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GENE：DDIT3

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol DDIT3
FullNmae DNA damage inducible transcript 3
LocusType gene with protein product
Status Approved
HGNC_id HGNC:2726
EnsembleID ENSG00000175197
Uniprot P0DPQ6|P35638

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
DDIT3 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
DDIT3 ferroptosis 38178888 Subsequently, 13 ferroptosis-related genes (DRD5, TSC22D3, TFAP2A, STMN1, DDIT3, MYCN, ELAVL1, JUN, DUSP1, MIB1, PSAT1, LCE2C, and MIR27A) were identified from the interaction between differentially expressed genes and FerrDb database, which are regarded as the potential targets of CPAP-treated OSA. retulator signature
DDIT3 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
DDIT3 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
DDIT3 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
DDIT3 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
DDIT3 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
DDIT3 GO:0000122,GO:0000122,GO:0000122,GO:0000122,GO:0000122,GO:0000785,GO:0000976,GO:0000976,GO:0000976,GO:0000978,GO:0000978,GO:0000981,GO:0001228,GO:0001228,GO:0001955,GO:0003677,GO:0003700,GO:0003700,GO:0003700,GO:0005515,GO:0005634,GO:0005634,GO:0005667,GO:0005737,GO:0005737,GO:0005770,GO:0005829,GO:0006355,GO:0006357,GO:0006357,GO:0006974,GO:0006983,GO:0006986,GO:0007049,GO:0007605,GO:0008134,GO:0008140,GO:0008140,GO:0009611,GO:0009948,GO:0010467,GO:0010506,GO:0016055,GO:0030968,GO:0032088,GO:0032689,GO:0032700,GO:0032713,GO:0032757,GO:0032792,GO:0032792,GO:0032792,GO:0032993,GO:0034976,GO:0036119,GO:0036488,GO:0036488,GO:0036488,GO:0036488,GO:0036499,GO:0036500,GO:0042594,GO:0042802,GO:0042803,GO:0043161,GO:0043433,GO:0043433,GO:0043522,GO:0043525,GO:0043525,GO:0043618,GO:0045454,GO:0045599,GO:0045662,GO:0045892,GO:0045893,GO:0045944,GO:0045944,GO:0046982,GO:0046982,GO:0051091,GO:0051091,GO:0051209,GO:0051726,GO:0051898,GO:0060840,GO:0061629,GO:0070059,GO:0070059,GO:0070059,GO:0070059,GO:0072655,GO:0090090,GO:0090575,GO:0120163,GO:0140416,GO:0140467,GO:1902237,GO:1903026,GO:1904738,GO:1990440,GO:1990440,GO:1990440,GO:1990440,GO:1990440,GO:1990442,GO:1990617,GO:1990617,GO:1990617,GO:1990622,GO:1990622,GO:1990874,GO:2000016,GO:2001244,GO:2001244

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
DDIT3 hsa:1649 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
DDIT3 hsa:1649 path:hsa04141 Protein processing in endoplasmic reticulum - Homo sapiens (human)
DDIT3 hsa:1649 path:hsa04210 Apoptosis - Homo sapiens (human)
DDIT3 hsa:1649 path:hsa04932 Non-alcoholic fatty liver disease - Homo sapiens (human)
DDIT3 hsa:1649 path:hsa05010 Alzheimer disease - Homo sapiens (human)
DDIT3 hsa:1649 path:hsa05012 Parkinson disease - Homo sapiens (human)
DDIT3 hsa:1649 path:hsa05014 Amyotrophic lateral sclerosis - Homo sapiens (human)
DDIT3 hsa:1649 path:hsa05020 Prion disease - Homo sapiens (human)
DDIT3 hsa:1649 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
DDIT3 hsa:1649 path:hsa05202 Transcriptional misregulation in cancer - Homo sapiens (human)
DDIT3 hsa:1649 path:hsa05417 Lipid and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
EP300 DDIT3 15286281 23180781 physical association anti tag coimmunoprecipitation InnateDB
ATF4 DDIT3 20038797 23180781 physical association anti tag coimmunoprecipitation InnateDB
DDIT3 ATG5 20038797 23180781 physical association anti tag coimmunoprecipitation InnateDB
DDIT3 PPP1R15A 20038797 23180781 physical association anti tag coimmunoprecipitation InnateDB
IL23A DDIT3 20876114 23180781 physical association anti tag coimmunoprecipitation InnateDB
