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GENE：IL10RA

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol IL10RA
FullNmae interleukin 10 receptor subunit alpha
LocusType gene with protein product
Status Approved
HGNC_id HGNC:5964
EnsembleID ENSG00000110324
Uniprot Q13651

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
IL10RA autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
IL10RA autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
IL10RA GO:0004920,GO:0004920,GO:0005515,GO:0005829,GO:0005886,GO:0005886,GO:0010507,GO:0016324,GO:0019221,GO:0019969,GO:0032496,GO:0038023,GO:0046427,GO:0050728,GO:0050807,GO:0060729,GO:0070086

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
IL10RA hsa:3587 path:hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
IL10RA hsa:3587 path:hsa04061 Viral protein interaction with cytokine and cytokine receptor - Homo sapiens (human)
IL10RA hsa:3587 path:hsa04630 JAK-STAT signaling pathway - Homo sapiens (human)
IL10RA hsa:3587 path:hsa05145 Toxoplasmosis - Homo sapiens (human)
IL10RA hsa:3587 path:hsa05152 Tuberculosis - Homo sapiens (human)
IL10RA hsa:3587 path:hsa05163 Human cytomegalovirus infection - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
IL10 IL10RA 10433356 10542212 10623821 11207245 11875494 12818165 14607900 14610620 15282297 15579430 15833879 16200688 16424049 16713974 17208301 17404308 19833085 20184663 21071413 21115385 21191065 21220452 21840487 23331499 26192618 26755705 7512720 7521688 7543512 8248239 9834059 interaction type,stimulation N/A ACSN,SignaLink,SignaLink
IL10RB IL10RA 10433356 10542212 10623821 11207245 11875494 12818165 14607900 14610620 15282297 15579430 15833879 16200688 16424049 16713974 17404308 19833085 20184663 21115385 21191065 21220452 21840487 26192618 26755705 7512720 7521688 7543512 9834059 interaction type N/A ACSN
JAK1 IL10RA 10433356 10542212 10623821 11207245 11875494 12818165 14607900 14610620 15282297 15579430 15833879 16200688 16424049 16713974 17404308 19833085 20184663 21115385 21191065 21220452 21840487 26192618 26755705 7512720 7521688 7543512 9834059 interaction type N/A ACSN
TYK2 IL10RA 10433356 10542212 10623821 11207245 11875494 12818165 14607900 14610620 15282297 15579430 15833879 16200688 16424049 16713974 17404308 19833085 20184663 21115385 21191065 21220452 21840487 26192618 26755705 7512720 7521688 7543512 9834059 interaction type N/A ACSN
IL10RA STAT3 10433356 10542212 10582086 10623821 11207245 11875494 12818165 14607900 14610620 15282297 15579430 16200688 16424049 16713974 17404308 19833085 20184663 21115385 21191065 21220452 21840487 23331499 26192618 26755705 7512720 7521688 7543512 9834059 interaction type,stimulation N/A ACSN,SignaLink,SignaLink
IL10RA IL10 10788470 11717514 23180781 9568901 physical association filter binding,isothermal titration calorimetry,x-ray crystallography InnateDB
IFNAR2 IL10RA 23180781 9312047 physical association anti tag coimmunoprecipitation,cross-linking study InnateDB
IL10RA JAK1 12133952 12974481 23180781 23331499 stimulation,physical association pull down InnateDB,SignaLink,SignaLink
IL10RA TYK2 12974481 23331499 stimulation N/A SignaLink,SignaLink

Source Target Pmid Interactiontype Methods Database
GATA1 IL10RA 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 IL10RA 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 IL10RA 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 IL10RA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF IL10RA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 IL10RA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 IL10RA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 IL10RA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS IL10RA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 IL10RA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 IL10RA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 IL10RA 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000003575B IL10RA 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000075AB0E IL10RA 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000258D51 IL10RA 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001D6605 IL10RA 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000171CD1 IL10RA 25416803 26631117 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00002367FA IL10RA 25416803 26631117 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000044FD7 IL10RA 25416803 26631117 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
IL10RA STAT3 25361965 interaction type N/A PTMCode2
STAT3 IL10RA 25361965 interaction type N/A PTMCode2
IL10RA IL10RB 25361965 interaction type N/A PTMCode2
IL10RB IL10RA 25361965 interaction type N/A PTMCode2
IL10RA JAK1 25361965 interaction type N/A PTMCode2
JAK1 IL10RA 25361965 interaction type N/A PTMCode2
IL10RA JAK2 25361965 interaction type N/A PTMCode2
JAK2 IL10RA 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
SMCO4 IL10RA 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TMEM242 IL10RA 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BTRC IL10RA 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
JAK1 IL10RA 10433356 12133952 12374810 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
YIPF6 IL10RA 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CMTM3 IL10RA 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
IL10RB IL10RA 14525934 25348397 9312047 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
IL10RA IL10 10231374 11485736 11717514 12513909 14525934 15837194 20462497 24234451 25348397 7759550 8248239 8897595 enzymatic reaction,physical association affinity chromatography technology,experimental interaction detection,isothermal titration calorimetry,molecular sieving,surface plasmon resonance,x-ray crystallography,physical interaction,enzyme linked immunosorbent assay,surface plasmon resonance array ComPPI,HPRD,IntAct
IL10RA NIPAL4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
IL10RA C1QL4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
IL10RA PLPP6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
IL10RA SLC66A2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
IL10RA TMUB2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
IL10RA CDS2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
IL10RA SLC7A14 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
IL10RA RUSF1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
IL10RA SLC38A7 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
IL10RA SELENOK 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
IL10 IL10RA 10231374 10347215 10788470 11485736 11591769 11717514 12513909 15837194 17208301 20462497 26260587 27898060 7759550 8120391 8248239 8897595 9568901 stimulant N/A OmniPath
JAK1 IL10RA 10433356 12133952 12374810 27898060 N/A N/A OmniPath
IL10RA JAK1 10347215 10433356 12133952 12374810 12974481 26260587 27898060 stimulant N/A OmniPath
TYK2 IL10RA 10433356 27898060 N/A N/A OmniPath
IL10RA TYK2 12974481 27898060 stimulant N/A OmniPath
IL10RB IL10RA 15985167 27898060 9312047 N/A N/A OmniPath
IL10RA STAT3 10582086 27898060 stimulant N/A OmniPath
IL10RA JAK2 26260587 27898060 stimulant N/A OmniPath
IL10RA IFNAR2 27898060 9312047 N/A N/A OmniPath

Visualization










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