GENE：EFNB2
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | EFNB2 |
| FullNmae | ephrin B2 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:3227 |
| EnsembleID | ENSG00000125266 |
| Uniprot | P52799 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| EFNB2 | autophagy | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| EFNB2 | GO:0001618,GO:0001945,GO:0002042,GO:0005515,GO:0005886,GO:0005886,GO:0005886,GO:0005912,GO:0005925,GO:0007155,GO:0007267,GO:0007411,GO:0008284,GO:0009653,GO:0009887,GO:0010839,GO:0010977,GO:0031295,GO:0034332,GO:0043616,GO:0046718,GO:0046875,GO:0046875,GO:0048013,GO:0048013,GO:0048514,GO:0048845,GO:0050920,GO:0072178,GO:0098685,GO:0098839,GO:0098978,GO:0099072,GO:0099149,GO:1903849,GO:2000727 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| EFNB2 | hsa:1948 | path:hsa04360 | Axon guidance - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| EFNB2 | EPHB4 | 12051776 18988627 23331499 9576626 9718367 | stimulation | N/A | SignaLink,SignaLink |
| EFNB2 | EPHB2 | 11780069 23331499 9267020 | stimulation | N/A | SignaLink |
| EFNB2 | EPHB1 | 23331499 9576626 | stimulation | N/A | SignaLink |
| EFNB2 | EPHB3 | 23331499 9576626 | stimulation | N/A | SignaLink |
| EFNB2 | EPHA3 | 23331499 8559144 9195962 | stimulation | N/A | SignaLink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | EFNB2 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| GATA3 | EFNB2 | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXA1 | EFNB2 | 18971253 21878914 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| FOXP3 | EFNB2 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| PRDM14 | EFNB2 | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | EFNB2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | EFNB2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | EFNB2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | EFNB2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | EFNB2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | EFNB2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| GATA2 | EFNB2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | EFNB2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | EFNB2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS000029D9F1 | EFNB2 | 23204229 | rna interference,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | miRSponge |
| URS00002B3783 | EFNB2 | 22438230 | rna interference,inhibition | miRNA interference luciferase reporter assay | miRSponge |
| URS00002B3783 | EFNB2 | 22438230 25416803 | mrna cleavage,inhibition | miRNA interference luciferase reporter assay | TarBase |
| URS000029D9F1 | EFNB2 | 23204229 25416803 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS00000ED600 | EFNB2 | 20215506 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00000F31F4 | EFNB2 | 19074876 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00000B59A2 | EFNB2 | 19074876 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS000016FF9C | EFNB2 | 20371350 25416803 | mrna cleavage,inhibition | nucleotide sequence identification | TarBase |
| URS00001597DC | EFNB2 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00000B0E50 | EFNB2 | 25176332 25416803 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS000000EF0B | EFNB2 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000D5659 | EFNB2 | 20371350 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003E226A | EFNB2 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000040FA88 | EFNB2 | 20371350 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000475586 | EFNB2 | 20371350 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000759F6E | EFNB2 | 20371350 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075A760 | EFNB2 | 20371350 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000003FD55 | EFNB2 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003A5E54 | EFNB2 | 20371350 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003808EC | EFNB2 | 20371350 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000041CB9C | EFNB2 | 20371350 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000171CD1 | EFNB2 | 20371350 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000040EE1D | EFNB2 | 20371350 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000F0F49 | EFNB2 | 20371350 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000007D64A | EFNB2 | 20371350 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000F6E49 | EFNB2 | 20371350 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| NCK2 | EFNB2 | 25361965 | interaction type | N/A | PTMCode2 |
