Gene Information gene info

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GENE：CLU

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CLU
FullNmae clusterin
LocusType gene with protein product
Status Approved
HGNC_id HGNC:2095
EnsembleID ENSG00000120885
Uniprot P10909

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CLU parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CLU lysosomal_cd 36341760 220 lysosome-dependent cell death genes. retulator signature
CLU lysosomal_cd 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
CLU immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CLU autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CLU autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CLU autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
CLU apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CLU apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
CLU GO:0000902,GO:0001540,GO:0001540,GO:0001774,GO:0001836,GO:0002434,GO:0005102,GO:0005515,GO:0005576,GO:0005576,GO:0005615,GO:0005615,GO:0005615,GO:0005634,GO:0005634,GO:0005737,GO:0005737,GO:0005739,GO:0005743,GO:0005794,GO:0005829,GO:0005856,GO:0006629,GO:0006956,GO:0006958,GO:0009615,GO:0009986,GO:0010628,GO:0016020,GO:0017038,GO:0031093,GO:0031333,GO:0031333,GO:0031334,GO:0031625,GO:0032286,GO:0032436,GO:0032436,GO:0032760,GO:0032991,GO:0034366,GO:0042127,GO:0042583,GO:0042981,GO:0043065,GO:0043231,GO:0043524,GO:0043691,GO:0044877,GO:0045087,GO:0045202,GO:0045429,GO:0048156,GO:0048260,GO:0048260,GO:0048471,GO:0050750,GO:0050821,GO:0051082,GO:0051087,GO:0051092,GO:0051131,GO:0051787,GO:0051787,GO:0051787,GO:0051788,GO:0061077,GO:0061518,GO:0061740,GO:0062023,GO:0070062,GO:0071944,GO:0072562,GO:0090201,GO:0097418,GO:0097440,GO:0099020,GO:0140597,GO:1900221,GO:1902004,GO:1902230,GO:1902430,GO:1902847,GO:1902949,GO:1902998,GO:1903573,GO:1905907,GO:1905907,GO:1905908,GO:2000060

