005715 21071413 N/A N/A SignaLink
RPTOR RPS6KB1 12150926 12150926 12604610 12604610 16183647 18988627 20005715 20005715 21071413 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR RPTOR 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 RPTOR 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 RPTOR 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 RPTOR 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
POU2F1 RPTOR 21060808 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
RARA RPTOR 21060808 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
TFAP2C RPTOR 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 RPTOR 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 RPTOR 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 RPTOR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA RPTOR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF RPTOR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 RPTOR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 RPTOR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 RPTOR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 RPTOR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS RPTOR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A RPTOR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF RPTOR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 RPTOR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 RPTOR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 RPTOR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 RPTOR 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000330617 RPTOR 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001B341F RPTOR 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000338542 RPTOR 25416803 27284727 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
PRKAA1 RPTOR 22135298 phosphorylation N/A PhosphoSite
MAPK11 RPTOR 22135298 phosphorylation N/A PhosphoSite
MAPK3 RPTOR 22135298 phosphorylation N/A PhosphoSite
ULK1 RPTOR 22135298 phosphorylation N/A PhosphoSite
CDK1 RPTOR 22135298 phosphorylation N/A PhosphoSite
GSK3B RPTOR 22135298 phosphorylation N/A PhosphoSite
NLK RPTOR 22135298 phosphorylation N/A PhosphoSite
MAPK1 RPTOR 22135298 phosphorylation N/A PhosphoSite
RPS6KA1 RPTOR 22135298 phosphorylation N/A PhosphoSite
MTOR RPTOR 22135298 phosphorylation N/A PhosphoSite
CILK1 RPTOR 22135298 phosphorylation N/A PhosphoSite
MAPK8 RPTOR 22135298 phosphorylation N/A PhosphoSite
RHEB RPTOR 25361965 interaction type N/A PTMCode2
RPTOR RHEB 25361965 interaction type N/A PTMCode2
MAPKAP1 RPTOR 25361965 interaction type N/A PTMCode2
RPTOR MAPKAP1 25361965 interaction type N/A PTMCode2
PLD2 RPTOR 25361965 interaction type N/A PTMCode2
RPTOR PLD2 25361965 interaction type N/A PTMCode2
RPS6KB1 RPTOR 25361965 interaction type N/A PTMCode2
RPTOR RPS6KB1 25361965 interaction type N/A PTMCode2
IRS1 RPTOR 25361965 interaction type N/A PTMCode2
RPTOR IRS1 25361965 interaction type N/A PTMCode2
RPTOR EIF4EBP1 25361965 interaction type N/A PTMCode2
EIF4EBP1 RPTOR 25361965 interaction type N/A PTMCode2
RPTOR AKT1S1 25361965 interaction type N/A PTMCode2
AKT1S1 RPTOR 25361965 interaction type N/A PTMCode2
RPTOR RICTOR 25361965 interaction type N/A PTMCode2
RICTOR RPTOR 25361965 interaction type N/A PTMCode2
RPTOR ULK2 25361965 interaction type N/A PTMCode2
ULK2 RPTOR 25361965 interaction type N/A PTMCode2
RPTOR MLST8 25361965 interaction type N/A PTMCode2
MLST8 RPTOR 25361965 interaction type N/A PTMCode2
RRAGA RPTOR 25361965 interaction type N/A PTMCode2
RPTOR RRAGA 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PRKAA2 RPTOR 25348397 N/A physical interaction ComPPI
