GENE：WNT5A
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | WNT5A |
| FullNmae | Wnt family member 5A |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:12784 |
| EnsembleID | ENSG00000114251 |
| Uniprot | P41221 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| WNT5A | pyroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| WNT5A | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| WNT5A | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| WNT5A | autophagy | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| WNT5A | GO:0001736,GO:0001756,GO:0001822,GO:0001837,GO:0001938,GO:0001947,GO:0002053,GO:0002088,GO:0002720,GO:0003138,GO:0003139,GO:0003283,GO:0003323,GO:0003402,GO:0003408,GO:0005109,GO:0005109,GO:0005109,GO:0005115,GO:0005125,GO:0005515,GO:0005543,GO:0005576,GO:0005615,GO:0005615,GO:0005788,GO:0005796,GO:0005886,GO:0006954,GO:0007223,GO:0007223,GO:0007254,GO:0007411,GO:0007442,GO:0007494,GO:0008104,GO:0008543,GO:0008584,GO:0008595,GO:0009986,GO:0010033,GO:0010463,GO:0010595,GO:0010628,GO:0010631,GO:0010742,GO:0010800,GO:0010820,GO:0010976,GO:0016055,GO:0019904,GO:0021891,GO:0030182,GO:0030182,GO:0030216,GO:0030324,GO:0030509,GO:0030514,GO:0030666,GO:0030669,GO:0032148,GO:0032722,GO:0032729,GO:0032731,GO:0032731,GO:0032755,GO:0032757,GO:0032760,GO:0033138,GO:0035567,GO:0036342,GO:0036517,GO:0036518,GO:0038031,GO:0040037,GO:0042060,GO:0042733,GO:0043032,GO:0043066,GO:0043122,GO:0043507,GO:0043507,GO:0045165,GO:0045198,GO:0045599,GO:0045732,GO:0045766,GO:0045778,GO:0045807,GO:0045836,GO:0045892,GO:0045893,GO:0045944,GO:0046330,GO:0048018,GO:0048022,GO:0048146,GO:0048341,GO:0048570,GO:0048706,GO:0048806,GO:0048843,GO:0048846,GO:0048850,GO:0050680,GO:0050727,GO:0050729,GO:0050807,GO:0050807,GO:0051092,GO:0051216,GO:0051885,GO:0051964,GO:0060028,GO:0060029,GO:0060065,GO:0060067,GO:0060068,GO:0060070,GO:0060071,GO:0060157,GO:0060324,GO:0060340,GO:0060599,GO:0060638,GO:0060686,GO:0060744,GO:0060750,GO:0060760,GO:0060762,GO:0060775,GO:0060809,GO:0060907,GO:0061036,GO:0061347,GO:0061348,GO:0061349,GO:0061350,GO:0061354,GO:0062009,GO:0062023,GO:0070062,GO:0070242,GO:0070245,GO:0071222,GO:0071277,GO:0071300,GO:0071346,GO:0071425,GO:0071560,GO:0072201,GO:0090009,GO:0090037,GO:0090082,GO:0090090,GO:0090103,GO:0090179,GO:0097325,GO:0098685,GO:0098794,GO:0098978,GO:0098978,GO:0099054,GO:0099068,GO:0099170,GO:0099175,GO:0099175,GO:0099566,GO:0099566,GO:0140013,GO:0150012,GO:1900020,GO:1902035,GO:1902379,GO:1902474,GO:1904861,GO:1904862,GO:1904934,GO:1904938,GO:1904953,GO:1904955,GO:2000049,GO:2000052,GO:2001235 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| WNT5A | hsa:7474 | path:hsa04150 | mTOR signaling pathway - Homo sapiens (human) |
| WNT5A | hsa:7474 | path:hsa04310 | Wnt signaling pathway - Homo sapiens (human) |
| WNT5A | hsa:7474 | path:hsa04360 | Axon guidance - Homo sapiens (human) |
| WNT5A | hsa:7474 | path:hsa04390 | Hippo signaling pathway - Homo sapiens (human) |
| WNT5A | hsa:7474 | path:hsa04550 | Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) |
| WNT5A | hsa:7474 | path:hsa04916 | Melanogenesis - Homo sapiens (human) |
| WNT5A | hsa:7474 | path:hsa04934 | Cushing syndrome - Homo sapiens (human) |
| WNT5A | hsa:7474 | path:hsa05010 | Alzheimer disease - Homo sapiens (human) |
| WNT5A | hsa:7474 | path:hsa05022 | Pathways of neurodegeneration - multiple diseases - Homo sapiens (human) |
| WNT5A | hsa:7474 | path:hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| WNT5A | hsa:7474 | path:hsa05200 | Pathways in cancer - Homo sapiens (human) |
