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GENE：IGF1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol IGF1
FullNmae insulin like growth factor 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:5464
EnsembleID ENSG00000017427
Uniprot P05019

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
IGF1 pyroptosis 38011754 Our results showed that overexpression of MIR22HG promoted autophagy and inhibited pyroptosis and fibrosis through the miR-9-3p/IGF1 pathway, thus slowing the occurrence and development of NASH. retulator signature
IGF1 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
IGF1 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
IGF1 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
IGF1 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
IGF1 GO:0001501,GO:0001775,GO:0001837,GO:0001932,GO:0005158,GO:0005159,GO:0005159,GO:0005159,GO:0005159,GO:0005178,GO:0005179,GO:0005179,GO:0005515,GO:0005576,GO:0005576,GO:0005615,GO:0005615,GO:0007165,GO:0007265,GO:0007517,GO:0008083,GO:0008283,GO:0008283,GO:0008284,GO:0008284,GO:0008284,GO:0009408,GO:0009441,GO:0010468,GO:0010560,GO:0010613,GO:0010613,GO:0010628,GO:0010629,GO:0014834,GO:0014896,GO:0014904,GO:0014911,GO:0016942,GO:0030166,GO:0030166,GO:0030335,GO:0031093,GO:0032148,GO:0032691,GO:0032720,GO:0034392,GO:0035630,GO:0035867,GO:0042060,GO:0042104,GO:0042531,GO:0042567,GO:0043066,GO:0043066,GO:0043388,GO:0043410,GO:0043568,GO:0045445,GO:0045669,GO:0045725,GO:0045821,GO:0045840,GO:0045893,GO:0045893,GO:0045944,GO:0046326,GO:0046579,GO:0048009,GO:0048009,GO:0048009,GO:0048146,GO:0048661,GO:0050679,GO:0050714,GO:0050731,GO:0050821,GO:0051450,GO:0051897,GO:0051897,GO:0051897,GO:0051897,GO:0060283,GO:0061051,GO:0061051,GO:0070374,GO:0070382,GO:0070886,GO:0090201,GO:0150079,GO:1902430,GO:1904075,GO:1904646,GO:1904707,GO:1905460,GO:2000679,GO:2001237

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
IGF1 hsa:3479 path:hsa01521 EGFR tyrosine kinase inhibitor resistance - Homo sapiens (human)
IGF1 hsa:3479 path:hsa01522 Endocrine resistance - Homo sapiens (human)
IGF1 hsa:3479 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
IGF1 hsa:3479 path:hsa04014 Ras signaling pathway - Homo sapiens (human)
IGF1 hsa:3479 path:hsa04015 Rap1 signaling pathway - Homo sapiens (human)
IGF1 hsa:3479 path:hsa04066 HIF-1 signaling pathway - Homo sapiens (human)
IGF1 hsa:3479 path:hsa04068 FoxO signaling pathway - Homo sapiens (human)
IGF1 hsa:3479 path:hsa04114 Oocyte meiosis - Homo sapiens (human)
IGF1 hsa:3479 path:hsa04115 p53 signaling pathway - Homo sapiens (human)
IGF1 hsa:3479 path:hsa04150 mTOR signaling pathway - Homo sapiens (human)
IGF1 hsa:3479 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
IGF1 hsa:3479 path:hsa04152 AMPK signaling pathway - Homo sapiens (human)
IGF1 hsa:3479 path:hsa04211 Longevity regulating pathway - Homo sapiens (human)
IGF1 hsa:3479 path:hsa04213 Longevity regulating pathway - multiple species - Homo sapiens (human)
IGF1 hsa:3479 path:hsa04510 Focal adhesion - Homo sapiens (human)
IGF1 hsa:3479 path:hsa04550 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
IGF1 hsa:3479 path:hsa04730 Long-term depression - Homo sapiens (human)
IGF1 hsa:3479 path:hsa04750 Inflammatory mediator regulation of TRP channels - Homo sapiens (human)
IGF1 hsa:3479 path:hsa04913 Ovarian steroidogenesis - Homo sapiens (human)
IGF1 hsa:3479 path:hsa04914 Progesterone-mediated oocyte maturation - Homo sapiens (human)
IGF1 hsa:3479 path:hsa04935 Growth hormone synthesis, secretion and action - Homo sapiens (human)
IGF1 hsa:3479 path:hsa04960 Aldosterone-regulated sodium reabsorption - Homo sapiens (human)
IGF1 hsa:3479 path:hsa05200 Pathways in cancer - Homo sapiens (human)
IGF1 hsa:3479 path:hsa05202 Transcriptional misregulation in cancer - Homo sapiens (human)
IGF1 hsa:3479 path:hsa05205 Proteoglycans in cancer - Homo sapiens (human)
IGF1 hsa:3479 path:hsa05214 Glioma - Homo sapiens (human)
IGF1 hsa:3479 path:hsa05215 Prostate cancer - Homo sapiens (human)
IGF1 hsa:3479 path:hsa05218 Melanoma - Homo sapiens (human)
IGF1 hsa:3479 path:hsa05224 Breast cancer - Homo sapiens (human)
IGF1 hsa:3479 path:hsa05410 Hypertrophic cardiomyopathy - Homo sapiens (human)
IGF1 hsa:3479 path:hsa05414 Dilated cardiomyopathy - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
IGF1 IGF1R 11237532 12067807 12181198 17145802 1852007 19631971 21071413 23331499 26192618 interaction type,stimulation N/A ACSN,SignaLink,SignaLink
IGF1 IGFBP1 14568572 23331499 inhibition N/A SignaLink,SignaLink
ESR1 IGF1 10749889 23331499 stimulation N/A SignaLink,SignaLink

