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GENE：HSPB8

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol HSPB8
FullNmae heat shock protein family B (small) member 8
LocusType gene with protein product
Status Approved
HGNC_id HGNC:30171
EnsembleID ENSG00000152137
Uniprot Q9UJY1

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
HSPB8 pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
HSPB8 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
HSPB8 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
HSPB8 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
HSPB8 GO:0005515,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0005737,GO:0005737,GO:0005829,GO:0034620,GO:0034620,GO:0042802,GO:0042803,GO:0101031,GO:0101031,GO:1905337

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ESR1 HSPB8 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA3 HSPB8 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXA1 HSPB8 18971253 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 HSPB8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA HSPB8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF HSPB8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 HSPB8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 HSPB8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS HSPB8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 HSPB8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 HSPB8 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00002971AB HSPB8 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000042935A HSPB8 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00005ACA7C HSPB8 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00000AA464 HSPB8 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00002B7450 HSPB8 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00003E226A HSPB8 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000010BD8D HSPB8 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000013ABA3 HSPB8 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS0000412AC7 HSPB8 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS0000759EB8 HSPB8 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000002103A HSPB8 24398324 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PRKACA HSPB8 22135298 phosphorylation N/A PhosphoSite
MAPK3 HSPB8 22135298 phosphorylation N/A PhosphoSite
HSPB1 HSPB8 25361965 interaction type N/A PTMCode2
HSPB8 HSPB1 25361965 interaction type N/A PTMCode2
HSPB8 HSPB2 25361965 interaction type N/A PTMCode2
HSPB2 HSPB8 25361965 interaction type N/A PTMCode2
HSPB8 BAG3 25361965 interaction type N/A PTMCode2
BAG3 HSPB8 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
QRICH1 HSPB8 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
BAG3 HSPB8 11591653 14525934 16189514 21516116 24234451 25036637 25348397 26496610 association,physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,in vivo,luminescence based mammalian interactome mapping,two hybrid prey pooling approach ComPPI,HPRD,IntAct
CRYAB HSPB8 16225851 24234451 25348397 physical association two hybrid,fluorescent resonance energy transfer,physical interaction ComPPI,IntAct
TRAPPC6A HSPB8 25348397 N/A two hybrid ComPPI
RPIA HSPB8 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
KCTD13 HSPB8 25348397 N/A physical interaction ComPPI
NUDT12 HSPB8 25348397 N/A physical interaction ComPPI
DUSP12 HSPB8 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
HSPB8 PRKCA 11342557 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
HSPB8 MAPK3 11342557 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
HSPB8 CSNK2A1 11342557 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
HSPB8 HSPB1 11342557 14525934 14594798 15122253 24234451 25348397 physical association two hybrid,experimental interaction detection,fluorescent resonance energy transfer,physical interaction,in vitro,two hybrid ComPPI,HPRD,IntAct
HSPB8 HSPB7 14594798 16189514 24234451 25348397 25416956 physical association anti tag coimmunoprecipitation,two hybrid,fluorescent resonance energy transfer,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
HSPB8 HSPB6 14525934 16225851 24234451 25348397 physical association two hybrid,experimental interaction detection,fluorescent resonance energy transfer,physical interaction,in vivo,two hybrid ComPPI,HPRD,IntAct
HSPB8 HSPB2 14594798 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,fluorescent resonance energy transfer,physical interaction ComPPI,IntAct
HSPB8 HSPB3 16225851 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
HSPB8 SNCA 25348397 N/A physical interaction ComPPI
HSPB8 CIAPIN1 25348397 N/A physical interaction ComPPI
HSPB8 DSTN 25348397 N/A physical interaction ComPPI
HSPB8 ASB4 25348397 N/A physical interaction ComPPI
HSPB8 DNAJB6 25348397 N/A physical interaction ComPPI
HSPB8 XPO1 25348397 N/A physical interaction ComPPI
HSPB8 KIF11 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HSPB8 LONRF2 25348397 N/A physical interaction ComPPI
HSPB8 BRCA2 25348397 N/A physical interaction ComPPI
HSPB8 FAM83H 25348397 N/A physical interaction ComPPI
HSPB8 ACAD11 25348397 N/A physical interaction ComPPI
HSPB8 SETD2 25348397 N/A physical interaction ComPPI
HSPB8 VWA8 25348397 N/A physical interaction ComPPI
HSPB8 ZNF92 25348397 N/A physical interaction ComPPI
HSPB8 RFX1 25348397 N/A physical interaction ComPPI
HSPB8 ALMS1 25348397 N/A physical interaction ComPPI
HSPB8 EXPH5 25348397 N/A physical interaction ComPPI
HSPB8 WDR20 25348397 N/A physical interaction ComPPI
HSPB8 ESR1 25348397 N/A physical interaction ComPPI
HSPB8 MLF2 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
HSPB8 SOCS7 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
HSPB8 MISP 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
HSPB8 FAM214B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
HSPB8 C2CD6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
HSPB8 SLC16A5 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
EEF1A2 HSPB8 25348397 N/A physical interaction ComPPI
HSPB8 HSPB8 14525934 14594798 24234451 physical association anti tag coimmunoprecipitation,two hybrid,cross-linking study,experimental interaction detection,two hybrid HPRD,IntAct
PRKCA HSPB8 11342557 18212344 22721717 27898060 stimulant N/A OmniPath
MAPK3 HSPB8 11342557 18212344 18298377 20068231 21526341 22721717 27898060 stimulant N/A OmniPath
ZAP70 HSPB8 11342557 27898060 N/A N/A OmniPath

Visualization










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