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CLU hsa:1191 path:hsa04610 Complement and coagulation cascades - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CLU CTNNB1 15735679 23180781 physical association anti tag coimmunoprecipitation InnateDB
PITX3 CLU 22278372 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ESR1 CLU 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
ESR2 CLU 20034404 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
ETS1 CLU 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOS CLU 10406964 18971253 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
FOSL2 CLU 10406964 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
GATA1 CLU 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 CLU 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA3 CLU 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXA1 CLU 18971253 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
JUNB CLU 10406964 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
JUND CLU 10406964 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
YBX1 CLU 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TP73 CLU 19558638 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
FOSL1 CLU 10406964 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
SMARCA4 CLU 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA CLU 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF CLU 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 CLU 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A CLU 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 CLU 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 CLU 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 CLU 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MYCN CLU 23362253 trascriptional regulation,stimulation inferred by curator TFlink
JUN CLU N/A trascriptional regulation,stimulation inferred by curator TFlink
MYB CLU N/A trascriptional regulation,stimulation inferred by curator TFlink
TFAP2A CLU N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000048BA36 CLU 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000035CC3E CLU 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00002075FA CLU 23436804 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,immunohistochemistry TarBase
URS000009262D CLU 24327270 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS0000100748 CLU 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000009EA8F CLU 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002EF20A CLU 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000171CD1 CLU 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000041CB9C CLU 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000040EE1D CLU 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000C4DB5 CLU 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000C85B2 CLU 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002394F5 CLU 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000116F83 CLU 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000A939F CLU 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000007A060 CLU 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00004A6E26 CLU 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000075A9CF CLU 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000F0F49 CLU 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00004D84DB CLU 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000419B5A CLU 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000759B6A CLU 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000BD6DC CLU 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000C403E CLU 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000077DDE CLU 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000913AC CLU 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000006372A CLU 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000007D64A CLU 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000209F04 CLU 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
MAPK9 CLU 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TTR CLU 25348397 N/A physical interaction ComPPI
IGHG1 CLU 15174051 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
MMP3 CLU 25348397 N/A physical interaction ComPPI
RAD21 CLU 25348397 N/A physical interaction ComPPI
KEAP1 CLU 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
MCM2 CLU 25348397 N/A physical interaction ComPPI
HBA1 CLU 25348397 N/A physical interaction ComPPI
DPPA4 CLU 25348397 N/A physical interaction ComPPI
TUFM CLU 25348397 N/A physical interaction ComPPI
BCL2L1 CLU 21527247 21567405 25348397 27898060 N/A anti bait coimmunoprecipitation,physical interaction ComPPI,OmniPath
CBY1 CLU 25348397 N/A physical interaction ComPPI
TGFBR2 CLU 25348397 N/A two hybrid,physical interaction,in vitro,in vivo ComPPI
SUMF2 CLU 25348397 N/A physical interaction ComPPI
C9 CLU 25348397 N/A physical interaction,in vitro ComPPI
VEGFA CLU 25348397 N/A physical interaction ComPPI
GRB2 CLU 18624398 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
LIG4 CLU 25348397 N/A physical interaction ComPPI
PAXIP1 CLU 25348397 N/A physical interaction ComPPI
CLU PON1 25348397 27898060 8292612 N/A physical interaction,in vitro,in vivo ComPPI,OmniPath
CLU PRNP 25348397 N/A physical interaction,in vivo ComPPI
CLU VLDLR 25348397 N/A in vitro,in vivo ComPPI
CLU C7 25348397 N/A physical interaction,in vitro ComPPI
CLU LRP8 25348397 N/A in vitro,in vivo ComPPI
CLU MMP25 12860995 25348397 27898060 N/A physical interaction,in vitro,in vivo ComPPI,OmniPath
CLU C8B 25348397 N/A physical interaction,in vitro ComPPI
CLU LEPR 25348397 N/A in vitro ComPPI
CLU CLUAP1 15480429 25348397 27898060 N/A two hybrid,physical interaction,in vivo ComPPI,OmniPath
CLU XRCC6 10219089 12551933 19118032 19177010 21042904 25348397 27898060 N/A two hybrid,physical interaction,in vitro,in vivo ComPPI,OmniPath
CLU LEP 25348397 N/A in vitro,in vivo ComPPI
CLU TNC 25348397 N/A pull down ComPPI
CLU LRP2 17260971 25348397 27898060 7768901 9228033 N/A physical interaction ComPPI,OmniPath
CLU TGFBR1 25348397 N/A physical interaction ComPPI
CLU SYVN1 25348397 N/A physical interaction ComPPI
CLU H2AX 20000738 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CLU COMMD1 25348397 N/A physical interaction ComPPI
CLU NFKB1 25348397 N/A physical interaction ComPPI
CLU CUL1 25348397 N/A physical interaction ComPPI
CLU BTRC 25348397 N/A physical interaction ComPPI
CLU DISC1 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CLU TNIK 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CLU VHL 22532874 25348397 27898060 N/A physical interaction ComPPI,OmniPath
CLU CHUK 25348397 N/A physical interaction ComPPI
