GENE：LRP5
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | LRP5 |
| FullNmae | LDL receptor related protein 5 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:6697 |
| EnsembleID | ENSG00000162337 |
| Uniprot | O75197 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| LRP5 | mitotic_cd | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| LRP5 | autophagy | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| LRP5 | GO:0001702,GO:0002053,GO:0002076,GO:0005515,GO:0005783,GO:0005886,GO:0005886,GO:0006007,GO:0006865,GO:0006897,GO:0008078,GO:0008203,GO:0008217,GO:0008284,GO:0009952,GO:0010467,GO:0015026,GO:0015026,GO:0017147,GO:0017147,GO:0017147,GO:0017147,GO:0033687,GO:0033690,GO:0035019,GO:0035426,GO:0042074,GO:0042632,GO:0042632,GO:0042733,GO:0042813,GO:0042813,GO:0042813,GO:0042981,GO:0043235,GO:0043434,GO:0045600,GO:0045668,GO:0045669,GO:0045840,GO:0045893,GO:0045944,GO:0045944,GO:0046849,GO:0048539,GO:0048539,GO:0060033,GO:0060042,GO:0060070,GO:0060070,GO:0060070,GO:0060070,GO:0060349,GO:0060349,GO:0060444,GO:0060612,GO:0060612,GO:0060764,GO:0060856,GO:0061178,GO:0061304,GO:0061304,GO:0071901,GO:0098609,GO:0110135,GO:1902262,GO:1990851,GO:1990909,GO:1990963 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| LRP5 | hsa:4041 | path:hsa04150 | mTOR signaling pathway - Homo sapiens (human) |
| LRP5 | hsa:4041 | path:hsa04310 | Wnt signaling pathway - Homo sapiens (human) |
| LRP5 | hsa:4041 | path:hsa04928 | Parathyroid hormone synthesis, secretion and action - Homo sapiens (human) |
| LRP5 | hsa:4041 | path:hsa05010 | Alzheimer disease - Homo sapiens (human) |
| LRP5 | hsa:4041 | path:hsa05022 | Pathways of neurodegeneration - multiple diseases - Homo sapiens (human) |
| LRP5 | hsa:4041 | path:hsa05200 | Pathways in cancer - Homo sapiens (human) |
| LRP5 | hsa:4041 | path:hsa05224 | Breast cancer - Homo sapiens (human) |
| LRP5 | hsa:4041 | path:hsa05225 | Hepatocellular carcinoma - Homo sapiens (human) |
| LRP5 | hsa:4041 | path:hsa05226 | Gastric cancer - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| LRP5 | AXIN1 | 11336703 18632848 21071413 23331499 | stimulation | N/A | SignaLink,SignaLink |
| NDP | LRP5 | 24186977 | interaction type,stimulation | N/A | SignaLink |
| TDGF1 | LRP5 | 23022962 | interaction type,stimulation | N/A | SignaLink |
| CSNK1G1 | LRP5 | 16341016 23331499 | stimulation | N/A | SignaLink |
| GSK3B | LRP5 | 16341017 23331499 | stimulation | N/A | SignaLink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | LRP5 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | LRP5 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA2 | LRP5 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| YBX1 | LRP5 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SP1 | LRP5 | 20141633 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| KLF15 | LRP5 | 20141633 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| FOXP3 | LRP5 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| SMARCA4 | LRP5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | LRP5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | LRP5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | LRP5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | LRP5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | LRP5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | LRP5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | LRP5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | LRP5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RUNX2 | LRP5 | 21542013 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| DAND5 | LRP5 | 20141633 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000237AF9 | LRP5 | 18185580 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00001CC864 | LRP5 | 25416803 26774446 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS00000ED600 | LRP5 | 25416803 28158288 | mrna cleavage,inhibition | miRNA interference luciferase reporter assay | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| LRP5 | DKK1 | 25361965 | interaction type | N/A | PTMCode2 |
| DKK1 | LRP5 | 25361965 | interaction type | N/A | PTMCode2 |
| LRP5 | FZD8 | 25361965 | interaction type | N/A | PTMCode2 |
| FZD8 | LRP5 | 25361965 | interaction type | N/A | PTMCode2 |
| LRP5 | NDP | 25361965 | interaction type | N/A | PTMCode2 |
| NDP | LRP5 | 25361965 | interaction type | N/A | PTMCode2 |
| LRP5 | DVL1 | 25361965 | interaction type | N/A | PTMCode2 |
| DVL1 | LRP5 | 25361965 | interaction type | N/A | PTMCode2 |
| AXIN1 | LRP5 | 25361965 | interaction type | N/A | PTMCode2 |
| LRP5 | AXIN1 | 25361965 | interaction type | N/A | PTMCode2 |
| WNT1 | LRP5 | 25361965 | interaction type | N/A | PTMCode2 |
