GENE：PER1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | PER1 |
| FullNmae | period circadian regulator 1 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:8845 |
| EnsembleID | ENSG00000179094 |
| Uniprot | O15534 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| PER1 | pyroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| PER1 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| PER1 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| PER1 | autophagy | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| PER1 | GO:0000122,GO:0000122,GO:0000976,GO:0000978,GO:0001222,GO:0002028,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005737,GO:0005829,GO:0006338,GO:0007623,GO:0009649,GO:0010608,GO:0019900,GO:0031490,GO:0031625,GO:0032922,GO:0032922,GO:0042634,GO:0042752,GO:0043124,GO:0043153,GO:0043153,GO:0045892,GO:0045944,GO:0046329,GO:0051591,GO:0070888,GO:0097167,GO:0140297,GO:1900015,GO:1900744,GO:2000323 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| PER1 | hsa:5187 | path:hsa04710 | Circadian rhythm - Homo sapiens (human) |
| PER1 | hsa:5187 | path:hsa04713 | Circadian entrainment - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| PER1 | BTRC | 15917222 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| PER1 | FBXW11 | 15917222 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| PER1 | CSNK1E | 15917222 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| CSNK1G2 | PER1 | 15917222 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | PER1 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | PER1 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| MYC | PER1 | 12695333 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| FOXP3 | PER1 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| SMARCA4 | PER1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | PER1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | PER1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | PER1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXP1 | PER1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | PER1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| GATA2 | PER1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ARNTL | PER1 | 17660446 17994337 21479263 22750052 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CLOCK | PER1 | 17660446 17994337 20551151 21479263 22750052 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| NPAS2 | PER1 | 17660446 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SIRT1 | PER1 | 22149272 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000237AF9 | PER1 | 18185580 22012620 25416803 | mrna cleavage,inhibition | array technology,clip | TarBase |
| URS00005651EE | PER1 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00002075FA | PER1 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS0000324096 | PER1 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS0000076995 | PER1 | 24578160 25416803 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS0000272A3D | PER1 | 24578160 25416803 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS00006DE17B | PER1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000077DDE | PER1 | 20371350 22012620 23446348 23592263 23706177 25416803 26701625 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS00000C403E | PER1 | 20371350 22012620 23446348 23592263 23706177 25416803 26701625 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS00000D6C3F | PER1 | 20371350 22012620 23446348 23592263 23706177 25416803 26701625 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS000032BDF4 | PER1 | 20371350 22012620 23446348 23592263 23706177 25416803 26701625 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS000075AB14 | PER1 | 20371350 21572407 23446348 23592263 25416803 26701625 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS00005FDCD1 | PER1 | 20371350 21572407 23446348 23592263 25416803 26701625 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS00000C48FA | PER1 | 20371350 21572407 23446348 23592263 25416803 26701625 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS00001CC4BD | PER1 | 20371350 21572407 23446348 23592263 25416803 26701625 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS00001799A3 | PER1 | 20371350 21572407 23446348 23592263 25416803 26701625 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS00002394F5 | PER1 | 20371350 22012620 23446348 23706177 25416803 26701625 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS000004DB7E | PER1 | 20371350 23446348 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS000041E949 | PER1 | 20371350 22012620 23446348 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS0000346991 | PER1 | 20371350 22012620 23446348 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS000054A671 | PER1 | 20371350 22012620 23446348 23706177 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS000043F369 | PER1 | 20371350 22012620 23446348 23706177 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS000006DA05 | PER1 | 20371350 22012620 23446348 23706177 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS000008F0CF | PER1 | 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000003575B | PER1 | 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002C7B2B | PER1 | 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000166778 | PER1 | 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000427B68 | PER1 | 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000331800 | PER1 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004AC389 | PER1 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000015F70F | PER1 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000508C13 | PER1 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000027080C | PER1 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000070CD2 | PER1 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000037D7E5 | PER1 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003883FE | PER1 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003E5ECC | PER1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000024A59E | PER1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000204177 | PER1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000100748 | PER1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000EED18 | PER1 | 25416803 25864118 26923637 | mrna cleavage,inhibition | array technology,quantitative reverse transcription pcr | TarBase |
