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GENE：WIPI2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol WIPI2
FullNmae WD repeat domain, phosphoinositide interacting 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:32225
EnsembleID ENSG00000157954
Uniprot Q9Y4P8

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
WIPI2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
WIPI2 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
WIPI2 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
WIPI2 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
WIPI2 GO:0000045,GO:0000045,GO:0000407,GO:0000422,GO:0005515,GO:0005654,GO:0005829,GO:0005829,GO:0005829,GO:0006497,GO:0009267,GO:0016020,GO:0019898,GO:0032266,GO:0032266,GO:0032991,GO:0034045,GO:0034045,GO:0034497,GO:0034497,GO:0044804,GO:0080025,GO:0080025,GO:0098792

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
WIPI2 hsa:26100 path:hsa04136 Autophagy - other - Homo sapiens (human)
WIPI2 hsa:26100 path:hsa04140 Autophagy - animal - Homo sapiens (human)
WIPI2 hsa:26100 path:hsa05010 Alzheimer disease - Homo sapiens (human)
WIPI2 hsa:26100 path:hsa05014 Amyotrophic lateral sclerosis - Homo sapiens (human)
WIPI2 hsa:26100 path:hsa05016 Huntington disease - Homo sapiens (human)
WIPI2 hsa:26100 path:hsa05017 Spinocerebellar ataxia - Homo sapiens (human)
WIPI2 hsa:26100 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
WIPI2 hsa:26100 path:hsa05131 Shigellosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
WIPI2 TECPR1 21575909 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 WIPI2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 WIPI2 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 WIPI2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF WIPI2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 WIPI2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 WIPI2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 WIPI2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A WIPI2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 WIPI2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000017EA6A WIPI2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003D5391 WIPI2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000171CD1 WIPI2 21572407 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS000041CB9C WIPI2 21572407 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS000040EE1D WIPI2 21572407 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00000F0F49 WIPI2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000007D64A WIPI2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000022B729 WIPI2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000475586 WIPI2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000075994C WIPI2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002AB575 WIPI2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000078918 WIPI2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000032BDF4 WIPI2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00003AD231 WIPI2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000F6E49 WIPI2 21572407 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
TXLNA WIPI2 25348397 N/A physical interaction ComPPI
BAG3 WIPI2 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
HSPBP1 WIPI2 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
OPTN WIPI2 25348397 N/A physical interaction ComPPI
RABAC1 WIPI2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
COPS5 WIPI2 25348397 N/A physical interaction ComPPI
FLNC WIPI2 20562859 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
AIP WIPI2 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
PFKP WIPI2 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
VTN WIPI2 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
STIP1 WIPI2 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
NAGK WIPI2 25348397 N/A physical interaction ComPPI
RABGAP1 WIPI2 25348397 N/A physical interaction ComPPI
HUWE1 WIPI2 25348397 N/A physical interaction ComPPI
EGFR WIPI2 25348397 N/A physical interaction ComPPI
EIF3I WIPI2 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
COPS6 WIPI2 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
MAGED1 WIPI2 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
TIMM13 WIPI2 25348397 N/A physical interaction ComPPI
PPP5C WIPI2 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
ARL6IP1 WIPI2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
RB1CC1 WIPI2 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
POT1 WIPI2 21044950 24234451 25348397 physical association pull down,physical interaction,bimolecular fluorescence complementation ComPPI,IntAct
ZFAND6 WIPI2 25348397 N/A physical interaction ComPPI
STRN4 WIPI2 14525934 16169070 24234451 25348397 physical association two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
DNAJB1 WIPI2 20562859 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NUDC WIPI2 20562859 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PHAF1 WIPI2 25348397 N/A physical interaction ComPPI
TERF2IP WIPI2 21044950 24234451 25348397 physical association physical interaction,bimolecular fluorescence complementation ComPPI,IntAct
DPH1 WIPI2 25348397 N/A physical interaction ComPPI
FAF2 WIPI2 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
ATG12 WIPI2 25348397 N/A physical interaction ComPPI
ULK2 WIPI2 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
ATG16L1 WIPI2 25348397 N/A physical interaction ComPPI
TCAF1 WIPI2 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
DNAJB4 WIPI2 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
WIPI2 BTBD8 20562859 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
WIPI2 GCN1 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
WIPI2 DNM2 25348397 N/A physical interaction ComPPI
WIPI2 ATG5 25348397 N/A physical interaction ComPPI
WIPI2 BCAS3 25348397 N/A physical interaction ComPPI
WIPI2 BNIP3L 25348397 N/A physical interaction ComPPI
WIPI2 DPH2 25348397 N/A physical interaction ComPPI
WIPI2 BBS7 25348397 N/A physical interaction ComPPI
WIPI2 NDUFA10 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
WIPI2 ECHDC1 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
WIPI2 SDF4 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
WIPI2 WIPI2 20562859 24234451 association,physical association anti tag coimmunoprecipitation IntAct
ZKSCAN3 WIPI2 23434374 27898060 N/A N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00009BCC31 WIPI2 27087310 direct interaction,inhibition N/A NPInter

Visualization










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