GENE:TNFSF11
GeneInfo:
GeneAttribute | GeneDescription |
---|---|
GeneSymbol | TNFSF11 |
FullNmae | TNF superfamily member 11 |
LocusType | gene with protein product |
Status | Approved |
HGNC_id | HGNC:11926 |
EnsembleID | ENSG00000120659 |
Uniprot | O14788 |
Protein Structure:
Gene Description in Publicaton:
GeneSymbol | CellDeathType | PMID | Description | GeneType |
---|---|---|---|---|
TNFSF11 | autophagy | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
GeneSymbol | Go id |
---|---|
TNFSF11 | GO:0000122,GO:0001503,GO:0002158,GO:0002548,GO:0005125,GO:0005125,GO:0005164,GO:0005515,GO:0005576,GO:0005576,GO:0005615,GO:0005737,GO:0005886,GO:0005886,GO:0006955,GO:0007249,GO:0007254,GO:0010628,GO:0019221,GO:0019722,GO:0030316,GO:0030316,GO:0030316,GO:0032813,GO:0033209,GO:0033598,GO:0034112,GO:0036035,GO:0038001,GO:0042802,GO:0043123,GO:0043406,GO:0043491,GO:0044691,GO:0045453,GO:0045672,GO:0045780,GO:0045944,GO:0046330,GO:0050870,GO:0051091,GO:0051092,GO:0051466,GO:0051897,GO:0055074,GO:0060749,GO:0070371,GO:0071812,GO:0071847,GO:0071848,GO:1902533,GO:1990830,GO:2001206 |
KEGG Annotation:
GeneSymbol | GeneID | Pathway | Pathway Name |
---|---|---|---|
TNFSF11 | hsa:8600 | path:hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
TNFSF11 | hsa:8600 | path:hsa04064 | NF-kappa B signaling pathway - Homo sapiens (human) |
TNFSF11 | hsa:8600 | path:hsa04380 | Osteoclast differentiation - Homo sapiens (human) |
TNFSF11 | hsa:8600 | path:hsa04917 | Prolactin signaling pathway - Homo sapiens (human) |
TNFSF11 | hsa:8600 | path:hsa04928 | Parathyroid hormone synthesis, secretion and action - Homo sapiens (human) |
TNFSF11 | hsa:8600 | path:hsa05207 | Chemical carcinogenesis - receptor activation - Homo sapiens (human) |
TNFSF11 | hsa:8600 | path:hsa05224 | Breast cancer - Homo sapiens (human) |
TNFSF11 | hsa:8600 | path:hsa05323 | Rheumatoid arthritis - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
CEBPB | TNFSF11 | 20225273 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
E2F1 | TNFSF11 | 18381203 | trascriptional regulation,stimulation | inferred by curator,electrophoretic mobility shift assay | TFlink |
SMARCA4 | TNFSF11 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
CEBPA | TNFSF11 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
CTCF | TNFSF11 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
E2F4 | TNFSF11 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
EGR1 | TNFSF11 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
FOXA1 | TNFSF11 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
GATA2 | TNFSF11 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
TAL1 | TNFSF11 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
DACH1 | TNFSF11 | 17891780 | trascriptional regulation,stimulation | inferred by curator | TFlink |
HSF2 | TNFSF11 | 15731115 | trascriptional regulation,stimulation | inferred by curator | TFlink |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
URS000035CC3E | TNFSF11 | 16331254 | rna interference,inhibition | miRNA interference luciferase reporter assay | miRSponge |
URS000035CC3E | TNFSF11 | 16331254 25416803 | mrna cleavage,inhibition | array technology,northern blot,miRNA interference luciferase reporter assay | TarBase |
URS00000600E6 | TNFSF11 | 25416803 26053181 | mrna cleavage,inhibition | array technology,experimental interaction detection,experimental interaction detection,experimental interaction detection,western blot,northern blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay | TarBase |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
MAPK1 | TNFSF11 | 25361965 | interaction type | N/A | PTMCode2 |
TNFSF11 | MAPK1 | 25361965 | interaction type | N/A | PTMCode2 |
NFKB1 | TNFSF11 | 25361965 | interaction type | N/A | PTMCode2 |
TNFSF11 | NFKB1 | 25361965 | interaction type | N/A | PTMCode2 |
TNFRSF10A | TNFSF11 | 25361965 | interaction type | N/A | PTMCode2 |
TNFSF11 | TNFRSF10A | 25361965 | interaction type | N/A | PTMCode2 |
TNFSF11 | AKT1 | 25361965 | interaction type | N/A | PTMCode2 |
AKT1 | TNFSF11 | 25361965 | interaction type | N/A | PTMCode2 |
TNFSF11 | TNFRSF11B | 25361965 | interaction type | N/A | PTMCode2 |
TNFRSF11B | TNFSF11 | 25361965 | interaction type | N/A | PTMCode2 |
TNFSF11 | ADAM17 | 25361965 | interaction type | N/A | PTMCode2 |
ADAM17 | TNFSF11 | 25361965 | interaction type | N/A | PTMCode2 |
