Gene Information gene info

GENE:BMP2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol BMP2
FullNmae bone morphogenetic protein 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:1069
EnsembleID ENSG00000125845
Uniprot P12643

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
BMP2 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
BMP2 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
BMP2 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
BMP2 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
BMP2 GO:0000122,GO:0001501,GO:0001649,GO:0001658,GO:0001666,GO:0001701,GO:0001837,GO:0001837,GO:0001934,GO:0002062,GO:0003129,GO:0003133,GO:0003176,GO:0003181,GO:0003203,GO:0003210,GO:0003272,GO:0003308,GO:0003331,GO:0005102,GO:0005125,GO:0005125,GO:0005125,GO:0005515,GO:0005576,GO:0005615,GO:0005615,GO:0006029,GO:0006355,GO:0006366,GO:0006954,GO:0007219,GO:0007267,GO:0007507,GO:0008083,GO:0008284,GO:0008285,GO:0009617,GO:0009887,GO:0009986,GO:0010628,GO:0010628,GO:0010628,GO:0010628,GO:0010629,GO:0010718,GO:0010894,GO:0010922,GO:0019211,GO:0021537,GO:0021978,GO:0030177,GO:0030282,GO:0030316,GO:0030335,GO:0030501,GO:0030509,GO:0030509,GO:0030509,GO:0030509,GO:0030509,GO:0030509,GO:0030512,GO:0030858,GO:0031648,GO:0032092,GO:0032348,GO:0033690,GO:0035051,GO:0035051,GO:0035054,GO:0035360,GO:0036305,GO:0039706,GO:0042475,GO:0042482,GO:0042487,GO:0043065,GO:0043231,GO:0043407,GO:0043410,GO:0043539,GO:0043569,GO:0045165,GO:0045599,GO:0045600,GO:0045666,GO:0045669,GO:0045778,GO:0045786,GO:0045892,GO:0045893,GO:0045944,GO:0045944,GO:0046332,GO:0048662,GO:0048662,GO:0048708,GO:0048711,GO:0048762,GO:0048839,GO:0051042,GO:0051091,GO:0055007,GO:0055008,GO:0060039,GO:0060128,GO:0060129,GO:0060317,GO:0060348,GO:0060391,GO:0060391,GO:0060426,GO:0060485,GO:0061036,GO:0070374,GO:0070374,GO:0070700,GO:0070724,GO:0071407,GO:0071773,GO:0071773,GO:0072138,GO:0090090,GO:1900159,GO:1900745,GO:1901522,GO:1902895,GO:1905072,GO:1905222,GO:2000065,GO:2000726

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
BMP2 hsa:650 path:hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
BMP2 hsa:650 path:hsa04350 TGF-beta signaling pathway - Homo sapiens (human)
BMP2 hsa:650 path:hsa04390 Hippo signaling pathway - Homo sapiens (human)
BMP2 hsa:650 path:hsa05200 Pathways in cancer - Homo sapiens (human)
BMP2 hsa:650 path:hsa05217 Basal cell carcinoma - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
BMP2 BMP2 11178121 11811553 12589053 16672363 19855020 21793042 22298955 23180781 26467481 7791754 interaction type,bind,physical association,up-regulates,down-regulates quantity by repression,transcriptional regulation x-ray crystallography InnateDB,Signor
BMP2 BMPR1A 16672363 17483092 18937504 23180781 physical association isothermal titration calorimetry,nuclear magnetic resonance,surface plasmon resonance,x-ray crystallography InnateDB
BMP2 ACVR2A 17295905 17483092 23180781 physical association surface plasmon resonance InnateDB
BMP2 BMPR2 16446785 17295905 18342887 23180781 23331499 stimulation,physical association surface plasmon resonance InnateDB,SignaLink,SignaLink
ACVR2B BMP2 17295905 23180781 physical association surface plasmon resonance,x-ray crystallography InnateDB
E2F1 BMP2 23180781 24912499 physical association anti tag coimmunoprecipitation InnateDB
BMP2 ACVR2B 15064755 16446785 18988627 23331499 stimulation N/A SignaLink,SignaLink
NEO1 BMP2 21149453 interaction type,inhibition N/A SignaLink
BMP2 ACTR2 16446785 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
SMARCA4 BMP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA BMP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF BMP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 BMP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 BMP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A BMP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF BMP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
