GENE:BMP2
GeneInfo:
GeneAttribute | GeneDescription |
---|---|
GeneSymbol | BMP2 |
FullNmae | bone morphogenetic protein 2 |
LocusType | gene with protein product |
Status | Approved |
HGNC_id | HGNC:1069 |
EnsembleID | ENSG00000125845 |
Uniprot | P12643 |
Protein Structure:
Gene Description in Publicaton:
GeneSymbol | CellDeathType | PMID | Description | GeneType |
---|---|---|---|---|
BMP2 | mitotic_cd | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
BMP2 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
BMP2 | autophagy | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
BMP2 | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
GeneSymbol | Go id |
---|---|
BMP2 | GO:0000122,GO:0001501,GO:0001649,GO:0001658,GO:0001666,GO:0001701,GO:0001837,GO:0001837,GO:0001934,GO:0002062,GO:0003129,GO:0003133,GO:0003176,GO:0003181,GO:0003203,GO:0003210,GO:0003272,GO:0003308,GO:0003331,GO:0005102,GO:0005125,GO:0005125,GO:0005125,GO:0005515,GO:0005576,GO:0005615,GO:0005615,GO:0006029,GO:0006355,GO:0006366,GO:0006954,GO:0007219,GO:0007267,GO:0007507,GO:0008083,GO:0008284,GO:0008285,GO:0009617,GO:0009887,GO:0009986,GO:0010628,GO:0010628,GO:0010628,GO:0010628,GO:0010629,GO:0010718,GO:0010894,GO:0010922,GO:0019211,GO:0021537,GO:0021978,GO:0030177,GO:0030282,GO:0030316,GO:0030335,GO:0030501,GO:0030509,GO:0030509,GO:0030509,GO:0030509,GO:0030509,GO:0030509,GO:0030512,GO:0030858,GO:0031648,GO:0032092,GO:0032348,GO:0033690,GO:0035051,GO:0035051,GO:0035054,GO:0035360,GO:0036305,GO:0039706,GO:0042475,GO:0042482,GO:0042487,GO:0043065,GO:0043231,GO:0043407,GO:0043410,GO:0043539,GO:0043569,GO:0045165,GO:0045599,GO:0045600,GO:0045666,GO:0045669,GO:0045778,GO:0045786,GO:0045892,GO:0045893,GO:0045944,GO:0045944,GO:0046332,GO:0048662,GO:0048662,GO:0048708,GO:0048711,GO:0048762,GO:0048839,GO:0051042,GO:0051091,GO:0055007,GO:0055008,GO:0060039,GO:0060128,GO:0060129,GO:0060317,GO:0060348,GO:0060391,GO:0060391,GO:0060426,GO:0060485,GO:0061036,GO:0070374,GO:0070374,GO:0070700,GO:0070724,GO:0071407,GO:0071773,GO:0071773,GO:0072138,GO:0090090,GO:1900159,GO:1900745,GO:1901522,GO:1902895,GO:1905072,GO:1905222,GO:2000065,GO:2000726 |
KEGG Annotation:
GeneSymbol | GeneID | Pathway | Pathway Name |
---|---|---|---|
BMP2 | hsa:650 | path:hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
BMP2 | hsa:650 | path:hsa04350 | TGF-beta signaling pathway - Homo sapiens (human) |
BMP2 | hsa:650 | path:hsa04390 | Hippo signaling pathway - Homo sapiens (human) |
BMP2 | hsa:650 | path:hsa05200 | Pathways in cancer - Homo sapiens (human) |
BMP2 | hsa:650 | path:hsa05217 | Basal cell carcinoma - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
BMP2 | BMP2 | 11178121 11811553 12589053 16672363 19855020 21793042 22298955 23180781 26467481 7791754 | interaction type,bind,physical association,up-regulates,down-regulates quantity by repression,transcriptional regulation | x-ray crystallography | InnateDB,Signor |
BMP2 | BMPR1A | 16672363 17483092 18937504 23180781 | physical association | isothermal titration calorimetry,nuclear magnetic resonance,surface plasmon resonance,x-ray crystallography | InnateDB |
BMP2 | ACVR2A | 17295905 17483092 23180781 | physical association | surface plasmon resonance | InnateDB |
BMP2 | BMPR2 | 16446785 17295905 18342887 23180781 23331499 | stimulation,physical association | surface plasmon resonance | InnateDB,SignaLink,SignaLink |
ACVR2B | BMP2 | 17295905 23180781 | physical association | surface plasmon resonance,x-ray crystallography | InnateDB |
E2F1 | BMP2 | 23180781 24912499 | physical association | anti tag coimmunoprecipitation | InnateDB |
BMP2 | ACVR2B | 15064755 16446785 18988627 23331499 | stimulation | N/A | SignaLink,SignaLink |
NEO1 | BMP2 | 21149453 | interaction type,inhibition | N/A | SignaLink |
BMP2 | ACTR2 | 16446785 23331499 | stimulation | N/A | SignaLink |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
SMARCA4 | BMP2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
CEBPA | BMP2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
CTCF | BMP2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
FOXA1 | BMP2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
GATA2 | BMP2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
HNF4A | BMP2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
MITF | BMP2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
PRDM14 | BMP2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
TP53 | BMP2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
DNMT1 | BMP2 | 21551187 | trascriptional regulation,stimulation | inferred by curator | TFlink |
