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GENE：ATG2A

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ATG2A
FullNmae autophagy related 2A
LocusType gene with protein product
Status Approved
HGNC_id HGNC:29028
EnsembleID ENSG00000110046
Uniprot Q2TAZ0

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ATG2A autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ATG2A autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
ATG2A GO:0000045,GO:0000045,GO:0000407,GO:0000422,GO:0005515,GO:0005789,GO:0005811,GO:0032266,GO:0034045,GO:0034727,GO:0044232,GO:0044805,GO:0061709,GO:0120009,GO:0120013,GO:2000786

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ATG2A hsa:23130 path:hsa04136 Autophagy - other - Homo sapiens (human)
ATG2A hsa:23130 path:hsa04140 Autophagy - animal - Homo sapiens (human)
ATG2A hsa:23130 path:hsa05010 Alzheimer disease - Homo sapiens (human)
ATG2A hsa:23130 path:hsa05014 Amyotrophic lateral sclerosis - Homo sapiens (human)
ATG2A hsa:23130 path:hsa05016 Huntington disease - Homo sapiens (human)
ATG2A hsa:23130 path:hsa05017 Spinocerebellar ataxia - Homo sapiens (human)
ATG2A hsa:23130 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
E2F4 ATG2A 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 ATG2A 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 ATG2A 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 ATG2A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA ATG2A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ATG2A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 ATG2A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 ATG2A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS ATG2A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A ATG2A 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00002394F5 ATG2A 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00000600E6 ATG2A 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000042E1F ATG2A 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS000075B538 ATG2A 20371350 21572407 23313552 23446348 23592263 23706177 24398324 24906430 25416803 26701625 27292025 28735896 mrna cleavage,inhibition clip TarBase
URS0000419B5A ATG2A 20371350 21572407 23446348 23706177 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000033B548 ATG2A 21572407 23446348 23706177 25416803 mrna cleavage,inhibition clip TarBase
URS0000246356 ATG2A 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000023BE29 ATG2A 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00000F31F4 ATG2A 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00000B59A2 ATG2A 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000353492 ATG2A 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00001BCAC5 ATG2A 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000075D814 ATG2A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075CC78 ATG2A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00006DE17B ATG2A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001012BC ATG2A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000021202F ATG2A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 ATG2A 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 ATG2A 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00000DDD35 ATG2A 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00002075FA ATG2A 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS000042619A ATG2A 25416803 26701625 27292025 28735896 mrna cleavage,inhibition clip TarBase
URS00004900F1 ATG2A 25416803 26701625 27292025 28735896 mrna cleavage,inhibition clip TarBase
URS00003AD231 ATG2A 25416803 26701625 27292025 28735896 mrna cleavage,inhibition clip TarBase
URS000075BDAA ATG2A 25416803 26701625 27292025 28735896 mrna cleavage,inhibition clip TarBase
URS000050CCE0 ATG2A 25416803 28735896 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
GABARAPL2 ATG2A 20562859 24234451 25348397 physical association pull down ComPPI,IntAct
MAP1LC3B ATG2A 20562859 24234451 25348397 physical association pull down ComPPI,IntAct
XPO1 ATG2A 25348397 N/A physical interaction ComPPI
DNAJC7 ATG2A 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SMC1A ATG2A 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PHB2 ATG2A 25348397 N/A physical interaction ComPPI
GABARAP ATG2A 20562859 24234451 25348397 physical association pull down ComPPI,IntAct
TRIM25 ATG2A 25348397 N/A physical interaction ComPPI
DNAJB1 ATG2A 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ESR2 ATG2A 21182203 24234451 25348397 association affinity chromatography technology ComPPI,IntAct
TMEM132A ATG2A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
WAPL ATG2A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
GABARAPL1 ATG2A 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
BABAM2 ATG2A 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MAGED2 ATG2A 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
WIPI1 ATG2A 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ATG2A WDR45 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ATG2A MAP1LC3C 20562859 24234451 25348397 N/A pull down ComPPI,IntAct
H2BC9 ATG2A 24234451 30021884 physical association cross-linking study IntAct

Visualization










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