CLU BAX 16113678 19118032 19177010 21567405 23538443 25348397 27898060 N/A physical interaction ComPPI,OmniPath
CLU CD209 22013110 25348397 27898060 N/A physical interaction ComPPI,OmniPath
CLU XPO1 25348397 N/A physical interaction ComPPI
CLU ACTN1 17974975 25348397 27898060 N/A physical interaction ComPPI,OmniPath
CLU ZWINT 25348397 N/A physical interaction ComPPI
CLU KATNA1 25348397 N/A physical interaction ComPPI
CLU KNSTRN 25348397 N/A physical interaction ComPPI
CLU SLC4A1 25348397 N/A physical interaction ComPPI
CLU ELN 25348397 N/A physical interaction ComPPI
CLU APP 25348397 27898060 8328966 8752142 9228033 N/A physical interaction ComPPI,OmniPath
CLU LYZ 25348397 N/A physical interaction ComPPI
CLU ATP7B 21242307 22130675 25348397 27898060 N/A physical interaction ComPPI,OmniPath
CLU ATP7A 25348397 N/A physical interaction ComPPI
CLU IL24 25348397 N/A physical interaction ComPPI
CLU HSPD1 22012253 25348397 27898060 N/A physical interaction ComPPI,OmniPath
CLU PRNP 15146195 18786636 25348397 27898060 N/A physical interaction ComPPI,OmniPath
CLU FBXO6 25348397 N/A physical interaction ComPPI
CLU MDC1 25348397 N/A physical interaction ComPPI
CLU PDIA3 17170699 24234451 25348397 26496610 disulfide bond,association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CLU POLR1C 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CLU BAG6 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CLU CYP2E1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CLU RBBP8 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CLU KLF11 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CLU TSC22D4 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CLU FOS 20195357 24234451 25348397 physical association display technology,physical interaction,tandem affinity purification ComPPI,IntAct
CLU MDM2 20195357 24234451 25348397 physical association display technology,physical interaction ComPPI,IntAct
CLU CDK19 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
CLU HSPA1L 25348397 N/A physical interaction ComPPI
CLU NUCB2 25348397 N/A physical interaction ComPPI
CLU TUBB6 25348397 N/A physical interaction ComPPI
CLU HSPA5 22689054 23457489 25348397 27898060 N/A physical interaction ComPPI,OmniPath
CLU HSP90B1 25348397 N/A physical interaction ComPPI
CLU HYOU1 25348397 N/A physical interaction ComPPI
CLU UBC 25348397 N/A physical interaction ComPPI
CLU EGFR 25348397 N/A physical interaction ComPPI
CLU RPE 25348397 N/A physical interaction ComPPI
CLU HLA-DPA1 25348397 N/A physical interaction ComPPI
CLU HAX1 25348397 N/A physical interaction ComPPI
CLU CCND3 25348397 N/A physical interaction ComPPI
CLU IL20RB 25348397 N/A physical interaction ComPPI
CLU GPR180 25348397 N/A physical interaction ComPPI
CLU GINM1 25348397 N/A physical interaction ComPPI
CLU SDF4 25348397 N/A physical interaction ComPPI
CLU RASSF7 25348397 N/A physical interaction ComPPI
CLU TNF 25348397 N/A physical interaction ComPPI
CLU RNASE13 25348397 N/A physical interaction ComPPI
CLU IFNA5 25348397 N/A physical interaction ComPPI
CLU PLK1 25348397 N/A physical interaction ComPPI
CLU EPPIN 25348397 N/A physical interaction ComPPI
CLU LTF 25348397 N/A physical interaction ComPPI
CLU SEMG1 25348397 N/A physical interaction ComPPI
CLU ADCYAP1R1 25348397 N/A physical interaction ComPPI
CLU SRPK2 25348397 N/A physical interaction ComPPI
CLU CANX 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CLU PDGFRA 25348397 N/A physical interaction ComPPI
CLU ARMC6 25348397 N/A physical interaction ComPPI
CLU TUBGCP5 25348397 N/A physical interaction ComPPI
CLU FXR1 25348397 N/A physical interaction ComPPI
CLU SETX 25348397 N/A physical interaction ComPPI
CLU DOCK6 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CLU GPAM 25348397 N/A physical interaction ComPPI
CLU ATG3 25348397 N/A physical interaction ComPPI
CLU MAP1LC3A 25348397 N/A physical interaction ComPPI
CLU MMP9 25348397 N/A physical interaction ComPPI
CLU SDK2 25348397 N/A physical interaction ComPPI
CLU ATP2B2 25348397 N/A physical interaction ComPPI
CLU PTPRS 25348397 N/A physical interaction ComPPI
CLU TENM3 25348397 N/A physical interaction ComPPI
CLU FAT4 25348397 N/A physical interaction ComPPI
CLU FBXO27 25348397 N/A physical interaction ComPPI
CLU CBWD3 25348397 N/A physical interaction ComPPI
CLU GARRE1 25348397 N/A physical interaction ComPPI
CLU DHX57 25348397 N/A physical interaction ComPPI
CLU ITGA8 25348397 N/A physical interaction ComPPI
CLU EDEM2 25348397 N/A physical interaction ComPPI
CLU MANEA 25348397 N/A physical interaction ComPPI
CLU DDX31 25348397 N/A physical interaction ComPPI
CLU ARHGAP36 25348397 N/A physical interaction ComPPI
CLU EXTL2 25348397 N/A physical interaction ComPPI
CLU TOR1A 25348397 N/A physical interaction ComPPI
CLU MAN1A1 25348397 N/A physical interaction ComPPI
CLU TNFSF9 25348397 N/A physical interaction ComPPI
CLU PCYOX1L 25348397 N/A physical interaction ComPPI
CLU PTPRF 25348397 N/A physical interaction ComPPI
CLU GNB2 25348397 N/A physical interaction ComPPI
CLU MAN1A2 25348397 N/A physical interaction ComPPI
CLU CELSR1 25348397 N/A physical interaction ComPPI
CLU NLGN2 25348397 N/A physical interaction ComPPI
CLU TXNDC11 25348397 N/A physical interaction ComPPI
CLU INTS5 25348397 N/A physical interaction ComPPI
CLU PCYOX1 25348397 N/A physical interaction ComPPI
CLU MTMR9 25348397 N/A physical interaction ComPPI
CLU OCIAD1 25348397 N/A physical interaction ComPPI
CLU LMAN2L 25348397 N/A physical interaction ComPPI
CLU EIF3F 25348397 N/A physical interaction ComPPI
CLU MSRB1 25348397 N/A physical interaction ComPPI
CLU IGHA1 15174051 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
CLU NR4A1 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
CLU NR3C1 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
CLU PPARG 20195357 24234451 25348397 physical association display technology,tandem affinity purification ComPPI,IntAct
CLU ZNF24 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
CLU ADCYAP1 24234451 25348397 25451228 colocalization,physical association anti tag coimmunoprecipitation,two hybrid,fluorescence microscopy ComPPI,IntAct
CLU SAV1 22570112 24234451 25348397 physical association two hybrid ComPPI,IntAct
APOA1 CLU 15174051 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
NFKBIA CLU 25348397 N/A physical interaction ComPPI
RPL23 CLU 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
AKT1 CLU 25348397 N/A physical interaction ComPPI
CLU PDK1 25348397 N/A physical interaction ComPPI
CLU DALLY 24234451 25294943 25348397 association pull down ComPPI,IntAct
METTL14 CLU 24234451 29507755 association anti tag coimmunoprecipitation IntAct

Visualization










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