| EFNB2 | NCK2 | 25361965 | interaction type | N/A | PTMCode2 |
| EFNB2 | RGS3 | 25361965 | interaction type | N/A | PTMCode2 |
| RGS3 | EFNB2 | 25361965 | interaction type | N/A | PTMCode2 |
| EFNB2 | SDCBP | 25361965 | interaction type | N/A | PTMCode2 |
| SDCBP | EFNB2 | 25361965 | interaction type | N/A | PTMCode2 |
| EFNB2 | EPHA4 | 25361965 | interaction type | N/A | PTMCode2 |
| EPHA4 | EFNB2 | 25361965 | interaction type | N/A | PTMCode2 |
| EFNB2 | RHBDL2 | 25361965 | interaction type | N/A | PTMCode2 |
| RHBDL2 | EFNB2 | 25361965 | interaction type | N/A | PTMCode2 |
| EFNB2 | EPHA3 | 25361965 | interaction type | N/A | PTMCode2 |
| EPHA3 | EFNB2 | 25361965 | interaction type | N/A | PTMCode2 |
| EFNB2 | SRC | 25361965 | interaction type | N/A | PTMCode2 |
| SRC | EFNB2 | 25361965 | interaction type | N/A | PTMCode2 |
| EFNB2 | EPHB2 | 25361965 | interaction type | N/A | PTMCode2 |
| EPHB2 | EFNB2 | 25361965 | interaction type | N/A | PTMCode2 |
| EFNB2 | EPHB6 | 25361965 | interaction type | N/A | PTMCode2 |
| EPHB6 | EFNB2 | 25361965 | interaction type | N/A | PTMCode2 |
| EFNB2 | EPHB1 | 25361965 | interaction type | N/A | PTMCode2 |
| EPHB1 | EFNB2 | 25361965 | interaction type | N/A | PTMCode2 |
| EFNB1 | EFNB2 | 25361965 | interaction type | N/A | PTMCode2 |
| EFNB2 | EFNB1 | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| NCK2 | EFNB2 | 12206665 12606549 14525934 15764601 24234451 25348397 27898060 | association | circular dichroism,experimental interaction detection,nuclear magnetic resonance,in vitro | ComPPI,HPRD,IntAct,OmniPath |
| PIK3R2 | EFNB2 | 25348397 | N/A | physical interaction | ComPPI |
| EIF2B2 | EFNB2 | 25348397 | N/A | physical interaction | ComPPI |
| TYK2 | EFNB2 | 25348397 | N/A | physical interaction | ComPPI |
| DLG4 | EFNB2 | 14525934 15458844 25348397 | N/A | two hybrid,two hybrid | ComPPI,HPRD |
| PICK1 | EFNB2 | 14525934 15458844 25348397 | N/A | two hybrid,physical interaction,two hybrid | ComPPI,HPRD |
| PECAM1 | EFNB2 | 16357318 25348397 27898060 | N/A | in vivo | ComPPI,OmniPath |
| PIK3R1 | EFNB2 | 25348397 | N/A | physical interaction | ComPPI |
| SRC | EFNB2 | 14525934 25348397 8878483 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| EPHB2 | EFNB2 | 11780069 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD |
| EPHB6 | EFNB2 | 25348397 | N/A | in vitro,in vivo | ComPPI |
| SDC2 | EFNB2 | 25348397 | N/A | physical interaction | ComPPI |
| PIK3CB | EFNB2 | 25348397 | N/A | physical interaction | ComPPI |
| PIK3CA | EFNB2 | 25348397 | N/A | physical interaction | ComPPI |
| PIK3R3 | EFNB2 | 25348397 | N/A | physical interaction | ComPPI |
| USO1 | EFNB2 | 25348397 | N/A | physical interaction | ComPPI |
| PKP2 | EFNB2 | 25348397 | N/A | physical interaction | ComPPI |
| HNRNPL | EFNB2 | 25348397 | N/A | physical interaction | ComPPI |
| GRM1 | EFNB2 | 25348397 | N/A | in vivo | ComPPI |
| SDCBP | EFNB2 | 10473577 14525934 25348397 27898060 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD,OmniPath |
| EPHA3 | EFNB2 | 14525934 25348397 8559144 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD |
| EFNB2 | EPHB4 | 12051776 14525934 24234451 25348397 26481148 9718367 | N/A | experimental interaction detection,surface plasmon resonance,physical interaction,in vivo,surface plasmon resonance array | ComPPI,HPRD,IntAct |
| EFNB2 | EPHB1 | 10066262 14525934 25348397 8559144 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| EFNB2 | EPHA4 | 12761826 14525934 19836338 24234451 25348397 | physical association | experimental interaction detection,molecular sieving,pull down,surface plasmon resonance,x-ray crystallography,physical interaction,in vivo,surface plasmon resonance array | ComPPI,HPRD,IntAct |
| EFNB2 | PDZRN3 | 14525934 15458844 25348397 | N/A | two hybrid,two hybrid | ComPPI,HPRD |
| EFNB2 | RGS3 | 14525934 15458844 25348397 | N/A | two hybrid,physical interaction,two hybrid | ComPPI,HPRD |
| EFNB2 | GRM5 | 25348397 | N/A | in vivo | ComPPI |