HEY1 | BMP2 | 21945409 | trascriptional regulation,stimulation | inferred by curator | TFlink |
NFKB1 | BMP2 | 16835229 | trascriptional regulation,stimulation | inferred by curator | TFlink |
RELA | BMP2 | 16835229 | trascriptional regulation,stimulation | inferred by curator | TFlink |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
URS0000237AF9 | BMP2 | 18185580 25416803 | mrna cleavage,inhibition | array technology | TarBase |
URS000003ABC4 | BMP2 | 19088304 25416803 | mrna cleavage,inhibition | array technology | TarBase |
URS00002075FA | BMP2 | 23399447 23592263 25416803 | mrna cleavage,inhibition | experimental interaction detection,western blot,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay | TarBase |
URS000039E1E1 | BMP2 | 23399447 23592263 25416803 | mrna cleavage,inhibition | experimental interaction detection,western blot,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay | TarBase |
URS00003E5ECC | BMP2 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00005F9738 | BMP2 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS0000148B91 | BMP2 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS0000192A75 | BMP2 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000006F90B | BMP2 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00000DDD35 | BMP2 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS0000298BA3 | BMP2 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS0000042E1F | BMP2 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00000600E6 | BMP2 | 23592263 25416803 28108317 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,clip | TarBase |
URS00002B3783 | BMP2 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000017EA6A | BMP2 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000020CEC2 | BMP2 | 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS0000427B68 | BMP2 | 20371350 21572407 23313552 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00004719AB | BMP2 | 20371350 21572407 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
FSTL1 | BMP2 | 25361965 | interaction type | N/A | PTMCode2 |
BMP2 | FSTL1 | 25361965 | interaction type | N/A | PTMCode2 |
NOG | BMP2 | 25361965 | interaction type | N/A | PTMCode2 |
BMP2 | NOG | 25361965 | interaction type | N/A | PTMCode2 |
BMPR1B | BMP2 | 25361965 | interaction type | N/A | PTMCode2 |
BMP2 | BMPR1B | 25361965 | interaction type | N/A | PTMCode2 |
GREM2 | BMP2 | 25361965 | interaction type | N/A | PTMCode2 |
BMP2 | GREM2 | 25361965 | interaction type | N/A | PTMCode2 |
BMPER | BMP2 | 25361965 | interaction type | N/A | PTMCode2 |
BMP2 | BMPER | 25361965 | interaction type | N/A | PTMCode2 |
GREM1 | BMP2 | 25361965 | interaction type | N/A | PTMCode2 |
BMP2 | GREM1 | 25361965 | interaction type | N/A | PTMCode2 |
BMP2 | DIP2A | 25361965 | interaction type | N/A | PTMCode2 |
DIP2A | BMP2 | 25361965 | interaction type | N/A | PTMCode2 |
SMAD4 | BMP2 | 25361965 | interaction type | N/A | PTMCode2 |
BMP2 | SMAD4 | 25361965 | interaction type | N/A | PTMCode2 |
ACVR2B | BMP2 | 25361965 | interaction type | N/A | PTMCode2 |
BMP2 | ACVR2B | 25361965 | interaction type | N/A | PTMCode2 |
TGFB1 | BMP2 | 25361965 | interaction type | N/A | PTMCode2 |
BMP2 | TGFB1 | 25361965 | interaction type | N/A | PTMCode2 |
BMPR1A | BMP2 | 25361965 | interaction type | N/A | PTMCode2 |
BMP2 | BMPR1A | 25361965 | interaction type | N/A | PTMCode2 |
ACVR2A | BMP2 | 25361965 | interaction type | N/A | PTMCode2 |
BMP2 | ACVR2A | 25361965 | interaction type | N/A | PTMCode2 |
ACVR1 | BMP2 | 25361965 | interaction type | N/A | PTMCode2 |
BMP2 | ACVR1 | 25361965 | interaction type | N/A | PTMCode2 |
BMPR2 | BMP2 | 25361965 | interaction type | N/A | PTMCode2 |
BMP2 | BMPR2 | 25361965 | interaction type | N/A | PTMCode2 |
CTNNB1 | BMP2 | 25361965 | interaction type | N/A | PTMCode2 |
BMP2 | CTNNB1 | 25361965 | interaction type | N/A | PTMCode2 |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
TGFB1 | BMP2 | 11456401 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
BMPR2 | BMP2 | 10880444 14525934 24234451 25348397 25938661 | N/A | experimental interaction detection,surface plasmon resonance,physical interaction,in vivo,surface plasmon resonance array | ComPPI,HPRD,IntAct |
CHRD | BMP2 | 14525934 15064755 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
TGFB2 | BMP2 | 24234451 25241761 25348397 27898060 9493905 | physical association | physical interaction,in vivo,proximity ligation assay | ComPPI,IntAct,OmniPath |
