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GENE：AKT1S1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol AKT1S1
FullNmae AKT1 substrate 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:28426
EnsembleID ENSG00000204673
Uniprot Q96B36

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
AKT1S1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
AKT1S1 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
AKT1S1 GO:0004860,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0005829,GO:0005829,GO:0006469,GO:0006469,GO:0030291,GO:0031931,GO:0032007,GO:0032007,GO:0042981,GO:0043523,GO:0045792,GO:0048011,GO:1904262

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
AKT1S1 hsa:84335 path:hsa04140 Autophagy - animal - Homo sapiens (human)
AKT1S1 hsa:84335 path:hsa04150 mTOR signaling pathway - Homo sapiens (human)
AKT1S1 hsa:84335 path:hsa04152 AMPK signaling pathway - Homo sapiens (human)
AKT1S1 hsa:84335 path:hsa04211 Longevity regulating pathway - Homo sapiens (human)
AKT1S1 hsa:84335 path:hsa04213 Longevity regulating pathway - multiple species - Homo sapiens (human)
AKT1S1 hsa:84335 path:hsa04714 Thermogenesis - Homo sapiens (human)
AKT1S1 hsa:84335 path:hsa05131 Shigellosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AKT1S1 MTOR 17277771 17517883 17604271 18030348 18570873 19114562 23180781 phosphorylation reaction,physical association anti tag coimmunoprecipitation,pull down,in-gel kinase assay,protein kinase assay InnateDB
AKT1S1 RPTOR 17517883 17604271 18030348 18215133 23180781 phosphorylation reaction,physical association anti tag coimmunoprecipitation,far western blotting,pull down,in-gel kinase assay,protein kinase assay InnateDB
RICTOR AKT1S1 18030348 23180781 phosphorylation reaction in-gel kinase assay InnateDB
MTOR AKT1S1 17277771 17386266 23180781 physical association anti tag coimmunoprecipitation InnateDB
AKT1S1 TCEA2 16169070 23180781 physical association two hybrid pooling approach InnateDB
AKT1S1 MMP24OS 16169070 23180781 physical association two hybrid pooling approach InnateDB
YWHAZ AKT1S1 15161933 23180781 physical association pull down InnateDB
AKT1 AKT1S1 12524439 23180781 phosphorylation reaction in-gel kinase assay,protein kinase assay InnateDB
AKT1S1 PIM1 19276681 23180781 phosphorylation reaction protein kinase assay InnateDB
LYL1 AKT1S1 18160048 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AKT1S1 AKT1 20005715 interaction type N/A PSP,SignaLink
AKT1S1 AKT2 20005715 interaction type N/A PSP,SignaLink
AKT1S1 MTOR 20005715 interaction type N/A PSP
AKT1S1 MTOR 17277771 18988627 20005715 20005715 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
ETS1 AKT1S1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 AKT1S1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 AKT1S1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
HIF1A AKT1S1 19828020 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
FOXP3 AKT1S1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 AKT1S1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA AKT1S1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 AKT1S1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 AKT1S1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 AKT1S1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 AKT1S1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS AKT1S1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF AKT1S1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 AKT1S1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00005651EE AKT1S1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00002367FA AKT1S1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001E0AEA AKT1S1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS000023BE29 AKT1S1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002373FD AKT1S1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000C4DB5 AKT1S1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000019907A AKT1S1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000137EDE AKT1S1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000053B1E8 AKT1S1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000017CCCB AKT1S1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00004818BD AKT1S1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000171020 AKT1S1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000086A4D AKT1S1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000105D19 AKT1S1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000221168 AKT1S1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00003BFB30 