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GENE：CAMKK2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CAMKK2
FullNmae calcium/calmodulin dependent protein kinase kinase 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:1470
EnsembleID ENSG00000110931
Uniprot Q96RR4

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CAMKK2 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CAMKK2 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CAMKK2 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
CAMKK2 GO:0000165,GO:0001934,GO:0004674,GO:0004683,GO:0004713,GO:0005509,GO:0005516,GO:0005524,GO:0005654,GO:0005829,GO:0005829,GO:0005829,GO:0006468,GO:0006468,GO:0019722,GO:0032147,GO:0034614,GO:0043005,GO:0045859,GO:0045893,GO:0046777,GO:0061762,GO:0061762,GO:0106310,GO:1903599

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CAMKK2 hsa:10645 path:hsa04140 Autophagy - animal - Homo sapiens (human)
CAMKK2 hsa:10645 path:hsa04152 AMPK signaling pathway - Homo sapiens (human)
CAMKK2 hsa:10645 path:hsa04211 Longevity regulating pathway - Homo sapiens (human)
CAMKK2 hsa:10645 path:hsa04920 Adipocytokine signaling pathway - Homo sapiens (human)
CAMKK2 hsa:10645 path:hsa04921 Oxytocin signaling pathway - Homo sapiens (human)
CAMKK2 hsa:10645 path:hsa04936 Alcoholic liver disease - Homo sapiens (human)
CAMKK2 hsa:10645 path:hsa05034 Alcoholism - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CAMKK2 EGFR 1309762 20542890 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
ETS1 CAMKK2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 CAMKK2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 CAMKK2 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 CAMKK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA CAMKK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF CAMKK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 CAMKK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 CAMKK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 CAMKK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 CAMKK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS CAMKK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A CAMKK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 CAMKK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR CAMKK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00002367FA CAMKK2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001A405B CAMKK2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000042B108 CAMKK2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00001B0D1E CAMKK2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000079F78 CAMKK2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00001B968D CAMKK2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000043C1C3 CAMKK2 23313552 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
DAPK1 CAMKK2 22135298 phosphorylation N/A PhosphoSite
CAMKK2 CAMKK2 22135298 phosphorylation N/A PhosphoSite
CAMKK2 PRKAA1 22135298 phosphorylation N/A PhosphoSite
CAMK1 CAMKK2 25361965 interaction type N/A PTMCode2
CAMKK2 CAMK1 25361965 interaction type N/A PTMCode2
CAMKK2 PRKAG1 25361965 interaction type N/A PTMCode2
PRKAG1 CAMKK2 25361965 interaction type N/A PTMCode2
CAMKK2 PRKAA2 25361965 interaction type N/A PTMCode2
PRKAA2 CAMKK2 25361965 interaction type N/A PTMCode2
PRKAB1 CAMKK2 25361965 interaction type N/A PTMCode2
CAMKK2 PRKAB1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PRKAA2 CAMKK2 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CALM1 CAMKK2 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
HSP90AB1 CAMKK2 22939624 24234451 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
PRKDC CAMKK2 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MAPK14 CAMKK2 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FLNC CAMKK2 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FLNA CAMKK2 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PRKACA CAMKK2 25348397 N/A physical interaction ComPPI
HSP90AA1 CAMKK2 25348397 N/A physical interaction ComPPI
ESYT2 CAMKK2 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
IRAK1 CAMKK2 25348397 N/A physical interaction ComPPI
PKM CAMKK2 25348397 N/A protein kinase assay ComPPI
IQGAP2 CAMKK2 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SMC1A CAMKK2 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ALOX5 CAMKK2 25348397 N/A physical interaction ComPPI
SMC3 CAMKK2 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NEDD4 CAMKK2 25348397 N/A physical interaction ComPPI
CAMK1 CAMKK2 11395482 14525934 25348397 9822657 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
SGK1 CAMKK2 25348397 N/A physical interaction ComPPI
CAMK4 CAMKK2 11395482 14525934 25348397 9822657 N/A experimental interaction detection,in vitro ComPPI,HPRD
GCHFR CAMKK2 25348397 N/A physical interaction ComPPI
TRIM25 CAMKK2 25348397 N/A physical interaction ComPPI
XPOT CAMKK2 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PRKAG1 CAMKK2 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CAMKK2 OBSL1 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CAMKK2 GCN1 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CAMKK2 ATG4B 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CAMKK2 FANCI 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CAMKK2 SLC25A11 25348397 N/A physical interaction ComPPI
CAMKK2 CEP63 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CAMKK2 APP 25348397 N/A physical interaction ComPPI
CAMKK2 HSP90AA2P 25348397 N/A physical interaction ComPPI
CAMKK2 C6ORF141 25348397 N/A physical interaction ComPPI
CAMKK2 INSYN2A 25348397 N/A physical interaction ComPPI
CAMKK2 CALM2 11395482 14525934 20562859 24234451 9822657 physical association anti tag coimmunoprecipitation,experimental interaction detection HPRD,IntAct
CAMKK2 CAMKK2 20562859 24234451 physical association anti tag coimmunoprecipitation IntAct
VIM CAMKK2 24234451 30021884 physical association cross-linking study IntAct
CDK5 CAMKK2 22778263 27898060 inhibition N/A OmniPath
CAMKK2 PRKAA2 15980064 19958286 27898060 stimulant N/A OmniPath
PRKACA CAMKK2 10187789 27898060 inhibition N/A OmniPath
PLK1 CAMKK2 15209507 27898060 N/A N/A OmniPath
CAMKK2 AKT1 27898060 9859994 stimulant N/A OmniPath
GSK3A CAMKK2 22778263 27898060 inhibition N/A OmniPath
DAPK1 CAMKK2 15209507 27898060 inhibition N/A OmniPath
GSK3B CAMKK2 22778263 27898060 inhibition N/A OmniPath
CAMKK2 PRKAG1 16054096 17244528 27898060 stimulant N/A OmniPath
CAMKK2 PRKAA1 21918180 27898060 stimulant N/A OmniPath
CAMKK2 CAMK1 10187789 10400638 11395482 27898060 7641687 7642608 8631893 9822657 stimulant N/A OmniPath
CAMKK2 CAMK4 11395482 15143065 19506079 27898060 7642608 8631893 8702940 9822657 stimulant N/A OmniPath
CAMKK2 CAMK1D 12935886 18669648 27898060 N/A N/A OmniPath

Visualization










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