PRDM14 BMP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 BMP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
DNMT1 BMP2 21551187 trascriptional regulation,stimulation inferred by curator TFlink
HEY1 BMP2 21945409 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 BMP2 16835229 trascriptional regulation,stimulation inferred by curator TFlink
RELA BMP2 16835229 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 BMP2 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS000003ABC4 BMP2 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS00002075FA BMP2 23399447 23592263 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay TarBase
URS000039E1E1 BMP2 23399447 23592263 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay TarBase
URS00003E5ECC BMP2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00005F9738 BMP2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000148B91 BMP2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000192A75 BMP2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000006F90B BMP2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000DDD35 BMP2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 BMP2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000042E1F BMP2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000600E6 BMP2 23592263 25416803 28108317 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,clip TarBase
URS00002B3783 BMP2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000017EA6A BMP2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000020CEC2 BMP2 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000427B68 BMP2 20371350 21572407 23313552 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00004719AB BMP2 20371350 21572407 23313552 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
FSTL1 BMP2 25361965 interaction type N/A PTMCode2
BMP2 FSTL1 25361965 interaction type N/A PTMCode2
NOG BMP2 25361965 interaction type N/A PTMCode2
BMP2 NOG 25361965 interaction type N/A PTMCode2
BMPR1B BMP2 25361965 interaction type N/A PTMCode2
BMP2 BMPR1B 25361965 interaction type N/A PTMCode2
GREM2 BMP2 25361965 interaction type N/A PTMCode2
BMP2 GREM2 25361965 interaction type N/A PTMCode2
BMPER BMP2 25361965 interaction type N/A PTMCode2
BMP2 BMPER 25361965 interaction type N/A PTMCode2
GREM1 BMP2 25361965 interaction type N/A PTMCode2
BMP2 GREM1 25361965 interaction type N/A PTMCode2
BMP2 DIP2A 25361965 interaction type N/A PTMCode2
DIP2A BMP2 25361965 interaction type N/A PTMCode2
SMAD4 BMP2 25361965 interaction type N/A PTMCode2
BMP2 SMAD4 25361965 interaction type N/A PTMCode2
ACVR2B BMP2 25361965 interaction type N/A PTMCode2
BMP2 ACVR2B 25361965 interaction type N/A PTMCode2
TGFB1 BMP2 25361965 interaction type N/A PTMCode2
BMP2 TGFB1 25361965 interaction type N/A PTMCode2
BMPR1A BMP2 25361965 interaction type N/A PTMCode2
BMP2 BMPR1A 25361965 interaction type N/A PTMCode2
ACVR2A BMP2 25361965 interaction type N/A PTMCode2
BMP2 ACVR2A 25361965 interaction type N/A PTMCode2
ACVR1 BMP2 25361965 interaction type N/A PTMCode2
BMP2 ACVR1 25361965 interaction type N/A PTMCode2
BMPR2 BMP2 25361965 interaction type N/A PTMCode2
BMP2 BMPR2 25361965 interaction type N/A PTMCode2
CTNNB1 BMP2 25361965 interaction type N/A PTMCode2
BMP2 CTNNB1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
TGFB1 BMP2 11456401 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
BMPR2 BMP2 10880444 14525934 24234451 25348397 25938661 N/A experimental interaction detection,surface plasmon resonance,physical interaction,in vivo,surface plasmon resonance array ComPPI,HPRD,IntAct
CHRD BMP2 14525934 15064755 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
TGFB2 BMP2 24234451 25241761 25348397 27898060 9493905 physical association physical interaction,in vivo,proximity ligation assay ComPPI,IntAct,OmniPath
BMPR1B BMP2 14525934 15064755 19229295 24234451 25348397 7811286 9872992 N/A experimental interaction detection,surface plasmon resonance,physical interaction,in vitro,in vivo,surface plasmon resonance array ComPPI,HPRD,IntAct
