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GENE：HMOX1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol HMOX1
FullNmae heme oxygenase 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:5013
EnsembleID ENSG00000100292
Uniprot P09601

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
HMOX1 parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
HMOX1 mpt 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
HMOX1 lysosomal_cd 36341760 220 lysosome-dependent cell death genes. retulator signature
HMOX1 lysosomal_cd 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
HMOX1 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
HMOX1 ferroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
HMOX1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
HMOX1 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
HMOX1 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
HMOX1 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
HMOX1 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
HMOX1 GO:0001525,GO:0001935,GO:0002246,GO:0002686,GO:0004392,GO:0004392,GO:0004392,GO:0005198,GO:0005515,GO:0005615,GO:0005634,GO:0005654,GO:0005741,GO:0005783,GO:0005783,GO:0005789,GO:0005789,GO:0005789,GO:0005829,GO:0006788,GO:0006788,GO:0006879,GO:0006879,GO:0006979,GO:0006979,GO:0014806,GO:0016020,GO:0016236,GO:0016239,GO:0016242,GO:0019899,GO:0020037,GO:0020037,GO:0032722,GO:0034101,GO:0034383,GO:0034395,GO:0034605,GO:0035094,GO:0035556,GO:0042167,GO:0042167,GO:0042542,GO:0042802,GO:0042803,GO:0043123,GO:0043619,GO:0045765,GO:0045766,GO:0046872,GO:0048471,GO:0048661,GO:0048662,GO:0051090,GO:0060586,GO:0071243,GO:0071276,GO:0071456,GO:0072719,GO:0090050,GO:1902042,GO:1903589,GO:1904019,GO:1904037

