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GENE：CSF1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CSF1
FullNmae colony stimulating factor 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:2432
EnsembleID ENSG00000184371
Uniprot P09603

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CSF1 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
CSF1 GO:0001780,GO:0001954,GO:0002158,GO:0002931,GO:0003006,GO:0005125,GO:0005125,GO:0005157,GO:0005157,GO:0005515,GO:0005576,GO:0005615,GO:0005615,GO:0005788,GO:0005886,GO:0005886,GO:0006954,GO:0007169,GO:0007265,GO:0008083,GO:0008284,GO:0008284,GO:0010628,GO:0010743,GO:0010744,GO:0010759,GO:0016020,GO:0016604,GO:0030224,GO:0030225,GO:0030278,GO:0030316,GO:0030316,GO:0030335,GO:0032946,GO:0035702,GO:0038145,GO:0040018,GO:0042117,GO:0042488,GO:0042802,GO:0042803,GO:0045087,GO:0045651,GO:0045651,GO:0045657,GO:0045672,GO:0045860,GO:0046579,GO:0048471,GO:0048873,GO:0051247,GO:0060444,GO:0060611,GO:0060763,GO:0061518,GO:0061519,GO:0097529,GO:1902228,GO:1904141,GO:1905523,GO:1990682

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CSF1 hsa:1435 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
CSF1 hsa:1435 path:hsa04014 Ras signaling pathway - Homo sapiens (human)
CSF1 hsa:1435 path:hsa04015 Rap1 signaling pathway - Homo sapiens (human)
CSF1 hsa:1435 path:hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
CSF1 hsa:1435 path:hsa04061 Viral protein interaction with cytokine and cytokine receptor - Homo sapiens (human)
CSF1 hsa:1435 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
CSF1 hsa:1435 path:hsa04380 Osteoclast differentiation - Homo sapiens (human)
CSF1 hsa:1435 path:hsa04640 Hematopoietic cell lineage - Homo sapiens (human)
CSF1 hsa:1435 path:hsa04668 TNF signaling pathway - Homo sapiens (human)
CSF1 hsa:1435 path:hsa05010 Alzheimer disease - Homo sapiens (human)
CSF1 hsa:1435 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
CSF1 hsa:1435 path:hsa05323 Rheumatoid arthritis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CSF1 IL10 11306493 15749884 16713974 17404308 20547845 24669294 26192618 interaction type N/A ACSN
CSF1 CCL2 11306493 15749884 16713974 17404308 20547845 24669294 26192618 interaction type N/A ACSN
IL4 CSF1 10485906 10820262 11160275 11371360 11870632 12401408 12433365 12496409 12818165 18250477 1825141 20184663 20856220 21097505 23124025 26192618 2965306 9834059 interaction type N/A ACSN
GAPDH CSF1 15867372 23180781 physical association electrophoretic mobility shift assay InnateDB
ABL1 CSF1 18619508 23180781 physical association anti tag coimmunoprecipitation InnateDB
CSF1 CSF2RA 10572088 23331499 stimulation N/A SignaLink
CSF1 CSF3R 16492764 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR CSF1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
GATA1 CSF1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 CSF1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 CSF1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
STAT1 CSF1 15624698 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
TP63 CSF1 17521434 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 CSF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA CSF1 18971253 9632776 trascriptional regulation,stimulation inferred by curator TFlink
CTCF CSF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 CSF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 CSF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS CSF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A CSF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF CSF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
PRDM14 CSF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 CSF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 CSF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ABL1 CSF1 18619508 23418320 trascriptional regulation,stimulation inferred by curator TFlink
JUN CSF1 7642615 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 CSF1 11949945 18566389 trascriptional regulation,stimulation inferred by curator TFlink
PPARG CSF1 18566389 trascriptional regulation,stimulation inferred by curator TFlink
RELA CSF1 11949945 18566389 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 CSF1 9632776 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 CSF1 9632776 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 CSF1 N/A trascriptional regulation,stimulation inferred by curator TFlink
MYB CSF1 N/A trascriptional regulation,stimulation inferred by curator TFlink
TP53 CSF1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000315338 CSF1 14697198 18823650 rna interference,inhibition experimental interaction detection,western blot,miRNA interference luciferase reporter assay miRSponge
URS00002C0FCB CSF1 22005523 rna interference,inhibition experimental interaction detection,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000521626 CSF1 23238785 rna interference,inhibition western blot miRSponge
URS0000315338 CSF1 14697198 18823650 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,miRNA interference luciferase reporter assay TarBase
URS00002C0FCB CSF1 22005523 25416803 mrna cleavage,inhibition experimental interaction detection,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000521626 CSF1 23233531 23238785 25416803 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase
URS0000237AF9 CSF1 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS000017EA6A CSF1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00002152A8 CSF1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000000C73C CSF1 22909061 25416803 mrna cleavage,inhibition experimental interaction detection,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000235862 CSF1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00001012BC CSF1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00006097A6 CSF1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00002367FA CSF1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000032015F CSF1 20371350 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CSF1 GAB3 25361965 interaction type N/A PTMCode2
GAB3 CSF1 25361965 interaction type N/A PTMCode2
CBL CSF1 25361965 interaction type N/A PTMCode2
CSF1 CBL 25361965 interaction type N/A PTMCode2
CSF1R CSF1 25361965 interaction type N/A PTMCode2
CSF1 CSF1R 25361965 interaction type N/A PTMCode2
KIT CSF1 25361965 interaction type N/A PTMCode2
CSF1 KIT 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
FHL3 CSF1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
KRTAP10-8 CSF1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SGTA CSF1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CBL CSF1 25348397 N/A physical interaction ComPPI
SOCS1 CSF1 11297560 14525934 25348397 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
GAB3 CSF1 11739737 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SLA2 CSF1 25348397 N/A physical interaction ComPPI
MYC CSF1 21150319 24234451 25348397 association tandem affinity purification ComPPI,IntAct
TNF CSF1 14525934 25348397 8336080 N/A experimental interaction detection,in vivo ComPPI,HPRD
CSF1R CSF1 14525934 22153499 22483114 22902366 2408759 24234451 25348397 26235028 8355686 N/A transmission electron microscopy,experimental interaction detection,isothermal titration calorimetry,light scattering,molecular sieving,x-ray crystallography,physical interaction,in vivo,x ray scattering,bio-layer interferometry,field flow fractionation ComPPI,HPRD,IntAct
TRIM25 CSF1 25348397 N/A physical interaction ComPPI
HLA-B CSF1 14525934 15494511 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
CSF1 NOTCH2NLA 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CSF1 CYSRT1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CSF1 KRTAP1-1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CSF1 CSF1 14525934 1733926 22153499 22902366 24234451 8422357 N/A experimental interaction detection,light scattering,molecular sieving,x-ray crystallography,comigration in sds page,field flow fractionation HPRD,IntAct
NCBP3 CSF1 24234451 26382858 association pull down IntAct
NCBP2 CSF1 24234451 26382858 association pull down IntAct
CSF1 CSF2RA 10572088 27898060 stimulant N/A OmniPath
CSF1 CSF3R 16492764 27898060 stimulant N/A OmniPath
SPI1 CSF1 15676205 27898060 stimulant N/A OmniPath
CSF1 CSF1R 1702217 22153499 22483114 22902366 2408759 26235028 27898060 7883784 8355686 stimulant N/A OmniPath

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