ACVR2B BMP2 14525934 15064755 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
COL2A1 BMP2 10085302 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
BMP2 ACVR1 14525934 25348397 8006002 N/A experimental interaction detection,in vivo ComPPI,HPRD
BMP2 ENG 14525934 25348397 9872992 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
BMP2 MGP 11741887 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
BMP2 BMPR1A 10692589 10881198 11263668 14525934 15064755 16672363 19804412 20860622 21054789 24234451 25348397 25938661 physical association anti bait coimmunoprecipitation,cross-linking study,experimental interaction detection,light scattering,molecular sieving,surface plasmon resonance,x-ray crystallography,physical interaction,competition binding,enzyme linked immunosorbent assay,in vitro,in vivo,surface plasmon resonance array ComPPI,HPRD,IntAct
BMP2 NOG 10657699 14525934 15064755 19804412 24234451 25348397 N/A experimental interaction detection,surface plasmon resonance,in vitro,in vivo,surface plasmon resonance array ComPPI,HPRD,IntAct
BMP2 SOSTDC1 14525934 14623234 15020244 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
BMP2 BMPER 12897139 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
BMP2 GREM2 14525934 15039429 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
BMP2 ASCL1 14525934 25348397 27898060 9197246 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
BMP2 GREM1 14525934 15064755 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
BMP2 BMP1 25348397 N/A coimmunoprecipitation ComPPI
BMP2 ACTR2 25348397 N/A physical interaction ComPPI
BMP2 RGMB 24234451 25348397 25938661 physical association light scattering,molecular sieving,surface plasmon resonance,x-ray crystallography,physical interaction,x ray scattering,surface plasmon resonance array ComPPI,IntAct
BMP2 ACVR2A 25348397 N/A physical interaction,surface plasmon resonance array ComPPI
BMP2 HJV 18335997 24234451 25348397 physical association surface plasmon resonance,x-ray crystallography,physical interaction,surface plasmon resonance array ComPPI,IntAct
BMP2 RGMA 25348397 N/A x-ray crystallography,physical interaction,surface plasmon resonance array ComPPI
BMP2 FSTL1 20860622 24234451 25348397 physical association surface plasmon resonance,competition binding,surface plasmon resonance array ComPPI,IntAct
BMP2 DIP2A 20860622 24234451 25348397 physical association competition binding ComPPI,IntAct
BMP2 WFIKKN1 21054789 24234451 25348397 N/A surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
BMP2 WFIKKN2 21054789 24234451 25348397 N/A surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
BMP2 NEO1 18335997 24234451 25348397 physical association surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
CHRDL2 BMP2 14525934 14660436 N/A experimental interaction detection HPRD
BMP2 BMP2 10074410 10692589 10881198 14525934 23122408 24234451 N/A cross-linking study,experimental interaction detection HPRD,IntAct
BMP2 SMAD1 22298955 27898060 stimulant N/A OmniPath
BMP2 SHH 19855020 27898060 inhibition N/A OmniPath
BMP2 SMAD5 22298955 27898060 stimulant N/A OmniPath
RUNX2 BMP2 22298955 27898060 stimulant N/A OmniPath
BMP2 SMAD9 22298955 27898060 stimulant N/A OmniPath
BMP2 BMPR1A 10692589 10712517 10880444 10881198 11263668 12700180 15064755 16672363 17483092 18937504 19804412 20860622 21054789 25938661 27898060 N/A N/A OmniPath
BMP2 BMPR1B 12700180 15064755 19229295 27898060 7811286 9872992 N/A N/A OmniPath
BMP2 ALPL 11811553 27898060 stimulant N/A OmniPath
BMP2 BMPR2 10712517 10880444 17295905 18342887 25938661 27898060 7791754 stimulant N/A OmniPath
BMP2 ACVR2B 15064755 1644679 17295905 27898060 stimulant N/A OmniPath
BMP2 ACTR2 16446785 27898060 stimulant N/A OmniPath
BMP2 ACVR2A 10880444 17295905 17483092 21702718 25938661 27898060 N/A N/A OmniPath
NOG BMP2 10657699 12700180 15064755 19804412 27898060 inhibition N/A OmniPath
BMP2 HJV 18287331 25938661 27898060 N/A N/A OmniPath

Visualization