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
HMOX1 hsa:3162 path:hsa00860 Porphyrin metabolism - Homo sapiens (human)
HMOX1 hsa:3162 path:hsa01100 Metabolic pathways - Homo sapiens (human)
HMOX1 hsa:3162 path:hsa04066 HIF-1 signaling pathway - Homo sapiens (human)
HMOX1 hsa:3162 path:hsa04216 Ferroptosis - Homo sapiens (human)
HMOX1 hsa:3162 path:hsa04978 Mineral absorption - Homo sapiens (human)
HMOX1 hsa:3162 path:hsa05200 Pathways in cancer - Homo sapiens (human)
HMOX1 hsa:3162 path:hsa05206 MicroRNAs in cancer - Homo sapiens (human)
HMOX1 hsa:3162 path:hsa05208 Chemical carcinogenesis - reactive oxygen species - Homo sapiens (human)
HMOX1 hsa:3162 path:hsa05225 Hepatocellular carcinoma - Homo sapiens (human)
HMOX1 hsa:3162 path:hsa05418 Fluid shear stress and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
NFE2L2 HMOX1 10441483 10821856 10874044 11279008 11909699 12356737 12511571 15521073 16219762 17512463 18761713 19027064 19747488 23850759 26192618 interaction type N/A ACSN
BACH1 HMOX1 10821856 10874044 12356737 12511571 26192618 interaction type N/A ACSN
HMOX1 NOS2 11399519 11875494 15644117 16127449 17260466 17689680 22461508 23390297 26192618 6357187 8871614 interaction type N/A ACSN
HMOX1 MMP9 11399519 11875494 15644117 16127449 17260466 17689680 22461508 23390297 26192618 6357187 8871614 interaction type N/A ACSN
HMOX1 TNF 11399519 11875494 15644117 16127449 17260466 17689680 22461508 23390297 26192618 6357187 8871614 interaction type N/A ACSN
HMOX1 HNRNPD 19289500 23180781 physical association anti tag coimmunoprecipitation InnateDB
HMOX1 TIA1 19289500 23180781 physical association anti tag coimmunoprecipitation InnateDB
HMOX1 TIAL1 19289500 23180781 physical association anti tag coimmunoprecipitation InnateDB
HMOX1 ILF3 19289500 23180781 physical association affinity chromatography technology,anti tag coimmunoprecipitation InnateDB
HMOX1 ELAVL1 19289500 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR HMOX1 11965035 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
E2F4 HMOX1 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
HIF1A HMOX1 19828020 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
MYC HMOX1 12695333 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 HMOX1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
USF1 HMOX1 15242350 18971253 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
USF2 HMOX1 15242350 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 HMOX1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA HMOX1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 HMOX1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 HMOX1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 HMOX1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 HMOX1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS HMOX1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A HMOX1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF HMOX1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 HMOX1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 HMOX1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
BACH1 HMOX1 17409198 17942419 18550526 21982894 trascriptional regulation,stimulation inferred by curator TFlink
BRIP1 HMOX1 17409198 17942419 18550526 21982894 trascriptional regulation,stimulation inferred by curator TFlink
CREB1 HMOX1 14523007 trascriptional regulation,stimulation inferred by curator TFlink
ERG HMOX1 10022513 trascriptional regulation,stimulation inferred by curator TFlink
KCNH2 HMOX1 10022513 trascriptional regulation,stimulation inferred by curator TFlink
ETS1 HMOX1 10022513 trascriptional regulation,stimulation inferred by curator TFlink
FLI1 HMOX1 10022513 trascriptional regulation,stimulation inferred by curator TFlink
NFE2L2 HMOX1 16551619 17942419 21982894 22459801 22484158 24035498 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 HMOX1 8016102 trascriptional regulation,stimulation inferred by curator TFlink
PPARA HMOX1 17413033 trascriptional regulation,stimulation inferred by curator TFlink
PPARG HMOX1 17413033 trascriptional regulation,stimulation inferred by curator TFlink
RELA HMOX1 8016102 trascriptional regulation,stimulation inferred by curator TFlink
SMAD7 HMOX1 11018038 trascriptional regulation,stimulation inferred by curator TFlink
SREBF1 HMOX1 17452746 trascriptional regulation,stimulation inferred by curator TFlink
STAT1 HMOX1 19129475 trascriptional regulation,stimulation inferred by curator TFlink
STAT3 HMOX1 19129475 trascriptional regulation,stimulation inferred by curator TFlink
TFAP2A HMOX1 8016102 trascriptional regulation,stimulation inferred by curator TFlink
NFIC HMOX1 N/A trascriptional regulation,stimulation inferred by curator TFlink
SP1 HMOX1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00003380CC HMOX1 20633528 rna interference,inhibition western blot,quantitative reverse transcription pcr miRSponge
URS0000237AF9 HMOX1 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS0000521626 HMOX1 17612493 25416803 mrna cleavage,inhibition array technology TarBase
URS00003380CC HMOX1 17612493 20633528 25416803 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr TarBase
URS000003ABC4 HMOX1 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS00004D84DB HMOX1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001067D1 HMOX1 23592263 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001F373E HMOX1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000027F5F3 HMOX1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000045ED38 HMOX1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000221168 HMOX1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000047E28E HMOX1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000022AAA HMOX1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000075E2C3 HMOX1 23592263 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000011DF HMOX1 23592263 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000224AEA HMOX1 23592263 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000013ABA3 HMOX1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000000EF0B HMOX1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00005F305A HMOX1 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
AKT1 HMOX1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
HMOX1 BLVRB 25361965 interaction type N/A PTMCode2
BLVRB HMOX1 25361965 interaction type N/A PTMCode2
HMOX1 AKT1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
TBC1D22B HMOX1 25348397 N/A physical interaction ComPPI
LMNA HMOX1 25348397 N/A physical interaction ComPPI
KASH5 HMOX1 25348397 N/A two hybrid,physical interaction ComPPI
HMOX1 AKT1 14525934 15581622 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
HMOX1 POR 12626517 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
HMOX1 BLVRB 12626517 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
HMOX1 NOS1 11849436 14525934 25348397 27898060 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
HMOX1 UFD1 25348397 N/A physical interaction ComPPI
HMOX1 PSMD2 25348397 N/A physical interaction ComPPI
HMOX1 ELAVL1 25348397 N/A physical interaction ComPPI
HMOX1 TERF1 21044950 24234451 25348397 physical association physical interaction,bimolecular fluorescence complementation ComPPI,IntAct
HMOX1 POT1 21044950 24234451 25348397 physical association pull down,physical interaction,bimolecular fluorescence complementation ComPPI,IntAct
HMOX1 TUT1 25348397 N/A physical interaction ComPPI
HMOX1 ASL 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
HMOX1 DERL1 25348397 N/A physical interaction ComPPI
HMOX1 SYVN1 25348397 N/A physical interaction ComPPI
HMOX1 SRPRB 25348397 N/A physical interaction ComPPI
HMOX1 UGT8 25348397 N/A physical interaction ComPPI
HMOX1 TEX264 25348397 N/A physical interaction ComPPI
HMOX1 HLA-C 25348397 N/A physical interaction ComPPI
HMOX1 NRG1 25348397 N/A physical interaction ComPPI
HMOX1 ZSCAN20 25348397 N/A physical interaction ComPPI
HMOX1 CDC20B 25348397 N/A physical interaction ComPPI
HMOX1 CHRNA9 25348397 N/A physical interaction ComPPI
HMOX1 CREB3 21516116 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
HMOX1 ADAM33 25348397 N/A physical interaction ComPPI
HMOX1 LRRC27 25348397 N/A physical interaction ComPPI
HMOX1 CDK15 25348397 N/A physical interaction ComPPI
HMOX1 C5AR2 25348397 N/A physical interaction ComPPI
HMOX1 SLC39A8 25348397 N/A physical interaction ComPPI
HMOX1 PCDHAC2 25348397 N/A physical interaction ComPPI
HMOX1 ADGRE5 25348397 N/A physical interaction ComPPI
HMOX1 STIM2 25348397 N/A physical interaction ComPPI
HMOX1 ERGIC3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
HMOX1 FAM210B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
HMOX1 SEC11C 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
HMOX1 STX1A 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
HMOX1 CYBRD1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
HMOX1 COQ9 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
HMOX1 JAGN1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
HMOX1 TMEM14B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
HMOX1 PDZK1IP1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
HMOX1 CPLX4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
HMOX1 ARL13B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
HMOX1 CD79A 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
HMOX1 TLCD4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
HMOX1 GPR152 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
HMOX1 SLC16A7 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
HMOX1 TM4SF19 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
HMOX1 FAM209A 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
HMOX1 AQP6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
HMOX1 ELOVL4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
HMOX1 FAM174A 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
HMOX1 MSMO1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
HMOX1 CYB561 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DDX19B HMOX1 25348397 N/A physical interaction ComPPI
CPSF1 HMOX1 25348397 N/A physical interaction ComPPI
HMOX1 HMOX1 12500973 14525934 N/A experimental interaction detection HPRD
PTGER4 HMOX1 24234451 28298427 physical association ubiquitin reconstruction IntAct
SMO HMOX1 24234451 28298427 physical association ubiquitin reconstruction IntAct
BLVRA HMOX1 14988408 27898060 stimulant N/A OmniPath
AKT1 HMOX1 15581622 27898060 stimulant N/A OmniPath
TNF HMOX1 18202225 27898060 N/A N/A OmniPath
NFE2L2 HMOX1 18241676 18535259 27898060 stimulant N/A OmniPath
HMOX1 HBA1 10490932 27898060 inhibition N/A OmniPath
MT3 HMOX1 18554677 27898060 stimulant N/A OmniPath

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