TNFSF11 | TRAF6 | 25361965 | interaction type | N/A | PTMCode2 |
TRAF6 | TNFSF11 | 25361965 | interaction type | N/A | PTMCode2 |
TNFSF11 | MMP1 | 25361965 | interaction type | N/A | PTMCode2 |
MMP1 | TNFSF11 | 25361965 | interaction type | N/A | PTMCode2 |
TNFSF11 | SRC | 25361965 | interaction type | N/A | PTMCode2 |
SRC | TNFSF11 | 25361965 | interaction type | N/A | PTMCode2 |
TNFSF11 | MAPK10 | 25361965 | interaction type | N/A | PTMCode2 |
MAPK10 | TNFSF11 | 25361965 | interaction type | N/A | PTMCode2 |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
LMO4 | TNFSF11 | 21900206 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
MMP3 | TNFSF11 | 14525934 15894268 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
TRAF6 | TNFSF11 | 10635328 14525934 25348397 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
B4GALT7 | TNFSF11 | 25348397 | N/A | physical interaction | ComPPI |
UPK2 | TNFSF11 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
OLFM4 | TNFSF11 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
MMP7 | TNFSF11 | 14525934 15894268 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
MAPK1 | TNFSF11 | 10635328 14525934 25348397 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
EZH2 | TNFSF11 | 21900206 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
MAPK8 | TNFSF11 | 14525934 25348397 9396779 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
SRC | TNFSF11 | 25348397 | N/A | physical interaction | ComPPI |
MAPK3 | TNFSF11 | 10635328 14525934 25348397 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
MED24 | TNFSF11 | 21900206 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
PLK1 | TNFSF11 | 21900206 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
NFKBIA | TNFSF11 | 10635328 14525934 25348397 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
EEF1A1 | TNFSF11 | 21900206 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
TNFSF11 | TNFRSF11A | 14525934 22664871 24234451 25348397 9367155 | N/A | experimental interaction detection,pull down,in vivo | ComPPI,HPRD,IntAct |
TNFSF11 | TNFRSF11B | 12221720 14525934 22664871 24234451 25348397 9520411 | N/A | experimental interaction detection,pull down,surface plasmon resonance,x-ray crystallography,physical interaction,in vivo | ComPPI,HPRD,IntAct |
TNFSF11 | ADAM17 | 10224132 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
TNFSF11 | ADAM19 | 25348397 | N/A | in vitro | ComPPI |
TNFSF11 | NFKB1 | 10635328 14525934 25348397 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
TNFSF11 | AKT1 | 10635328 14525934 25348397 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
TNFSF11 | PRXL2B | 21900206 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
TNFSF11 | TMOD3 | 21900206 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
TNFSF11 | TRMT2A | 21900206 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
TNFSF11 | BBS10 | 21900206 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
TNFSF11 | SNRNP35 | 21900206 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
TNFSF11 | CEP126 | 21900206 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
TNFSF11 | SBF1 | 21900206 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
TNFSF11 | PHAX | 21900206 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
TNFSF11 | MBTPS1 | 21900206 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
TNFSF11 | EEF1A1P5 | 25348397 | N/A | physical interaction | ComPPI |
TNFSF11 | ZC3HC1 | 21900206 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
TNFSF11 | GALNT7 | 25348397 | N/A | physical interaction | ComPPI |
TNFSF11 | GOSR1 | 25348397 | N/A | physical interaction | ComPPI |
TNFSF11 | MT-ND1 | 25348397 | N/A | physical interaction | ComPPI |
TNFSF11 | DNAJB9 | 25348397 | N/A | physical interaction | ComPPI |
TNFSF11 | TNFAIP6 | 18586671 24234451 25348397 | N/A | surface plasmon resonance,enzyme linked immunosorbent assay | ComPPI,IntAct |
DDAH2 | TNFSF11 | 21900206 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
ATP5MC1 | TNFSF11 | 25348397 | N/A | physical interaction | ComPPI |
TNFSF11 | TNFSF11 | 10635328 14525934 | N/A | experimental interaction detection | HPRD |
MMP1 | TNFSF11 | 10224132 14525934 | N/A | experimental interaction detection | HPRD |
TNFSF11 | TNFRSF11A | 11581298 12897775 15110169 27898060 9367155 | stimulant | N/A | OmniPath |
TNFSF11 | TNFRSF11B | 11733492 12221720 27898060 9520411 9568710 | stimulant | N/A | OmniPath |