GENE：DDRGK1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | DDRGK1 |
| FullNmae | DDRGK domain containing 1 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:16110 |
| EnsembleID | ENSG00000198171 |
| Uniprot | Q96HY6 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| DDRGK1 | autophagy | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| DDRGK1 | autophagy | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| DDRGK1 | GO:0005515,GO:0005730,GO:0005737,GO:0005783,GO:0005789,GO:0008284,GO:0010628,GO:0010629,GO:0030335,GO:0031647,GO:0032435,GO:0032436,GO:0033146,GO:0034976,GO:0034976,GO:0043066,GO:0044389,GO:0045944,GO:0051092,GO:0051216,GO:0061629,GO:0061709,GO:0070972,GO:0071569,GO:1901800,GO:1902808,GO:1903721,GO:1903895,GO:1905050,GO:1905552,GO:1905636,GO:1990592 |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ETS1 | DDRGK1 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| CEBPA | DDRGK1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | DDRGK1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | DDRGK1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | DDRGK1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | DDRGK1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ZNF263 | DDRGK1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CDK5RAP3 | DDRGK1 | 17353931 24234451 25348397 | physical association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| JUN | DDRGK1 | 24234451 25348397 25609649 | association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| CANX | DDRGK1 | 24234451 25348397 29568061 | association | proximity-dependent biotin identification | ComPPI,IntAct |
| EVC2 | DDRGK1 | 24234451 25348397 26638075 | association | physical interaction,proximity-dependent biotin identification | ComPPI,IntAct |
| ACTL6A | DDRGK1 | 25348397 | N/A | physical interaction | ComPPI |
| TNFRSF10A | DDRGK1 | 25348397 | N/A | physical interaction | ComPPI |
| TLR5 | DDRGK1 | 25348397 | N/A | physical interaction | ComPPI |
| GNAI1 | DDRGK1 | 25348397 | N/A | physical interaction | ComPPI |
| SRPRB | DDRGK1 | 25348397 | N/A | physical interaction | ComPPI |
| UNC5CL | DDRGK1 | 25348397 | N/A | physical interaction | ComPPI |
| APP | DDRGK1 | 25348397 | N/A | physical interaction | ComPPI |
| UFC1 | DDRGK1 | 25348397 | N/A | physical interaction | ComPPI |
| DDRGK1 | PLS1 | 25348397 | N/A | physical interaction | ComPPI |
| TRIM26 | DDRGK1 | 25348397 | N/A | physical interaction | ComPPI |
| HTR6 | DDRGK1 | 24234451 28298427 | physical association | ubiquitin reconstruction | IntAct |