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GENE：IL10

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol IL10
FullNmae interleukin 10
LocusType gene with protein product
Status Approved
HGNC_id HGNC:5962
EnsembleID ENSG00000136634
Uniprot P22301

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
IL10 immunogenic 37275552 To identify genes associated with ICD, we collected 34 ICD-related genes from previously reported literature. retulator signature
IL10 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
IL10 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
IL10 GO:0001818,GO:0001819,GO:0001938,GO:0002237,GO:0002439,GO:0002639,GO:0002719,GO:0002875,GO:0002904,GO:0005125,GO:0005141,GO:0005515,GO:0005576,GO:0005615,GO:0007165,GO:0007253,GO:0008083,GO:0008285,GO:0009410,GO:0010468,GO:0010507,GO:0014823,GO:0014854,GO:0030097,GO:0030183,GO:0030595,GO:0030886,GO:0030889,GO:0032687,GO:0032689,GO:0032692,GO:0032695,GO:0032701,GO:0032715,GO:0032715,GO:0032717,GO:0032720,GO:0032868,GO:0034115,GO:0034116,GO:0034465,GO:0035729,GO:0042092,GO:0042100,GO:0042130,GO:0042742,GO:0042832,GO:0043032,GO:0043066,GO:0045019,GO:0045191,GO:0045347,GO:0045347,GO:0045348,GO:0045787,GO:0045893,GO:0045893,GO:0045930,GO:0045944,GO:0046427,GO:0046983,GO:0050728,GO:0050728,GO:0050807,GO:0051045,GO:0051091,GO:0051384,GO:0060302,GO:0060670,GO:0071222,GO:0071222,GO:0071392,GO:0071650,GO:0072577,GO:0097421,GO:1900100,GO:1902895,GO:1903034,GO:1903377,GO:1903672,GO:1904706,GO:1904707,GO:2000273

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
IL10 hsa:3586 path:hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
IL10 hsa:3586 path:hsa04061 Viral protein interaction with cytokine and cytokine receptor - Homo sapiens (human)
IL10 hsa:3586 path:hsa04068 FoxO signaling pathway - Homo sapiens (human)
IL10 hsa:3586 path:hsa04148 Efferocytosis - Homo sapiens (human)
IL10 hsa:3586 path:hsa04625 C-type lectin receptor signaling pathway - Homo sapiens (human)
IL10 hsa:3586 path:hsa04630 JAK-STAT signaling pathway - Homo sapiens (human)
IL10 hsa:3586 path:hsa04660 T cell receptor signaling pathway - Homo sapiens (human)
IL10 hsa:3586 path:hsa04672 Intestinal immune network for IgA production - Homo sapiens (human)
IL10 hsa:3586 path:hsa05133 Pertussis - Homo sapiens (human)
IL10 hsa:3586 path:hsa05135 Yersinia infection - Homo sapiens (human)
IL10 hsa:3586 path:hsa05140 Leishmaniasis - Homo sapiens (human)
IL10 hsa:3586 path:hsa05142 Chagas disease - Homo sapiens (human)
IL10 hsa:3586 path:hsa05143 African trypanosomiasis - Homo sapiens (human)
IL10 hsa:3586 path:hsa05144 Malaria - Homo sapiens (human)
IL10 hsa:3586 path:hsa05145 Toxoplasmosis - Homo sapiens (human)
IL10 hsa:3586 path:hsa05146 Amoebiasis - Homo sapiens (human)
IL10 hsa:3586 path:hsa05150 Staphylococcus aureus infection - Homo sapiens (human)
IL10 hsa:3586 path:hsa05152 Tuberculosis - Homo sapiens (human)
IL10 hsa:3586 path:hsa05310 Asthma - Homo sapiens (human)
IL10 hsa:3586 path:hsa05320 Autoimmune thyroid disease - Homo sapiens (human)
IL10 hsa:3586 path:hsa05321 Inflammatory bowel disease - Homo sapiens (human)
IL10 hsa:3586 path:hsa05322 Systemic lupus erythematosus - Homo sapiens (human)
IL10 hsa:3586 path:hsa05330 Allograft rejection - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
IL10 IL10RA 10433356 10542212 10623821 11207245 11875494 12818165 14607900 14610620 15282297 15579430 15833879 16200688 16424049 16713974 17208301 17404308 19833085 20184663 21071413 21115385 21191065 21220452 21840487 23331499 26192618 26755705 7512720 7521688 7543512 8248239 9834059 interaction type,stimulation N/A ACSN,SignaLink,SignaLink
IL10 IL10RB 10433356 10542212 10623821 11207245 11485736 11875494 12818165 14607900 14610620 15282297 15579430 15833879 16200688 16424049 16713974 17208301 17404308 19833085 20184663 21115385 21191065 21220452 21840487 23331499 26192618 26755705 7512720 7521688 7543512 9312047 9834059 interaction type,stimulation N/A ACSN,SignaLink
JAK1 IL10 10433356 10542212 10623821 11207245 11875494 12818165 14607900 14610620 15282297 15579430 15833879 16200688 16424049 16713974 17404308 19833085 20184663 21115385 21191065 21220452 21840487 26192618 26755705 7512720 7521688 7543512 9834059 interaction type N/A ACSN
