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GENE：RUNX2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol RUNX2
FullNmae RUNX family transcription factor 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:10472
EnsembleID ENSG00000124813
Uniprot Q13950

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
RUNX2 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
RUNX2 GO:0000785,GO:0000785,GO:0000978,GO:0000981,GO:0000981,GO:0001228,GO:0001503,GO:0001503,GO:0001649,GO:0001649,GO:0001649,GO:0001958,GO:0002051,GO:0002062,GO:0002063,GO:0002076,GO:0003700,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005654,GO:0005667,GO:0005737,GO:0005829,GO:0006357,GO:0007224,GO:0010467,GO:0010628,GO:0019904,GO:0030097,GO:0030182,GO:0030217,GO:0030278,GO:0030509,GO:0031490,GO:0032332,GO:0033591,GO:0035115,GO:0036076,GO:0040036,GO:0042475,GO:0042487,GO:0043425,GO:0045595,GO:0045669,GO:0045879,GO:0045892,GO:0045893,GO:0045944,GO:0048469,GO:0048701,GO:0048863,GO:0050673,GO:0050679,GO:0060395,GO:0071773,GO:0072089,GO:1901522,GO:1904383,GO:1990837,GO:2000648

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
RUNX2 hsa:860 path:hsa04928 Parathyroid hormone synthesis, secretion and action - Homo sapiens (human)
RUNX2 hsa:860 path:hsa05202 Transcriptional misregulation in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
LGALS3 RUNX2 18438928 19020999 23180781 physical association affinity chromatography technology,anti tag coimmunoprecipitation InnateDB
RUNX2 PMF1 18438928 23180781 physical association affinity chromatography technology InnateDB
RUNX2 KIR3DL1 22467658 23180781 physical association electrophoretic mobility supershift assay InnateDB
RUNX2 KIR2DL4 22467658 23180781 physical association electrophoretic mobility supershift assay InnateDB
RUNX2 RUNX2 11331591 15765505 22298955 26467481 up-regulates quantity by expression,transcriptional regulation N/A Signor

