GeneInfo:
GeneAttribute
GeneDescription
GeneSymbol
DEPDC5
FullNmae
DEP domain containing 5, GATOR1 subcomplex subunit
LocusType
gene with protein product
Status
Approved
HGNC_id
HGNC:18423
EnsembleID
ENSG00000100150
Uniprot
O75140
Protein Structure:
Gene Description in Publicaton:
GeneSymbol
CellDeathType
PMID
Description
GeneType
DEPDC5
autophagy
38538696
The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore)
retulator signature
DEPDC5
autophagy
36341760
The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns.
regulator signature
Go Annotation:
GeneSymbol
Go id
DEPDC5
GO:0005096,GO:0005096,GO:0005764,GO:0005765,GO:0005765,GO:0005765,GO:0005765,GO:0005765,GO:0005829,GO:0010508,GO:0031267,GO:0032007,GO:0034198,GO:0034198,GO:0034198,GO:0035556,GO:0044877,GO:0048471,GO:1904262,GO:1904262,GO:1904262,GO:1904262,GO:1990130,GO:1990130,GO:1990130
KEGG Annotation:
GeneSymbol
GeneID
Pathway
Pathway Name
DEPDC5
hsa:9681
path:hsa04150
mTOR signaling pathway - Homo sapiens (human)
Protein-Protein Interaction(String):
Signalink 3.0 modificators
Source
Target
Pmid
Interactiontype
Methods
Database
AR
DEPDC5
20610535
trascriptional regulation,stimulation
chromatin immunoprecipitation array
TFlink
ETS1
DEPDC5
20019798
trascriptional regulation,stimulation
chromatin immunoprecipitation assay
TFlink
GATA2
DEPDC5
18971253
19941826
trascriptional regulation,stimulation
inferred by curator,chromatin immunoprecipitation assay
TFlink
YBX1
DEPDC5
19151767
trascriptional regulation,stimulation
chromatin immunoprecipitation assay
TFlink
SMARCA4
DEPDC5
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
CEBPA
DEPDC5
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
CTCF
DEPDC5
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
E2F4
DEPDC5
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
EGR1
DEPDC5
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
FOXA1
DEPDC5
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
FOS
DEPDC5
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
HNF4A
DEPDC5
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
MITF
DEPDC5
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
Source
Target
Pmid
Interactiontype
Methods
Database
URS0000237AF9
DEPDC5
18185580
25416803
mrna cleavage,inhibition
array technology
TarBase
URS00001597DC
DEPDC5
23622248
25416803
mrna cleavage,inhibition
clash
TarBase
Source
Target
Pmid
Interactiontype
Methods
Database
JUN
DEPDC5
24234451
25348397
25609649
association
anti bait coimmunoprecipitation
ComPPI,IntAct
RRAGC
DEPDC5
25348397
N/A
anti tag coimmunoprecipitation,physical interaction,physical interaction
ComPPI
RRAGB
DEPDC5
25348397
N/A
physical interaction
ComPPI
RRAGA
DEPDC5
25348397
N/A
anti tag coimmunoprecipitation,physical interaction,physical interaction
ComPPI
KPTN
DEPDC5
25348397
N/A
physical interaction
ComPPI
NPRL2
DEPDC5
24234451
25263562
25348397
association
anti tag coimmunoprecipitation,physical interaction
ComPPI,IntAct
H2BC9
DEPDC5
24234451
30021884
physical association
cross-linking study
IntAct
Visualization