GENE：IRGM
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | IRGM |
| FullNmae | immunity related GTPase M |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:29597 |
| EnsembleID | ENSG00000237693 |
| Uniprot | A1A4Y4 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| IRGM | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| IRGM | autophagy | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| IRGM | autophagy | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| IRGM | GO:0000045,GO:0000139,GO:0000421,GO:0001891,GO:0001934,GO:0003924,GO:0003924,GO:0003925,GO:0005515,GO:0005525,GO:0005739,GO:0005765,GO:0005789,GO:0005794,GO:0005829,GO:0006952,GO:0006954,GO:0010508,GO:0010508,GO:0010800,GO:0019901,GO:0030670,GO:0030674,GO:0031648,GO:0031902,GO:0031966,GO:0032480,GO:0032689,GO:0033138,GO:0035458,GO:0042742,GO:0042742,GO:0042995,GO:0043032,GO:0043124,GO:0043254,GO:0043539,GO:0043539,GO:0045087,GO:0050687,GO:0050700,GO:0050728,GO:0050821,GO:0050829,GO:0051434,GO:0060335,GO:0061635,GO:0061739,GO:0061762,GO:0061912,GO:0065003,GO:0070431,GO:0071211,GO:0071222,GO:0071902,GO:0097352,GO:0098586,GO:0160049,GO:1900226,GO:1901098,GO:1901526,GO:1904417,GO:1905673 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| IRGM | hsa:345611 | path:hsa04621 | NOD-like receptor signaling pathway - Homo sapiens (human) |
| IRGM | hsa:345611 | path:hsa05145 | Toxoplasmosis - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| GATA2 | IRGM | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | IRGM | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | IRGM | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | IRGM | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | IRGM | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | IRGM | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| BECN1 | IRGM | 25348397 | N/A | physical interaction | ComPPI |
| NOD1 | IRGM | 25348397 | N/A | physical interaction | ComPPI |
| TLR3 | IRGM | 25348397 | N/A | physical interaction | ComPPI |
| ULK1 | IRGM | 25348397 | N/A | physical interaction | ComPPI |
| NOD2 | IRGM | 25348397 | N/A | physical interaction | ComPPI |
| ATG16L1 | IRGM | 25348397 | N/A | physical interaction | ComPPI |
| DDX58 | IRGM | 25348397 | N/A | physical interaction | ComPPI |
| AMBRA1 | IRGM | 25348397 | N/A | physical interaction | ComPPI |
| ATG14 | IRGM | 25348397 | N/A | physical interaction | ComPPI |
| CFL1 | IRGM | 24234451 30021884 | physical association | cross-linking study | IntAct |