Source Target Pmid Interactiontype Methods Database
AR RUNX2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 RUNX2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 RUNX2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 RUNX2 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 RUNX2 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 RUNX2 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 RUNX2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA RUNX2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF RUNX2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 RUNX2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 RUNX2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 RUNX2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 RUNX2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 RUNX2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS RUNX2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A RUNX2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF RUNX2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 RUNX2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 RUNX2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 RUNX2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR RUNX2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 RUNX2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CBFB RUNX2 24648201 trascriptional regulation,stimulation inferred by curator TFlink
ESR1 RUNX2 11604227 trascriptional regulation,stimulation inferred by curator TFlink
HDAC4 RUNX2 19509297 trascriptional regulation,stimulation inferred by curator TFlink
JUN RUNX2 11604227 trascriptional regulation,stimulation inferred by curator TFlink
PITX1 RUNX2 21425961 trascriptional regulation,stimulation inferred by curator TFlink
TRPS1 RUNX2 16140555 trascriptional regulation,stimulation inferred by curator TFlink
TWIST1 RUNX2 12270142 21503964 21931630 trascriptional regulation,stimulation inferred by curator TFlink
TWIST2 RUNX2 12270142 21931630 trascriptional regulation,stimulation inferred by curator TFlink
NFIC RUNX2 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000338542 RUNX2 20427544 rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS000029D9F1 RUNX2 22871591 rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000065D58 RUNX2 21767385 rna interference,inhibition experimental interaction detection,western blot miRSponge
URS000005CF5F RUNX2 21767385 rna interference,inhibition experimental interaction detection,western blot miRSponge
URS0000237AF9 RUNX2 21164520 rna interference,inhibition array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS000024DFCE RUNX2 23353875 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS000001C659 RUNX2 19795981 25416803 mrna cleavage,inhibition quantitative reverse transcription pcr TarBase
URS0000338542 RUNX2 20427544 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000237AF9 RUNX2 21164520 25416803 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00004DA9DB RUNX2 21159887 25416803 25634212 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000007D64A RUNX2 21350001 25416803 mrna cleavage,inhibition western blot,northern blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000040EE1D RUNX2 21350001 25416803 mrna cleavage,inhibition western blot,northern blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000029D9F1 RUNX2 22871591 25416803 25806689 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000024DFCE RUNX2 23353875 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS00000254A6 RUNX2 23380982 25416803 mrna cleavage,inhibition detection by mass spectrometry TarBase
URS000005CF5F RUNX2 21767385 25416803 mrna cleavage,inhibition experimental interaction detection,western blot TarBase
URS0000065D58 RUNX2 21767385 25264196 25416803 26449831 26596830 26708080 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000017EA6A RUNX2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00005651EE RUNX2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00002152A8 RUNX2 23316327 23622248 25416803 mrna cleavage,inhibition array technology,quantitative reverse transcription pcr,clash,miRNA interference luciferase reporter assay TarBase
URS0000183BED RUNX2 24613919 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00002C7B2B RUNX2 23720736 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000016914 RUNX2 25416803 27035764 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS00003CF1AD RUNX2 25416803 27965096 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000153377 RUNX2 25416803 26809090 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr TarBase
URS0000170CF4 RUNX2 25416803 28123639 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00004B83FE RUNX2 25416803 28035362 mrna cleavage,inhibition detection by mass spectrometry,miRNA interference luciferase reporter assay TarBase
URS00001B9F58 RUNX2 25416803 27760788 mrna cleavage,inhibition array technology,western blot,rna immunoprecipitation,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
MAPK3 RUNX2 22135298 phosphorylation N/A PhosphoSite
CDK1 RUNX2 22135298 phosphorylation N/A PhosphoSite
MAPK8 RUNX2 22135298 phosphorylation N/A PhosphoSite
AKT1 RUNX2 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
PIN1 RUNX2 24113655 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down ComPPI,IntAct,OmniPath
SMURF2 RUNX2 25348397 N/A physical interaction ComPPI
TLE1 RUNX2 20160071 24234451 25348397 27898060 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct,OmniPath
SMAD1 RUNX2 25348397 N/A physical interaction ComPPI
FBXW7 RUNX2 25348397 N/A physical interaction ComPPI
PRKCD RUNX2 14525934 16421932 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
