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GENE：EIF4G2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol EIF4G2
FullNmae eukaryotic translation initiation factor 4 gamma 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:3297
EnsembleID ENSG00000110321
Uniprot P78344

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
EIF4G2 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
EIF4G2 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
EIF4G2 GO:0003723,GO:0003729,GO:0003743,GO:0003743,GO:0005515,GO:0005829,GO:0005829,GO:0005912,GO:0006413,GO:0006446,GO:0007507,GO:0008135,GO:0008219,GO:0009059,GO:0010507,GO:0016020,GO:0016281,GO:0016281,GO:0030307,GO:0030424,GO:0045296,GO:0045727,GO:0045773,GO:0051726,GO:0060999

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
EIF4G2 hsa:1982 path:hsa05416 Viral myocarditis - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
EIF4E EIF4G2 16467844 17289916 23180781 29145629 physical association affinity chromatography technology,inferred by curator InnateDB,Reactome
EIF4G2 MKNK1 23180781 9878069 physical association anti tag coimmunoprecipitation InnateDB
EIF4G2 EIF4E3 17289916 29145629 physical association inferred by curator Reactome
EIF4G2 EIF4A2 17289916 29145629 physical association inferred by curator Reactome
EIF4A1 EIF4G2 17289916 29145629 physical association inferred by curator Reactome
EIF4E2 EIF4G2 17289916 29145629 physical association inferred by curator Reactome
EIF4G2 ARIH1 17289916 29145629 physical association inferred by curator Reactome