BAG3 RPTOR 25348397 N/A physical interaction ComPPI
TRAF6 RPTOR 25348397 N/A physical interaction ComPPI
FKBP1A RPTOR 25348397 N/A physical interaction ComPPI
LAMTOR4 RPTOR 22980980 24234451 25348397 25561175 association anti tag coimmunoprecipitation,cross-linking study ComPPI,IntAct
SPAG5 RPTOR 23953116 24234451 25348397 association,physical association anti bait coimmunoprecipitation,proximity ligation assay ComPPI,IntAct
CBY1 RPTOR 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
MAPK1 RPTOR 25348397 N/A physical interaction ComPPI
MAPK8 RPTOR 24234451 25348397 27043084 association,physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
NFATC1 RPTOR 25348397 N/A physical interaction ComPPI
MAPK3 RPTOR 25348397 N/A physical interaction ComPPI
EP300 RPTOR 25348397 N/A physical interaction ComPPI
HIF1A RPTOR 25348397 N/A physical interaction ComPPI
RTKN RPTOR 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
GIGYF1 RPTOR 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
PDIA3 RPTOR 25348397 N/A physical interaction ComPPI
IRS2 RPTOR 25348397 N/A physical interaction ComPPI
PRKAA1 RPTOR 25348397 N/A physical interaction ComPPI
NTRK1 RPTOR 25348397 N/A physical interaction ComPPI
PLD2 RPTOR 14525934 16837165 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
MAGI1 RPTOR 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
IKBKB RPTOR 25348397 N/A physical interaction ComPPI
TIRAP RPTOR 21903422 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LAMTOR3 RPTOR 24234451 25348397 25561175 association anti tag coimmunoprecipitation ComPPI,IntAct
HNRNPL RPTOR 25348397 N/A physical interaction ComPPI
RPS6KA1 RPTOR 25348397 N/A physical interaction ComPPI
EIF4EBP1 RPTOR 12150926 12604610 12747827 12912989 14525934 16824195 18337751 24234451 25348397 association,physical association anti tag coimmunoprecipitation,experimental interaction detection,far western blotting,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
IQGAP1 RPTOR 25348397 N/A physical interaction ComPPI
MARK4 RPTOR 25348397 N/A physical interaction ComPPI
NFATC2 RPTOR 25348397 N/A physical interaction ComPPI
SQSTM1 RPTOR 25348397 N/A physical interaction ComPPI
CILK1 RPTOR 25348397 N/A physical interaction ComPPI
EIF3C RPTOR 25348397 N/A physical interaction ComPPI
RAB1A RPTOR 24234451 25348397 25446900 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction,proximity ligation assay ComPPI,IntAct
RAP1B RPTOR 25348397 N/A physical interaction ComPPI
XPO1 RPTOR 25348397 N/A physical interaction ComPPI
YWHAQ RPTOR 25348397 N/A physical interaction ComPPI
RPS6 RPTOR 21045808 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
RPS6KB1 RPTOR 12150926 12604610 14525934 16183647 24234451 25348397 26348909 physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct
CUL4B RPTOR 25348397 N/A physical interaction ComPPI
CUL4A RPTOR 25348397 N/A physical interaction ComPPI
IRS1 RPTOR 14525934 16354680 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
CCT7 RPTOR 25348397 N/A physical interaction ComPPI
HSPA4 RPTOR 25348397 N/A physical interaction ComPPI
SH3PXD2A RPTOR 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
CCNB1 RPTOR 25348397 N/A physical interaction ComPPI
RHEB RPTOR 14525934 16631613 24234451 25348397 25446900 physical association experimental interaction detection,physical interaction,in vitro,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
CHUK RPTOR 25348397 N/A physical interaction ComPPI
SIRT1 RPTOR 21471201 24234451 25348397 association,physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
UCHL1 RPTOR 25348397 N/A physical interaction ComPPI