Source Target Pmid Interactiontype Methods Database
AR IGF1 17363459 trascriptional regulation,stimulation electrophoretic mobility shift assay TFlink
CEBPD IGF1 19103645 trascriptional regulation,stimulation electrophoretic mobility shift assay TFlink
ETS1 IGF1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 IGF1 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
IRF8 IGF1 19103645 trascriptional regulation,stimulation electrophoretic mobility shift assay TFlink
JUN IGF1 19103645 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
STAT5A IGF1 15677453 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay TFlink
STAT5B IGF1 15677453 22419735 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay TFlink
FOXP3 IGF1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 IGF1 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
HNF1A IGF1 15933209 trascriptional regulation,stimulation inferred by curator TFlink
SMARCA4 IGF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA IGF1 18971253 7708053 trascriptional regulation,stimulation inferred by curator TFlink
CTCF IGF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 IGF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 IGF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 IGF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS IGF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A IGF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 IGF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
BRCA1 IGF1 18045956 trascriptional regulation,stimulation inferred by curator TFlink
EP300 IGF1 18281476 trascriptional regulation,stimulation inferred by curator TFlink
HDAC2 IGF1 18193094 trascriptional regulation,stimulation inferred by curator TFlink
NCOR1 IGF1 18193094 trascriptional regulation,stimulation inferred by curator TFlink
NCOR2 IGF1 18193094 trascriptional regulation,stimulation inferred by curator TFlink
OTX2 IGF1 21047732 trascriptional regulation,stimulation inferred by curator TFlink
RB1 IGF1 18281476 trascriptional regulation,stimulation inferred by curator TFlink
WT1 IGF1 9076342 trascriptional regulation,stimulation inferred by curator TFlink
ESR1 IGF1 N/A trascriptional regulation,stimulation inferred by curator TFlink
MYB IGF1 N/A trascriptional regulation,stimulation inferred by curator TFlink
STAT3 IGF1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00001B341F IGF1 21643012 rna interference,inhibition experimental interaction detection,western blot,rna immunoprecipitation,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00001B341F IGF1 21643012 25416803 mrna cleavage,inhibition experimental interaction detection,experimental interaction detection,experimental interaction detection,western blot,rna immunoprecipitation,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000003575B IGF1 23403580 25416803 mrna cleavage,inhibition experimental interaction detection,experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000000B1C9 IGF1 24582811 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00000FFE5F IGF1 24586785 25416803 mrna cleavage,inhibition array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000017DBB8 IGF1 23362143 25416803 mrna cleavage,inhibition quantitative reverse transcription pcr TarBase
URS0000237CBD IGF1 25305490 25416803 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase
URS00004719AB IGF1 21572407 23446348 24962367 25416803 mrna cleavage,inhibition quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay TarBase
