Gene Information gene info

  1. Home

GENE：TNFSF11

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol TNFSF11
FullNmae TNF superfamily member 11
LocusType gene with protein product
Status Approved
HGNC_id HGNC:11926
EnsembleID ENSG00000120659
Uniprot O14788

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
TNFSF11 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
TNFSF11 GO:0000122,GO:0001503,GO:0002158,GO:0002548,GO:0005125,GO:0005125,GO:0005164,GO:0005515,GO:0005576,GO:0005576,GO:0005615,GO:0005737,GO:0005886,GO:0005886,GO:0006955,GO:0007249,GO:0007254,GO:0010628,GO:0019221,GO:0019722,GO:0030316,GO:0030316,GO:0030316,GO:0032813,GO:0033209,GO:0033598,GO:0034112,GO:0036035,GO:0038001,GO:0042802,GO:0043123,GO:0043406,GO:0043491,GO:0044691,GO:0045453,GO:0045672,GO:0045780,GO:0045944,GO:0046330,GO:0050870,GO:0051091,GO:0051092,GO:0051466,GO:0051897,GO:0055074,GO:0060749,GO:0070371,GO:0071812,GO:0071847,GO:0071848,GO:1902533,GO:1990830,GO:2001206

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
TNFSF11 hsa:8600 path:hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
TNFSF11 hsa:8600 path:hsa04064 NF-kappa B signaling pathway - Homo sapiens (human)
TNFSF11 hsa:8600 path:hsa04380 Osteoclast differentiation - Homo sapiens (human)
TNFSF11 hsa:8600 path:hsa04917 Prolactin signaling pathway - Homo sapiens (human)
TNFSF11 hsa:8600 path:hsa04928 Parathyroid hormone synthesis, secretion and action - Homo sapiens (human)
TNFSF11 hsa:8600 path:hsa05207 Chemical carcinogenesis - receptor activation - Homo sapiens (human)
TNFSF11 hsa:8600 path:hsa05224 Breast cancer - Homo sapiens (human)
TNFSF11 hsa:8600 path:hsa05323 Rheumatoid arthritis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
TNFSF11 NFATC3 19671684 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
CEBPB TNFSF11 20225273 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
E2F1 TNFSF11 18381203 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
SMARCA4 TNFSF11 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA TNFSF11 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF TNFSF11 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 TNFSF11 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 TNFSF11 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 TNFSF11 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 TNFSF11 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 TNFSF11 18971253 trascriptional regulation,stimulation inferred by curator TFlink
DACH1 TNFSF11 17891780 trascriptional regulation,stimulation inferred by curator TFlink
HSF2 TNFSF11 15731115 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000035CC3E TNFSF11 16331254 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS000035CC3E TNFSF11 16331254 25416803 mrna cleavage,inhibition array technology,northern blot,miRNA interference luciferase reporter assay TarBase
URS00000600E6 TNFSF11 25416803 26053181 mrna cleavage,inhibition array technology,experimental interaction detection,experimental interaction detection,experimental interaction detection,western blot,northern blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
MAPK1 TNFSF11 25361965 interaction type N/A PTMCode2
TNFSF11 MAPK1 25361965 interaction type N/A PTMCode2
NFKB1 TNFSF11 25361965 interaction type N/A PTMCode2
TNFSF11 NFKB1 25361965 interaction type N/A PTMCode2
TNFRSF10A TNFSF11 25361965 interaction type N/A PTMCode2
TNFSF11 TNFRSF10A 25361965 interaction type N/A PTMCode2
TNFSF11 AKT1 25361965 interaction type N/A PTMCode2
AKT1 TNFSF11 25361965 interaction type N/A PTMCode2
TNFSF11 TNFRSF11B 25361965 interaction type N/A PTMCode2
TNFRSF11B TNFSF11 25361965 interaction type N/A PTMCode2
TNFSF11 ADAM17 25361965 interaction type N/A PTMCode2
ADAM17 TNFSF11 25361965 interaction type N/A PTMCode2
TNFSF11 TRAF6 25361965 interaction type N/A PTMCode2
TRAF6 TNFSF11 25361965 interaction type N/A PTMCode2
TNFSF11 MMP1 25361965 interaction type N/A PTMCode2
MMP1 TNFSF11 25361965 interaction type N/A PTMCode2
TNFSF11 SRC 25361965 interaction type N/A PTMCode2
SRC TNFSF11 25361965 interaction type N/A PTMCode2
TNFSF11 MAPK10 25361965 interaction type N/A PTMCode2
MAPK10 TNFSF11 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
LMO4 TNFSF11 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MMP3 TNFSF11 14525934 15894268 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
TRAF6 TNFSF11 10635328 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
B4GALT7 TNFSF11 25348397 N/A physical interaction ComPPI
UPK2 TNFSF11 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
OLFM4 TNFSF11 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MMP7 TNFSF11 14525934 15894268 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
MAPK1 TNFSF11 10635328 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
EZH2 TNFSF11 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MAPK8 TNFSF11 14525934 25348397 9396779 N/A experimental interaction detection,in vivo ComPPI,HPRD
SRC TNFSF11 25348397 N/A physical interaction ComPPI
MAPK3 TNFSF11 10635328 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
MED24 TNFSF11 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PLK1 TNFSF11 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NFKBIA TNFSF11 10635328 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
EEF1A1 TNFSF11 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TNFSF11 TNFRSF11A 14525934 22664871 24234451 25348397 9367155 N/A experimental interaction detection,pull down,in vivo ComPPI,HPRD,IntAct
TNFSF11 TNFRSF11B 12221720 14525934 22664871 24234451 25348397 9520411 N/A experimental interaction detection,pull down,surface plasmon resonance,x-ray crystallography,physical interaction,in vivo ComPPI,HPRD,IntAct
TNFSF11 ADAM17 10224132 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
TNFSF11 ADAM19 25348397 N/A in vitro ComPPI
TNFSF11 NFKB1 10635328 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
TNFSF11 AKT1 10635328 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
TNFSF11 PRXL2B 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TNFSF11 TMOD3 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TNFSF11 TRMT2A 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TNFSF11 BBS10 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TNFSF11 SNRNP35 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TNFSF11 CEP126 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TNFSF11 SBF1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TNFSF11 PHAX 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TNFSF11 MBTPS1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TNFSF11 EEF1A1P5 25348397 N/A physical interaction ComPPI
TNFSF11 ZC3HC1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TNFSF11 GALNT7 25348397 N/A physical interaction ComPPI
TNFSF11 GOSR1 25348397 N/A physical interaction ComPPI
TNFSF11 MT-ND1 25348397 N/A physical interaction ComPPI
TNFSF11 DNAJB9 25348397 N/A physical interaction ComPPI
TNFSF11 TNFAIP6 18586671 24234451 25348397 N/A surface plasmon resonance,enzyme linked immunosorbent assay ComPPI,IntAct
DDAH2 TNFSF11 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ATP5MC1 TNFSF11 25348397 N/A physical interaction ComPPI
TNFSF11 TNFSF11 10635328 14525934 N/A experimental interaction detection HPRD
MMP1 TNFSF11 10224132 14525934 N/A experimental interaction detection HPRD
TNFSF11 TNFRSF11A 11581298 12897775 15110169 27898060 9367155 stimulant N/A OmniPath
TNFSF11 TNFRSF11B 11733492 12221720 27898060 9520411 9568710 stimulant N/A OmniPath

Visualization










  Return