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GENE：TNFRSF11A

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol TNFRSF11A
FullNmae TNF receptor superfamily member 11a
LocusType gene with protein product
Status Approved
HGNC_id HGNC:11908
EnsembleID ENSG00000141655
Uniprot Q9Y6Q6

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
TNFRSF11A autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
TNFRSF11A GO:0001503,GO:0002250,GO:0002548,GO:0004888,GO:0005031,GO:0005031,GO:0005515,GO:0005829,GO:0005886,GO:0005886,GO:0007165,GO:0007267,GO:0008284,GO:0009612,GO:0009897,GO:0009897,GO:0014070,GO:0019955,GO:0019955,GO:0030316,GO:0032496,GO:0032868,GO:0033209,GO:0034097,GO:0034224,GO:0034612,GO:0038023,GO:0043507,GO:0045121,GO:0045471,GO:0045780,GO:0046872,GO:0048535,GO:0051091,GO:0051091,GO:0051092,GO:0051092,GO:0051092,GO:0060086,GO:0060749,GO:0070555,GO:0070555,GO:0071812,GO:0071847,GO:0071847,GO:0071848,GO:0072674

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
TNFRSF11A hsa:8792 path:hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
TNFRSF11A hsa:8792 path:hsa04064 NF-kappa B signaling pathway - Homo sapiens (human)
TNFRSF11A hsa:8792 path:hsa04380 Osteoclast differentiation - Homo sapiens (human)
TNFRSF11A hsa:8792 path:hsa04917 Prolactin signaling pathway - Homo sapiens (human)
TNFRSF11A hsa:8792 path:hsa05323 Rheumatoid arthritis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
TNFRSF11A TRAF6 10025951 11406619 11809792 23180781 9685412 physical association anti tag coimmunoprecipitation,gst pull down InnateDB
TNFRSF11A MAP3K7 11809792 23180781 physical association anti tag coimmunoprecipitation InnateDB
TNFRSF11A TAB2 11809792 23180781 physical association anti tag coimmunoprecipitation InnateDB
TNFRSF11A TRAF2 23180781 9685412 physical association anti tag coimmunoprecipitation InnateDB
TNFRSF11A TRAF5 23180781 9685412 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
TAB2 TNFRSF11A 20005715 interaction type N/A PSP
TRAF1 TNFRSF11A 20005715 interaction type N/A PSP
TRAF2 TNFRSF11A 20005715 interaction type N/A PSP
TRAF3 TNFRSF11A 20005715 interaction type N/A PSP
TRAF5 TNFRSF11A 20005715 interaction type N/A PSP
TAB2 TNFRSF11A 11809792 11809792 18988627 20005715 20005715 21071413 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
YBX1 TNFRSF11A 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 TNFRSF11A 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 TNFRSF11A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA TNFRSF11A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF TNFRSF11A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 TNFRSF11A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 TNFRSF11A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS TNFRSF11A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 TNFRSF11A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A TNFRSF11A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 TNFRSF11A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 TNFRSF11A 16083856 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000003ABC4 TNFRSF11A 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS00000F6E49 TNFRSF11A 23821519 25416803 mrna cleavage,inhibition array technology,western blot,northern blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000195F5B TNFRSF11A 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000006FDD4 TNFRSF11A 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002ECEE4 TNFRSF11A 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000043D2C1 TNFRSF11A 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00004BC299 TNFRSF11A 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000020CEC2 TNFRSF11A 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000272039 TNFRSF11A 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000383DF4 TNFRSF11A 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000014F13C TNFRSF11A 21572407 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
TRAF6 TNFRSF11A 10025951 10075662 10635328 14525934 24234451 25348397 9685412 physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
RACK1 TNFRSF11A 25348397 N/A physical interaction ComPPI
CBL TNFRSF11A 11406619 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CBLB TNFRSF11A 11406619 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SP1 TNFRSF11A 25348397 N/A physical interaction ComPPI
SRC TNFRSF11A 10635328 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
VAV3 TNFRSF11A 25348397 N/A physical interaction ComPPI
GAB2 TNFRSF11A 14525934 15750601 25348397 27898060 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD,OmniPath
FHL2 TNFRSF11A 14525934 16184196 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
TMPRSS15 TNFRSF11A 23954298 24234451 25348397 27898060 cleavage reaction cleavage assay ComPPI,IntAct,OmniPath
TRAF3 TNFRSF11A 10025951 14525934 25348397 9774460 9852070 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
TNFSF11 TNFRSF11A 14525934 22664871 24234451 25348397 9367155 N/A experimental interaction detection,pull down,in vivo ComPPI,HPRD,IntAct
TRAF1 TNFRSF11A 10025951 14525934 25348397 9774460 9852070 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
TRAF2 TNFRSF11A 10025951 10075662 14525934 24234451 25348397 29844572 9774460 9852070 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
TRAF5 TNFRSF11A 10025951 10075662 14525934 24234451 25348397 9774460 physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct
MAP3K7 TNFRSF11A 11809792 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
TAB2 TNFRSF11A 11809792 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
TNFRSF11A NXF1 25348397 N/A physical interaction ComPPI
TNFRSF11A TNFRSF11B 23333834 24234451 25348397 physical association surface plasmon resonance,enzyme linked immunosorbent assay ComPPI,IntAct
MAP3K7 TNFRSF11A 11809792 27898060 N/A N/A OmniPath
TNFRSF11A MAP3K7 11809792 27898060 N/A N/A OmniPath
TNFRSF11A TRAF2 10025951 10075662 27898060 9685412 9774460 9852070 stimulant N/A OmniPath
TRAF6 TNFRSF11A 10025951 10075662 10635328 11406619 11809792 14500659 26038599 27898060 9685412 9774460 9852070 stimulant N/A OmniPath
TNFRSF11A TRAF6 10025951 10075662 10635328 11406619 11809792 14500659 26038599 27898060 9685412 9774460 9852070 stimulant N/A OmniPath
TAB2 TNFRSF11A 11809792 27898060 N/A N/A OmniPath
TNFRSF11A TAB2 11809792 27898060 N/A N/A OmniPath
TNFSF11 TNFRSF11A 11581298 12897775 15110169 27898060 9367155 stimulant N/A OmniPath

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