GENE：WNT10B
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | WNT10B |
| FullNmae | Wnt family member 10B |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:12775 |
| EnsembleID | ENSG00000169884 |
| Uniprot | O00744 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| WNT10B | mitotic_cd | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| WNT10B | autophagy | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| WNT10B | GO:0000086,GO:0000122,GO:0001649,GO:0002062,GO:0005109,GO:0005125,GO:0005515,GO:0005576,GO:0005615,GO:0005615,GO:0006366,GO:0006629,GO:0007224,GO:0010971,GO:0014835,GO:0030182,GO:0030182,GO:0030217,GO:0030501,GO:0030855,GO:0030858,GO:0032434,GO:0043065,GO:0045165,GO:0045444,GO:0045582,GO:0045599,GO:0045669,GO:0045899,GO:0048018,GO:0048627,GO:0048641,GO:0048741,GO:0050680,GO:0050821,GO:0050909,GO:0051885,GO:0060070,GO:0060070,GO:0060346,GO:0061196,GO:0071300,GO:0071320,GO:0071374,GO:0071425,GO:0090263,GO:0120163,GO:1902035 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| WNT10B | hsa:7480 | path:hsa04150 | mTOR signaling pathway - Homo sapiens (human) |
| WNT10B | hsa:7480 | path:hsa04310 | Wnt signaling pathway - Homo sapiens (human) |
| WNT10B | hsa:7480 | path:hsa04390 | Hippo signaling pathway - Homo sapiens (human) |
| WNT10B | hsa:7480 | path:hsa04550 | Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) |
| WNT10B | hsa:7480 | path:hsa04916 | Melanogenesis - Homo sapiens (human) |
| WNT10B | hsa:7480 | path:hsa04934 | Cushing syndrome - Homo sapiens (human) |
| WNT10B | hsa:7480 | path:hsa05010 | Alzheimer disease - Homo sapiens (human) |
| WNT10B | hsa:7480 | path:hsa05022 | Pathways of neurodegeneration - multiple diseases - Homo sapiens (human) |
| WNT10B | hsa:7480 | path:hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| WNT10B | hsa:7480 | path:hsa05200 | Pathways in cancer - Homo sapiens (human) |
| WNT10B | hsa:7480 | path:hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
| WNT10B | hsa:7480 | path:hsa05217 | Basal cell carcinoma - Homo sapiens (human) |
| WNT10B | hsa:7480 | path:hsa05224 | Breast cancer - Homo sapiens (human) |
| WNT10B | hsa:7480 | path:hsa05225 | Hepatocellular carcinoma - Homo sapiens (human) |
| WNT10B | hsa:7480 | path:hsa05226 | Gastric cancer - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | WNT10B | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| GATA2 | WNT10B | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| MYC | WNT10B | 12747840 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| CEBPA | WNT10B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | WNT10B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | WNT10B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | WNT10B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | WNT10B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | WNT10B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ZNF263 | WNT10B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000237AF9 | WNT10B | 18185580 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS0000122ED0 | WNT10B | 19088304 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00003BBF48 | WNT10B | 22890324 25416803 | mrna cleavage,inhibition | array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS000005E58C | WNT10B | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002075FA | WNT10B | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002E1509 | WNT10B | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001B9F58 | WNT10B | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| COL6A2 | WNT10B | 25348397 | N/A | physical interaction | ComPPI |
| LRP6 | WNT10B | 25348397 | N/A | physical interaction | ComPPI |
| PPP6R2 | WNT10B | 25348397 | N/A | physical interaction | ComPPI |
| PPP2R2D | WNT10B | 25348397 | N/A | physical interaction | ComPPI |
| MCPH1 | WNT10B | 25348397 | N/A | physical interaction | ComPPI |
| FSTL1 | WNT10B | 25348397 | N/A | physical interaction | ComPPI |
| JMJD8 | WNT10B | 25348397 | N/A | physical interaction | ComPPI |
| WNT10B | LRP5 | 15578921 27898060 | stimulant | N/A | OmniPath |
| WNT10B | LRP6 | 15578921 27898060 | stimulant | N/A | OmniPath |
| WNT10B | FZD2 | 12055200 27898060 | stimulant | N/A | OmniPath |
| WNT10B | FZD5 | 11092808 12055200 27898060 | stimulant | N/A | OmniPath |
| WNT10B | FZD3 | 15578921 27898060 | stimulant | N/A | OmniPath |
| WNT10B | FZD1 | 12055200 19008118 27898060 | stimulant | N/A | OmniPath |