RB1 DDIT3 20971808 23180781 physical association anti tag coimmunoprecipitation InnateDB
DDIT3 CEBPD 20971808 23180781 physical association anti tag coimmunoprecipitation InnateDB
DDIT3 E2F1 20971808 23180781 physical association anti tag coimmunoprecipitation InnateDB
CEBPE DDIT3 15588942 23180781 physical association two hybrid InnateDB
TRIB3 DDIT3 15775988 23180781 physical association anti tag coimmunoprecipitation InnateDB
DDIT3 CEBPB 12706815 15775988 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
CEBPG DDIT3 12618752 23180781 physical association anti tag coimmunoprecipitation InnateDB
MAPK14 DDIT3 23331499 8650547 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
ETS1 DDIT3 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXO3 DDIT3 18226221 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 DDIT3 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
MAX DDIT3 15021909 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
MYC DDIT3 15021909 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
CEBPA DDIT3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 DDIT3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS DDIT3 18971253 20188076 trascriptional regulation,stimulation inferred by curator TFlink
MITF DDIT3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ATF3 DDIT3 22753726 trascriptional regulation,stimulation inferred by curator TFlink
ATF4 DDIT3 16246168 17276738 17455323 20020050 21044953 21966512 22691366 trascriptional regulation,stimulation inferred by curator TFlink
ATF6 DDIT3 17455323 trascriptional regulation,stimulation inferred by curator TFlink
BRCA1 DDIT3 21700680 trascriptional regulation,stimulation inferred by curator TFlink
CEBPB DDIT3 16757577 trascriptional regulation,stimulation inferred by curator TFlink
CEBPD DDIT3 20971808 22347430 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 DDIT3 20971808 trascriptional regulation,stimulation inferred by curator TFlink
FUS DDIT3 11162437 trascriptional regulation,stimulation inferred by curator TFlink
JDP2 DDIT3 18396163 trascriptional regulation,stimulation inferred by curator TFlink
JUN DDIT3 22622069 trascriptional regulation,stimulation inferred by curator TFlink
NFYA DDIT3 20023394 trascriptional regulation,stimulation inferred by curator TFlink
RB1 DDIT3 20971808 trascriptional regulation,stimulation inferred by curator TFlink
STAT3 DDIT3 23288901 trascriptional regulation,stimulation inferred by curator TFlink
XBP1 DDIT3 17455323 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 DDIT3 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS000016FF9C DDIT3 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS0000044FD7 DDIT3 24039954 25416803 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000010BD8D DDIT3 20371350 22012620 23446348 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CSNK2A1 DDIT3 22135298 phosphorylation N/A PhosphoSite
PRKAA1 DDIT3 22135298 phosphorylation N/A PhosphoSite
MAPK14 DDIT3 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
KPNA2 DDIT3 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
VPS37C DDIT3 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TXN2 DDIT3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PPIB DDIT3 25348397 N/A physical interaction ComPPI
ATPAF2 DDIT3 25348397 N/A physical interaction ComPPI
ATF4 DDIT3 12805554 14525934 18330356 20102225 24234451 25348397 physical association two hybrid,experimental interaction detection,peptide array,physical interaction,in vitro ComPPI,HPRD,IntAct
CEBPG DDIT3 14525934 16189514 20102225 24234451 25348397 physical association two hybrid,peptide array,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