TYK2 IL10 10433356 10542212 10623821 11207245 11875494 12818165 14607900 14610620 15282297 15579430 15833879 16200688 16424049 16713974 17404308 19833085 20184663 21115385 21191065 21220452 21840487 26192618 26755705 7512720 7521688 7543512 9834059 interaction type N/A ACSN
PTPN11 IL10 10358138 11447289 11449354 11572860 12138178 12176909 1238444 12393695 12421919 12707331 12773515 12917349 15169881 15240681 15699106 15713798 16204085 19833085 20363967 20435894 21469115 22483603 22513334 22683124 22952938 22955274 25355530 26192618 26667266 26755705 27474009 8976179 8986721 9751747 9765283 interaction type N/A ACSN
PTPN6 IL10 10358138 11447289 11449354 11572860 12138178 12176909 1238444 12393695 12421919 12707331 12773515 12917349 15169881 15240681 15699106 15713798 16204085 19833085 20363967 20435894 21469115 22483603 22513334 22683124 22952938 22955274 25355530 26192618 26667266 26755705 27474009 8976179 8986721 9751747 9765283 interaction type N/A ACSN
TIGIT IL10 22285893 22427644 25866972 26192618 26755705 26763253 27620276 28893624 interaction type N/A ACSN
IL10 CD80 10433356 10542212 10623821 10925299 11207245 11438547 11875494 12193690 12811837 12818165 14607900 15282297 15579430 15749903 15833879 16200688 16424049 16713974 17404308 17485448 20184663 20435894 20547845 21115385 21191065 21220452 23124025 23508573 24378531 26192618 26755705 9834059 interaction type N/A ACSN
MAF IL10 15749884 16713974 17404308 20547845 26192618 interaction type N/A ACSN
MIF IL10 10878343 12782713 12803886 15749884 16283355 16713974 17404308 18490733 20547845 20861157 23390297 26192618 8195715 9637476 interaction type N/A ACSN
CSF1 IL10 11306493 15749884 16713974 17404308 20547845 24669294 26192618 interaction type N/A ACSN
BCL3 IL10 12907458 14668329 15465827 15749884 16713974 17404308 20547845 26192618 interaction type N/A ACSN
FOS IL10 15067049 15749884 16243976 16327802 16393692 16394015 16413922 16713974 17404308 17485448 19667062 20547845 21372296 21385848 22634314 23390297 23430059 26192618 9064320 interaction type N/A ACSN
TRAF3 IL10 15749884 16306937 16713974 17404308 20547845 26192618 interaction type N/A ACSN
CD14 IL10 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
IRAK2 IL10 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
IRAK4 IL10 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
LY96 IL10 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
MYD88 IL10 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
TIRAP IL10 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
FLT3LG IL10 10477595 14670306 15749884 16418395 16713974 17404308 20547845 25215878 26192618 8920882 9268501 interaction type N/A ACSN
DEPTOR IL10 12150925 12408816 12906785 15749884 15755954 16469695 16713974 17404308 17604271 17680028 18372248 18492954 19022819 19143636 19446321 19568798 19706736 19864431 20547845 20805416 21157483 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 26192618 28216025 interaction type N/A ACSN
MLST8 IL10 12150925 12408816 12906785 15749884 15755954 16469695 16713974 17404308 17604271 17680028 18372248 18492954 19022819 19143636 19446321 19568798 19706736 19864431 20547845 20805416 21157483 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 26192618 28216025 interaction type N/A ACSN
MTOR IL10 12150925 12408816 12906785 15749884 15755954 16469695 16713974 17404308 17604271 17680028 18372248 18492954 19022819 19143636 19446321 19568798 19706736 19864431 20547845 20805416 21157483 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 26192618 28216025 interaction type N/A ACSN
RPTOR IL10 12150925 12408816 12906785 15749884 15755954 16469695 16713974 17404308 17604271 17680028 18372248 18492954 19022819 19143636 19446321 19568798 19706736 19864431 20547845 20805416 21157483 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 26192618 28216025 interaction type N/A ACSN
IFNG IL10 10485906 11489965 11579131 11777960 11870632 11964313 12413632 12818165 14607900 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 1825141 18272812 19833085 20038811 20819927 21149606 21411734 24658051 26192618 26755705 2965306 6425450 9834059 9864217 interaction type N/A ACSN
CREB1 IL10 11579131 15187187 15749884 16007092 16713974 17404308 20547845 26192618 interaction type N/A ACSN
IRF5 IL10 15749884 16243976 16413922 16713974 17404308 17485448 20547845 21240265 23180781 23390297 26192618 interaction type,physical association anti tag coimmunoprecipitation ACSN,InnateDB
