GENE:CLOCK
GeneInfo:
GeneAttribute | GeneDescription |
---|---|
GeneSymbol | CLOCK |
FullNmae | clock circadian regulator |
LocusType | gene with protein product |
Status | Approved |
HGNC_id | HGNC:2082 |
EnsembleID | ENSG00000134852 |
Uniprot | O15516 |
Protein Structure:
Gene Description in Publicaton:
GeneSymbol | CellDeathType | PMID | Description | GeneType |
---|---|---|---|---|
CLOCK | autophagy | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
GeneSymbol | Go id |
---|---|
CLOCK | GO:0000077,GO:0000785,GO:0000978,GO:0000978,GO:0000981,GO:0000981,GO:0000981,GO:0001228,GO:0003677,GO:0003700,GO:0004402,GO:0005515,GO:0005634,GO:0005654,GO:0005654,GO:0005694,GO:0005829,GO:0006338,GO:0006355,GO:0006357,GO:0006473,GO:0007165,GO:0007283,GO:0007623,GO:0009648,GO:0031490,GO:0032922,GO:0032922,GO:0032922,GO:0032922,GO:0033391,GO:0042634,GO:0042752,GO:0042753,GO:0043161,GO:0043231,GO:0043565,GO:0045892,GO:0045893,GO:0045893,GO:0045944,GO:0046983,GO:0050729,GO:0050796,GO:0051092,GO:0051775,GO:0070888,GO:0070888,GO:0071479,GO:1990513,GO:1990513,GO:1990837,GO:2000074,GO:2000323 |
KEGG Annotation:
GeneSymbol | GeneID | Pathway | Pathway Name |
---|---|---|---|
CLOCK | hsa:9575 | path:hsa04710 | Circadian rhythm - Homo sapiens (human) |
CLOCK | hsa:9575 | path:hsa04728 | Dopaminergic synapse - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
AR | CLOCK | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
ETS1 | CLOCK | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
GATA2 | CLOCK | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
SMARCA4 | CLOCK | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
CEBPA | CLOCK | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
CTCF | CLOCK | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
E2F4 | CLOCK | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
FOXA1 | CLOCK | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
FOS | CLOCK | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
HNF4A | CLOCK | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
KAT2B | CLOCK | 14645221 | trascriptional regulation,stimulation | inferred by curator | TFlink |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
URS000003E1A9 | CLOCK | N/A 15131085 16762633 \N | rna interference,inhibition | experimental interaction detection,western blot,northern blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | miRSponge |
URS00001CC379 | CLOCK | 20656788 | rna interference,inhibition | quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | miRSponge |
URS000003E1A9 | CLOCK | 15131085 16762633 18927107 25416803 | mrna cleavage,inhibition | experimental interaction detection,western blot,northern blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | miR2Disease,TarBase |
URS00001CC379 | CLOCK | 20656788 25416803 | mrna cleavage,inhibition | quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
URS00000600E6 | CLOCK | 17242205 22473208 25416803 | mrna cleavage,inhibition | array technology,clip | TarBase |
URS00001E0AEA | CLOCK | 17612493 25416803 | mrna cleavage,inhibition | array technology | TarBase |
URS000003ABC4 | CLOCK | 19088304 25416803 | mrna cleavage,inhibition | array technology | TarBase |
URS000009262D | CLOCK | 18591254 25416803 | mrna cleavage,inhibition | array technology | TarBase |
URS000000C73C | CLOCK | 22815788 25416803 | mrna cleavage,inhibition | array technology,quantitative reverse transcription pcr | TarBase |
URS00000EED18 | CLOCK | 22815788 25416803 | mrna cleavage,inhibition | array technology,quantitative reverse transcription pcr | TarBase |
URS0000042E1F | CLOCK | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00004DA9DB | CLOCK | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000023F8DA | CLOCK | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00001481F9 | CLOCK | 22291592 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00003FBC84 | CLOCK | 22291592 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00003B59DF | CLOCK | 22291592 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000075C1E1 | CLOCK | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00002A8BC6 | CLOCK | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000032AE90 | CLOCK | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00003E5ECC | CLOCK | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00004E008F | CLOCK | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00002FF522 | CLOCK | 22012620 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000043F369 | CLOCK | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000041E949 | CLOCK | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS0000346991 | CLOCK | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00000F7766 | CLOCK | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00000ECE9C | CLOCK | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00001270D3 | CLOCK | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000012930C | CLOCK | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000006FDD4 | CLOCK | 22012620 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00005E6F45 | CLOCK | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00000D2680 | CLOCK | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00004283FE | CLOCK | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS0000298BA3 | CLOCK | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00002B3783 | CLOCK | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00000DDD35 | CLOCK | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00002075FA | CLOCK | 22473208 25416803 27440219 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,immunohistochemistry,clip,miRNA interference luciferase reporter assay | TarBase |
URS000008F0CF | CLOCK | 25416803 25522185 | mrna cleavage,inhibition | western blot,miRNA interference luciferase reporter assay | TarBase |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
GSK3B | CLOCK | 22135298 | phosphorylation | N/A | PhosphoSite |
CDK5 | CLOCK | 22135298 | phosphorylation | N/A | PhosphoSite |
PER2 | CLOCK | 25361965 | interaction type | N/A | PTMCode2 |
CLOCK | PER2 | 25361965 | interaction type | N/A | PTMCode2 |
CLOCK | PER1 | 25361965 | interaction type | N/A | PTMCode2 |
PER1 | CLOCK | 25361965 | interaction type | N/A | PTMCode2 |
CLOCK | ARNTL | 25361965 | interaction type | N/A | PTMCode2 |
ARNTL | CLOCK | 25361965 | interaction type | N/A | PTMCode2 |
CLOCK | RXRA | 25361965 | interaction type | N/A | PTMCode2 |
RXRA | CLOCK | 25361965 | interaction type | N/A | PTMCode2 |
SIRT1 | CLOCK | 25361965 | interaction type | N/A | PTMCode2 |
CLOCK | SIRT1 | 25361965 | interaction type | N/A | PTMCode2 |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
TEKT4 | CLOCK | 25348397 | N/A | physical interaction | ComPPI |
TFAP4 | CLOCK | 25348397 | N/A | physical interaction | ComPPI |
OIP5 | CLOCK | 24234451 25348397 | physical association | physical interaction,inference by socio-affinity scoring | ComPPI,IntAct |
TFPT | CLOCK | 24234451 25348397 | physical association | physical interaction,inference by socio-affinity scoring | ComPPI,IntAct |
PPP1CC | CLOCK | 25348397 | N/A | physical interaction | ComPPI |
RARA | CLOCK | 25348397 | N/A | physical interaction | ComPPI |
TP53BP1 | CLOCK | 24234451 25348397 29656893 | association | proximity-dependent biotin identification | ComPPI,IntAct |
PPP1CB | CLOCK | 25348397 | N/A | physical interaction | ComPPI |
CREBBP | CLOCK | 16606840 16678094 25348397 27898060 | N/A | physical interaction | ComPPI,OmniPath |
EP300 | CLOCK | 25348397 | N/A | physical interaction | ComPPI |
KAT2B | CLOCK | 25348397 | N/A | physical interaction | ComPPI |
CSNK1E | CLOCK | 25348397 | N/A | physical interaction | ComPPI |
PPP1CA | CLOCK | 25348397 | N/A | physical interaction | ComPPI |
HMG20A | CLOCK | 24234451 25348397 | physical association | physical interaction,inference by socio-affinity scoring | ComPPI,IntAct |
PPP2R5E | CLOCK | 25348397 | N/A | physical interaction | ComPPI |
GOLGA5 | CLOCK | 24234451 25348397 | physical association | physical interaction,inference by socio-affinity scoring | ComPPI,IntAct |
RABEP1 | CLOCK | 24234451 25348397 | physical association | physical interaction,inference by socio-affinity scoring | ComPPI,IntAct |
RABGEF1 | CLOCK | 24234451 25348397 | physical association | physical interaction,inference by socio-affinity scoring | ComPPI,IntAct |
EXOC1 | CLOCK | 25348397 | N/A | physical interaction | ComPPI |
SOX2 | CLOCK | 25348397 | N/A | physical interaction | ComPPI |
PER3 | CLOCK | 14525934 14701732 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
SIRT1 | CLOCK | 25348397 | N/A | physical interaction | ComPPI |
GIT2 | CLOCK | 24234451 25348397 | physical association | physical interaction,inference by socio-affinity scoring | ComPPI,IntAct |
GRIPAP1 | CLOCK | 24234451 25348397 | physical association | physical interaction,inference by socio-affinity scoring | ComPPI,IntAct |
TUFT1 | CLOCK | 24234451 25348397 | physical association | physical interaction,inference by socio-affinity scoring | ComPPI,IntAct |
ARNTL | CLOCK | 11018023 14525934 24234451 25348397 9989497 | physical association | two hybrid,experimental interaction detection,physical interaction,in vivo,inference by socio-affinity scoring | ComPPI,HPRD,IntAct |
RCOR1 | CLOCK | 24234451 25348397 | physical association | physical interaction,inference by socio-affinity scoring | ComPPI,IntAct |
