Gene Information gene info

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GENE：CLOCK

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CLOCK
FullNmae clock circadian regulator
LocusType gene with protein product
Status Approved
HGNC_id HGNC:2082
EnsembleID ENSG00000134852
Uniprot O15516

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CLOCK autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
CLOCK GO:0000077,GO:0000785,GO:0000978,GO:0000978,GO:0000981,GO:0000981,GO:0000981,GO:0001228,GO:0003677,GO:0003700,GO:0004402,GO:0005515,GO:0005634,GO:0005654,GO:0005654,GO:0005694,GO:0005829,GO:0006338,GO:0006355,GO:0006357,GO:0006473,GO:0007165,GO:0007283,GO:0007623,GO:0009648,GO:0031490,GO:0032922,GO:0032922,GO:0032922,GO:0032922,GO:0033391,GO:0042634,GO:0042752,GO:0042753,GO:0043161,GO:0043231,GO:0043565,GO:0045892,GO:0045893,GO:0045893,GO:0045944,GO:0046983,GO:0050729,GO:0050796,GO:0051092,GO:0051775,GO:0070888,GO:0070888,GO:0071479,GO:1990513,GO:1990513,GO:1990837,GO:2000074,GO:2000323

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CLOCK hsa:9575 path:hsa04710 Circadian rhythm - Homo sapiens (human)
CLOCK hsa:9575 path:hsa04728 Dopaminergic synapse - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR CLOCK 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 CLOCK 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 CLOCK 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 CLOCK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA CLOCK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF CLOCK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 CLOCK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 CLOCK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS CLOCK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A CLOCK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
KAT2B CLOCK 14645221 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000003E1A9 CLOCK N/A 15131085 16762633 \N rna interference,inhibition experimental interaction detection,western blot,northern blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00001CC379 CLOCK 20656788 rna interference,inhibition quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS000003E1A9 CLOCK 15131085 16762633 18927107 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,northern blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miR2Disease,TarBase
URS00001CC379 CLOCK 20656788 25416803 mrna cleavage,inhibition quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00000600E6 CLOCK 17242205 22473208 25416803 mrna cleavage,inhibition array technology,clip TarBase
URS00001E0AEA CLOCK 17612493 25416803 mrna cleavage,inhibition array technology TarBase
URS000003ABC4 CLOCK 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS000009262D CLOCK 18591254 25416803 mrna cleavage,inhibition array technology TarBase
URS000000C73C CLOCK 22815788 25416803 mrna cleavage,inhibition array technology,quantitative reverse transcription pcr TarBase
URS00000EED18 CLOCK 22815788 25416803 mrna cleavage,inhibition array technology,quantitative reverse transcription pcr TarBase
URS0000042E1F CLOCK 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00004DA9DB CLOCK 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS000023F8DA CLOCK 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00001481F9 CLOCK 22291592 25416803 mrna cleavage,inhibition clip TarBase
URS00003FBC84 CLOCK 22291592 25416803 mrna cleavage,inhibition clip TarBase
URS00003B59DF CLOCK 22291592 25416803 mrna cleavage,inhibition clip TarBase
URS000075C1E1 CLOCK 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00002A8BC6 CLOCK 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000032AE90 CLOCK 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00003E5ECC CLOCK 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00004E008F CLOCK 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00002FF522 CLOCK 22012620 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000043F369 CLOCK 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000041E949 CLOCK 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000346991 CLOCK 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00000F7766 CLOCK 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00000ECE9C CLOCK 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00001270D3 CLOCK 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000012930C CLOCK 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000006FDD4 CLOCK 22012620 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00005E6F45 CLOCK 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000D2680 CLOCK 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004283FE CLOCK 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 CLOCK 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 CLOCK 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00000DDD35 CLOCK 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00002075FA CLOCK 22473208 25416803 27440219 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,immunohistochemistry,clip,miRNA interference luciferase reporter assay TarBase
URS000008F0CF CLOCK 25416803 25522185 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
GSK3B CLOCK 22135298 phosphorylation N/A PhosphoSite
CDK5 CLOCK 22135298 phosphorylation N/A PhosphoSite
PER2 CLOCK 25361965 interaction type N/A PTMCode2