IL10 STAT3 10433356 10542212 10623821 11207245 11875494 12818165 14607900 14610620 15282297 15579430 16200688 16424049 16713974 17404308 19833085 20184663 21115385 21191065 21220452 21840487 26192618 26755705 7512720 7521688 7543512 9834059 interaction type N/A ACSN
IL10 NFKBID 10433356 10542212 10623821 10925299 11207245 11438547 11875494 12193690 12811837 12818165 14607900 15282297 15579430 15749903 15833879 16200688 16424049 16713974 17404308 17485448 20184663 20435894 20547845 21115385 21191065 21220452 23124025 23508573 24378531 26192618 26755705 9834059 interaction type N/A ACSN
IL10 TNIP3 10433356 10542212 10623821 10925299 11207245 11438547 11875494 12193690 12811837 12818165 14607900 15282297 15579430 15749903 15833879 16200688 16424049 16713974 17404308 17485448 20184663 20435894 20547845 21115385 21191065 21220452 23124025 23508573 24378531 26192618 26755705 9834059 interaction type N/A ACSN
IL10 THBS1 10433356 10542212 10623821 10925299 11207245 11438547 11875494 12193690 12811837 12818165 14607900 15282297 15579430 15749903 15833879 16200688 16424049 16713974 17404308 17485448 20184663 20435894 20547845 21115385 21191065 21220452 23124025 23508573 24378531 26192618 26755705 9834059 interaction type N/A ACSN
IL10 ICAM1 10433356 10542212 10623821 10925299 11207245 11438547 11875494 12193690 12811837 12818165 14607900 15282297 15579430 15749903 15833879 16200688 16424049 16713974 17404308 17485448 20184663 20435894 20547845 21115385 21191065 21220452 23124025 23508573 24378531 26192618 26755705 9834059 interaction type N/A ACSN
IL10 DUSP1 10433356 10542212 10623821 10925299 11207245 11438547 11875494 12193690 12811837 12818165 14607900 15282297 15579430 15749903 15833879 16200688 16424049 16713974 17404308 17485448 20184663 20435894 20547845 21115385 21191065 21220452 23124025 23508573 24378531 26192618 26755705 9834059 interaction type N/A ACSN
IRAK1 IL10 15465816 23180781 physical association anti tag coimmunoprecipitation InnateDB
IL10RA IL10 10788470 11717514 23180781 9568901 physical association filter binding,isothermal titration calorimetry,x-ray crystallography InnateDB
RELA IL10 19122653 23180781 physical association anti tag coimmunoprecipitation InnateDB
IL10 IL10 23180781 8590020 physical association x-ray crystallography InnateDB
IFNAR2 IL10 23180781 9312047 physical association cross-linking study InnateDB
HNRNPA1 IL10 19349988 23180781 physical association anti tag coimmunoprecipitation InnateDB
SPI1 IL10 20072143 23180781 physical association anti tag coimmunoprecipitation InnateDB
SP1 IL10 20072143 23180781 physical association anti tag coimmunoprecipitation InnateDB
STAT3 IL10 21257710 21398617 23180781 physical association anti tag coimmunoprecipitation InnateDB
STAT1 IL10 21398617 23180781 physical association anti tag coimmunoprecipitation InnateDB
NFATC2 IL10 21398617 23180781 physical association anti tag coimmunoprecipitation InnateDB
NFATC1 IL10 21398617 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
CREB1 IL10 10540320 17202341 19564345 22140263 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
ETS1 IL10 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 IL10 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 IL10 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 IL10 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SP1 IL10 11278848 17202341 18971253 20072143 21309719 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SPI1 IL10 20072143 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SPIB IL10 20072143 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
VDR IL10 20691220 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay TFlink
FOXP3 IL10 20554955 24315995 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
TBP IL10 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SMARCA4 IL10 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF IL10 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 IL10 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF IL10 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 IL10 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ATF1 IL10 10540320 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA IL10 12219016 trascriptional regulation,stimulation inferred by curator TFlink
CEBPB IL10 12493739 trascriptional regulation,stimulation inferred by curator TFlink
FLI1 IL10 20879862 trascriptional regulation,stimulation inferred by curator TFlink