BMPR1B | BMP2 | 14525934 15064755 19229295 24234451 25348397 7811286 9872992 | N/A | experimental interaction detection,surface plasmon resonance,physical interaction,in vitro,in vivo,surface plasmon resonance array | ComPPI,HPRD,IntAct |
ACVR2B | BMP2 | 14525934 15064755 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
COL2A1 | BMP2 | 10085302 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
BMP2 | ACVR1 | 14525934 25348397 8006002 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
BMP2 | ENG | 14525934 25348397 9872992 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
BMP2 | MGP | 11741887 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
BMP2 | BMPR1A | 10692589 10881198 11263668 14525934 15064755 16672363 19804412 20860622 21054789 24234451 25348397 25938661 | physical association | anti bait coimmunoprecipitation,cross-linking study,experimental interaction detection,light scattering,molecular sieving,surface plasmon resonance,x-ray crystallography,physical interaction,competition binding,enzyme linked immunosorbent assay,in vitro,in vivo,surface plasmon resonance array | ComPPI,HPRD,IntAct |
BMP2 | NOG | 10657699 14525934 15064755 19804412 24234451 25348397 | N/A | experimental interaction detection,surface plasmon resonance,in vitro,in vivo,surface plasmon resonance array | ComPPI,HPRD,IntAct |
BMP2 | SOSTDC1 | 14525934 14623234 15020244 25348397 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD |
BMP2 | BMPER | 12897139 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
BMP2 | GREM2 | 14525934 15039429 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
BMP2 | ASCL1 | 14525934 25348397 27898060 9197246 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD,OmniPath |
BMP2 | GREM1 | 14525934 15064755 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
BMP2 | BMP1 | 25348397 | N/A | coimmunoprecipitation | ComPPI |
BMP2 | ACTR2 | 25348397 | N/A | physical interaction | ComPPI |
BMP2 | RGMB | 24234451 25348397 25938661 | physical association | light scattering,molecular sieving,surface plasmon resonance,x-ray crystallography,physical interaction,x ray scattering,surface plasmon resonance array | ComPPI,IntAct |
BMP2 | ACVR2A | 25348397 | N/A | physical interaction,surface plasmon resonance array | ComPPI |
BMP2 | HJV | 18335997 24234451 25348397 | physical association | surface plasmon resonance,x-ray crystallography,physical interaction,surface plasmon resonance array | ComPPI,IntAct |
BMP2 | RGMA | 25348397 | N/A | x-ray crystallography,physical interaction,surface plasmon resonance array | ComPPI |
BMP2 | FSTL1 | 20860622 24234451 25348397 | physical association | surface plasmon resonance,competition binding,surface plasmon resonance array | ComPPI,IntAct |
BMP2 | DIP2A | 20860622 24234451 25348397 | physical association | competition binding | ComPPI,IntAct |
BMP2 | WFIKKN1 | 21054789 24234451 25348397 | N/A | surface plasmon resonance,surface plasmon resonance array | ComPPI,IntAct |
BMP2 | WFIKKN2 | 21054789 24234451 25348397 | N/A | surface plasmon resonance,surface plasmon resonance array | ComPPI,IntAct |
BMP2 | NEO1 | 18335997 24234451 25348397 | physical association | surface plasmon resonance,surface plasmon resonance array | ComPPI,IntAct |
CHRDL2 | BMP2 | 14525934 14660436 | N/A | experimental interaction detection | HPRD |
BMP2 | BMP2 | 10074410 10692589 10881198 14525934 23122408 24234451 | N/A | cross-linking study,experimental interaction detection | HPRD,IntAct |
BMP2 | SMAD1 | 22298955 27898060 | stimulant | N/A | OmniPath |
BMP2 | SHH | 19855020 27898060 | inhibition | N/A | OmniPath |
BMP2 | SMAD5 | 22298955 27898060 | stimulant | N/A | OmniPath |
RUNX2 | BMP2 | 22298955 27898060 | stimulant | N/A | OmniPath |
BMP2 | SMAD9 | 22298955 27898060 | stimulant | N/A | OmniPath |
BMP2 | BMPR1A | 10692589 10712517 10880444 10881198 11263668 12700180 15064755 16672363 17483092 18937504 19804412 20860622 21054789 25938661 27898060 | N/A | N/A | OmniPath |
BMP2 | BMPR1B | 12700180 15064755 19229295 27898060 7811286 9872992 | N/A | N/A | OmniPath |
BMP2 | ALPL | 11811553 27898060 | stimulant | N/A | OmniPath |
BMP2 | BMPR2 | 10712517 10880444 17295905 18342887 25938661 27898060 7791754 | stimulant | N/A | OmniPath |
BMP2 | ACVR2B | 15064755 1644679 17295905 27898060 | stimulant | N/A | OmniPath |
BMP2 | ACTR2 | 16446785 27898060 | stimulant | N/A | OmniPath |
BMP2 | ACVR2A | 10880444 17295905 17483092 21702718 25938661 27898060 | N/A | N/A | OmniPath |
NOG | BMP2 | 10657699 12700180 15064755 19804412 27898060 | inhibition | N/A | OmniPath |
BMP2 | HJV | 18287331 25938661 27898060 | N/A | N/A | OmniPath |