| EFNB2 | HOMER1 | 14525934 15745950 25348397 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| EFNB2 | PTPN13 | 14525934 25348397 9920925 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| EFNB2 | GRIP1 | 14525934 25348397 9883737 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| EFNB2 | PSEN1 | 14525934 16511561 25348397 27898060 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD,OmniPath |
| EFNB2 | EFNB1 | 25348397 | N/A | physical interaction | ComPPI |
| EFNB2 | PHLPP1 | 25348397 | N/A | physical interaction | ComPPI |
| EFNB2 | CAND2 | 25348397 | N/A | physical interaction | ComPPI |
| EFNB2 | EIF2B4 | 25348397 | N/A | physical interaction | ComPPI |
| EFNB2 | MAP7D2 | 25348397 | N/A | physical interaction | ComPPI |
| EFNB2 | EPHB3 | 25348397 | N/A | physical interaction | ComPPI |
| EFNB2 | EPHA5 | 25348397 | N/A | physical interaction | ComPPI |
| EFNB2 | SAAL1 | 25348397 | N/A | physical interaction | ComPPI |
| EFNB2 | DIP2B | 25348397 | N/A | physical interaction | ComPPI |
| EFNB2 | DIP2A | 25348397 | N/A | physical interaction | ComPPI |
| EFNB2 | PLEKHH3 | 25348397 | N/A | physical interaction | ComPPI |
| EFNB2 | POM121 | 25348397 | N/A | physical interaction | ComPPI |
| EFNB2 | SBF1 | 25348397 | N/A | physical interaction | ComPPI |
| EFNB2 | KIF14 | 25348397 | N/A | physical interaction | ComPPI |
| EFNB2 | RETSAT | 25348397 | N/A | physical interaction | ComPPI |
| EFNB2 | EEF1AKNMT | 25348397 | N/A | physical interaction | ComPPI |
| EFNB2 | UBE3C | 25348397 | N/A | physical interaction | ComPPI |
| EFNB2 | ME1 | 25348397 | N/A | physical interaction | ComPPI |
| EFNB2 | DNM3 | 25348397 | N/A | physical interaction | ComPPI |
| EFNB2 | MAP7D3 | 25348397 | N/A | physical interaction | ComPPI |
| EFNB2 | ATP2B2 | 25348397 | N/A | physical interaction | ComPPI |
| EFNB2 | MED16 | 25348397 | N/A | physical interaction | ComPPI |
| EFNB2 | HPS3 | 25348397 | N/A | physical interaction | ComPPI |
| EFNB2 | AAAS | 25348397 | N/A | physical interaction | ComPPI |
| EFNB2 | PLEKHG4 | 25348397 | N/A | physical interaction | ComPPI |
| EFNB2 | MTMR1 | 25348397 | N/A | physical interaction | ComPPI |
| EFNB2 | FAM120A | 25348397 | N/A | physical interaction | ComPPI |
| EFNB2 | PI4K2B | 25348397 | N/A | physical interaction | ComPPI |
| EFNB2 | PKN3 | 25348397 | N/A | physical interaction | ComPPI |
| EFNB2 | PRORP | 25348397 | N/A | physical interaction | ComPPI |
| EFNB2 | FAM171A2 | 25348397 | N/A | physical interaction | ComPPI |
| EFNB2 | NF1 | 25348397 | N/A | physical interaction | ComPPI |
| EFNB2 | DPH1 | 25348397 | N/A | physical interaction | ComPPI |
| EFNB2 | LMBR1 | 25348397 | N/A | physical interaction | ComPPI |
| EFNB2 | DENND6A | 25348397 | N/A | physical interaction | ComPPI |
| EFNB2 | EIF2B5 | 25348397 | N/A | physical interaction | ComPPI |
| EFNB2 | DAD1 | 25348397 | N/A | physical interaction | ComPPI |
| EFNB2 | TIGD5 | 25348397 | N/A | physical interaction | ComPPI |
| EFNB2 | RADIL | 25348397 | N/A | physical interaction | ComPPI |
| EFNB2 | TMEM17 | 24234451 25348397 26638075 | association | physical interaction,proximity-dependent biotin identification | ComPPI,IntAct |
| EFNB2 | TMEM216 | 24234451 25348397 26638075 | association | physical interaction,proximity-dependent biotin identification | ComPPI,IntAct |
| EFNB2 | TEX2 | 25348397 | N/A | physical interaction | ComPPI |
| EFNB2 | NUS1 | 25348397 | N/A | physical interaction | ComPPI |
| EFNB2 | TSPAN3 | 25348397 | N/A | physical interaction | ComPPI |
| EFNB2 | SDC3 | 25348397 | N/A | physical interaction | ComPPI |
| EFNB2 | EFNB2 | 14525934 9883737 | N/A | experimental interaction detection | HPRD |
| RHBDL2 | EFNB2 | 14525934 15047175 | N/A | experimental interaction detection | HPRD |
| EPHB2 | EFNB2 | 11780069 12606549 15096211 26186194 27898060 | stimulant | N/A | OmniPath |
| ABL1 | EFNB2 | 12606549 27898060 | N/A | N/A | OmniPath |
| EFNB2 | RASGRP3 | 27898060 9233798 | stimulant | N/A | OmniPath |
| EFNB2 | EPHB1 | 10066262 27898060 8559144 9330863 | N/A | N/A | OmniPath |
| EFNB2 | DOK1 | 27898060 9233798 | stimulant | N/A | OmniPath |
| EPHB6 | EFNB2 | 10648835 15114347 27898060 | N/A | N/A | OmniPath |
| EFNB2 | EPHB3 | 27898060 8559144 9330863 | stimulant | N/A | OmniPath |
| EFNB2 | EPHA6 | 10648835 27898060 | N/A | N/A | OmniPath |
| EFNB2 | EPHB4 | 12051776 27898060 7534404 9718367 | N/A | N/A | OmniPath |