GATA3 IL10 21507199 trascriptional regulation,stimulation inferred by curator TFlink
HDAC11 IL10 19011628 trascriptional regulation,stimulation inferred by curator TFlink
HDAC4 IL10 17610967 trascriptional regulation,stimulation inferred by curator TFlink
IRF1 IL10 12817009 trascriptional regulation,stimulation inferred by curator TFlink
IRF8 IL10 20709027 trascriptional regulation,stimulation inferred by curator TFlink
MSC IL10 19561533 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 IL10 19124729 9310124 trascriptional regulation,stimulation inferred by curator TFlink
NR1I2 IL10 22285937 trascriptional regulation,stimulation inferred by curator TFlink
PARP1 IL10 20181890 trascriptional regulation,stimulation inferred by curator TFlink
PGR IL10 18685848 trascriptional regulation,stimulation inferred by curator TFlink
REL IL10 9310124 trascriptional regulation,stimulation inferred by curator TFlink
RELA IL10 19124729 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 IL10 11278848 17202341 21309719 trascriptional regulation,stimulation inferred by curator TFlink
STAT1 IL10 20709027 trascriptional regulation,stimulation inferred by curator TFlink
STAT3 IL10 10903771 12817009 15034082 17404037 18403020 18765795 19124156 trascriptional regulation,stimulation inferred by curator TFlink
TBX21 IL10 21507199 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 IL10 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000039E1E1 IL10 19307576 \N rna interference,inhibition quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS000039E1E1 IL10 19307576 25416803 mrna cleavage,inhibition quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000031E12 IL10 22835429 25416803 mrna cleavage,inhibition quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000122ED0 IL10 25416803 26367177 27605397 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000006FDD4 IL10 25416803 28386366 mrna cleavage,inhibition experimental interaction detection,western blot,chromatin immunoprecipitation assay,quantitative reverse transcription pcr TarBase
URS00000EED18 IL10 25416803 28097098 mrna cleavage,inhibition array technology TarBase
URS00000F6E49 IL10 25416803 26580839 mrna cleavage,inhibition experimental interaction detection,experimental interaction detection,quantitative reverse transcription pcr TarBase

Source Target Pmid Interactiontype Methods Database
KRTAP10-8 IL10 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
GLRX3 IL10 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
YY1 IL10 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
A2M IL10 10714547 14525934 24234451 25241761 25348397 27898060 physical association experimental interaction detection,physical interaction,proximity ligation assay ComPPI,HPRD,IntAct,OmniPath
IL10RB IL10 11485736 12513909 14525934 20462497 24234451 25348397 9312047 physical association cross-linking study,experimental interaction detection,surface plasmon resonance,physical interaction,surface plasmon resonance array ComPPI,HPRD,IntAct
IL10RA IL10 10231374 11485736 11717514 12513909 14525934 15837194 20462497 24234451 25348397 7759550 8248239 8897595 enzymatic reaction,physical association affinity chromatography technology,experimental interaction detection,isothermal titration calorimetry,molecular sieving,surface plasmon resonance,x-ray crystallography,physical interaction,enzyme linked immunosorbent assay,surface plasmon resonance array ComPPI,HPRD,IntAct
NOTCH2NLA IL10 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
IL10 IL10 11717514 12513909 14525934 24234451 7759550 8590020 N/A experimental interaction detection,molecular sieving HPRD,IntAct
ATF1 IL10 20154735 27898060 stimulant N/A OmniPath
IL10 NFKB1 12773629 27898060 inhibition N/A OmniPath
GATA3 IL10 20154735 27898060 stimulant N/A OmniPath
MAF IL10 15749884 27898060 stimulant N/A OmniPath
IL10 IL10RA 10231374 10347215 10788470 11485736 11591769 11717514 12513909 15837194 17208301 20462497 26260587 27898060 7759550 8120391 8248239 8897595 9568901 stimulant N/A OmniPath
IRF5 IL10 21240265 27898060 N/A N/A OmniPath
SP1 IL10 18843277 27898060 stimulant N/A OmniPath
IL10 IL10RB 10347215 11035029 11485736 20462497 27898060 9312047 stimulant N/A OmniPath
IL10 IFNAR2 27898060 9312047 N/A N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00009C1B34 IL10 27087310 direct interaction,inhibition N/A NPInter

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