| WNT5A | hsa:7474 | path:hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
| WNT5A | hsa:7474 | path:hsa05217 | Basal cell carcinoma - Homo sapiens (human) |
| WNT5A | hsa:7474 | path:hsa05224 | Breast cancer - Homo sapiens (human) |
| WNT5A | hsa:7474 | path:hsa05225 | Hepatocellular carcinoma - Homo sapiens (human) |
| WNT5A | hsa:7474 | path:hsa05226 | Gastric cancer - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| WNT5A | WNT5A | 15578921 16273260 21078818 21903638 26467481 | interaction type,bind,up-regulates activity | N/A | Signor |
| WNT5A | FZD5 | 23331499 9054360 | stimulation | N/A | SignaLink,SignaLink |
| WNT5A | FZD4 | 10990458 23331499 | stimulation | N/A | SignaLink,SignaLink |
| WNT5A | ROR2 | 17203201 23331499 | stimulation | N/A | SignaLink,SignaLink |
| GPC3 | WNT5A | 15537637 23331499 | inhibition | N/A | SignaLink,SignaLink |
| FRZB | WNT5A | 21494614 | interaction type,inhibition | N/A | SignaLink |
| WNT5A | ROR1 | 21481194 23331499 | stimulation | N/A | SignaLink |
| WNT5A | NLK | 20706670 23331499 | stimulation | N/A | SignaLink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | WNT5A | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ESR1 | WNT5A | 20034404 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| CTCF | WNT5A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | WNT5A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | WNT5A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CUX1 | WNT5A | 17227781 23359789 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CUX1 | WNT5A | 17227781 23359789 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HOXB7 | WNT5A | 21183939 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| PITX2 | WNT5A | 23250740 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000065D58 | WNT5A | 18668040 25416803 | mrna cleavage,inhibition | experimental interaction detection,experimental interaction detection,experimental interaction detection | TarBase |
| URS0000338542 | WNT5A | 20584899 25416803 | mrna cleavage,inhibition | experimental interaction detection | TarBase |
| URS000021D7C8 | WNT5A | 20371350 25416803 | mrna cleavage,inhibition | nucleotide sequence identification | TarBase |
| URS000009262D | WNT5A | 18591254 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS000031BC7D | WNT5A | 22942087 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS0000285DCB | WNT5A | 24832599 25416803 | mrna cleavage,inhibition | experimental interaction detection,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS0000031E12 | WNT5A | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004719AB | WNT5A | 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000427B68 | WNT5A | 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000015B295 | WNT5A | 23426183 25416803 | mrna cleavage,inhibition | array technology,western blot,chromatin immunoprecipitation assay,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS0000345DEB | WNT5A | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000036B845 | WNT5A | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000CBE63 | WNT5A | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000003ABC4 | WNT5A | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000008931A | WNT5A | 25416803 26708300 27013470 | mrna cleavage,inhibition | western blot,miRNA interference luciferase reporter assay | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| WNT5A | FZD1 | 25361965 | interaction type | N/A | PTMCode2 |
