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GENE：SEMA4D

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SEMA4D
FullNmae semaphorin 4D
LocusType gene with protein product
Status Approved
HGNC_id HGNC:10732
EnsembleID ENSG00000187764
Uniprot Q92854

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SEMA4D pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SEMA4D autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
SEMA4D GO:0000122,GO:0000122,GO:0001755,GO:0001934,GO:0004888,GO:0005102,GO:0005515,GO:0005615,GO:0005615,GO:0005886,GO:0005886,GO:0006955,GO:0007155,GO:0007162,GO:0007411,GO:0008360,GO:0010693,GO:0010693,GO:0030215,GO:0030215,GO:0030215,GO:0030335,GO:0030335,GO:0030335,GO:0031344,GO:0038023,GO:0043066,GO:0043547,GO:0043547,GO:0043547,GO:0043931,GO:0043931,GO:0045499,GO:0045668,GO:0048672,GO:0048814,GO:0048843,GO:0050731,GO:0050732,GO:0050919,GO:0051897,GO:0070486,GO:0071526,GO:0071526,GO:0071526,GO:1900220,GO:1905704

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
SEMA4D hsa:10507 path:hsa04360 Axon guidance - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 SEMA4D 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 SEMA4D 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 SEMA4D 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 SEMA4D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA SEMA4D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF SEMA4D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 SEMA4D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 SEMA4D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 SEMA4D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF SEMA4D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 SEMA4D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 SEMA4D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR SEMA4D 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000B59A2 SEMA4D 16822819 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS0000237AF9 SEMA4D 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS00000F31F4 SEMA4D 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00005651EE SEMA4D 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000C85B2 SEMA4D 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000D0BB4 SEMA4D 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000CF1D2 SEMA4D 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000353492 SEMA4D 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00002F0130 SEMA4D 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00003808EC SEMA4D 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000122ED0 SEMA4D 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00002F8148 SEMA4D 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000324096 SEMA4D 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000021D08 SEMA4D 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00001FFA8C SEMA4D 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000043D2C1 SEMA4D 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000008AA34 SEMA4D 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000118224 SEMA4D 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00002C02E4 SEMA4D 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000015188E SEMA4D 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00002CE0C6 SEMA4D 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000160683 SEMA4D 25416803 26718213 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
CD72 SEMA4D 25361965 interaction type N/A PTMCode2
SEMA4D CD72 25361965 interaction type N/A PTMCode2
SEMA4D PTPRC 25361965 interaction type N/A PTMCode2
PTPRC SEMA4D 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
CRK SEMA4D 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,validated two hybrid ComPPI,IntAct
CD72 SEMA4D 11114375 12882840 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SEMA4D PLXNB1 11937491 14525934 25348397 N/A experimental interaction detection,molecular sieving,x-ray crystallography,physical interaction,in vitro,in vivo,surface plasmon resonance array ComPPI,HPRD
SEMA4D PTPRC 10648410 11254687 24234451 25348397 27898060 8955171 physical association anti bait coimmunoprecipitation,physical interaction,in vitro,in vivo ComPPI,IntAct,OmniPath
SEMA4D ELAVL1 25348397 N/A physical interaction ComPPI
SEMA4D SCGB2A2 25348397 N/A physical interaction ComPPI
SEMA4D SCGB1D1 25348397 N/A physical interaction ComPPI
SEMA4D VCAM1 25348397 N/A physical interaction ComPPI
SEMA4D ST8SIA4 25348397 N/A physical interaction ComPPI
SEMA4D HNRNPL 25348397 N/A physical interaction ComPPI
SEMA4D SEMA4D 11254687 14525934 1530858 N/A experimental interaction detection HPRD
SEMA4D ERBB2 15210733 27898060 N/A N/A OmniPath
SEMA4D PLXNB2 15330859 27898060 stimulant N/A OmniPath
PLXNB1 SEMA4D 11937491 20877282 22325954 27898060 stimulant N/A OmniPath
SEMA4D PLXNB1 10520995 11937491 12198496 20877282 27898060 stimulant N/A OmniPath

Visualization










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