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GENE：SMAD5

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SMAD5
FullNmae SMAD family member 5
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6771
EnsembleID ENSG00000113658
Uniprot Q99717

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SMAD5 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SMAD5 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
SMAD5 GO:0000122,GO:0000785,GO:0000978,GO:0000978,GO:0000981,GO:0000981,GO:0001227,GO:0001649,GO:0001657,GO:0001880,GO:0002051,GO:0003161,GO:0003700,GO:0005515,GO:0005634,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0005829,GO:0006357,GO:0007165,GO:0007179,GO:0007179,GO:0007281,GO:0009653,GO:0009880,GO:0010629,GO:0017151,GO:0030154,GO:0030218,GO:0030509,GO:0030509,GO:0030509,GO:0031625,GO:0032991,GO:0043066,GO:0045669,GO:0045893,GO:0046872,GO:0051216,GO:0060048,GO:0060348,GO:0060395,GO:0060395,GO:0060395,GO:0070411,GO:0071141,GO:0071144,GO:0071407,GO:1901522,GO:1901522,GO:1902045,GO:1990837

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
SMAD5 hsa:4090 path:hsa04350 TGF-beta signaling pathway - Homo sapiens (human)
SMAD5 hsa:4090 path:hsa04550 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
SMAD2 SMAD5 18729074 23180781 physical association tandem affinity purification InnateDB
SMAD3 SMAD5 18729074 23180781 physical association tandem affinity purification InnateDB
SMAD5 SMAD5 20957627 26467481 phosphorylation reaction,up-regulates N/A Signor
BMPR1B SMAD5 23331499 9766532 stimulation N/A SignaLink,SignaLink
ACVR1 SMAD5 10504300 23331499 stimulation N/A SignaLink,SignaLink
TGFB1I1 SMAD5 21996749 interaction type,inhibition N/A SignaLink
SMAD5 SMAD4 10531362 14534577 15231748 23331499 stimulation N/A SignaLink
SMURF1 SMAD5 12857866 14711801 15221015 18641638 23331499 interaction type N/A SignaLink
Q9W629 SMAD5 10354489 19190757 21559328 stimulation N/A SignaFish
B3DJ37 SMAD5 21559328 stimulation N/A SignaFish