| URS000050CCE0 | PER1 | 25416803 25771167 | mrna cleavage,inhibition | miRNA interference luciferase reporter assay | TarBase |
| URS000000C73C | PER1 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| FBXW11 | PER1 | 25361965 | interaction type | N/A | PTMCode2 |
| PER1 | FBXW11 | 25361965 | interaction type | N/A | PTMCode2 |
| PER2 | PER1 | 25361965 | interaction type | N/A | PTMCode2 |
| PER1 | PER2 | 25361965 | interaction type | N/A | PTMCode2 |
| CLOCK | PER1 | 25361965 | interaction type | N/A | PTMCode2 |
| PER1 | CLOCK | 25361965 | interaction type | N/A | PTMCode2 |
| PER1 | CSNK1D | 25361965 | interaction type | N/A | PTMCode2 |
| CSNK1D | PER1 | 25361965 | interaction type | N/A | PTMCode2 |
| PER1 | NPAS2 | 25361965 | interaction type | N/A | PTMCode2 |
| NPAS2 | PER1 | 25361965 | interaction type | N/A | PTMCode2 |
| PER1 | CSNK1E | 25361965 | interaction type | N/A | PTMCode2 |
| CSNK1E | PER1 | 25361965 | interaction type | N/A | PTMCode2 |
| PER1 | PER3 | 25361965 | interaction type | N/A | PTMCode2 |
| PER3 | PER1 | 25361965 | interaction type | N/A | PTMCode2 |
| PER1 | BTRC | 25361965 | interaction type | N/A | PTMCode2 |
| BTRC | PER1 | 25361965 | interaction type | N/A | PTMCode2 |
| PER1 | ARNTL | 25361965 | interaction type | N/A | PTMCode2 |
| ARNTL | PER1 | 25361965 | interaction type | N/A | PTMCode2 |
| PER1 | CRY2 | 25361965 | interaction type | N/A | PTMCode2 |
| CRY2 | PER1 | 25361965 | interaction type | N/A | PTMCode2 |
| CRY1 | PER1 | 25361965 | interaction type | N/A | PTMCode2 |
| PER1 | CRY1 | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| RBPMS | PER1 | 25348397 | N/A | physical interaction | ComPPI |
| ZNRD2 | PER1 | 25348397 | N/A | physical interaction | ComPPI |
| CSNK1G2 | PER1 | 25348397 | N/A | physical interaction | ComPPI |
| QPRT | PER1 | 25348397 | N/A | physical interaction | ComPPI |
| KBTBD7 | PER1 | 25348397 | N/A | physical interaction | ComPPI |
| PRKACB | PER1 | 25348397 | N/A | physical interaction | ComPPI |
| CSNK1D | PER1 | 11165242 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD |
| TEX264 | PER1 | 25348397 | N/A | physical interaction | ComPPI |
| TXNIP | PER1 | 25348397 | N/A | physical interaction | ComPPI |
| SKAP1 | PER1 | 25348397 | N/A | physical interaction | ComPPI |
| HIF1A | PER1 | 11726537 14525934 25348397 27898060 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD,OmniPath |
| PAXIP1 | PER1 | 25348397 | N/A | physical interaction | ComPPI |
| BCAT1 | PER1 | 25348397 | N/A | physical interaction | ComPPI |
| BTRC | PER1 | 25348397 | N/A | physical interaction | ComPPI |
| TNS2 | PER1 | 24234451 25348397 25814554 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| CSNK1E | PER1 | 10848614 11865049 14525934 16790549 23455922 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo,tandem affinity purification | ComPPI,HPRD,IntAct |
| NXF2 | PER1 | 25348397 | N/A | physical interaction | ComPPI |
| XPO1 | PER1 | 25348397 | N/A | physical interaction | ComPPI |
| PER3 | PER1 | 10837028 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
| GPRASP1 | PER1 | 11597585 14525934 25348397 27898060 | N/A | two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid | ComPPI,HPRD,OmniPath |
| PER1 | PER2 | 10848614 11165242 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| PER1 | TIMELESS | 14525934 25348397 9856465 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| PER1 | CRY2 | 12782655 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD |
| PER1 | CRY1 | 10531061 12782655 14525934 25348397 | N/A | two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid | ComPPI,HPRD |
| PER1 | FBXW11 | 25348397 | N/A | physical interaction | ComPPI |
| PER1 | RIPOR2 | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| PER1 | CCDC57 | 25348397 | N/A | physical interaction | ComPPI |
| PER1 | CSNK2B | 25348397 | N/A | physical interaction | ComPPI |
| PER1 | DELEC1 | 25348397 | N/A | physical interaction | ComPPI |
| PER1 | RFPL4B | 25348397 | N/A | physical interaction | ComPPI |
| PER1 | GFOD1 | 25348397 | N/A | physical interaction | ComPPI |
| PER1 | AP2M1 | 25348397 | N/A | physical interaction | ComPPI |
| PER1 | ARHGAP25 | 25348397 | N/A | physical interaction | ComPPI |
| PER1 | GTSE1 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| PER1 | FOXK2 | 24234451 25348397 25609649 | association | physical interaction,tandem affinity purification | ComPPI,IntAct |
| PER1 | GPR156 | 25348397 | N/A | physical interaction | ComPPI |
| PER1 | BMT2 | 25348397 | N/A | physical interaction | ComPPI |
| PER1 | GATD1 | 25348397 | N/A | physical interaction | ComPPI |
| PER1 | ARNTL2 | 25348397 | N/A | physical interaction | ComPPI |
| PER1 | DQX1 | 25348397 | N/A | physical interaction | ComPPI |
| PER1 | KLHL40 | 25348397 | N/A | physical interaction | ComPPI |
| PER1 | BBS7 | 25348397 | N/A | physical interaction | ComPPI |
| PER1 | TRIM25 | 25348397 | N/A | physical interaction | ComPPI |
| LTB4R2 | PER1 | 24234451 28298427 | physical association | ubiquitin reconstruction | IntAct |
| PER1 | ARNTL | 14701732 16717091 18662546 21680841 21966515 27898060 | inhibition | N/A | OmniPath |
| CSNK1E | PER1 | 10848614 11865049 15917222 21680841 21966515 23455922 23555304 26496610 27898060 | inhibition,stimulant | N/A | OmniPath |
| NPAS2 | PER1 | 19106159 27898060 | stimulant | N/A | OmniPath |
| PER1 | ATM | 16678109 17644383 27898060 | stimulant | N/A | OmniPath |
| BTRC | PER1 | 15917222 15917223 17463251 27898060 | inhibition | N/A | OmniPath |
| FBXW11 | PER1 | 15917222 15917223 25515538 27898060 | inhibition | N/A | OmniPath |
| CSNK1G2 | PER1 | 15917222 27898060 | inhibition | N/A | OmniPath |