AKT1S1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00004DE2FC AKT1S1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000005E58C AKT1S1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000045ED38 AKT1S1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000027F5F3 AKT1S1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00003E5ECC AKT1S1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000C403E AKT1S1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000547F6A AKT1S1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000156390 AKT1S1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000077DDE AKT1S1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001BCAC5 AKT1S1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001F373E AKT1S1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00004F859B AKT1S1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00004929F1 AKT1S1 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
DYRK3 AKT1S1 22135298 phosphorylation N/A PhosphoSite
MTOR AKT1S1 22135298 phosphorylation N/A PhosphoSite
PKM AKT1S1 22135298 phosphorylation N/A PhosphoSite
AKT1 AKT1S1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
YWHAG AKT1S1 25361965 interaction type N/A PTMCode2
AKT1S1 YWHAG 25361965 interaction type N/A PTMCode2
AKT1S1 MLST8 25361965 interaction type N/A PTMCode2
MLST8 AKT1S1 25361965 interaction type N/A PTMCode2
AKT1S1 AKT2 25361965 interaction type N/A PTMCode2
AKT2 AKT1S1 25361965 interaction type N/A PTMCode2
YWHAB AKT1S1 25361965 interaction type N/A PTMCode2
AKT1S1 YWHAB 25361965 interaction type N/A PTMCode2
AKT1S1 AKT1 25361965 interaction type N/A PTMCode2
RPTOR AKT1S1 25361965 interaction type N/A PTMCode2
AKT1S1 RPTOR 25361965 interaction type N/A PTMCode2
YWHAH AKT1S1 25361965 interaction type N/A PTMCode2
AKT1S1 YWHAH 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
YWHAG AKT1S1 25348397 N/A in vivo ComPPI
CBY1 AKT1S1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
YWHAB AKT1S1 18372248 24234451 24255178 25348397 association anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
YWHAZ AKT1S1 15161933 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
ITGB3BP AKT1S1 16169070 24234451 25348397 physical association two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
EIF6 AKT1S1 25348397 N/A two hybrid,physical interaction ComPPI
SQSTM1 AKT1S1 25348397 N/A physical interaction ComPPI
RAB3IP AKT1S1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
XPO1 AKT1S1 25348397 N/A physical interaction ComPPI
YWHAQ AKT1S1 25348397 N/A physical interaction ComPPI
YWHAH AKT1S1 12524439 17979178 24234451 25348397 association pull down,tandem affinity purification ComPPI,IntAct
RPS6KA5 AKT1S1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SGK1 AKT1S1 25348397 N/A physical interaction ComPPI
TRIM25 AKT1S1 25348397 N/A physical interaction ComPPI
MTOR AKT1S1 19446321 23953116 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction,in vivo ComPPI,IntAct
AKT1 AKT1S1 25348397 N/A physical interaction,in vitro,in vivo ComPPI
RPTOR AKT1S1 19446321 23953116 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
AKT2 AKT1S1 25348397 N/A in vitro,in vivo ComPPI
AKT1S1 TCEA2 16169070 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
AKT1S1 FAM114A1 25348397 N/A physical interaction ComPPI
SRC AKT1S1 12524439 17130464 17277771 17517883 27898060 N/A N/A OmniPath
PIM1 AKT1S1 19276681 27898060 N/A N/A OmniPath
AKT1 AKT1S1 12524439 14973226 17081983 17386266 18669648 19413330 19651622 19690332 20068231 27898060 inhibition N/A OmniPath
RICTOR AKT1S1 18030348 27898060 N/A N/A OmniPath
YWHAZ AKT1S1 15161933 27898060 N/A N/A OmniPath
AKT1S1 YWHAZ 15161933 27898060 N/A N/A OmniPath
AKT3 AKT1S1 17440074 27898060 inhibition N/A OmniPath
RPTOR AKT1S1 17277771 17386266 17517883 17604271 18030348 18215133 18570873 19446321 20169205 27898060 N/A N/A OmniPath
AKT1S1 RPTOR 17277771 17386266 17510057 17517883 17604271 18030348 18215133 18570873 19446321 20169205 27898060 inhibition N/A OmniPath
AKT2 AKT1S1 12524439 14973226 17277771 17386266 18669648 19413330 19651622 20068231 27898060 inhibition N/A OmniPath
MTOR AKT1S1 17277771 17386266 17510057 17517883 17604271 18030348 18372248 18570873 19114562 19446321 27898060 inhibition N/A OmniPath
AKT1S1 MTOR 17277771 17386266 17510057 17517883 17604271 18030348 18372248 18570873 19114562 19446321 27898060 inhibition N/A OmniPath
TCEA2 AKT1S1 16169070 27898060 N/A N/A OmniPath
DYRK3 AKT1S1 23415227 27898060 inhibition N/A OmniPath

Visualization










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