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GENE：ATF6

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ATF6
FullNmae activating transcription factor 6
LocusType gene with protein product
Status Approved
HGNC_id HGNC:791
EnsembleID ENSG00000118217
Uniprot P18850

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ATF6 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ATF6 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
ATF6 GO:0000139,GO:0000785,GO:0000976,GO:0000977,GO:0000978,GO:0000978,GO:0000981,GO:0000981,GO:0001228,GO:0001654,GO:0003700,GO:0005515,GO:0005634,GO:0005634,GO:0005634,GO:0005635,GO:0005654,GO:0005783,GO:0005789,GO:0005789,GO:0005789,GO:0005794,GO:0005829,GO:0006357,GO:0006357,GO:0006457,GO:0007165,GO:0007601,GO:0010508,GO:0016020,GO:0030968,GO:0030968,GO:0036500,GO:0036500,GO:0036503,GO:0042802,GO:0043065,GO:0043565,GO:0045944,GO:0046982,GO:0090575,GO:1903893,GO:1990440,GO:1990837

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ATF6 hsa:22926 path:hsa04141 Protein processing in endoplasmic reticulum - Homo sapiens (human)
ATF6 hsa:22926 path:hsa05010 Alzheimer disease - Homo sapiens (human)
ATF6 hsa:22926 path:hsa05012 Parkinson disease - Homo sapiens (human)
ATF6 hsa:22926 path:hsa05014 Amyotrophic lateral sclerosis - Homo sapiens (human)
ATF6 hsa:22926 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
ATF6 hsa:22926 path:hsa05417 Lipid and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ATF6 XBP1 17991856 18360008 23180781 23850759 24269637 26192618 26587781 interaction type,physical association anti tag coimmunoprecipitation,electrophoretic mobility shift assay ACSN,InnateDB
ATF6 ERO1A 17991856 18360008 23850759 26192618 26587781 interaction type N/A ACSN
ATF6 SEL1L 17991856 18360008 23850759 26192618 26587781 interaction type N/A ACSN
ATF6 SYVN1 17991856 18360008 23850759 26192618 26587781 interaction type N/A ACSN
ATF6 ATP2A2 17991856 18360008 23850759 26192618 26587781 interaction type N/A ACSN
APP ATF6 21832049 23180781 physical association protein array InnateDB

Source Target Pmid Interactiontype Methods Database
AR ATF6 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 ATF6 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 ATF6 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 ATF6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA ATF6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ATF6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 ATF6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 ATF6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 ATF6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MYC ATF6 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000F0F49 ATF6 19956200 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS00000F6E49 ATF6 19956200 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS00000F6E49 ATF6 19956200 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS00000F0F49 ATF6 19956200 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS0000237AF9 ATF6 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS00002B2B5C ATF6 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000075A760 ATF6 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002152A8 ATF6 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001C770D ATF6 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000034979B ATF6 23313552 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075AAA0 ATF6 23313552 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
MAPK14 ATF6 22135298 phosphorylation N/A PhosphoSite
YY1 ATF6 25361965 interaction type N/A PTMCode2
ATF6 YY1 25361965 interaction type N/A PTMCode2
GTF2I ATF6 25361965 interaction type N/A PTMCode2
ATF6 GTF2I 25361965 interaction type N/A PTMCode2
SRF ATF6 25361965 interaction type N/A PTMCode2
ATF6 SRF 25361965 interaction type N/A PTMCode2
NFYA ATF6 25361965 interaction type N/A PTMCode2
ATF6 NFYA 25361965 interaction type N/A PTMCode2
ATF6 CREB1 25361965 interaction type N/A PTMCode2
CREB1 ATF6 25361965 interaction type N/A PTMCode2
CREB3L3 ATF6 25361965 interaction type N/A PTMCode2
ATF6 CREB3L3 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
NFYA ATF6 25348397 N/A physical interaction ComPPI
COP1 ATF6 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
MAPK14 ATF6 25348397 N/A physical interaction ComPPI
SRF ATF6 14525934 25348397 9271374 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
GTF2I ATF6 11287625 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
UBC ATF6 25348397 N/A physical interaction ComPPI
CDH5 ATF6 25348397 N/A physical interaction ComPPI
APOD ATF6 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
HSPA5 ATF6 24234451 25348397 27238082 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TNFRSF1A ATF6 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
HNRNPL ATF6 25348397 N/A physical interaction ComPPI
SREBF2 ATF6 25348397 N/A physical interaction ComPPI
SYVN1 ATF6 25348397 N/A physical interaction ComPPI
YY1 ATF6 10866666 14525934 15899857 25348397 27898060 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,OmniPath
NFYC ATF6 20936779 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,in vitro ComPPI,IntAct
GABRD ATF6 25348397 N/A physical interaction ComPPI
ATF6B ATF6 11158310 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
ATF6 CREB3L3 14525934 16469704 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,in vivo ComPPI,HPRD,IntAct,OmniPath
ATF6 CREB1 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
ATF6 WFS1 25348397 N/A physical interaction ComPPI
ATF6 APP 25348397 N/A physical interaction ComPPI
ATF6 XBP1 20102225 24234451 25348397 N/A peptide array,physical interaction ComPPI,IntAct
ATF6 BPGM 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
ATF6 DDC 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
ATF6 NNMT 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
ATF6 FBXO6 25348397 N/A physical interaction ComPPI
ATF6 HLA-E 25348397 N/A physical interaction ComPPI
ATF6 ERLEC1 25348397 N/A physical interaction ComPPI
ATF6 SH3TC1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
ATF6 STK40 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
ATF6 PARG 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
ATF6 PCDH20 25348397 N/A physical interaction ComPPI
ATF6 PCDHAC1 25348397 N/A physical interaction ComPPI
ATF6 PCDHB11 25348397 N/A physical interaction ComPPI
ATF6 CLEC3A 25348397 N/A physical interaction ComPPI
ATF6 CLEC2D 25348397 N/A physical interaction ComPPI
ATF6 CD300E 25348397 N/A physical interaction ComPPI
ATF6 OS9 25348397 N/A physical interaction ComPPI
ATF6 MGAT4C 25348397 N/A physical interaction ComPPI
ATF6 PCDHB16 25348397 N/A physical interaction ComPPI
ATF6 LRRN2 25348397 N/A physical interaction ComPPI
ATF6 TRIM25 25348397 N/A physical interaction ComPPI
ATF6 CRTC2 19543265 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
ATF6 SAR1A 19822759 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
ATF6 DAPK1 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
ACLY ATF6 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
PLGRKT ATF6 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
ATF6 ATF6 12805554 14525934 20102225 24234451 25609649 association experimental interaction detection,peptide array,tandem affinity purification HPRD,IntAct
HSPA5 ATF6 18624755 27898060 inhibition N/A OmniPath
MAPK14 ATF6 25135476 27898060 stimulant N/A OmniPath
PCSK7 ATF6 12076252 27898060 stimulant N/A OmniPath

Visualization










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