| FZD1 | WNT5A | 25361965 | interaction type | N/A | PTMCode2 |
| WNT5A | FZD5 | 25361965 | interaction type | N/A | PTMCode2 |
| FZD5 | WNT5A | 25361965 | interaction type | N/A | PTMCode2 |
| WNT5A | ROR2 | 25361965 | interaction type | N/A | PTMCode2 |
| ROR2 | WNT5A | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ROR2 | WNT5A | 12839624 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| WIF1 | WNT5A | 24234451 25348397 26342861 | N/A | surface plasmon resonance,surface plasmon resonance array | ComPPI,IntAct |
| FZD5 | WNT5A | 14525934 24234451 25241761 25348397 9054360 | physical association | experimental interaction detection,physical interaction,in vivo,proximity ligation assay | ComPPI,HPRD,IntAct |
| WNT5A | FZD1 | 10557084 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| WNT5A | FZD2 | 25348397 | N/A | physical interaction | ComPPI |
| WNT5A | LRP6 | 25348397 | N/A | physical interaction | ComPPI |
| WNT5A | ANTXR1 | 25348397 | N/A | physical interaction | ComPPI |
| WNT5A | PTPRK | 25348397 | N/A | physical interaction | ComPPI |
| WNT5A | WNT4 | 25348397 | N/A | physical interaction | ComPPI |
| WNT5A | WNT5B | 25348397 | N/A | physical interaction | ComPPI |
| WNT5A | WNT7A | 25348397 | N/A | physical interaction | ComPPI |
| WNT5A | WLS | 25348397 | N/A | physical interaction | ComPPI |
| WNT5A | PLA2G10 | 25348397 | N/A | physical interaction | ComPPI |
| WNT5A | TCTN2 | 25348397 | N/A | physical interaction | ComPPI |
| WNT5A | SDF2L1 | 25348397 | N/A | physical interaction | ComPPI |
| WNT5A | LYPD1 | 25348397 | N/A | physical interaction | ComPPI |
| WNT5A | WNT16 | 25348397 | N/A | physical interaction | ComPPI |
| WNT5A | FSTL1 | 25348397 | N/A | physical interaction | ComPPI |
| WNT5A | DEFA1 | 25348397 | N/A | physical interaction | ComPPI |
| WNT5A | NPTX1 | 25348397 | N/A | physical interaction | ComPPI |
| WNT5A | POTEF | 25348397 | N/A | physical interaction | ComPPI |
| WNT5A | PROC | 25348397 | N/A | physical interaction | ComPPI |
| WNT5A | EPHA7 | 25348397 | N/A | physical interaction | ComPPI |
| WNT5A | ROR1 | 25348397 | N/A | anti tag coimmunoprecipitation,physical interaction | ComPPI |
| WNT5A | LRP5 | 16602827 27898060 | N/A | N/A | OmniPath |
| WNT5A | LRP6 | 15578921 27898060 | stimulant | N/A | OmniPath |
| WNT5A | DVL1 | 21078818 27898060 | stimulant | N/A | OmniPath |
| WNT5A | FZD2 | 19008118 19910923 24032637 27898060 2808370 | inhibition,stimulant | N/A | OmniPath |
| WNT5A | ROR2 | 12839624 16602827 17203201 20215527 21069266 26690702 27898060 | stimulant | N/A | OmniPath |
| STAT3 | WNT5A | 17203201 19424602 27898060 | stimulant | N/A | OmniPath |
| WNT5A | NLK | 20706670 27898060 | stimulant | N/A | OmniPath |
| WNT5A | FZD5 | 24032637 25241761 27898060 9054360 | stimulant | N/A | OmniPath |
| WNT5A | FZD3 | 15578921 16273260 21903638 24032637 27898060 | stimulant | N/A | OmniPath |
| WNT5A | RYK | 15598975 27898060 | stimulant | N/A | OmniPath |
| WNT5A | FZD8 | 21518267 27898060 | stimulant | N/A | OmniPath |
| WNT5A | ROR1 | 18287027 21481194 22343533 23151663 26690702 27898060 | stimulant | N/A | OmniPath |
| WNT5A | FZD7 | 10990458 27898060 | stimulant | N/A | OmniPath |
| WNT5A | FZD1 | 10557084 24032637 27898060 | stimulant | N/A | OmniPath |
| WNT5A | FZD6 | 16273260 21665003 24032637 27898060 | stimulant | N/A | OmniPath |
| WNT5A | FZD4 | 10990458 27898060 | stimulant | N/A | OmniPath |
| GPC4 | WNT5A | 22302992 27898060 | stimulant | N/A | OmniPath |
| WNT5A | MCAM | 24335906 27898060 | N/A | N/A | OmniPath |