Source Target Pmid Interactiontype Methods Database
AR EIF4G2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 EIF4G2 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 EIF4G2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
PRDM14 EIF4G2 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 EIF4G2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA EIF4G2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF EIF4G2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS EIF4G2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A EIF4G2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
JUN EIF4G2 N/A trascriptional regulation,stimulation inferred by curator TFlink
POU2F1 EIF4G2 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000338542 EIF4G2 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS0000237CBD EIF4G2 21572407 23592263 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000029979D EIF4G2 21572407 23592263 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000A07C1 EIF4G2 21572407 23592263 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000324096 EIF4G2 18668040 21572407 23592263 25416803 27292025 mrna cleavage,inhibition experimental interaction detection,clip TarBase
URS000016C318 EIF4G2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00004505E4 EIF4G2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00005651EE EIF4G2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000F0F49 EIF4G2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001597DC EIF4G2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000021D7C8 EIF4G2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000039E1E1 EIF4G2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000DDD35 EIF4G2 22473208 23622248 25416803 mrna cleavage,inhibition clip,clash TarBase
URS00000C85B2 EIF4G2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000042E1F EIF4G2 22473208 23622248 25416803 mrna cleavage,inhibition clip,clash TarBase
URS00002075FA EIF4G2 22473208 23622248 25416803 mrna cleavage,inhibition clip,clash TarBase
URS00000600E6 EIF4G2 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000021D08 EIF4G2 21572407 23592263 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000246356 EIF4G2 20371350 21572407 23592263 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000C48FA EIF4G2 21572407 23592263 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00001799A3 EIF4G2 20371350 21572407 23592263 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00004526F6 EIF4G2 21572407 23592263 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000000B1C9 EIF4G2 21572407 23592263 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000031E12 EIF4G2 21572407 23592263 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000032EF64 EIF4G2 21572407 23592263 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000122ED0 EIF4G2 21572407 23592263 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000075994C EIF4G2 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000B0E50 EIF4G2 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000054D341 EIF4G2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000065FDF EIF4G2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00000D5659 EIF4G2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00000C5BAA EIF4G2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000003ABC4 EIF4G2 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 EIF4G2 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 EIF4G2 22473208 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
SNW1 EIF4G2 20467437 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
CDC5L EIF4G2 20467437 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
CIAO1 EIF4G2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
EIF3H EIF4G2 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
NPM1 EIF4G2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SKIL EIF4G2 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MAGEA1 EIF4G2 25348397 N/A physical interaction ComPPI
MAGEA6 EIF4G2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
QPRT EIF4G2 25348397 N/A physical interaction ComPPI
DCUN1D1 EIF4G2 25348397 N/A physical interaction ComPPI
KEAP1 EIF4G2 25348397 N/A physical interaction ComPPI
MCM2 EIF4G2 25348397 N/A physical interaction ComPPI
OPTN EIF4G2 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
EIF5 EIF4G2 25348397 N/A in vitro ComPPI
CASP3 EIF4G2 25348397 N/A in vitro,in vivo ComPPI
EIF4G1 EIF4G2 25348397 N/A physical interaction ComPPI
RAB7A EIF4G2 25348397 N/A physical interaction ComPPI
NTRK1 EIF4G2 25348397 N/A physical interaction ComPPI
CDH1 EIF4G2 25348397 N/A physical interaction ComPPI
HSPA5 EIF4G2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EIF2S1 EIF4G2 16932749 24234451 25348397 colocalization,physical association cosedimentation through density gradient,pull down ComPPI,IntAct
EIF3F EIF4G2 25348397 N/A physical interaction ComPPI
XPO1 EIF4G2 25348397 N/A physical interaction ComPPI
RPA2 EIF4G2 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CYP1A1 EIF4G2 25348397 N/A physical interaction ComPPI
EGFR EIF4G2 25348397 N/A physical interaction ComPPI
HSPB1 EIF4G2 24234451 25277244 25348397 physical association anti bait coimmunoprecipitation,reverse ras recruitment system,physical interaction ComPPI,IntAct
VCAM1 EIF4G2 22623428 24234451 25348397 association cross-linking study ComPPI,IntAct
ITGA4 EIF4G2 25348397 N/A physical interaction ComPPI
NCBP1 EIF4G2 25348397 N/A in vivo ComPPI
EIF2S2 EIF4G2 16932749 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,in vitro,in vivo ComPPI,IntAct
EIF3J EIF4G2 16932749 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
EIF4B EIF4G2 25348397 N/A physical interaction ComPPI
EIF4G2 EIF3A 25348397 N/A physical interaction,in vitro,in vivo ComPPI
EIF4G2 EIF4A1 16166382 16932749 24234451 25348397 physical association anti tag coimmunoprecipitation,isothermal titration calorimetry,molecular sieving,nuclear magnetic resonance,pull down,physical interaction,in vitro,in vivo ComPPI,IntAct
EIF4G2 EIF4A2 11172724 17353931 24234451 25348397 physical association affinity chromatography technology,anti bait coimmunoprecipitation,physical interaction,in vitro ComPPI,IntAct
EIF4G2 EIF4E 25348397 N/A in vitro ComPPI
EIF4G2 MKNK1 25348397 N/A physical interaction ComPPI
EIF4G2 EIF4G3 25348397 N/A physical interaction ComPPI
EIF4G2 EIF4H 25348397 N/A physical interaction ComPPI
EIF4G2 SLIRP 25348397 N/A physical interaction ComPPI
EIF4G2 POLDIP3 25348397 N/A physical interaction ComPPI
EIF4G2 FN1 25348397 N/A physical interaction ComPPI
EIF4G2 UNK 25348397 N/A physical interaction ComPPI
EIF4G2 RNF126 25348397 N/A physical interaction ComPPI
EIF4G2 G3BP1 25348397 N/A physical interaction ComPPI
EIF4G2 PTP4A3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
EIF4G2 GSTK1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
EIF4G2 C1QTNF9 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
EIF4G2 PTBP3 22575643 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
EIF4G2 BCAR1 24234451 25348397 28007913 association anti bait coimmunoprecipitation ComPPI,IntAct
EIF4G2 RRP1B 20926688 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
TRAF2 EIF4G2 24234451 30561431 association virotrap IntAct
TANK EIF4G2 24234451 30561431 association virotrap IntAct
EIF4G2 APAF1 11943866 27898060 stimulant N/A OmniPath
CASP3 EIF4G2 10371215 10611228 10672017 11175261 27898060 inhibition,stimulant N/A OmniPath
EIF4G2 BCL2 18450493 27898060 stimulant N/A OmniPath
EIF3J EIF4G2 11022043 16932749 27898060 stimulant N/A OmniPath
EIF4G2 XIAP 11943866 27898060 stimulant N/A OmniPath
EIF4G2 CDK1 18450493 27898060 stimulant N/A OmniPath
EIF4G2 BIRC2 14960583 27898060 stimulant N/A OmniPath
EIF4E EIF4G2 10394359 10944120 16467844 27898060 N/A N/A OmniPath
MKNK1 EIF4G2 27898060 9878069 N/A N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00009B5165 EIF4G2 27087310 direct interaction,inhibition N/A NPInter

Visualization










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