LAMP2 RPTOR 23953116 24234451 25348397 physical association proximity ligation assay ComPPI,IntAct
PRKN RPTOR 25348397 N/A physical interaction ComPPI
GNG2 RPTOR 25348397 N/A physical interaction ComPPI
PDK1 RPTOR 25348397 N/A physical interaction ComPPI
FKBP8 RPTOR 25348397 N/A physical interaction ComPPI
SGK1 RPTOR 25348397 N/A physical interaction ComPPI
PDCD1 RPTOR 25348397 N/A physical interaction ComPPI
TRIM25 RPTOR 25348397 N/A physical interaction ComPPI
SCAP RPTOR 25348397 N/A physical interaction ComPPI
CD79B RPTOR 25348397 N/A physical interaction ComPPI
DDB1 RPTOR 25348397 N/A physical interaction ComPPI
GTF3C2 RPTOR 20543138 24234451 25348397 association,physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
HTR6 RPTOR 25348397 N/A physical interaction ComPPI
CGN RPTOR 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
KIF13B RPTOR 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
ESR1 RPTOR 25348397 N/A physical interaction ComPPI
BRAF RPTOR 25348397 N/A physical interaction ComPPI
MTOR RPTOR 12150925 12150926 12408816 14525934 15066126 16354680 1683716516603397 17461779 17565979 18955708 19446321 19619545 19875983 21045808 21614075 22424946 23263282 23953116 24036451 24234451 24375676 25348397 25446900 26348909 26678875 27043084 colocalization,association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,cosedimentation through density gradient,experimental interaction detection,light scattering,molecular sieving,x-ray crystallography,physical interaction,electron tomography,in vitro,in vivo,proximity ligation assay,solid phase assay ComPPI,HPRD,IntAct
MLST8 RPTOR 12408816 12718876 14525934 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
TESK2 RPTOR 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
BRCA1 RPTOR 25348397 N/A physical interaction ComPPI
AKT1 RPTOR 25348397 N/A physical interaction ComPPI
FBXO9 RPTOR 23263282 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EIF4E RPTOR 25348397 N/A physical interaction ComPPI
EIF3A RPTOR 23953116 24234451 25348397 physical association proximity ligation assay ComPPI,IntAct
EIF3B RPTOR 25348397 N/A physical interaction ComPPI
ULK1 RPTOR 24234451 25348397 25686248 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SRGAP2 RPTOR 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
ZNF638 RPTOR 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
SIPA1L1 RPTOR 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
LAMTOR2 RPTOR 22980980 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
FAF2 RPTOR 25348397 N/A physical interaction ComPPI
ZBTB21 RPTOR 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
EIF4E2 RPTOR 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
GTF3C1 RPTOR 25348397 N/A physical interaction ComPPI
RPTOR RRAGA 24234451 25348397 25561175 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RPTOR RRAGC 24234451 25348397 25446900 25561175 25567906 association,physical association anti tag coimmunoprecipitation,physical interaction,proximity ligation assay ComPPI,IntAct
RPTOR USP9X 25348397 N/A physical interaction ComPPI
RPTOR RRAGB 25348397 N/A physical interaction ComPPI
RPTOR AKT1S1 19446321 23953116 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RPTOR DEPTOR 19446321 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RPTOR RICTOR 19446321 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
RPTOR RRAGD 22424946 24234451 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RPTOR PREX1 17565979 21339740 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RPTOR LARS1 22424946 24234451 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction,fluorescence microscopy ComPPI,IntAct
