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GENE：ADRA1A

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ADRA1A
FullNmae adrenoceptor alpha 1A
LocusType gene with protein product
Status Approved
HGNC_id HGNC:277
EnsembleID ENSG00000120907
Uniprot P35348

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ADRA1A autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ADRA1A autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
ADRA1A GO:0000165,GO:0001985,GO:0001994,GO:0001996,GO:0001997,GO:0004937,GO:0004937,GO:0004937,GO:0004937,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0005886,GO:0005901,GO:0006915,GO:0006939,GO:0007165,GO:0007186,GO:0007200,GO:0007202,GO:0007204,GO:0007204,GO:0007267,GO:0007512,GO:0008285,GO:0009410,GO:0009725,GO:0010507,GO:0010613,GO:0031965,GO:0032230,GO:0035556,GO:0043231,GO:0043410,GO:0043410,GO:0045760,GO:0045907,GO:0045907,GO:0045987,GO:0046982,GO:0060402,GO:0060452,GO:0061049,GO:0070374,GO:0071880,GO:0090037,GO:0097195,GO:0150099

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ADRA1A hsa:148 path:hsa04020 Calcium signaling pathway - Homo sapiens (human)
ADRA1A hsa:148 path:hsa04022 cGMP-PKG signaling pathway - Homo sapiens (human)
ADRA1A hsa:148 path:hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human)
ADRA1A hsa:148 path:hsa04152 AMPK signaling pathway - Homo sapiens (human)
ADRA1A hsa:148 path:hsa04261 Adrenergic signaling in cardiomyocytes - Homo sapiens (human)
ADRA1A hsa:148 path:hsa04270 Vascular smooth muscle contraction - Homo sapiens (human)
ADRA1A hsa:148 path:hsa04970 Salivary secretion - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PPP1R9B ADRA1A 20005715 interaction type N/A PSP

Source Target Pmid Interactiontype Methods Database
GATA1 ADRA1A 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 ADRA1A 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 ADRA1A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA ADRA1A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ADRA1A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 ADRA1A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 ADRA1A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 ADRA1A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 ADRA1A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CREB1 ADRA1A 10520459 trascriptional regulation,stimulation inferred by curator TFlink
SP1 ADRA1A 10520459 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 ADRA1A 10520459 trascriptional regulation,stimulation inferred by curator TFlink
TFAP2A ADRA1A 10520459 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00005651EE ADRA1A 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
ADRA1D ADRA1A 14525934 15525470 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
FLNC ADRA1A 14525934 15525470 24234451 25348397 physical association two hybrid,two hybrid ComPPI,HPRD,IntAct
ADRA1B ADRA1A 14525934 15525470 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
ADRA1A RGS2 14525934 15917235 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
ADRA1A CXCR2 14525934 15946947 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
ADRA1A CXCR1 14525934 15946947 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
ADRA1A NOS1 12184796 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
ADRA1A BMP1 14525934 15525470 24234451 25348397 physical association two hybrid,two hybrid ComPPI,HPRD,IntAct
ADRA1A ABR 14525934 15525470 24234451 25348397 physical association two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD,IntAct
ADRA1A PPP1R9B 11154706 14525934 25348397 27898060 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD,OmniPath
ADRA1A CD81 24234451 28298427 physical association ubiquitin reconstruction IntAct
TMEM234 ADRA1A 24234451 28298427 physical association ubiquitin reconstruction IntAct
ADRA1A FAM50B 24234451 28298427 physical association ubiquitin reconstruction IntAct
ADRA1A FAM241B 24234451 28298427 physical association ubiquitin reconstruction IntAct
ADRA1A GDE1 24234451 28298427 physical association ubiquitin reconstruction IntAct
ADRA1A GPR37 24234451 28298427 physical association ubiquitin reconstruction IntAct
ADRA1A ADGRA3 24234451 28298427 physical association ubiquitin reconstruction IntAct
ADRA1A ATP6AP2 24234451 28298427 physical association ubiquitin reconstruction IntAct
ADRA1A SCN1B 24234451 28298427 physical association ubiquitin reconstruction IntAct
ADRA1A NTNG2 24234451 28298427 physical association ubiquitin reconstruction IntAct
ADRA1A UGT8 24234451 28298427 physical association ubiquitin reconstruction IntAct
ADRA1A UBR4 24234451 28298427 physical association ubiquitin reconstruction IntAct
ADRA1A HHATL 24234451 28298427 physical association ubiquitin reconstruction IntAct
ADRA1A KLHL22 24234451 28298427 physical association ubiquitin reconstruction IntAct
ADRA1A KIAA2013 24234451 28298427 physical association ubiquitin reconstruction IntAct
ADRA1A TBC1D20 24234451 28298427 physical association ubiquitin reconstruction IntAct
ADRA1A MBOAT7 24234451 28298427 physical association ubiquitin reconstruction IntAct
ADRA1A ANO8 24234451 28298427 physical association ubiquitin reconstruction IntAct
ADRA1A TPCN2 24234451 28298427 physical association ubiquitin reconstruction IntAct
ADRA1A SGCB 24234451 28298427 physical association ubiquitin reconstruction IntAct
VIM ADRA1A 24234451 30021884 physical association cross-linking study IntAct
ADRA1A GNAQ 1334487 27898060 stimulant N/A OmniPath
ADRA1A GNA11 1334487 27898060 stimulant N/A OmniPath

Visualization










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