CRY2 | CLOCK | 25348397 | N/A | physical interaction | ComPPI |
CAVIN1 | CLOCK | 24234451 25348397 | physical association | physical interaction,inference by socio-affinity scoring | ComPPI,IntAct |
PER2 | CLOCK | 25348397 | N/A | physical interaction | ComPPI |
KDM1A | CLOCK | 24234451 25348397 | physical association | physical interaction,inference by socio-affinity scoring | ComPPI,IntAct |
PHF21A | CLOCK | 24234451 25348397 | physical association | physical interaction,inference by socio-affinity scoring | ComPPI,IntAct |
YEATS4 | CLOCK | 24234451 25348397 | physical association | physical interaction,inference by socio-affinity scoring | ComPPI,IntAct |
PPP2R1B | CLOCK | 25348397 | N/A | physical interaction | ComPPI |
SRGAP3 | CLOCK | 25348397 | N/A | physical interaction | ComPPI |
CLOCK | ARNTL2 | 10864977 11018023 14525934 14701734 24234451 25348397 27898060 | physical association | two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD,IntAct,OmniPath |
CLOCK | RXRA | 25348397 | N/A | physical interaction | ComPPI |
CLOCK | CRY1 | 25348397 | N/A | physical interaction | ComPPI |
CLOCK | DELEC1 | 25348397 | N/A | physical interaction | ComPPI |
CLOCK | BHLHE41 | 25348397 | N/A | physical interaction | ComPPI |
CLOCK | NPAS2 | 25348397 | N/A | physical interaction | ComPPI |
CLOCK | CSNK2B | 25348397 | N/A | physical interaction | ComPPI |
CLOCK | NR1D2 | 25348397 | N/A | physical interaction | ComPPI |
CLOCK | RORB | 25348397 | N/A | physical interaction | ComPPI |
CLOCK | DBP | 25348397 | N/A | physical interaction | ComPPI |
CLOCK | RORC | 25348397 | N/A | physical interaction | ComPPI |
CLOCK | PKN3 | 24234451 25348397 | physical association | physical interaction,inference by socio-affinity scoring | ComPPI,IntAct |
CLOCK | NCKAP5L | 24234451 25348397 | physical association | physical interaction,inference by socio-affinity scoring | ComPPI,IntAct |
CLOCK | CCHCR1 | 24234451 25348397 | physical association | physical interaction,inference by socio-affinity scoring | ComPPI,IntAct |
CLOCK | RABGAP1L | 25348397 | N/A | physical interaction | ComPPI |
CLOCK | RABGAP1L | 24234451 25348397 | physical association | physical interaction,inference by socio-affinity scoring | ComPPI,IntAct |
CLOCK | PSMD9 | 24234451 25348397 | physical association | physical interaction,inference by socio-affinity scoring | ComPPI,IntAct |
CLOCK | VPS53 | 24234451 25348397 | physical association | physical interaction,inference by socio-affinity scoring | ComPPI,IntAct |
CLOCK | DZIP3 | 24234451 25348397 | physical association | physical interaction,inference by socio-affinity scoring | ComPPI,IntAct |
CLOCK | VPS50 | 24234451 25348397 | physical association | physical interaction,inference by socio-affinity scoring | ComPPI,IntAct |
CLOCK | CCDC93 | 24234451 25348397 | physical association | physical interaction,inference by socio-affinity scoring | ComPPI,IntAct |
CLOCK | PHLDB3 | 24234451 25348397 | physical association | physical interaction,inference by socio-affinity scoring | ComPPI,IntAct |
CLOCK | HAUS6 | 24234451 25348397 | physical association | physical interaction,inference by socio-affinity scoring | ComPPI,IntAct |
CLOCK | RPRD1A | 24234451 25348397 | physical association | physical interaction,inference by socio-affinity scoring | ComPPI,IntAct |
CLOCK | MAX | 24234451 25348397 | physical association | physical interaction,inference by socio-affinity scoring | ComPPI,IntAct |
CLOCK | KCTD7 | 25348397 | N/A | physical interaction | ComPPI |
CLOCK | NUF2 | 24234451 25348397 | physical association | physical interaction,inference by socio-affinity scoring | ComPPI,IntAct |
CLOCK | VPS51 | 24234451 25348397 | physical association | physical interaction,inference by socio-affinity scoring | ComPPI,IntAct |
CLOCK | EIPR1 | 24234451 25348397 | physical association | physical interaction,inference by socio-affinity scoring | ComPPI,IntAct |
CLOCK | CIART | 24234451 24737000 25348397 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
CLOCK | KMT2A | 24234451 25348397 25751424 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
PPP2R5D | CLOCK | 25348397 | N/A | physical interaction | ComPPI |
THAP11 | CLOCK | 24234451 25348397 | physical association | physical interaction,inference by socio-affinity scoring | ComPPI,IntAct |
CIPC | CLOCK | 25348397 | N/A | physical interaction | ComPPI |
CLOCK | CLOCK | 24234451 24737000 | physical association | two hybrid | IntAct |
CDK5 | CLOCK | 24235147 27898060 | stimulant | N/A | OmniPath |
CLOCK | H3C1 | 18022353 27898060 | stimulant | N/A | OmniPath |
GSK3B | CLOCK | 19946213 27898060 | N/A | N/A | OmniPath |
CLOCK | MAGEL2 | 22208286 27898060 | inhibition | N/A | OmniPath |