RPTOR AMBRA1 23524951 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RPTOR GNB1 25348397 N/A physical interaction ComPPI
RPTOR IKBKG 25348397 N/A physical interaction ComPPI
RPTOR MOV10 25348397 N/A physical interaction ComPPI
RPTOR NXF1 25348397 N/A physical interaction ComPPI
RPTOR TXNDC15 25348397 N/A physical interaction ComPPI
RPTOR NT5E 25348397 N/A physical interaction ComPPI
RPTOR BRAT1 25348397 N/A physical interaction ComPPI
RPTOR MTMR3 24234451 25348397 26787466 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RPTOR ZNRF2 25348397 N/A physical interaction ComPPI
RPTOR INTU 25348397 N/A physical interaction ComPPI
RPTOR IQCF1 25348397 N/A physical interaction ComPPI
RPTOR TPP1 25348397 N/A physical interaction ComPPI
RPTOR DKKL1 25348397 N/A physical interaction ComPPI
RPTOR IL13RA2 25348397 N/A physical interaction ComPPI
RPTOR TRIB2 25348397 N/A physical interaction ComPPI
RPTOR PMEL 25348397 N/A physical interaction ComPPI
RPTOR NTRK3 25348397 N/A physical interaction ComPPI
RPTOR CT55 25348397 N/A physical interaction ComPPI
RPTOR CCDC6 25348397 N/A physical interaction ComPPI
RPTOR KCTD3 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
RPTOR KSR1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
RPTOR LRFN1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
RPTOR DENND1A 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
RPTOR MAST3 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
RPTOR DENND4C 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
RPTOR PPM1H 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
RPTOR LIMA1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
RPTOR DCLK1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
RPTOR LPIN3 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
RPTOR INPP5E 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
RPTOR TELO2 23263282 24234451 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RPTOR TTI1 23263282 24234451 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RPTOR LAMTOR1 22980980 24234451 25348397 25561175 association anti tag coimmunoprecipitation,cross-linking study ComPPI,IntAct
RPTOR LAMTOR5 22980980 24234451 25348397 25561175 association anti tag coimmunoprecipitation,cross-linking study ComPPI,IntAct
RPTOR PIH1D1 24036451 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
RPTOR ETV7 24036451 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
RPTOR G3BP1 23953116 24234451 25348397 association,physical association anti bait coimmunoprecipitation,proximity ligation assay ComPPI,IntAct
EIF4EBP2 RPTOR 25348397 N/A physical interaction ComPPI
HSCB RPTOR 24234451 25348397 28380382 association anti bait coimmunoprecipitation ComPPI,IntAct
NUDCD1 RPTOR 24234451 29021621 association anti tag coimmunoprecipitation IntAct
PRKAA2 RPTOR 18220336 18439900 18669648 18722121 19369195 19413330 20083114 27898060 inhibition N/A OmniPath
RPTOR YWHAG 18439900 27898060 N/A N/A OmniPath
RPTOR AKT1S1 17277771 17386266 17517883 17604271 18030348 18215133 18570873 19446321 20169205 27898060 N/A N/A OmniPath
AKT1S1 RPTOR 17277771 17386266 17510057 17517883 17604271 18030348 18215133 18570873 19446321 20169205 27898060 inhibition N/A OmniPath
PRKAB1 RPTOR 21460634 27898060 inhibition N/A OmniPath
RPS6KA1 RPTOR 18220336 18439900 18669648 18722121 19369195 19413330 27898060 stimulant N/A OmniPath
ULK1 RPTOR 19864431 21325048 21460630 25686248 27898060 N/A N/A OmniPath
RPTOR MLST8 12408816 12718876 16798736 16919458 17565979 18030348 20169205 20562859 21321085 24403073 27898060 N/A N/A OmniPath
MLST8 RPTOR 12408816 12718876 16798736 16919458 17565979 18030348 20169205 20562859 21321085 24403073 27898060 N/A N/A OmniPath
