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GENE：SMAD9

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SMAD9
FullNmae SMAD family member 9
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6774
EnsembleID ENSG00000120693
Uniprot O15198

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SMAD9 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SMAD9 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
SMAD9 GO:0000785,GO:0000978,GO:0000978,GO:0000981,GO:0000981,GO:0003700,GO:0005515,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0005737,GO:0005829,GO:0005829,GO:0006357,GO:0007179,GO:0009653,GO:0030154,GO:0030509,GO:0030509,GO:0030509,GO:0046872,GO:0060395,GO:0060395,GO:0060395,GO:0070411,GO:0071141,GO:0071144,GO:0071773,GO:1901522

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
SMAD9 hsa:4093 path:hsa04350 TGF-beta signaling pathway - Homo sapiens (human)
SMAD9 hsa:4093 path:hsa04550 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR SMAD9 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
YBX1 SMAD9 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 SMAD9 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 SMAD9 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA SMAD9 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF SMAD9 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 SMAD9 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 SMAD9 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A SMAD9 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 SMAD9 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CREB1 SMAD9 N/A trascriptional regulation,stimulation inferred by curator TFlink
MYC SMAD9 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000600E6 SMAD9 17242205 25416803 mrna cleavage,inhibition array technology TarBase
URS00004DA9DB SMAD9 23807165 25416803 mrna cleavage,inhibition array technology TarBase
URS00001CF056 SMAD9 21572407 25416803 mrna cleavage,inhibition clip,clip TarBase
URS000061E50F SMAD9 21572407 25416803 mrna cleavage,inhibition clip,clip TarBase
URS00003E6EFA SMAD9 21572407 25416803 mrna cleavage,inhibition clip,clip TarBase
URS00004719AB SMAD9 21572407 25416803 mrna cleavage,inhibition clip,clip TarBase
URS00000B7E30 SMAD9 21572407 25416803 mrna cleavage,inhibition clip,clip TarBase
URS000028DE3F SMAD9 21572407 25416803 mrna cleavage,inhibition clip,clip TarBase
URS0000427B68 SMAD9 21572407 25416803 mrna cleavage,inhibition clip,clip TarBase
URS0000355E82 SMAD9 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002A8BC6 SMAD9 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075A760 SMAD9 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002152A8 SMAD9 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000137EDE SMAD9 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000019907A SMAD9 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001C770D SMAD9 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000006372A SMAD9 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001C0099 SMAD9 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003FBC84 SMAD9 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000041FA2C SMAD9 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000027352D SMAD9 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
MAPK14 SMAD9 22135298 phosphorylation N/A PhosphoSite
TOB1 SMAD9 25361965 interaction type N/A PTMCode2
SMAD9 TOB1 25361965 interaction type N/A PTMCode2
SMAD4 SMAD9 25361965 interaction type N/A PTMCode2
SMAD9 SMAD4 25361965 interaction type N/A PTMCode2
ACVR1 SMAD9 25361965 interaction type N/A PTMCode2
SMAD9 ACVR1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
LMO4 SMAD9 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
FTL SMAD9 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TINAGL1 SMAD9 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
DKK1 SMAD9 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ACTB SMAD9 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD4 SMAD9 16189514 24234451 25348397 25609649 association,physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,tandem affinity purification ComPPI,IntAct
EIF3E SMAD9 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
HEYL SMAD9 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TOB1 SMAD9 25348397 N/A physical interaction,in vivo ComPPI
SNRNP70 SMAD9 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD7 SMAD9 25348397 N/A physical interaction ComPPI
NOTCH1 SMAD9 23022380 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
FLI1 SMAD9 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
DSTN SMAD9 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD2 SMAD9 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD3 SMAD9 25348397 N/A two hybrid,physical interaction ComPPI
SF3B1 SMAD9 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MTMR10 SMAD9 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
KAT2B SMAD9 25348397 N/A physical interaction ComPPI
GRN SMAD9 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PKP2 SMAD9 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SVEP1 SMAD9 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD9 PIR 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD9 LRP5 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD9 KMT2D 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD9 RFX1 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD9 LEMD3 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD9 ZSCAN4 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD9 E4F1 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD9 RUBCN 25348397 N/A two hybrid ComPPI
SMAD9 SECISBP2 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD9 ZNF484 25348397 N/A two hybrid ComPPI
SMAD9 ZNF587 25348397 N/A two hybrid ComPPI