TRIB3 DDIT3 14525934 15775988 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
ZBTB25 DDIT3 25348397 N/A physical interaction ComPPI
CDK6 DDIT3 22094256 24234451 25348397 phosphorylation reaction physical interaction,protein kinase assay ComPPI,IntAct
KEAP1 DDIT3 25348397 N/A physical interaction ComPPI
JUNB DDIT3 20102225 24234451 25348397 N/A peptide array,physical interaction ComPPI,IntAct
BATF DDIT3 14525934 16189514 18330356 20102225 24234451 25348397 27107012 physical association two hybrid,peptide array,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,validated two hybrid,barcode fusion genetics two hybrid,two hybrid ComPPI,HPRD,IntAct
HSD17B14 DDIT3 14525934 16189514 24234451 25348397 27107012 physical association two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid prey pooling approach,validated two hybrid,barcode fusion genetics two hybrid,two hybrid ComPPI,HPRD,IntAct
DGCR2 DDIT3 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
JUN DDIT3 10523647 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
CREBBP DDIT3 25348397 N/A physical interaction ComPPI
FOSL2 DDIT3 20102225 24234451 25348397 27107012 physical association peptide array,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid,barcode fusion genetics two hybrid ComPPI,IntAct
EP300 DDIT3 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
ATF3 DDIT3 14525934 20102225 24234451 25348397 27107012 29997244 8622660 physical association bioluminescence resonance energy transfer,experimental interaction detection,peptide array,physical interaction,in vitro,in vivo,luminescence based mammalian interactome mapping,validated two hybrid,barcode fusion genetics two hybrid ComPPI,HPRD,IntAct
JDP2 DDIT3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MAPK14 DDIT3 14525934 25348397 8650547 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
JUND DDIT3 10523647 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CEBPB DDIT3 12706815 14525934 1547942 20102225 24234451 25348397 8662954 N/A two hybrid,experimental interaction detection,peptide array,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
MAFG DDIT3 25348397 N/A physical interaction ComPPI
MAFF DDIT3 25348397 N/A physical interaction ComPPI
CUL3 DDIT3 25348397 N/A physical interaction ComPPI
F2 DDIT3 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PICALM DDIT3 14525934 1547942 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
RPS3A DDIT3 10713066 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
CSNK2A1 DDIT3 12876286 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
GIPC1 DDIT3 18330356 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CRACR2A DDIT3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
LMO2 DDIT3 25348397 N/A physical interaction ComPPI
CUL1 DDIT3 25348397 N/A physical interaction ComPPI
CEBPE DDIT3 14525934 15588942 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
HDAC6 DDIT3 25348397 N/A physical interaction ComPPI
COPS3 DDIT3 25348397 N/A physical interaction ComPPI
COPS7A DDIT3 25348397 N/A physical interaction ComPPI
COPS8 DDIT3 25348397 N/A physical interaction ComPPI
CREB3 DDIT3 20102225 24234451 25348397 N/A peptide array,physical interaction ComPPI,IntAct
PRKN DDIT3 25348397 N/A physical interaction ComPPI
HDAC5 DDIT3 25348397 N/A physical interaction ComPPI
SSX3 DDIT3 25348397 N/A physical interaction ComPPI
EMSY DDIT3 25348397 N/A physical interaction ComPPI
BACH1 DDIT3 20102225 24234451 25348397 N/A peptide array,physical interaction ComPPI,IntAct
BACH2 DDIT3 25348397 N/A physical interaction ComPPI
SPOP DDIT3 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
DNMT3L DDIT3 25348397 N/A physical interaction ComPPI