CLOCK PER2 25361965 interaction type N/A PTMCode2
CLOCK PER1 25361965 interaction type N/A PTMCode2
PER1 CLOCK 25361965 interaction type N/A PTMCode2
CLOCK ARNTL 25361965 interaction type N/A PTMCode2
ARNTL CLOCK 25361965 interaction type N/A PTMCode2
CLOCK RXRA 25361965 interaction type N/A PTMCode2
RXRA CLOCK 25361965 interaction type N/A PTMCode2
SIRT1 CLOCK 25361965 interaction type N/A PTMCode2
CLOCK SIRT1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
TEKT4 CLOCK 25348397 N/A physical interaction ComPPI
TFAP4 CLOCK 25348397 N/A physical interaction ComPPI
OIP5 CLOCK 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TFPT CLOCK 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
PPP1CC CLOCK 25348397 N/A physical interaction ComPPI
RARA CLOCK 25348397 N/A physical interaction ComPPI
TP53BP1 CLOCK 24234451 25348397 29656893 association proximity-dependent biotin identification ComPPI,IntAct
PPP1CB CLOCK 25348397 N/A physical interaction ComPPI
CREBBP CLOCK 16606840 16678094 25348397 27898060 N/A physical interaction ComPPI,OmniPath
EP300 CLOCK 25348397 N/A physical interaction ComPPI
KAT2B CLOCK 25348397 N/A physical interaction ComPPI
CSNK1E CLOCK 25348397 N/A physical interaction ComPPI
PPP1CA CLOCK 25348397 N/A physical interaction ComPPI
HMG20A CLOCK 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
PPP2R5E CLOCK 25348397 N/A physical interaction ComPPI
GOLGA5 CLOCK 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
RABEP1 CLOCK 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
RABGEF1 CLOCK 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
EXOC1 CLOCK 25348397 N/A physical interaction ComPPI
SOX2 CLOCK 25348397 N/A physical interaction ComPPI
PER3 CLOCK 14525934 14701732 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SIRT1 CLOCK 25348397 N/A physical interaction ComPPI
GIT2 CLOCK 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
GRIPAP1 CLOCK 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TUFT1 CLOCK 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
ARNTL CLOCK 11018023 14525934 24234451 25348397 9989497 physical association two hybrid,experimental interaction detection,physical interaction,in vivo,inference by socio-affinity scoring ComPPI,HPRD,IntAct
RCOR1 CLOCK 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
CRY2 CLOCK 25348397 N/A physical interaction ComPPI
CAVIN1 CLOCK 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
PER2 CLOCK 25348397 N/A physical interaction ComPPI
KDM1A CLOCK 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
PHF21A CLOCK 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
YEATS4 CLOCK 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
PPP2R1B CLOCK 25348397 N/A physical interaction ComPPI
SRGAP3 CLOCK 25348397 N/A physical interaction ComPPI
CLOCK ARNTL2 10864977 11018023 14525934 14701734 24234451 25348397 27898060 physical association two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct,OmniPath
CLOCK RXRA 25348397 N/A physical interaction ComPPI
CLOCK CRY1 25348397 N/A physical interaction ComPPI
CLOCK DELEC1 25348397 N/A physical interaction ComPPI
CLOCK BHLHE41 25348397 N/A physical interaction ComPPI
CLOCK NPAS2 25348397 N/A physical interaction ComPPI
CLOCK CSNK2B 25348397 N/A physical interaction ComPPI
CLOCK NR1D2 25348397 N/A physical interaction ComPPI
CLOCK RORB 25348397 N/A physical interaction ComPPI
CLOCK DBP 25348397 N/A physical interaction ComPPI
CLOCK RORC 25348397 N/A physical interaction ComPPI
CLOCK PKN3 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
CLOCK NCKAP5L 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
CLOCK CCHCR1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
CLOCK RABGAP1L 25348397 N/A physical interaction ComPPI
CLOCK RABGAP1L 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
CLOCK PSMD9 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
CLOCK VPS53 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
CLOCK DZIP3 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
CLOCK VPS50 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
CLOCK CCDC93 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
CLOCK PHLDB3 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
CLOCK HAUS6 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
CLOCK RPRD1A 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
CLOCK MAX 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
CLOCK KCTD7 25348397 N/A physical interaction ComPPI
CLOCK NUF2 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
CLOCK VPS51 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
CLOCK EIPR1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
CLOCK CIART 24234451 24737000 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CLOCK KMT2A 24234451 25348397 25751424 physical association two hybrid,physical interaction ComPPI,IntAct
PPP2R5D CLOCK 25348397 N/A physical interaction ComPPI
THAP11 CLOCK 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
CIPC CLOCK 25348397 N/A physical interaction ComPPI
CLOCK CLOCK 24234451 24737000 physical association two hybrid IntAct
CDK5 CLOCK 24235147 27898060 stimulant N/A OmniPath
CLOCK H3C1 18022353 27898060 stimulant N/A OmniPath
GSK3B CLOCK 19946213 27898060 N/A N/A OmniPath
CLOCK MAGEL2 22208286 27898060 inhibition N/A OmniPath

Visualization










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