Source Target Pmid Interactiontype Methods Database
E2F4 SMAD5 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 SMAD5 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 SMAD5 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 SMAD5 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
PRDM14 SMAD5 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 SMAD5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF SMAD5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 SMAD5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 SMAD5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 SMAD5 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000338542 SMAD5 18367535 20133617 20427544 rna interference,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000338542 SMAD5 18367535 18668040 20133617 20427544 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000315338 SMAD5 22942087 23418453 25416803 mrna cleavage,inhibition array technology,quantitative reverse transcription pcr TarBase
URS000021D7C8 SMAD5 20371350 23592263 25416803 27292025 mrna cleavage,inhibition nucleotide sequence identification,clip TarBase
URS00004F4657 SMAD5 22942087 25416803 mrna cleavage,inhibition array technology TarBase
URS000001C659 SMAD5 24223191 24802670 25416803 26437223 mrna cleavage,inhibition array technology,western blot,chromatin immunoprecipitation assay,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00002075FA SMAD5 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS000006FDD4 SMAD5 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000042E1F SMAD5 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00000DDD35 SMAD5 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00000600E6 SMAD5 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 SMAD5 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 SMAD5 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS000039A25B SMAD5 20371350 23592263 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00002C02E4 SMAD5 20371350 23592263 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000008AA34 SMAD5 20371350 23592263 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00003A8BB2 SMAD5 20371350 23592263 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000080D0A SMAD5 20371350 23592263 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000496C56 SMAD5 20371350 23592263 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000319E1 SMAD5 20371350 23592263 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000037B2E0 SMAD5 20371350 23592263 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000118224 SMAD5 20371350 23592263 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00004283FE SMAD5 20371350 23592263 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000075AEA5 SMAD5 20371350 23592263 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000075B13F SMAD5 20371350 23592263 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00002CF3F0 SMAD5 19536157 20371350 23592263 23824327 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000007F792 SMAD5 20371350 23592263 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00005E1A16 SMAD5 20371350 23592263 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000753AD SMAD5 20371350 23592263 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000C48FA SMAD5 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000017DBB8 SMAD5 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000027464B SMAD5 24532688 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00000292B1 SMAD5 20371350 23592263 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00002E628F SMAD5 20371350 23592263 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000260A3A SMAD5 20371350 23592263 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000038718E SMAD5 20371350 23592263 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000075D15B SMAD5 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000075A281 SMAD5 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000070CD2 SMAD5 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000070B1D SMAD5 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000153377 SMAD5 25416803 26809090 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr TarBase
URS00001CC864 SMAD5 25416803 26400397 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00001B341F SMAD5 25416803 26400397 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00000EED18 SMAD5 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00004A6E26 SMAD5 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000065FDF SMAD5 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
SNRPA SMAD5 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
WBP2 SMAD5 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SMAD4 SMAD5 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMURF2 SMAD5 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
TOB1 SMAD5 11163184 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
SMAD1 SMAD5 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SNRNP70 SMAD5 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SOX5 SMAD5 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
RUNX2 SMAD5 22966907 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct,OmniPath
SMAD2 SMAD5 25348397 N/A physical interaction ComPPI
EP300 SMAD5 25348397 N/A physical interaction ComPPI
SMAD3 SMAD5 25348397 N/A physical interaction ComPPI
COPS5 SMAD5 17133595 25348397 27898060 N/A physical interaction ComPPI,OmniPath
SMAD5 SF3B1 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD5 MTMR10 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD5 PNKP 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD5 SFPQ 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD5 PSMD11 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD5 U2AF2 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD5 RBM4 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD5 RYR2 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD5 CHMP3 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD5 BCAT1 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD5 PPIL4 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD5 WWP1 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD5 FLNA 11278410 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
SMAD5 BMP6 10504300 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD5 ACVR1 10583507 10652350 14525934 25348397 9748228 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
SMAD5 ZEB2 10400677 12714599 14525934 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
SMAD5 GDF6 14525934 15246821 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
SMAD5 HOXA13 14525934 16087734 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
SMAD5 HOXD13 25348397 N/A two hybrid ComPPI
SMAD5 SUV39H1 14525934 15107829 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
SMAD5 SUV39H2 14525934 15107829 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
SMAD5 MEN1 12649288 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
SMAD5 MBD1 14525934 15231748 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
SMAD5 CXXC5 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD5 SOX7 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD5 PTPN12 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD5 RUNX1 25348397 N/A physical interaction ComPPI
SMAD5 RUNX3 25348397 N/A physical interaction ComPPI
SMAD5 SMURF1 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD5 PLEKHO1 25348397 N/A physical interaction ComPPI
SMAD5 HMGA2 25348397 N/A physical interaction ComPPI
SMAD5 KAT2A 25348397 N/A physical interaction ComPPI
SMAD5 SKI 25348397 N/A physical interaction ComPPI
SMAD5 HDAC1 25348397 N/A physical interaction ComPPI
SMAD5 STUB1 25348397 N/A physical interaction ComPPI
SMAD5 UBA1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD5 SF3B3 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD5 CDK8 25348397 N/A physical interaction ComPPI
SMAD5 YAP1 25348397 N/A physical interaction ComPPI
SMAD5 SMAD6 25348397 N/A physical interaction ComPPI
SMAD5 ELAVL1 25348397 N/A physical interaction ComPPI
SMAD5 HGS 25348397 N/A physical interaction ComPPI
SMAD5 PAX6 25348397 N/A physical interaction ComPPI
SMAD5 EPN1 25348397 N/A physical interaction ComPPI
SMAD5 NAA20 25348397 N/A physical interaction ComPPI
SMAD5 NEDD4 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD5 ANKRD13A 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD5 HECW2 25348397 N/A physical interaction ComPPI
SMAD5 XPO1 25348397 N/A physical interaction ComPPI
SMAD5 SSMEM1 25348397 N/A physical interaction ComPPI
SMAD5 LSR 25348397 N/A physical interaction ComPPI
SMAD5 IPPK 25348397 N/A physical interaction ComPPI
SMAD5 DDX5 18548003 24234451 25348397 association,physical association anti bait coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
SMAD5 DROSHA 18548003 24234451 25348397 association anti bait coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
SMAD5 POU6F2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
HBG2 SMAD5 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD5 ZNF8 12370310 14525934 N/A experimental interaction detection,two hybrid HPRD
PRKCA SMAD5 12601080 27898060 N/A N/A OmniPath
SMAD5 SMAD4 10531362 15231748 16516194 20957627 27898060 stimulant N/A OmniPath
STUB1 SMAD5 21454478 22298955 27898060 inhibition N/A OmniPath
BMPR1A SMAD5 10564272 19620713 27898060 stimulant N/A OmniPath
BMPR1B SMAD5 10564272 19620713 27898060 stimulant N/A OmniPath
SKIL SMAD5 12419246 27898060 inhibition N/A OmniPath
ACVR1 SMAD5 10583507 10652350 27898060 9748228 stimulant N/A OmniPath
BMP2 SMAD5 22298955 27898060 stimulant N/A OmniPath
SMURF2 SMAD5 15221015 15231748 20484049 22298955 27898060 inhibition N/A OmniPath
SMURF1 SMAD5 11278251 12857866 14711801 15221015 15231748 16516194 17676934 18641638 19914168 20484049 22298955 22670624 27898060 inhibition N/A OmniPath
SKI SMAD5 12419246 27898060 inhibition N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00003F04BC SMAD5 10049768 27087310 direct interaction,inhibition N/A NPInter

Visualization










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