SMAD9 ARHGAP9 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD9 PELP1 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD9 MACO1 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD9 ASH2L 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD9 HEY1 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD9 PSAP 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD9 TTC37 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD9 NAGK 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD9 PABPC4 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD9 PLEC 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD9 STAG1 25348397 N/A two hybrid ComPPI
SMAD9 CEP135 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD9 EVC2 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD9 ARID1B 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD9 MAN1C1 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD9 CHPF 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD9 RNF123 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD9 ABTB1 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD9 PSMD8 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD9 KDM6A 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD9 EIF3C 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD9 PPP2R5E 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD9 RANBP9 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD9 CTR9 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD9 AFF1 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD9 TRIM29 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD9 MCM3AP 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD9 PPARD 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD9 EIF3F 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD9 BAZ1A 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD9 MAN1A2 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD9 UBA6 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD9 RMND5A 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD9 PHKA2 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD9 DNAJC7 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD9 TBCD 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD9 PNPLA2 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD9 MTMR11 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD9 SMG1 25348397 N/A two hybrid ComPPI
SMAD9 DIAPH3 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD9 CYP11A1 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD9 CLPB 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD9 ZNF83 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD9 MGAT1 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD9 AP2A1 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD9 ASB2 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD9 MAN2B1 25348397 N/A two hybrid ComPPI
SMAD9 UNC45A 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD9 LNPEP 25348397 N/A two hybrid ComPPI
SMAD9 RRBP1 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD9 HUWE1 25348397 N/A two hybrid ComPPI
SMAD9 ACVR1 25348397 N/A in vivo ComPPI
SMAD9 SPTBN1 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD9 MBD1 25348397 N/A two hybrid ComPPI
SMAD9 CSH1 25348397 N/A two hybrid,two hybrid,physical interaction ComPPI
SMAD9 CSH2 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD9 QARS1 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD9 UBQLN4 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD9 CXXC5 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD9 UBQLN1 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD9 PAPPA 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD9 TRIP12 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD9 ZNF557 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD9 TWNK 25348397 N/A two hybrid,physical interaction ComPPI
SMAD9 ZEB2 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD9 TERF1 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD9 HMGA2 25348397 N/A physical interaction ComPPI
SMAD9 KAT2A 25348397 N/A physical interaction ComPPI
SMAD9 ARNT 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD9 METAP1 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD9 DST 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD9 CAMSAP1 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD9 VPS8 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD9 EXPH5 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD9 OTUB1 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD9 VCPIP1 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD9 ERVV-1 25348397 N/A physical interaction ComPPI
SMAD9 KDM1A 23455924 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct
SMAD9 PRMT6 23455924 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct
SMAD9 PSG9 25348397 N/A physical interaction ComPPI
SMAD9 DSG4 25348397 N/A physical interaction ComPPI
SMAD9 VSIG8 25348397 N/A physical interaction ComPPI
SMAD9 ZNF143 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
SMAD9 SMAP2 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
SMAD9 RBMS1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
SIL1 SMAD9 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
DNAJA3 SMAD9 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
BTG2 SMAD9 25348397 N/A in vivo ComPPI
XAB2 SMAD9 25348397 N/A two hybrid ComPPI
ZNF592 SMAD9 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
YWHAQ SMAD9 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD9 SMAD4 10583507 15231748 16189514 20957627 25609649 27898060 stimulant N/A OmniPath
BMPR1A SMAD9 19620713 27898060 stimulant N/A OmniPath
BMPR1B SMAD9 19620713 27898060 stimulant N/A OmniPath
BMP2 SMAD9 22298955 27898060 stimulant N/A OmniPath
SMURF2 SMAD9 22298955 27898060 inhibition N/A OmniPath
SMURF1 SMAD9 22298955 27898060 inhibition N/A OmniPath

Visualization










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