Gene Information gene info

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GENE：SOST

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SOST
FullNmae sclerostin
LocusType gene with protein product
Status Approved
HGNC_id HGNC:13771
EnsembleID ENSG00000167941
Uniprot Q9BQB4

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SOST autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
SOST GO:0001503,GO:0005515,GO:0005576,GO:0005615,GO:0005794,GO:0008201,GO:0009612,GO:0030178,GO:0030246,GO:0030279,GO:0030509,GO:0030514,GO:0030514,GO:0031333,GO:0032991,GO:0036122,GO:0045893,GO:0051179,GO:0060070,GO:0062023,GO:0071374,GO:0090090,GO:0140297,GO:0140678,GO:0140678

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
SOST hsa:50964 path:hsa04310 Wnt signaling pathway - Homo sapiens (human)
SOST hsa:50964 path:hsa04928 Parathyroid hormone synthesis, secretion and action - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 SOST 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 SOST 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 SOST 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
PRDM14 SOST 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
EGR1 SOST 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 SOST 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS SOST 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 SOST 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MEF2A SOST 17696759 trascriptional regulation,stimulation inferred by curator TFlink
MEF2C SOST 17696759 trascriptional regulation,stimulation inferred by curator TFlink
MEF2D SOST 17696759 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000029D9F1 SOST 23472141 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS000029D9F1 SOST 23472141 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS0000237AF9 SOST 18185580 25416803 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
KPNA4 SOST 25348397 N/A physical interaction ComPPI
GTF2I SOST 25348397 N/A physical interaction ComPPI
LRP5 SOST 15908424 21471202 24234451 25348397 association,physical association pull down,physical interaction,tandem affinity purification ComPPI,IntAct
CSH1 SOST 25348397 N/A physical interaction ComPPI
CSH2 SOST 25348397 N/A physical interaction ComPPI
AP2A1 SOST 25348397 N/A physical interaction ComPPI
SIRT1 SOST 25348397 N/A physical interaction ComPPI
SPOP SOST 25348397 N/A physical interaction ComPPI
SORL1 SOST 25348397 N/A physical interaction ComPPI
LRP6 SOST 15908424 21471202 21944579 24234451 25348397 association,physical association pull down,x-ray crystallography,physical interaction,tandem affinity purification,bio-layer interferometry ComPPI,IntAct
SRRT SOST 25348397 N/A physical interaction ComPPI
GLDC SOST 25348397 N/A physical interaction ComPPI
PRMT6 SOST 25348397 N/A physical interaction ComPPI
LRP2 SOST 25348397 N/A physical interaction ComPPI
KCTD10 SOST 25348397 N/A physical interaction ComPPI
DCAF5 SOST 25348397 N/A physical interaction ComPPI

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