GABBR1 DDIT3 25348397 N/A physical interaction ComPPI
NFIL3 DDIT3 20102225 24234451 25348397 N/A peptide array,physical interaction ComPPI,IntAct
ATF7 DDIT3 20102225 24234451 25348397 N/A peptide array ComPPI,IntAct
EPAS1 DDIT3 25348397 N/A physical interaction ComPPI
TNFSF12 DDIT3 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SNAPC5 DDIT3 25348397 N/A physical interaction ComPPI
GABBR2 DDIT3 25348397 N/A physical interaction ComPPI
LNX1 DDIT3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BATF2 DDIT3 25348397 N/A physical interaction ComPPI
ATF2 DDIT3 20102225 24234451 25348397 N/A peptide array,physical interaction ComPPI,IntAct
CEBPA DDIT3 20102225 24234451 25348397 N/A peptide array,physical interaction ComPPI,IntAct
DDIT3 MCMBP 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
DDIT3 FOS 10523647 14525934 20102225 24234451 25348397 29997244 physical association bioluminescence resonance energy transfer,experimental interaction detection,peptide array,physical interaction ComPPI,HPRD,IntAct
DDIT3 TEDC1 18330356 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct
DDIT3 RTL6 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DDIT3 HOXA5 25348397 N/A physical interaction ComPPI
DDIT3 RAI1 25348397 N/A physical interaction ComPPI
DDIT3 ZSCAN31 25348397 N/A physical interaction ComPPI
DDIT3 HDAC1 17872950 22242125 25348397 27898060 N/A physical interaction ComPPI,OmniPath
DDIT3 SRA1 25348397 N/A physical interaction ComPPI
DDIT3 DBP 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
DDIT3 FOSL1 25348397 N/A physical interaction ComPPI
DDIT3 CREB3L1 25348397 N/A physical interaction ComPPI
DDIT3 GP1BA 25348397 N/A physical interaction ComPPI
DDIT3 IKBKG 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
DDIT3 POLR1D 25348397 N/A physical interaction ComPPI
DDIT3 POLR1D 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
DDIT3 AMOTL2 25348397 N/A physical interaction ComPPI
DDIT3 ZC3H14 25348397 N/A physical interaction ComPPI
DDIT3 CCDC153 25348397 N/A physical interaction ComPPI
DDIT3 FANCA 25348397 N/A physical interaction ComPPI
DDIT3 CEBPD 20102225 24234451 25348397 N/A peptide array ComPPI,IntAct
DDIT3 HLF 20102225 24234451 25348397 N/A peptide array ComPPI,IntAct
DDIT3 CREBL2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DDIT3 TXNDC2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BATF3 DDIT3 20102225 24234451 25348397 physical association peptide array,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DDIT3 DDIT3 20562859 24234451 physical association anti tag coimmunoprecipitation IntAct
PRKCA DDIT3 12876286 27898060 N/A N/A OmniPath
DDIT3 BCL2 17652152 27898060 inhibition N/A OmniPath
DDIT3 JUND 10523647 11426938 27898060 stimulant N/A OmniPath
DDIT3 MAP1LC3B 20038797 27898060 N/A N/A OmniPath
DDIT3 FOSL1 10523647 27898060 stimulant N/A OmniPath
DDIT3 CEBPB 12706815 1547942 15775988 20102225 20562859 27898060 8662954 N/A N/A OmniPath
MAPK14 DDIT3 11163539 11426938 27898060 8650547 stimulant N/A OmniPath
DDIT3 BCL2L11 17604722 18471544 27898060 stimulant N/A OmniPath
TRIB3 DDIT3 15775988 17872950 27898060 N/A N/A OmniPath
EP300 DDIT3 15286281 17872950 21988832 24270407 27898060 N/A N/A OmniPath
DDIT3 ITGAM 19359519 27898060 stimulant N/A OmniPath
CSNK2A1 DDIT3 12876286 27898060 8650547 inhibition N/A OmniPath
DDIT3 ATG5 20038797 27898060 N/A N/A OmniPath
DDIT3 ATF4 12805554 18330356 20038797 20102225 23661758 27898060 N/A N/A OmniPath
CEBPG DDIT3 12618752 16189514 20102225 25416956 27898060 N/A N/A OmniPath
CEBPE DDIT3 15588942 27898060 N/A N/A OmniPath
CEBPD DDIT3 20102225 20971808 27898060 N/A N/A OmniPath

Visualization










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