URS0000076995 IGF1 23960076 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000020CEC2 IGF1 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS000039607D IGF1 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00000AD002 IGF1 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000075C4B1 IGF1 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000007F792 IGF1 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000070CD2 IGF1 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000355E82 IGF1 23446348 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000427B68 IGF1 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000044FD7 IGF1 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000215483 IGF1 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000040EC3B IGF1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00003AA845 IGF1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00004505E4 IGF1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000017EA6A IGF1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00002C0FCB IGF1 22012620 25416803 26953888 mrna cleavage,inhibition array technology,experimental interaction detection,western blot,clip,miRNA interference luciferase reporter assay TarBase
URS000029D793 IGF1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000016D2D4 IGF1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000075C1E1 IGF1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002A8BC6 IGF1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000032AE90 IGF1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003E5ECC IGF1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075A760 IGF1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002152A8 IGF1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000137EDE IGF1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000019907A IGF1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075B538 IGF1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001C770D IGF1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001FC26E IGF1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000160683 IGF1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000006372A IGF1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001C0099 IGF1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003FBC84 IGF1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001CF056 IGF1 23824327 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00000B7E30 IGF1 23824327 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00000A057E IGF1 25416803 25756952 26851511 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS00001799A3 IGF1 25416803 26160280 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000122ED0 IGF1 25416803 26722410 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000003ABC4 IGF1 25416803 26847596 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
CCN3 IGF1 25348397 N/A physical interaction ComPPI
E2F1 IGF1 25348397 N/A physical interaction ComPPI
IGFBP7 IGF1 25348397 N/A physical interaction ComPPI
HNRNPL IGF1 25348397 N/A physical interaction ComPPI
SOX4 IGF1 25348397 N/A physical interaction ComPPI
IGSF1 IGF1 25348397 N/A physical interaction ComPPI
INSR IGF1 24234451 25348397 8452530 physical association competition binding ComPPI,IntAct
IGFBP3 IGF1 22578544 24234451 25348397 N/A physical interaction,bio-layer interferometry ComPPI,IntAct
IGFBP4 IGF1 15642270 16924115 24234451 25348397 N/A isothermal titration calorimetry,molecular sieving,x-ray crystallography,physical interaction ComPPI,IntAct
IGF1R IGF1 21645859 24234451 25348397 26027733 8452530 physical association surface plasmon resonance,x-ray crystallography,physical interaction,affinity technology,biochemical,competition binding,mass spectrometry study of hydrogen/deuterium exchange ComPPI,IntAct
IGFBP5 IGF1 15642270 24234451 25348397 N/A isothermal titration calorimetry,physical interaction ComPPI,IntAct
IDE IGF1 25348397 N/A physical interaction ComPPI
IGFBP1 IGF1 16924115 22578544 24234451 25348397 N/A x-ray crystallography,physical interaction,bio-layer interferometry ComPPI,IntAct
IGFBP2 IGF1 25348397 N/A physical interaction ComPPI
TF IGF1 25348397 N/A physical interaction ComPPI
IGF1 IGFBP1 10350456 14568572 22578544 27898060 inhibition N/A OmniPath
IGF1 IGF1R 12067807 1852007 19029956 21645859 21798082 27898060 2877871 8408032 8452530 stimulant N/A OmniPath
ESR1 IGF1 10749889 27898060 stimulant N/A OmniPath
CTSB IGF1 16051222 27898060 N/A N/A OmniPath

Visualization










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