JUN RUNX2 11274169 11641401 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
RB1 RUNX2 14525934 15583032 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
AR RUNX2 10521447 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CREBBP RUNX2 25348397 N/A physical interaction ComPPI
RUNX2 CEBPB 11668178 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
RUNX2 CCNB1 14525934 16407259 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
RUNX2 HDAC6 12391164 14525934 23618908 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
RUNX2 SMAD2 10531362 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
RUNX2 SMAD3 10962029 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
RUNX2 HDAC4 14525934 15537544 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
RUNX2 KAT6B 11965546 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
RUNX2 HDAC3 14525934 15292260 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
RUNX2 YAP1 10228168 14525934 24234451 25348397 25751140 physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD,IntAct
RUNX2 CBFB 12434156 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
RUNX2 MSX2 11683913 14525934 15060165 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
RUNX2 DVL2 14525934 15262978 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
RUNX2 MAP3K4 14525934 15262978 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
RUNX2 AXIN1 14525934 15262978 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
RUNX2 EP300 12697832 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
RUNX2 UBTF 14525934 17251981 20160071 24234451 25348397 association,physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
RUNX2 TAF1A 14525934 17251981 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
RUNX2 SMAD6 14525934 16299379 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,in vitro ComPPI,HPRD,IntAct
RUNX2 XRCC6 12145308 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
RUNX2 XRCC5 12145311 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
RUNX2 ETS1 14525934 25348397 27898060 9794229 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
RUNX2 ALYREF 25348397 N/A physical interaction ComPPI
RUNX2 FOS 11641401 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
RUNX2 SMAD5 22966907 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct,OmniPath
RUNX2 STUB1 18541707 25348397 27898060 N/A physical interaction ComPPI,OmniPath
RUNX2 HDAC5 25348397 N/A physical interaction ComPPI
RUNX2 KAT2B 25348397 N/A physical interaction ComPPI
RUNX2 HDAC1 16728531 21972143 22393235 25348397 27898060 N/A physical interaction ComPPI,OmniPath
RUNX2 BMPR1A 25348397 N/A physical interaction ComPPI
RUNX2 HES1 25348397 N/A physical interaction ComPPI
RUNX2 HDAC7 25348397 N/A physical interaction ComPPI
RUNX2 NR0B2 25348397 N/A physical interaction ComPPI
RUNX2 SOX9 17142326 24234451 25348397 N/A pull down,physical interaction ComPPI,IntAct
RUNX2 RBM14 19585539 25348397 27898060 N/A physical interaction ComPPI,OmniPath
RUNX2 STAT3 25348397 N/A physical interaction ComPPI
RUNX2 SUV39H1 25348397 N/A physical interaction ComPPI
RUNX2 FHL2 25348397 N/A physical interaction ComPPI
RUNX2 WWP1 25348397 N/A physical interaction ComPPI
RUNX2 SMURF1 16299379 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RUNX2 HIF1A 25348397 N/A physical interaction ComPPI
RUNX2 PML 25348397 N/A physical interaction ComPPI
RUNX2 TP53 25348397 N/A physical interaction ComPPI
RUNX2 STAT5A 25348397 N/A physical interaction ComPPI
RUNX2 SKP2 25348397 N/A physical interaction ComPPI
RUNX2 PPM1D 22065775 24234451 25348397 dephosphorylation reaction,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,dephosphorylation reaction,physical interaction,phosphatase assay ComPPI,IntAct
RUNX2 MYC 21150319 24234451 25348397 association tandem affinity purification ComPPI,IntAct
RUNX2 TP73 24234451 25331851 25348397 27898060 colocalization,physical association anti bait coimmunoprecipitation,fluorescence microscopy ComPPI,IntAct,OmniPath
CDK1 RUNX2 14525934 16407259 N/A experimental interaction detection HPRD
LEF1 RUNX2 12551949 14525934 N/A experimental interaction detection HPRD
VDR RUNX2 15456860 27898060 N/A N/A OmniPath
WWTR1 RUNX2 22153608 27898060 stimulant N/A OmniPath
TTK RUNX2 12231506 16443755 19801668 27898060 N/A N/A OmniPath
YAP1 RUNX2 10228168 14765127 22153608 27898060 inhibition N/A OmniPath
SMAD1 RUNX2 10531362 10962029 17215250 19734454 20851880 22298955 27898060 stimulant N/A OmniPath
AKT1 RUNX2 23389849 27898060 N/A N/A OmniPath
CEBPB RUNX2 11668178 15713650 27898060 stimulant N/A OmniPath
MAPK3 RUNX2 19264160 19801668 25122769 25187572 27898060 stimulant N/A OmniPath
RUNX2 CREBBP 20551513 27898060 stimulant N/A OmniPath
TGFB1 RUNX2 11331591 27898060 inhibition N/A OmniPath
CDK1 RUNX2 16407259 21913213 27898060 stimulant N/A OmniPath
HDAC4 RUNX2 15537544 16613856 20097749 22298955 27898060 inhibition N/A OmniPath
DLX5 RUNX2 22298955 27898060 stimulant N/A OmniPath
EP300 RUNX2 12697832 16613856 16728531 20851880 22298955 27898060 stimulant N/A OmniPath
RUNX2 NOTCH1 20740684 27898060 inhibition N/A OmniPath
MAPK8 RUNX2 12231506 16443755 22247071 27898060 N/A N/A OmniPath
KAT6A RUNX2 11965546 27898060 stimulant N/A OmniPath
SMAD3 RUNX2 10531362 10962029 11331591 21986102 27898060 inhibition N/A OmniPath
DLX3 RUNX2 17060321 27898060 stimulant N/A OmniPath
RUNX2 BMP2 22298955 27898060 stimulant N/A OmniPath
HDAC5 RUNX2 15990875 16613856 22298955 27898060 inhibition N/A OmniPath
RUNX2 ALPL 11331591 27898060 stimulant N/A OmniPath
SMURF1 RUNX2 12738770 14701828 16299379 27898060 inhibition,stimulant N/A OmniPath
KAT6B RUNX2 11965546 27898060 stimulant N/A OmniPath

Visualization










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