RPTOR YWHAZ 18439900 27898060 N/A N/A OmniPath
RHEB RPTOR 15854902 15878852 16631613 17470430 24337580 25446900 27898060 stimulant N/A OmniPath
RPTOR RHEB 15854902 15878852 16631613 17470430 24337580 25446900 27898060 N/A N/A OmniPath
EIF4EBP1 RPTOR 12150926 12604610 12665511 12747827 12912989 15066126 15767663 16798736 16824195 16837165 17502379 18337751 18722121 18955708 19272448 21071439 22493283 24403073 27898060 inhibition N/A OmniPath
MAPK3 RPTOR 19864431 21071439 27898060 stimulant N/A OmniPath
CDK1 RPTOR 18722121 19276368 19864431 20019839 20169205 22493283 27898060 N/A N/A OmniPath
PIK3C3 RPTOR 12150926 27898060 N/A N/A OmniPath
RPS6KA3 RPTOR 18722121 27898060 stimulant N/A OmniPath
MAPK1 RPTOR 21071439 21325048 27898060 stimulant N/A OmniPath
HIF1A RPTOR 17502379 27898060 N/A N/A OmniPath
MTOR RPTOR 12150925 12150926 12408816 12665511 12718876 12719976 12747827 15066126 15268862 15459249 15467718 15661536 15809305 16183647 16354680 16603397 16631613 16798736 16837165 1683716516603397 16847060 16919458 16962653 17043309 17277771 17386266 17461779 17565979 17599906 17604271 18030348 18505677 18519641 18570873 18614546 18664580 18676370 18722121 18851840 18955708 19114562 19145465 19346248 19446321 19619545 19864431 19875983 20169205 20381137 20427287 20801936 21045808 21071439 21177249 21321085 22258093 22356909 22424946 22493283 22544753 23297343 23872070 23911927 23953116 24337580 24375676 24403073 24516643 25007995 25332233 25446900 27898060 stimulant N/A OmniPath
RPTOR MTOR 12150925 12150926 12408816 12665511 12718876 12719976 12747827 15066126 15268862 15459249 15467718 15661536 15809305 16183647 16354680 16603397 16631613 16798736 16837165 1683716516603397 16847060 16919458 16962653 17043309 17277771 17386266 17461779 17565979 17599906 17604271 18030348 18505677 18519641 18570873 18614546 18664580 18676370 18722121 18851840 18955708 19114562 19145465 19346248 19446321 19619545 19864431 19875983 20169205 20381137 20427287 20801936 21045808 21071439 21177249 21321085 22258093 22356909 22424946 22493283 22544753 23297343 23872070 23911927 23953116 24337580 24375676 24403073 24516643 25007995 25332233 25446900 27898060 inhibition,stimulant N/A OmniPath
MAPK11 RPTOR 21757713 27898060 N/A N/A OmniPath
GSK3B RPTOR 18722121 26588989 27898060 N/A N/A OmniPath
FKBP8 RPTOR 17991864 27898060 N/A N/A OmniPath
TIRAP RPTOR 21903422 27898060 N/A N/A OmniPath
YWHAQ RPTOR 21072212 27898060 inhibition N/A OmniPath
RRAGD RPTOR 18497260 20006481 22424946 24337580 27898060 inhibition,stimulant N/A OmniPath
RPTOR RRAGC 18497260 21816923 21981924 24337580 25446900 27898060 N/A N/A OmniPath
RRAGC RPTOR 18497260 20006481 21816923 21981924 24337580 25446900 27898060 inhibition,stimulant N/A OmniPath
RRAGB RPTOR 18497260 21981924 24337580 27898060 inhibition N/A OmniPath
RPTOR RRAGB 18497260 21981924 24337580 27898060 N/A N/A OmniPath
RPTOR PLD2 16837165 27898060 N/A N/A OmniPath
GRK2 RPTOR 19864431 27898060 N/A N/A OmniPath
EIF3B RPTOR 16286006 21045808 27898060 N/A N/A OmniPath
RPTOR PREX1 17565979 21339740 27898060 N/A N/A OmniPath
RRAGA RPTOR 18497260 21816923 23184942 24337580 26186194 27898060 inhibition N/A OmniPath
RPTOR RRAGA 18497260 21816923 23184942 24337580 26186194 27898060 N/A N/A OmniPath
RPS6KB2 RPTOR 12604610 27898060 N/A N/A OmniPath
PRKAA1 RPTOR 18439900 20169205 20227367 20354225 21460630 21460634 21900751 23142078 23928304 24247720 25728766 26212320 26348909 26391395 27898060 inhibition N/A OmniPath
RPTOR PRR5L 18030348 27898060 N/A N/A OmniPath
CILK1 RPTOR 22356909 27898060 stimulant N/A OmniPath

Visualization










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