| LRP5 | WNT1 | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| DKK1 | LRP5 | 11516963 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| JUN | LRP5 | 24234451 25348397 25609649 | association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| RASD2 | LRP5 | 25348397 | N/A | physical interaction | ComPPI |
| AXIN1 | LRP5 | 11336703 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| SMAD9 | LRP5 | 15231748 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| THBS1 | LRP5 | 14525934 25348397 7775583 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| LRP5 | MESD | 12581525 25348397 27898060 | N/A | in vivo | ComPPI,OmniPath |
| LRP5 | WNT1 | 11336703 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| LRP5 | FZD8 | 11448771 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| LRP5 | CAPRIN2 | 18762581 24234451 25348397 | physical association | anti tag coimmunoprecipitation,pull down,physical interaction | ComPPI,IntAct |
| LRP5 | SOST | 15908424 21471202 24234451 25348397 | association,physical association | pull down,physical interaction,tandem affinity purification | ComPPI,IntAct |
| LRP5 | TAZ | 25348397 | N/A | physical interaction | ComPPI |
| LRP5 | SUSD4 | 25348397 | N/A | physical interaction | ComPPI |
| LRP5 | PARP16 | 25348397 | N/A | physical interaction | ComPPI |
| LRP5 | POMK | 25348397 | N/A | physical interaction | ComPPI |
| LRP5 | B3GALT2 | 25348397 | N/A | physical interaction | ComPPI |
| LRP5 | CHST9 | 25348397 | N/A | physical interaction | ComPPI |
| LRP5 | LIPH | 25348397 | N/A | physical interaction | ComPPI |
| LRP5 | PRSS37 | 25348397 | N/A | physical interaction | ComPPI |
| LRP5 | CSNK1A1 | 25348397 | N/A | physical interaction | ComPPI |
| LRP5 | DKKL1 | 25348397 | N/A | physical interaction | ComPPI |
| LRP5 | SERPINA12 | 25348397 | N/A | physical interaction | ComPPI |
| LRP5 | ST8SIA4 | 25348397 | N/A | physical interaction | ComPPI |
| LRP5 | SCGB1D1 | 25348397 | N/A | physical interaction | ComPPI |
| LRP5 | DKK4 | 25348397 | N/A | physical interaction | ComPPI |
| LRP5 | MGAT4C | 25348397 | N/A | physical interaction | ComPPI |
| LRP5 | F9 | 25348397 | N/A | physical interaction | ComPPI |
| LRP5 | FAM3B | 25348397 | N/A | physical interaction | ComPPI |
| LRP5 | ODAPH | 25348397 | N/A | physical interaction | ComPPI |
| LRP5 | FCGRT | 25348397 | N/A | physical interaction | ComPPI |
| LRP5 | PODN | 25348397 | N/A | physical interaction | ComPPI |
| LRP5 | ADAM33 | 25348397 | N/A | physical interaction | ComPPI |
| LRP5 | BRINP3 | 25348397 | N/A | physical interaction | ComPPI |
| LRP5 | LRRC4C | 25348397 | N/A | physical interaction | ComPPI |
| LRP5 | CLPSL1 | 25348397 | N/A | physical interaction | ComPPI |
| LRP5 | NXPH2 | 25348397 | N/A | physical interaction | ComPPI |
| LRP5 | TRIM25 | 25348397 | N/A | physical interaction | ComPPI |
| LRP5 | HNRNPL | 25348397 | N/A | physical interaction | ComPPI |
| LRP5 | APCDD1 | 20393562 24234451 25348397 | physical association | anti tag coimmunoprecipitation,pull down,physical interaction | ComPPI,IntAct |
| LRP5 | NDP | 19837033 24234451 25348397 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| ETV6 | LRP5 | 25348397 | N/A | physical interaction | ComPPI |
| TGIF2LY | LRP5 | 25348397 | N/A | physical interaction | ComPPI |
| WNT2 | LRP5 | 15578921 27898060 | stimulant | N/A | OmniPath |
| WNT1 | LRP5 | 11336703 15578921 21078818 27898060 | stimulant | N/A | OmniPath |
| WNT5A | LRP5 | 16602827 27898060 | N/A | N/A | OmniPath |
| DKK1 | LRP5 | 11448771 11516963 15035989 26186194 27898060 | inhibition | N/A | OmniPath |
| LRP5 | AXIN1 | 11336703 18632848 1863285 18762581 19075000 27898060 | stimulant | N/A | OmniPath |
| GSK3B | LRP5 | 16341017 27898060 | stimulant | N/A | OmniPath |
| WNT4 | LRP5 | 15578921 27898060 | stimulant | N/A | OmniPath |
| WNT8A | LRP5 | 15578921 27898060 | stimulant | N/A | OmniPath |
| WNT3A | LRP5 | 15578921 21078818 27898060 | stimulant | N/A | OmniPath |
| FZD8 | LRP5 | 11448771 21078818 27898060 | stimulant | N/A | OmniPath |
| WNT10B | LRP5 | 15578921 27898060 | stimulant | N/A | OmniPath |
| WNT7A | LRP5 | 15578921 27898060 | stimulant | N/A | OmniPath |
| WNT6 | LRP5 | 15578921 27898060 | stimulant | N/A | OmniPath |
| WNT10A | LRP5 | 15578921 27898060 | stimulant | N/A | OmniPath |
| WNT5B | LRP5 | 15578921 27898060 | stimulant | N/A | OmniPath |
| WNT7B | LRP5 | 15578921 15923619 27898060 | stimulant | N/A | OmniPath |
| WNT9B | LRP5 | 15578921 27898060 | stimulant | N/A | OmniPath |
| WNT9A | LRP5 | 15578921 27898060 | stimulant | N/A | OmniPath |
| LRP5 | FZD10 | 15923619 27898060 | N/A | N/A | OmniPath |
| APOE | LRP5 | 27898060 9832610 | stimulant | N/A | OmniPath |
| WNT2B | LRP5 | 15578921 27898060 | stimulant | N/A | OmniPath |